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See detailUn héros dans les étoiles : l'ambiguïté d'Orion
Renaud, Jean-Michel ULg

Scientific conference (2001, March 21)

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See detailHéros et héroïnes dans les mythes et les cultes grecs. Actes du colloque de Valladolid (mai 1999)
Pirenne-Delforge, Vinciane ULg

Book published by Centre International d'Etude de la Religion Grecque Antique (2000)

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See detailL'herpes labial récidivant. Comment traiter et prévenir au mieux.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(5-6), 442-7

Labial herpes is a recurrent muco-cutaneous disorder caused by the herpes simplex virus (HSV), particularly the HSV type I. It affects 10 to 30% of the adult population. The recurrence rate varies from ... [more ▼]

Labial herpes is a recurrent muco-cutaneous disorder caused by the herpes simplex virus (HSV), particularly the HSV type I. It affects 10 to 30% of the adult population. The recurrence rate varies from episodic events to monthly recurrences. Several triggering factors have been identified. They include physical factors such as ultraviolet radiations and any local traumatism such as dental and neurosurgical interventions, and dermo-cosmetic procedures of the face. Hormonal factors are also involved including those related to menses and pregnancy. Psychogenic factors, particularly severe stress are also involved. Any other intercurrent infection may also be complicated by recurrent labial herpes. The management of recurrent labial herpes currently relies on the identification and possible avoidance of triggering factors, and on the use of antiviral agents. There is no curative treatment available so far. [less ▲]

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See detailHerpes Simplex Virus Infections of the Nipple
EL HAYDERI, Lara ULg; CAUCANAS, Marie ULg; NIKKELS, Arjen ULg

in Open Dermatology Journal (The) (2012)

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably ... [more ▼]

The usual sites of herpes simplex virus (HSV) type 1 and 2 infections are orolabial and anogenital, respectiverly. HSV infection of the nipple and periareolar area is exceptional but probably underrecognized. Typical features include severe pain and erosive or ulcerated erythematous confluent clusters of lesions of the nipple and periareolar area. It is usually unilateral and not recurring. HSV infection of the nipple is originating from autoinoculation, sexual transmission or breastfeeding. Diagnosis is often delayed. The Tzanck smear is the most rapid and adequate method of dagnosis. Immunohistochemistry enables viral identification. The treatment relies on topical disinfection and oral antiviral therapy, such as aciclovir, famciclovir or valaciclovir. Scarring is uncommon. [less ▲]

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See detailHERPES SIMPLEX VIRUS REACTIVATION AND DENTAL PROCEDURES
EL HAYDERI, Lara ULg; DELVENNE, Philippe ULg; ROMPEN, Eric ULg et al

in Clinical Oral Investigations (2013)

Objectives : Dental extraction is reportes to trigger recurrent herpes labialis (RHL). Aim : This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1 ... [more ▼]

Objectives : Dental extraction is reportes to trigger recurrent herpes labialis (RHL). Aim : This aims to prospectively study the clinical occurrence of RHL and the oral herpes simplex virus type 1 (HSV-1) viral shedding before and 3 days after different dental procedures. Materials and methods : Oral HSV-1 DNA was measured by real-time PCR before and 3 days after dental procedures of the inferior dentition in 57 immunocometent patients (mean age 32.4 years) who were selected and divided into four distinct subgroups (dental inspection without anesthesia, n=14; molar extraction under local anesthesia, n=15; and molar extraction under general anesthesia, n=9) and compared to 32 healthy controls (mean age 33 years). Results : None of the patients suffered from RHL at day 3. Oral HSV-1 DNA was detected before and after procedure in 1.7 % (1/57) and 5.3 % (3/57), respectively [dental inspection without anesthesia, 5.3 % (1/19); molar extraction under local anesthesia, 6.7 % (1/15); and molar extraction under general anesthesia, 11 % (1/9)]. None of the controls presented RHL or detectable oral HSV-1 DNA. There was no statistically significant difference between the study groups and controls. [less ▲]

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See detailHERPES SIMPLEX VIRUS TYPE_i AND PYOGENIC GRANULOMA : A VASCULAR ENDOTHELIAL GROWTH FACTOR-MEDIATED ASSOCIATION?
EL HAYDERI, Lara ULg; PAUROBALLY, Dilshad ULg; FASSOTTE, Marie-France ULg et al

in Case Reports in Dermatology (2013), 5

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not ... [more ▼]

Pyogenic granuloma (PG) is a vascular endothelial growth factor (VEGF)-related neoangiogenic process. Minor trauma, chronic irritation, certain drugs and pregnancy may favor PG. Viral triggers have not been reported up to date. A 52-year-old woman with hairly-cell leukemia presented because of a3-month history of a giant pseudotumoral lesion on her left cheek. All prior antibacterial, antifungal and anti-inflammatory treatments had failed. Histology revealed PG with sparse and isolated epithelial cell aggregates. Immunohistochemistry (IHC) identified herpes simplex virus type-I (HSV-I) antigens in the nuclei and cytoplasm of normal-appearing as well as cytopathic epithelial cells, suggesting a chronic, low-productive HSV infection. No HSV-I signal was evidenced in the endothelial cells of the PG. Furthermore, IHC revealed VEGF in the HSV-I infected epithelial cells as well as within the PG endothelial cells. These results incited oral treatment with valaciclovir, and the PG promptly resolved after 2 weeks. These findings suggest that a chronic HSV-I infection might play and indirect, partial role in neoangiogenesis, presumably via HSV-I infection-related stimulation of keratinocytic VEGF production. [less ▲]

