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See detailHEAT RECOVERY SYSTEMS FOR PASSENGERS VEHICLES
Glavatskaya, Yulia ULg; Olivier, Gérard; Shonda, Osoko et al

in Scientific Bulletin, Automotive series = Buletin Ştiinţific, Seria Autovehicule Rutiere (2011, November 02)

is wasted through the cooling liquid and the exhaust gases. Thus, it would be possible to convert this wasted heat in order to improve the engine overall efficiency and reduce the fuel consumption of the ... [more ▼]

is wasted through the cooling liquid and the exhaust gases. Thus, it would be possible to convert this wasted heat in order to improve the engine overall efficiency and reduce the fuel consumption of the vehicle. This shows the big interest in energy recovery systems. This paper presents the various systems enabling the recovery of this energy. A Rankine cycle, widely used in the industry, is of particular interest. The efficiency of energy conversion varies from 5 to 20 % depending of its conception (working fluid, architecture, coupling…). Moreover, the layout of the Rankine cycle integrated within a vehicle depends on the choice of the working fluid as well as the technologies of the components i.e. the expander, the evaporator, the condenser and the pump. Within this context, the issue regarding the mass and the size of the system has to be considered. Finally, we present several solutions of Rankine systems for passenger car application and show each advantage and limits. [less ▲]

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See detailHeat shock increases the activity of endothelial nitric oxide synthase via HSP90-independent mechanisms
Plumier, Jean-Christophe ULg; Salomone, Salvatore; Qiu, Janhua et al

Poster (2002)

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See detailHeat Shock Proteins ans antioxidative enzymes in myocardial protection
Currie, R.W.; Plumier, Jean-Christophe ULg

in Knowlton, A.A. (Ed.) Heat Shock Proteins and the Cardiovascular System (1996)

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See detailHeat shock proteins. I : Classification and roles in pathological processes
Wirth, Delphine; Gustin, Pascal ULg; Drion, Pierre ULg et al

in Annales de Médecine Vétérinaire (2002), 146(4), 201-216

All living systems have evolved mechanisms to maintain homeostasis in the face of rapid environmental changes. When exposed to elevated temperatures, most of the cells activate the synthesis of a specific ... [more ▼]

All living systems have evolved mechanisms to maintain homeostasis in the face of rapid environmental changes. When exposed to elevated temperatures, most of the cells activate the synthesis of a specific group of proteins called Heat Shock Proteins (Hsps). This heat shock response, under control of specific transcription factors, the Heat Shock factors (HSF), is an evolutionarily conserved mechanism, from bacteria to humans. Heat Shock Proteins are classified into families according to their molecular weight (Hsp 25, 40, 70, 90, 105). They play the role of molecular chaperones by binding and protecting other molecules (proteins, RNAs). The function of Hsp is to prevent accumulation of non-native proteins either by assisting proper folding of polypeptides or by driving them to proteosome pathway for degradation. Hsps are involved in various pathological processes that are accompanied by protein alterations such as chronic or degenerative diseases. This review describes structural and functional characteristics of the six main Hsps classes. It also focuses on their respective role in highly studied pathologies. The diversity of Hsps implications in these diseases explains that they became recently a strategic target in development of new therapeutic strategies. [less ▲]

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See detailThe Heat Shock Response and Tissue Protection
Currie, R.W.; Plumier, Jean-Christophe ULg

in Baxter, B.F.; Yellon, D.M. (Eds.) Delayed Preconditioning and Adaptative Cardioprotection (1998)

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See detailHeat shock RNAs in leaf and root explants of wheat.
Du Jardin, Patrick ULg; Lejour, C.; Jacquemin, J. M.

in Plant Physiology and Biochemistry (Paris) (1990), 28(2),

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See detailHeat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element
Molina, Alfredo; Di Martino, Emmanuel; Martial, Joseph ULg et al

in Biochemical Journal (2001), 356(Pt 2), 353-9

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell ... [more ▼]

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell culture and in microinjected zebrafish embryos. Here we present the first functional analysis of a fish HSP70 promoter, the tiHSP70 promoter. Using transient expression experiments in carp EPC (epithelioma papulosum cyprini) cells and in microinjected zebrafish embryos, we show that a distal heat shock response element (HSE1) at approx. -800 is predominantly responsible for the heat shock response of the tiHSP70 promoter. This element specifically binds an inducible transcription factor, most probably heat shock factor, and a constitutive factor. The constitutive complex is not observed with the non-functional, proximal HSE3 sequence, suggesting that both factors are required for the heat shock response mediated by HSE1. [less ▲]

