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See detailHDA cycloadditions of 1-diethoxyphosphonyl-1,3-butadiene with nitroso heterodienophiles: a computational investigation
Monbaliu, Jean-Christophe ULg; Dive, Georges ULg; Marchand-Brynaert, Jacqueline et al

in Journal of Molecular Structure : Theochem (2010), 959

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See detailThe HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
Crisanti, Cecilia; Wallace, Africa; Kapoor, Veena et al

in Molecular Cancer Therapeutics (2009), 8(8), 2221-2231

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that ... [more ▼]

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that cause increased acetylation of core histones and nonhistone proteins leading to modulation of gene expression and protein activityin - volved in cancer cell growth and survival pathways. We examined the efficacyof the HDACi panobinostat (LBH589) in a wide range of lung cancers and mesotheliomas. Panobinostat was cytotoxic in almost all 37 cancer cell lines tested. IC50 and LD50 values were in the low nmol/L range (4–470 nmol/L; median, 20 nmol/L). Small cell lung cancer (SCLC) cell lines were among the most sensitive lines, with LD50 values consistently <25 nmol/L. In lung cancer and mesothelioma animal models, panobinostat significantlyde creased tumor growth byan average of 62% when compared with vehicle control. Panobinostat was equallye ffective in immunocompetent and severe combined immunodeficiencymic e, indicating that the inhibition of tumor growth by panobinostat was not due to direct immunologic effects.Panobinostat was, however, particularlyeffective in SCLC xenografts, and the addition of the chemotherapyag ent etoposide augmented antitumor effects. Protein analysis of treated tumor biopsies revealed elevated amounts of cell cycle regulators such as p21 and proapoptosis factors, such as caspase 3 and 7 and cleaved poly[ADP-ribose] polymerase, coupled with decreased levels of antiapoptotic factors such as Bcl-2 and Bcl-XL. These studies together suggest that panobinostat maybe a useful adjunct in the treatment of thoracic malignancies, especiallySCLC. [less ▲]

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See detailHDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
Mottet, Denis ULg; Pirotte, Sophie ULg; Lamour, Virginie ULg et al

in Oncogene (2009), 28(2), 243-56

Cancer cells have complex, unique characteristics that distinguish them from normal cells, such as increased growth rates and evasion of anti-proliferative signals. Global inhibition of class I and II ... [more ▼]

Cancer cells have complex, unique characteristics that distinguish them from normal cells, such as increased growth rates and evasion of anti-proliferative signals. Global inhibition of class I and II histone deacetylases (HDACs) stops cancer cell proliferation in vitro and has proven effective against cancer in clinical trials, at least in part, through transcriptional reactivation of the p21(WAF1/Cip1)gene. The HDACs that regulate p21(WAF1/Cip1) are not fully identified. Using small interfering RNAs, we found that HDAC4 participates in the repression of p21(WAF1/Cip1) through Sp1/Sp3-, but not p53-binding sites. HDAC4 interacts with Sp1, binds and reduces histone H3 acetylation at the Sp1/Sp3 binding site-rich p21(WAF1/Cip1) proximal promoter, suggesting a key role for Sp1 in HDAC4-mediated repression of p21(WAF1/Cip1). Induction of p21(WAF1/Cip1) mediated by silencing of HDAC4 arrested cancer cell growth in vitro and inhibited tumor growth in an in vivo human glioblastoma model. Thus, HDAC4 could be a useful target for new anti-cancer therapies based on selective inhibition of specific HDACs. [less ▲]

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See detailHDAC5 depletion modulates heterochromatin plasticity and triggers programmed cell death of human cancer cells
Peixoto, P; Castronovo, V; Matheus, N et al

Poster (2012)

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See detailHDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells
Peixoto, Paul ULg; Castronovo, Vincenzo ULg; Matheus, Nicolas ULg et al

in Cell Death & Differentiation (2012)

Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer ... [more ▼]

Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. In this study, we further investigated the biological function of HDAC5 in cancer cells. We found HDAC5 is associated with actively replicating pericentric heterochromatin during late S phase. We demonstrated that specific depletion of HDAC5 by RNA interference resulted in profound changes in the heterochromatin structure and slowed down ongoing replication forks. This defect in heterochromatin maintenance and assembly are sensed by DNA damage checkpoint pathways, which triggered cancer cells to autophagy and apoptosis, and arrested their growth both in vitro and in vivo. Finally, we also demonstrated that HDAC5 depletion led to enhanced sensitivity of DNA to DNA-damaging agents, suggesting that heterochromatin de-condensation induced by histone HDAC5 silencing may enhance the efficacy of cytotoxic agents that act by targeting DNA in vitro. Together, these results highlighted for the first time an unrecognized link between HDAC5 and the maintenance/assembly of heterochromatin structure, and demonstrated that its specific inhibition might contribute to increase the efficacy of DNA alteration-based cancer therapies in clinic. [less ▲]