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See detailL'herpes virus de type 6. Quelle attention mérite-t'il en medecine générale?
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(5-6), 317-21

The human herpesvirus 6 (HHV6) is a member of the beta-herpes viridae family. The primary infection is usually asymptomatic and commonly occurs during childhood. The clinical form is called exanthema ... [more ▼]

The human herpesvirus 6 (HHV6) is a member of the beta-herpes viridae family. The primary infection is usually asymptomatic and commonly occurs during childhood. The clinical form is called exanthema subitum, or roseala infantum or the 6th disease. This biphasic disorder usually runs a benign course and requires no antiviral treatment. However, the HHV6 reactivation can lead to serious systemic diseases, especially encephalopathy, that may be fatal in the immunocompromised or grafted patient. In seronegative pregnant women, a primary HHV6 infection contracted from a child with roseola infantum can lead, in rare instances, to spontaneous abortion during the first trimester, or produce neurological complications in the newborn after HHV6 transplacental infection. Aciclovir, ganciclovir (GCV), foscarnet and cidofovir show anti-HHV6 in vitro efficacy, but GCV is currently the first line agent when of HHV6 infection is diagnosed in the immunocompromised patient. [less ▲]

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See detailHerpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Acta Dermato Venereologica (1998), 78

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See detailHerpes zoster in patients treated with biologicals
FAILLA, Valérie ULg; JACQUES, Jessica ULg; CASTRONOVO, Charlotte ULg et al

in Dermatology (2012)

Background : The incidence and severity of herpes zoster (HZ) appear increased in patients receiving tumor necrosis factor-alpha antagonists. Objective : To study the incidence and clinical features of HZ ... [more ▼]

Background : The incidence and severity of herpes zoster (HZ) appear increased in patients receiving tumor necrosis factor-alpha antagonists. Objective : To study the incidence and clinical features of HZ in 1,220 patients (4.206 patient-years) receiving either adalimumab, etanercept, infliximumab, rituximab or ustekinumab. Results: Twenty-two HZ cases were identified (1.26% of total cohort; adalimumab: 11/1,546 patient-years, incidence rate (IR) 7.1; etanercept: 4/789 patient-years, IR5.1; rituximab: 1/168 patient-years, IR 5.2; ustekinumab: 2/37 patient-years, IR53.5; infliximab: 4/1.666 patient-years, IR 2.4). The time to event varied widely (1.5-108 months). Extensive HZ was reported in 45 and 32% of the cases, respectively. Persistent postzoster neuralgia (PHN;>6months) was observed in 5/20 patients. Conclusions: The Hz incidence was 2.1-fold higher among patients over 60 years, compared with a reference population, although not statistically significant. Severe, multidermatomal HZ and persistent PHN were common. [less ▲]

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See detailHerpesviridae granulomas. Letter
Nikkels, Arjen ULg; Pierard, Gérald ULg

in European Journal of Dermatology (1996), 6(5), 394

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See detailL’herpèsvirose canine
Ronsse, V.; Poulet, H.; Verstegen, J. et al

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 65

Canine herpesvirus is known to be a causal agent of reproduction disorders and diseases of the upper respiratory system. Subclinical infections are also frequently observed. The interest for the virus has ... [more ▼]

Canine herpesvirus is known to be a causal agent of reproduction disorders and diseases of the upper respiratory system. Subclinical infections are also frequently observed. The interest for the virus has risen in recent years especially since latency has been demonstrated and a new vaccine has been developed. In this review article we will successively deal with virus characteristics, epidemiology, pathogenesis, clinical signs, diagnosis as well as therapy and prevention. [less ▲]

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See detailHerpèsvirose caprine et faux positifs en IBR?
Thiry, Julien ULg; Thiry, Etienne ULg

in Point Vétérinaire (2008), 285

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See detailLes herpèsviroses des petits ruminants
Thiry, Etienne ULg; Keuser, Véronique; Tempesta, Maria

in Point Vétérinaire (2002), 33(74-76),

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See detailL'herpèsvirus alcélaphin 1, l'agent responsable de la forme africaine du coryza gangreneux
Dewals, Benjamin G ULg; Boudry, Christel ULg; Markine-Goriaynoff, Nicolas ULg et al

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 1-15

Malignant catarrhal fever (MCF) is a pathology usually lethal which has been described in a large number of ruminant species. Based on the etiology, two main forms of MCF have been described, i.e., the ... [more ▼]