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See detailHeat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
McMillan, D Randy; Christians, Elisabeth; Forster, Michael et al

in Molecular & Cellular Biology (2002), 22(22), 8005-14

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress ... [more ▼]

Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 knockout mice. Here, we report that Hsf2(-/-) mice are viable and fertile and exhibit normal life span and behavioral functions. We conclude that HSF2, most probably because its physiological roles are integrated into a redundant network of gene regulation and function, is dispensable for normal development, fertility, and postnatal psychomotor function. [less ▲]

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See detailHeat shock-induced myocardial protection against ischemic injury: a role for Hsp70?
Plumier, Jean-Christophe ULg; Currie, R. W.

in Cell Stress & Chaperones (1996), 1(1), 13-7

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See detailHeat transfer and structural response modelling of concrete filled steel hollow section columns
Binh, Chu Thi; Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg

in Proc; ACOME (2012)

Numerical modelling is a very useful tool to predict the fire resistance of a structure, or to reproduce artificially what has happened during a real fire. SAFIR, a non linear computer code developed at ... [more ▼]

Numerical modelling is a very useful tool to predict the fire resistance of a structure, or to reproduce artificially what has happened during a real fire. SAFIR, a non linear computer code developed at the university of Liege-Belgium, is specifically written for modeling the behavior of structures subjected to fire. It allows a determination of the temperatures in the structure resulting from the fire and, in a subsequent analysis, determination of the successive positions of equilibrium of the structure until collapse. Ten steel hollow section columns filled with self-compacting concrete embedding another steel profile have been tested in the Fire Engineering Laboratory of the University of Liege - Belgium. SAFIR code has been used to simulate the thermal and structural behavior under fire conditions. A good agreement between numerical and experimental results has been obtained. This shows that SAFIR code can predict well the behavior of CFSHS columns subjected to fire. [less ▲]

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See detailHeat transfer by radiation in internal cavities with a complex shape
Franssen, Jean-Marc ULg

in Proceedings of the SEISFPE Conference on Designing structures for fire (2003)

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See detailHeat transfer characterization in a shallow aquifer using heat and dye tracer tests
Wildemeersch, Samuel ULg; Orban, Philippe ULg; Hermans, Thomas ULg et al

Conference (2013, July 22)

Very low enthalpy geothermal systems (open or closed) are increasingly considered for heating or cooling houses and offices using groundwater energy combined with heat pumps. However, the design and the ... [more ▼]

Very low enthalpy geothermal systems (open or closed) are increasingly considered for heating or cooling houses and offices using groundwater energy combined with heat pumps. However, the design and the impact of current shallow geothermal systems are often set up and assessed in a semi-empirical way. In our country, this situation seems accepted by most of the private partners but not by the authorities and responsible administrations evaluating the impact on groundwater with a mid- to long-term perspective. A rigorous methodology is needed based on a physically based estimation of heat transfer parameters. In this study, the simultaneous use of heat and dye tracers allows estimating simultaneously heat transfer and solute transport parameters in an alluvial aquifer. The experimental field site, located near Liege (Belgium), is equipped with 21 piezometers drilled in the alluvial deposits of the Meuse River. These alluvial deposits are composed of a loam layer (3 m) overlying a sand and gravel layer which constitutes the alluvial aquifer (7 m). The tracing experiment consisted in injecting simultaneously heated water and a dye tracer in a piezometer and monitoring the evolution of groundwater temperature and tracer concentration in a series of control panels set perpendicularly to the main groundwater flow. Results showed drastic differences between heat transfer and solute transport due to the main influence of thermal capacity of the saturated porous medium. The tracing experiment was then simulated using a numerical model and the best estimation of heat transfer and solute transport parameters is obtained by calibrating this numerical model using inversion tools. The developed concepts and tests may lead to real projects of various extents that can be now optimized by the use of a rigorous and efficient methodology at the field scale. [less ▲]

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See detailHeat transfer characterization using heat and solute tracer tests in a shallow alluvial aquifer
Dassargues, Alain ULg; Wildemeersch, Samuel ULg; Jamin, Pierre ULg et al

Poster (2013, December 09)