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See detailHDAC6 Inhibition compensates for the transport deficit in Huntington’s Disease by increasing tubulin acetylation
Godin, Juliette ULg; Dompierre; Charrin, Bénédicte C. et al

Conference (2008, March)

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See detailHDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck ULg; Kasler, Herbert; Fischle, Wolfgang et al

in Immunity (2003), 18(5), 687-98

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and ... [more ▼]

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T cell receptor activation, leading to Nur77 expression. A triple HDAC7 mutant (S155A, S318A, S448A) is not exported from the nucleus in response to TCR activation and suppresses TCR-mediated apoptosis. Conversely, a fusion of HDAC7 to the transcriptional activator VP16 activates Nur77 expression. Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes. [less ▲]

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See detailHDAC8 is required for myofibroblastic differentiation induced by TGFß
Glénisson, Wendy; Tran, Syv Li; Castronovo, Vincenzo ULg et al

Conference (2004)

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See detailHE 0435-1223 lensed QSO VRi light curves (Ricci+, 2011)
Ricci, Davide ULg; Poels, Joël ULg; Elyiv, Andrii ULg et al

Textual, factual or bibliographical database (2011)

We present VRi photometric observations of the quadruply imaged quasar HE0435-1223, carried out with the Danish 1.54m telescope at the La Silla Observatory. Our aim was to monitor and study the magnitudes ... [more ▼]

We present VRi photometric observations of the quadruply imaged quasar HE0435-1223, carried out with the Danish 1.54m telescope at the La Silla Observatory. Our aim was to monitor and study the magnitudes and colors of each lensed component as a function of time. [less ▲]

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See detailHe and Si surface inhomogeneities of four Bp variable stars
Briquet, Maryline ULg; Aerts, C.; Lüftinger, T. et al

in Astronomy and Astrophysics (2004), 413

We present ground-based multi-colour Geneva photometry and high-resolution spectra of four variable B-type stars: HD 105382, HD 131120, HD 138769 and HD 55522. All sets of data reveal monoperiodic stars ... [more ▼]

We present ground-based multi-colour Geneva photometry and high-resolution spectra of four variable B-type stars: HD 105382, HD 131120, HD 138769 and HD 55522. All sets of data reveal monoperiodic stars. A comparison of moment variations of two spectral lines, one silicon line and one helium line, allows us to exclude the pulsation model as being the cause of the observed variability of the four stars. We therefore delete the four stars from the list of candidate slowly pulsating B stars. We attribute the line-profile variations to non-homogeneous distributions of elements on the stellar surface and we derive abundance maps for both elements on the stellar surface by means of the Doppler Imaging technique. We confirm HD 131120 to be a He-weak star and we classify HD 105382, HD 138769 as new He-weak stars. HD 55522 has the solar helium abundance but the mean abundance value of He varies by 0.8 dex during the stellar rotation. For HD 131120 and HD 105382, helium is enhanced in regions of the stellar surface where silicon is depleted and depleted in regions where silicon is enhanced. Based on observations obtained with the Swiss photometric telescope and ESO's CAT/CES telescope, both situated at La Silla, Chile. Appendix A, Tables 1 and 2 and Figs. 9, 11, 13 are only available in electronic form at http://www.edpsciences.org [less ▲]

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See detailhe influence of transformational leadership on commitment: New underlying processes
Marique, Géraldine; Stinglhamber, Florence; Hanin, Dorothée et al

Poster (2012, April)

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See detailA He(I) Photoelectron Spectroscopic Study of the X2A"2state of NH3+ and ND3+. A Reanalysis and evidence for the Coriolis Coupling between the Bending nu2 and nu4 Modes.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1998), 233

In the He(I) photoelectron spectrum of NH3 and its isotopomer ND3 the complete vibrational structure of the X2A"2 state of NH3+ and ND3+ is examined in detail. Three vibrational progressions are ... [more ▼]

