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See detailEvaluating an ICT-mediated innovative training service from users' perspective: an explorative case study
Peters, Stéphanie ULg; Ledent, M.; Hansez, Isabelle ULg

in Proceedings of the ED-Media Conference 2008 (2008)

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The ... [more ▼]

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The originality of this article is twofold: (1) to question innovation, and (2) to consider the training more commonly as a service, whose major particularity is the implication of the user in the process. The theoretical framework emphasises on the definition of a service and on the concept of added-value. As this experience took place at the very beginning of the project development, an empirical methodology was developed. We assume that the so-called e-WOCCQ is an innovation as it represents an added value for the users. Results show that e-WOCCQ generates costs and benefits of different order, and that the ratio is influenced by factors mostly linked either with the user. Practical (improvements and targeting) and theoretical (modelisation) implications are discussed. [less ▲]

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See detailEvaluating analytical results reliability using a Bayesian probability criterion
Rozet, Eric ULg; Lebrun, Pierre ULg; Boulanger, Bruno ULg et al

Poster (2010, December 02)

In pharmaceutical industries, quantitative analytical methods such as HPLC play a key role. Indeed, the analytical results obtained from them are used to make crucial decisions such as the release of ... [more ▼]

In pharmaceutical industries, quantitative analytical methods such as HPLC play a key role. Indeed, the analytical results obtained from them are used to make crucial decisions such as the release of batches of drugs, the evaluation of safety and efficacy of new drug candidates or the monitoring of patients health. Prior to their routine use, analytical methods are submitted to a stringent validation study where they have to demonstrate that they are fit for their final purpose, i.e. providing accurate result . Typically this demonstration is made by either providing point estimates of systematic error (bias) and random error (variance) or sometimes by providing interval estimates of these statistical parameters at several well defined concentration levels of the target analyte. They are then compared to maximum acceptable levels. More recently, tolerance intervals approaches have been proposed that are evaluated in a similar way at these key concentration levels. However none of these decision approaches allow knowing the probability to obtain accurate results over the whole concentration range of interest. Frequentist approximations have been proposed to estimate this probability but only at the concentration levels experimentally tested and not for the whole range of interest. In this work, a linear hierarchical Bayesian approach is proposed. It takes into account the potential random characteristic of the slope and intercept observed from one analytical run to the other, and also integrates the possible covariance between the parameters. Additionally, heteroscedasticity of the residual variance over the concentration range investigated is taken into account. A situation regularly observed in practice. Finally a reliability profile for the whole concentration range studied is obtained using MCMC sampling. This profile provides the probability (Prel) to obtain accurate results over the full concentration range investigated. This profile is then compared to a minimum reliability probability (Pmin) that will define the valid concentration range of the analytical method. The usefulness of this approach is illustrated through the validation of a bioanalytical method and also compared with a one concentration level at a time frequentist approach derived from tolerance intervals. [less ▲]

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See detailEvaluating bound on voltage and thermal security margins under power transfer uncertainty.
Van Cutsem, Thierry ULg

(2002, June)

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximal pre-contingency power transfer between either a generation and ... [more ▼]

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximal pre-contingency power transfer between either a generation and a load area or two generation areas, such that specirfied contingencies do not overload lines or make the system voltage unstable. The minimum and maximum margins are computed for given intervals of variations of bus injections. Each bound is the solution of a constrained L1-norm minimization (or maximization) problem, for which specific algorithms are given. Thermal overloads are handled through linearization, while for voltage stability, fast time simulation and instability mode analysis are used. Nonlinear situations of branch overload are also considered. The method is illustrated on an 80-bus test system. [less ▲]

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See detailEvaluating bounds on voltage and thermal security margins under power transfer uncertainty
Capitanescu, Florin ULg; Van Cutsem, Thierry ULg

(2002, June)

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximual pre-contingency power transfer between either a generation ... [more ▼]

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximual pre-contingency power transfer between either a generation and a load area or two generation areas, such that the specified contingencies do not overload lines or make the system voltage unstable. The minimum and maximum margins are computed for given intervals of variations of bus injections. Each bound is the solution of a constrained L1-norm minimization (or maximization) problem, for which specific algorithms are given. Thermal overloads are handled through linearization, while for voltage stability, fast time simulation and instability mode analysis are used. Nonlinear situations of branch overloads are also considered. The method is illustrated on an 80-bus test system. [less ▲]

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See detailEvaluating climate model performance with various parameter sets using observations over the recent past
Loutre, M.-F.; Mouchet, Anne ULg; Fichefet, T. et al

in Climate of the Past (2011), 7

Detailed reference viewed: 18 (3 ULg)
See detailEvaluating COSMO’s lake module (FLake) for an East-African lake using a comprehensive set of lake temperature profiles
Thiery, Wim; Martynov, Andrey; Darchambeau, François ULg et al

Conference (2012, April)

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See detailEvaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling
Rahmouni, Souad ULg; Delacroix, Laurence ULg; Liu, Wallace et al

in Phosphatase Modulators, Methods in Molecular Biology (2013)

The importance of tyrosine phosphorylation in normal cell physiology is well established, highlighted by the many human diseases that stem from abnormalities in protein tyrosine kinase (PTK) and protein ... [more ▼]