Very low enthalpy geothermal systems are increasingly considered for heating or cooling using groundwater energy combined with heat pumps. The design and the impact of shallow geothermal systems are often ... [more ▼]

Very low enthalpy geothermal systems are increasingly considered for heating or cooling using groundwater energy combined with heat pumps. The design and the impact of shallow geothermal systems are often assessed in a semi-empirical way. It is accepted by most of the private partners but not by environmental authorities deploring a lack of rigorous evaluation of the mid- to long-term impact on groundwater. In view of a more rigorous methodology, heat and dye tracers are used for estimating simultaneously heat transfer and solute transport parameters in an alluvial aquifer. The experimental field site, is equipped with 21 piezometers drilled in alluvial deposits composed of a loam layer overlying a sand and gravel layer constituting the alluvial aquifer. The tracing experiment consisted in injecting simultaneously heated water and a dye tracer in a piezometer and monitoring evolution of groundwater temperature and tracer concentration in 3 control panels set perpendicularly to the main groundwater flow. Results showed drastic differences between heat transfer and solute transport due to the main influence of thermal capacity of the saturated porous medium. The tracing experiment was then simulated using a numerical model and the best estimation of heat transfer and solute transport parameters is obtained by calibrating this numerical model using inversion tools. The developed concepts and tests may lead to real projects of various extents that can be now optimized by the use of a rigorous and efficient methodology at the field scale. [less ▲]

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See detailHeat transfer in soils
Hermansson, Ake; Charlier, Robert ULg; Collin, Frédéric ULg et al

in Dawson, Andrew (Ed.) Water in road structures - Movement, Drainage and effects (2009)

Temperature highly affects pavement performance. High and low temperatures not only affects the viscosity of asphalt concrete but also has an impact on the moisture flow within the pavements. At ... [more ▼]

Temperature highly affects pavement performance. High and low temperatures not only affects the viscosity of asphalt concrete but also has an impact on the moisture flow within the pavements. At temperatures below 0°C the freezing of pavements dramatically changes the permeability and frost action might occur forcing water to flow upwards to the freezing front resulting in the frost heave and other pavement distress. [less ▲]

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See detailHeat transfer phenomena in trickle-bed reactors
Crine, Michel ULg

in Chemical Engineering Communications (1982), 19

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See detailHeat transport in dielectric crystals at low temperature: A variational formulation based on extended irreversible thermodynamics
Lebon, Georgy ULg; Dauby, Pierre ULg

in Physical Review (1990), 42

We propose a variational principle applicable to the heat-transport equations derived some years ago by Guyer and Krumhansl [Phys. Rev. 133, 1411 (1964); 148, 766 (1966); 148, 778 (1966)] to describe heat ... [more ▼]

We propose a variational principle applicable to the heat-transport equations derived some years ago by Guyer and Krumhansl [Phys. Rev. 133, 1411 (1964); 148, 766 (1966); 148, 778 (1966)] to describe heat-wave propagation in dielectric crystals at low temperature. The variational principle appears as a generalization of Prigogine's minimum-entropy production criterion. The analysis is based on extended irreversible thermodynamics, which is used to derive the Guyer-Krumhansl equations from macroscopic arguments. [less ▲]

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See detailHeat treatment of pigmented materials from es-Skhul (ca. 100 000 B.P., Israël)
Salomon, Hélène ULg; Vignaud, Colette; Coquinot, Yvan et al

Poster (2010)

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See detailHeat-shock treatment modifies gene expression following brain injury
Plumier, Jean-Christophe ULg; David, Jean-claude; Robertson, Harold A. et al

in Supplement ... to the European Journal of Neuroscience (1995), Suppl 8

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See detailHeat-stable enterotoxin from a pathogenic canine strain of Escherichia coli
Gerday, C.; Pennetreau-Césa, D.; Gérardin-Otthiers, N. et al

in Biochem (1987), 6

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See detailHeat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
Liu, Ji ULg; Detrembleur, Christophe ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Journal of Materials Chemistry B (2014), 2(1), 59-70

Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous ... [more ▼]

Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a “zero premature release” (<3% of the entire payload in 96 h release) under physiological conditions (37°C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heattriggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after 72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core–shell nanoparticles are envisaged to become promising DDS for “on-demand” heat-triggered release. [less ▲]

Detailed reference viewed: 17 (4 ULg)