In the He(I) photoelectron spectrum of NH3 and its isotopomer ND3 the complete vibrational structure of the X2A"2 state of NH3+ and ND3+ is examined in detail. Three vibrational progressions are identified. The well-known strongest progression, already unambiguously assigned to the nu2 out-of-plane bending mode, is observed from v=0-17 in NH3+ and v=0-20 in ND3+. For NH3+ this vibration could be characterized not only by its energy hcomega2= 0.109+/-0.001 eV (or omega2= 878+/-7 cm-1) but also by its first anharmonicity constant hcomega22x22=-(16.2+/-1.2)10-4 eV (or omega22x22=-13.0+/-1.0 cm-1). The best fit of the experimental data required the introduction of a second anharmonicity constant, i.e. hcomega22y22= -(30.7+/-4.2)x10-6 eV (or omega22y22=-0.248+/-0.034 cm-1). The earlier reported weak progression assigned to the vibrational combination nu1+nnu2 transitions has been reexamined. Suitable handling of the data leads to two possible energies for the nu1 degenerate NH stretching vibrational normal mode, i.e. hcomega1 =0.306+/-0.006 eV or 0.422+/-0.005 eV. Several arguments are brought to favour the value of hcomega1=0.422 eV (or omega1=3404 cm-1). Finally a third weak progression, reported for the first time, is assigned to nu4+nnu2 transitions where the nu4 in-plane bending mode is optically forbidden. This vibrational normal mode is characterized by an energy hcomega4=0.186+/-0.010 eV (omega4=1500+/-80 cm-1). In agreement with the theoretical predictions, this transition becomes allowed through a strong Coriolis vibro-rotational coupling between the nu4 and the nu2 vibrational normal modes. The same measurements and the isotope effect on the molecular constants are investigated in ND3+ too. [less ▲]

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See detailThe He(I), Threshold photoelectron and Constant Ion State spectroscopy of Vinylchloride (C2H3Cl).
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been ... [more ▼]

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been measured and reexamined. The threshold photoelectron spectrum has been measured between 9.0 and 25.0 eV and the photon energy range of 9.9-12.0 eV has been investigated in detail. Many features have been identified and tentatively assigned with the help of the photoabsorption spectroscopic results. These data were compared with the well-resolved He(I) photoelectron spectrum. The fine structure observed in the two first ionic states is assigned to progressions belonging partially to previously unobserved vibration normal modes. State-selected CIS spectra have been recorded for the first vibronic states between 10.0 and 11.67 eV. They exhibit fine structure assigned to autoionization of Rydberg states. [less ▲]

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See detailHead to head comparison of transesophageal and transthoracic contrast-enhanced echocardiography during dobutamine administration for the detection of coronary artery disease.
Cosyns, Bernard; LANCELLOTTI, Patrizio ULg; Van Camp, Guy et al

in International Journal of Cardiology (2008), 129(1), 105-10

Dobutamine stress echocardiography (DSE) has been shown to be a very useful non-invasive technique for the detection of coronary artery disease. However, inadequate transthoracic images preclude the use ... [more ▼]

Dobutamine stress echocardiography (DSE) has been shown to be a very useful non-invasive technique for the detection of coronary artery disease. However, inadequate transthoracic images preclude the use of DSE in a significant proportion of patients. Transesophageal (TEE) or transthoracic contrast echocardiography (CE) can however overcome this limitation. The comparison between the two techniques has never been investigated during a stress test. Therefore, we designed a prospective study to compare DSE-CE and DSE-TEE for the detection of coronary artery disease in patients with poor echo image quality. We studied 42 patients scheduled for quantitative coronary angiography. Prospective DSE-CE and DSE-TEE with maximum one day interval were performed in a random order. Significant coronary artery disease was detected in 30 patients, nine with single vessel disease and 21 with multivessel disease. Sensitivity of DSE was higher with CE than with TEE (90% vs 87%, p=NS). There was no significant difference with respect to specificity in both groups (100% vs 92%, p=NS). The diagnostic accuracy was similar in both groups (93% vs 88%, NS). The kappa value for identical interpretation of a stress echocardiography study was nearly identical with both modalities 0.75 to 0.78. In poorly echogenic patients, DSE-CE is a valuable alternative for the detection of myocardial ischemia in comparison with DSE-TEE. Because DSE-CE is more comfortable than TEE, it should be used in patients with suboptimal transthoracic echocardiograms for the evaluation of coronary artery disease during DSE. [less ▲]

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See detailHead Trauma
Bonhomme, Vincent ULg; Hans, Pol ULg; Brichant, Jean-François ULg

in Acta Anaesthesiologica Belgica (2006), 57(3), 239-47

this review is to provide the reader with the most commonly accepted principles for the management of head trauma patients. The initial clinical evaluation and resuscitation, radiological evaluation ... [more ▼]

this review is to provide the reader with the most commonly accepted principles for the management of head trauma patients. The initial clinical evaluation and resuscitation, radiological evaluation, monitoring, intracranial pressure and cerebral perfusion pressure management, brain protection, associated organ dysfunctions and complications, anaesthetic manage ment and the singularities of paediatric head trauma patients are described, either for the acute phase and the secondary phase of management. [less ▲]

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See detailHead Trauma and Distal Anterior Cerebral Artery Aneurysm: Potential Role of an Adhesion to the Falx
Scholtes, Félix ULg; HENROTEAUX, Adrienne ULg; OTTO, Bernard ULg et al

in Journal of Neurological Surgery. Part A, Central European Neurosurgery (2014), [Epub ahead of print]

Detailed reference viewed: 29 (11 ULg)