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See detailHypercalcémie réfractaire et sécrétion ectopique de calcitonine dans un cancer neuroendocrine du pancréas : Effets hypocalcémiants du Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; LOLY, Jean-Philippe ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, September), 74(4), 235-462

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailHypercholesterolaemia in a family of rough collie dogs.
Jeusette, Isabelle; Grauwels, Magda ULg; Cuvelier, Christine ULg et al

in Journal of Small Animal Practice (2004), 45(6), 319-24

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha ... [more ▼]

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha-2 high density lipoprotein-1 band and was due to an increase in the cholesterol content of the very low density lipoprotein, low density lipoprotein and possibly the high density lipoprotein-1 fractions. A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. Corneal lipidosis regressed with short-chain fructo-oligosaccharide supplementation. However, the effects of short-chain fructo-oligosaccharides on total cholesterol were transient and variable. [less ▲]

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See detailLes hyperconflits en organisation
Faulx, Daniel ULg; Delvaux, Sophie

in Actes du 15ème Congrès de Psychologie du Travail et des Organisation de Langue Française. CD-rom. Québec.. (2008)

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de ... [more ▼]

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de huit focus groups composés de professionnels du traitement des conflits, nous dégageons 24 indicateurs des hyperconflits. Plus généralement, il ressort de notre étude que ces situations sont liées à une réduction de la complexité du système organisationnel couplée à une généralisation de la dynamique conflictuelle du point de vue de l’espace-temps, des processus et des conséquences. Les implications en termes d’interventions sont également discutées. [less ▲]

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See detailHyperdiploid karyotypes in acute myeloid leukemia define a novel entity : a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH)
Luquet, I.; Laï, J. L.; Barin, C. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2008), 22(1), 132-137

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See detailHyperechogenic brain densities : relevance of perinatal etiologic factors
Battisti, Oreste ULg; Dehalleux, I.; Withofs, L. et al

Conference (1993)

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See detailHyperfine interactions and lattice dynamics of Sn21O6Cl16(OH)(14)
Sougrati, Moulay Tahar ULg; Jouen, S.; Hannoyer, Béatrice et al

in Journal of Solid State Chemistry (2008), 181(9), 2473-2479

In this study, the tin(II) oxy-hydroxychloride Sn21O6Cl16(OH)(14) has been synthesised and investigated, This compound is the synthetic equivalent of mineral abhurite, which was discovered in 1985 as a ... [more ▼]

In this study, the tin(II) oxy-hydroxychloride Sn21O6Cl16(OH)(14) has been synthesised and investigated, This compound is the synthetic equivalent of mineral abhurite, which was discovered in 1985 as a tin corrosion product formed on the surface of tin ingots after long immersion in seawater. The Mossbauer parameters of Sn(21)O6Cl(16)(OH)(14) determined at various temperatures are reported and discussed for the first time. At room temperature, the isomer shift and the quadrupole splitting are, respectively, delta = 3.22 mm s(-1) and Delta = 1.71 mm s(-1) relative to the centroid of the spectrum of BaSnO3. ne Mossbauer recoil-free fraction has been also evaluated over a wide range of temperature. At 300 K, the recoil-free fraction of Sn21O6Cl16(OH)(14) is f(300) = 0.09 +/- 0.02. (C) 2008 Elsevier Inc. All rights reserved. [less ▲]

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See detailHyperfine Structure and Isotope Shifts in Iron Atoms
Krins, Stéphanie ULg; Oppel, S.; Huet, Nicolas ULg et al

Conference (2009)

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See detailHyperfine structure and lifetimes of metastable states studied by means of laser excitation of stored ions
Norlin, L.-O.; Biémont, Emile ULg; Lidberg, J. et al

in Hyperfine Interactions (1999), 120-121

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See detailHyperfine structure for neutral manganese lines of astrophysical interest
Lefèbvre, P.-H.; Garnir, Henri-Pierre ULg; Biémont, Emile ULg

in Astronomy and Astrophysics (2003), 404(3), 1153-1158

The hyperfine structure of 40 levels of neutral manganese has been studied by means of Fourier transform emission spectroscopy. The light source was a home-made 99.5% pure manganese hollow-cathode lamp ... [more ▼]

The hyperfine structure of 40 levels of neutral manganese has been studied by means of Fourier transform emission spectroscopy. The light source was a home-made 99.5% pure manganese hollow-cathode lamp. From the analysis of the line profiles observed in the visible and infrared regions, we have been able to deduce new magnetic dipole constants for 18 levels and to revise previous results for 22 additional levels. [less ▲]

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See detailHyperfine structure of infrared Al II lines
Palmeri, P.; Biémont, Emile ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (1996), 29

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See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailHyperfine structure of neutral vanadium lines and livels
Lefèbvre, P.-H.; Garnir, Henri-Pierre ULg; Biémont, Emile ULg

in Physica Scripta (2002), 66

We have recorded hollow-cathode spectra of neutral vanadium by Fourier transform spectroscopy in the near infrared - visible region (9000-17 000 cm-1). 36 transitions showing hyperfine structure have been ... [more ▼]

We have recorded hollow-cathode spectra of neutral vanadium by Fourier transform spectroscopy in the near infrared - visible region (9000-17 000 cm-1). 36 transitions showing hyperfine structure have been analyzed, allowing us to deduce magnetic dipole constants for 27 levels belonging to the 3d44p and 3d34s4p configurations. For 22 of these levels no data were previously available. [less ▲]