Malignant catarrhal fever (MCF) is a pathology usually lethal which has been described in a large number of ruminant species. Based on the etiology, two main forms of MCF have been described, i.e., the European and the African forms due to ovine herpesvirus 2 (OvHV-2) and alcelaphine herpesvirus 1 (AlHV-1), respectively. The present review is devoted to the African form of MCF and to its causative agent AlHV-1. AlHV-1 belongs to the Gammaherpesvirinae subfamily of the Herpesviridae family. Wildebeests (Connochaetes spp) carry AlHV-1, which is lethal for a large number of ruminant species, while apparently harmless to its natural host. In hosts susceptible to MCF, the pathology is characterized by fever, extensive lymphadenopathy, ulcerative lesions of the digestive and the upper respiratory tracts mucous membranes and severe keratoconjunctivitis. In the present paper, we will review the data available to date on AlHV-1 and on the African form of MCF with emphasis on the pathogenesis, clinical signs and anatomo-pathological lesions of MCF. Finally, we will discuss the relationship between AlHV-1 and wildebeest as an example of symbiosis between a virus and its natural host. [less ▲]

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See detailL’herpèsvirus B du singe, un agent d’anthropozoonose méconnu
Meurens, F.; Gallego, P.; Bourgot, I. et al

in Annales de Médecine Vétérinaire (2002), 146(1, FEB-MAR), 1-8

B-virus or Cercopithecine herpesvirus 1 (CeHV-1) is a zoonotic alphaherpesvirus enzootic in Asian monkeys of the genus Macaca that is genetically and antigenically closely related to the human herpesvirus ... [more ▼]

B-virus or Cercopithecine herpesvirus 1 (CeHV-1) is a zoonotic alphaherpesvirus enzootic in Asian monkeys of the genus Macaca that is genetically and antigenically closely related to the human herpesvirus 1 and the human herpesvirus 2. CeHV-1 infection is highly prevalent (80% to 100%) in adult macaques and may lead to fulminant encephalomyelitis with severe aftereffects or even causing death in humans. Since its discovery in 1933, it has been positively linked with two dozen human deaths. B-virus disease in humans usually resulted from breach of primary skin or mucosal defenses and subsequent contamination of the site with virus. Timely antiviral intervention is a good mean of reducing CeHV-1 associated morbidity and preventing a fatal outcome. [less ▲]

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See detailL’herpèsvirus bovin 4
Markine-Goriaynoff, N.; Minner, F.; De Fays, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 215-247

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a ... [more ▼]

Bovine herpesvirus 4 (BoHV-4) belongs to the Herpesviridae family, Gammaherpesvirinae subfamily, Rhadinovirus genus like human herpesvirus 8 (HHV-8), the causative agent of Kaposi's sarcoma. BoHV-4 has a worldwide distribution in the cattle population. It has been isolated from cattle showing various clinical signs as well as from healthy cattle. The interest of the scientific community for BoHV-4 is explained by two reasons. Firstly, BoHV-4 represents an homologous virus/host species model to study the biology of gammaherpesviruses. Secondly, the use of BoHV-4 as a recombinant vector for expression both in vitro and in vivo has been proposed. For these reasons, a considerable amount of data has been collected on this virus. In the present paper, the authors will present a general overview of the literature published on this virus addressing clinical, epidemiological and fundamental aspects of BoHV-4. Finally, in the light of their recent phylogenetic data, the authors will discuss the origin and the host species of BoHV-4 leading to the conclusion that this virus should be considered as a virus of the African buffalo rather than cattle. [less ▲]

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See detailL'herpèsvirus bovin de type 4 : virus pathogène ou passager?
Thiry, Etienne ULg; Markine-Goriaynoff, Nicolas; Minner, Frédéric et al

in Point Vétérinaire (2000), 31

Bovine herpesvirus type 4 (BHV-4) is a ubiquitous herpesvirus in cattle. It has been isolated from animals showing a wide variety of clinical signs but few of the isolates have proven experimental ... [more ▼]

Bovine herpesvirus type 4 (BHV-4) is a ubiquitous herpesvirus in cattle. It has been isolated from animals showing a wide variety of clinical signs but few of the isolates have proven experimental pathogenicity. Species that are susceptible to BHV-4 include animals other than ruminants, notably cats and, surprisingly, a primate the owl monkey (Aotus trivirgatus). BHV-4 exists as a latent infection in mononuclear cells. In cattle, BHV-4 has been isolated in animals exhibiting ocular and respiratory conditions and it has been found in females with genital tract conditions such as post-partum metritis and vulvovaginitis. There is some epidemiological and experimental evidence that BHV-4 may be a cause of bovine abortion. There is no vaccine available in Europe and prevention is exclusively by hygiene measures. [less ▲]

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See detailLes herpèsvirus bovins : biologie et implications
Pastoret, Paul-Pierre ULg; Lemaire, Mylène; Denis, Martine et al

Part of book (1994)

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See detailEl herpesvirus caprino es altamente prevalente
Thiry, Julien ULg; Thiry, Etienne ULg

in Mundo Ganadero (2008), 214

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