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See detailHyperfine structure of Sc I by Infrared Fourier Transform Spectroscopy
Aboussaïd, A.; Carleer, M.; Hurtmans, D. et al

in Physica Scripta (1996), 53

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See detailHyperfine structure splitting of molecular-iodine transitions near 716 nm
Huet, Nicolas ULg; Krins, Stéphanie ULg; Dubé, P. et al

Poster (2010)

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See detailHyperfine-structure splitting of the 716 nm R(90)3–10 molecular iodine transition
Huet, Nicolas ULg; Krins, Stéphanie ULg; Dubé, Pierre et al

in Journal of the Optical Society of America. B, Optical Physics (2013), 30

We report on the hyperfine-structure splitting of the 716 nm R 90 3–10 molecular iodine transition. We show that this particular iodine line provides a very useful frequency reference in the context of a ... [more ▼]

We report on the hyperfine-structure splitting of the 716 nm R 90 3–10 molecular iodine transition. We show that this particular iodine line provides a very useful frequency reference in the context of a laser cooling experiment of iron atoms, an atomic species that has so far never been laser cooled and trapped to our knowledge. We provide experimental values for the hyperfine constants ΔeQq and ΔC of the investigated iodine transition. Dispersive signals of this transition are also presented and used to lock the frequency of a Ti:sapphire laser. The reported stabilization performance is fully compatible with the requirements of a laser cooling experiment of iron atoms. [less ▲]

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See detailHyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo
Rothley, M.; Schmid, A.; Thiele, W. et al

in International Journal of Cancer = Journal International du Cancer (2009), 125(1), 34-42

The phloroglucinol derivative hyperforin, a major bioactive constituent of St. John's wort, is increasingly recognized as being able to regulate a variety of pathobiological processes and, thus, to ... [more ▼]

The phloroglucinol derivative hyperforin, a major bioactive constituent of St. John's wort, is increasingly recognized as being able to regulate a variety of pathobiological processes and, thus, to possess potential therapeutic properties. In the context of cancer, hyperforin induces the apoptosis of cancer cells, inhibits angiogenesis and suppresses metastasis formation. Here, we report a new pharmacological function of hyperforin and its stabilized derivative aristoforin, namely the suppression of lymphatic endothelial cell (LEC) growth and lymphangiogenesis. At concentrations less than 10 M, we found that these compounds induce cell cycle arrest of LECs, and at higher concentrations induce apoptosis. The loss of mitochondrial membrane potential and the activation of caspase-9 during the induction of apoptosis indicate that the intrinsic pathway of apoptosis is stimulated by these compounds, similar to the situation in tumor cells. In thoracic duct ring outgrowth assays, hyperforin and aristoforin both inhibited lymphangiogenesis, as evidenced by the suppression of lymphatic capillary outgrowth. In an in vivo animal model, both compounds were able to inhibit tumor-induced lymphangiogenesis. Together these data substantiate a new role for hyperforin and its derivatives as suppressors of lymphangiogenesis, and support their further investigation as potential anticancer drugs that target tumor growth and metastasis at multiple levels. [less ▲]

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See detailHyperfractionated accelerated radiotherapy (HART) for inoperable, non metastatic non-small-cell lung carcinoma of the lung (NSCLC): result of a phase II study for patients ineligible for combination radio-chemotherapy.
Koutaissoff, S; Wellmann, D; COUCKE, Philippe ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (1999), 45(5), 1151-1156

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination ... [more ▼]

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination radiochemotherapy studies. Methods and Materials: From February 1989 through August 1994, 23 patients ineligible for available combined modality protocols in our institution were enrolled and treated with HART, consisting of 63 Gy given in 42 fractions of 1.5 Gy each, twice daily, with a minimum time interval of 6 h between fractions, 5 days a week, over an elapsed time of 4.2 weeks, or 29 days. There was no planned interruption. Results: The 1-, 2-, and 3-year survival rates were 61%, 39%, and 19%, respectively, with a median survival of 16.8 months. At the time of analysis, 4 patients are alive and 19 have died, 16 from NSCLC and 3 from cardiacdisease. Overall response rate was 48%, with 22% of patients achieving a complete response and 26% a partial response. Correlation between acute response rate and survival was poor. First site of relapse was local-regional in 8 patients (35%), distant in 6 patients (26%), and local-regional and distant in 4 (17%) patients. One patient had Grade IV and 2 had Grade III esophagitis. One patient presented with chronic Grade III lung toxicity. There were no treatment-related deaths. Conclusion: In this group of 23 patients ineligible for radiochemotherapy, this HART regime was quite feasible and was followed by little toxicity. Results in this particularly poor prognosis NSCLC patient category should be compared to series with a similar patient profile; however, median survival is at least similar to that obtained in recent series of combination radiochemotherapy. © 1999 Elsevier Science Inc. [less ▲]

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See detailhyperfractionated accelerated radiotherapy (HART) immediately followed by surgery in locally advanced rectal cancer (LARC)
Coucke, Philippe ULg; Bouzourenne, Hanifa; Zouhair, Abderrahim et al

in Radiotherapy & Oncology (1998), 48(Supp1), 73

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