The importance of tyrosine phosphorylation in normal cell physiology is well established, highlighted by the many human diseases that stem from abnormalities in protein tyrosine kinase (PTK) and protein tyrosine phosphatase (PTP) function. Contrary to earlier assumptions, it is now clear that both PTKs and PTPs are highly specific, non-redundant, and tightly regulated enzymes. Hematopoietic cells express particularly high numbers of PTKs and PTPs, and aberrant function of these proteins have been linked to many hematopoietic disorders. While PTK inhibitors are among FDA approved drugs for the treatment of leukemia and other cancers, efforts to develop therapeutics that target specific PTPs are still in its infancy. Here, we describe methods on how to evaluate effects of PTP inhibitors on T cell receptor signaling. Moreover, we provide a comprehensive strategy for compound prioritization, applicable to any drug discovery project involving T cells. We present a testing funnel that starts with relatively high-throughput luciferase reporter assays, followed by immunoblot, calcium flux, flow cytometry, and proliferation assays, continues with cytokine bead arrays, and finishes with specificity assays that involve RNA interference. We provide protocols for experiments in the Jurkat T cell line, but more importantly give detailed instructions, paired with numerous tips, on how to prepare and work with primary human T cells. [less ▲]

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See detailEvaluating ethane and methane emissions associated with the development of oil and natural gas extraction in North America
Franco, Bruno ULg; Mahieu, Emmanuel ULg; Emmons, L. K. et al

in Environmental Research Letters (2016), 11(4), 044010

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight ... [more ▼]

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight oil reservoirs in North America. Using time series of C2H6 total columns derived from ground-based FTIR observations made at five selected NDACC sites, we characterize the recent C2H6 evolution and determine growth rates of ~5%/yr at mid-latitudes and of ~3%/yr at remote sites. Results from CAM-chem simulations with the HTAP2 bottom-up inventory for anthropogenic emissions are found to greatly underestimate the current C2H6 abundances. Doubling global emissions is required to reconcile the simulations and the observations prior to 2009. We further estimate that North American anthropogenic C2H6 emissions have increased from 1.6 Tg/yr in 2008 to 2.8 Tg/yr in 2014, i.e. by 75% over these six years. We also completed a second simulation with new top-down emissions of C2H6 from North American oil and gas activities, biofuel consumption and biomass burning, inferred from space-borne observations of methane (CH4) from GOSAT. In this simulation, GEOS-Chem is able to reproduce FTIR measurements at the mid-latitudinal sites, underscoring the impact of the North American oil and gas development on the current C2H6 abundance. Finally we estimate that the North American oil and gas emissions of CH4, a major greenhouse gas, grew from 20 to 35 Tg/yr over the period 2008 to 2014, in association with the recent C2H6 rise. [less ▲]

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See detailEvaluating experimental design of ERT for soil moisture monitoring in contour hedgerow intercropping systems
Garré, Sarah ULg; Günther, Thomas; Diels, Jan et al

in Vadose Zone Journal (2012)

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See detailEvaluating functional data for the European Middle Palaeolithic
Rots, Veerle ULg

Conference (2014)

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See detailEvaluating global ocean carbon models: The importance of realistic physics
Doney, S. C.; Lindsay, K.; Caldeira, K. et al

in Global Biogeochemical Cycles (2004), 18(3),

A suite of standard ocean hydrographic and circulation metrics are applied to the equilibrium physical solutions from 13 global carbon models participating in phase 2 of the Ocean Carbon-cycle Model ... [more ▼]

A suite of standard ocean hydrographic and circulation metrics are applied to the equilibrium physical solutions from 13 global carbon models participating in phase 2 of the Ocean Carbon-cycle Model Intercomparison Project (OCMIP-2). Model-data comparisons are presented for sea surface temperature and salinity, seasonal mixed layer depth, meridional heat and freshwater transport, 3-D hydrographic fields, and meridional overturning. Considerable variation exists among the OCMIP-2 simulations, with some of the solutions falling noticeably outside available observational constraints. For some cases, model-model and model-data differences can be related to variations in surface forcing, subgrid-scale parameterizations, and model architecture. These errors in the physical metrics point to significant problems in the underlying model representations of ocean transport and dynamics, problems that directly affect the OCMIP predicted ocean tracer and carbon cycle variables (e.g., air-sea CO2 flux, chlorofluorocarbon and anthropogenic CO2 uptake, and export production). A substantial fraction of the large model-model ranges in OCMIP-2 biogeochemical fields (+/-25-40%) represents the propagation of known errors in model physics. Therefore the model-model spread likely overstates the uncertainty in our current understanding of the ocean carbon system, particularly for transport-dominated fields such as the historical uptake of anthropogenic CO2. A full error assessment, however, would need to account for additional sources of uncertainty such as more complex biological-chemical-physical interactions, biases arising from poorly resolved or neglected physical processes, and climate change. [less ▲]

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See detailEvaluating Portfolio Performance: Reconciling Asset Selection and Market Timing
Cavé, Arnaud; Hübner, Georges ULg; Lejeune, Thomas ULg

in Baker, H. Kent; Filbeck, Georges (Eds.) Portfolio Theory and Management (2013)

This chapter examines the performance measurement of mutual funds when both security selection and market timing management skills are considered. In an option replication approach, linear and quadratic ... [more ▼]

This chapter examines the performance measurement of mutual funds when both security selection and market timing management skills are considered. In an option replication approach, linear and quadratic coefficients of the Treynor and Mazuy regression are combined to assess performance in presence of market timing. This new correction has the potential to overcome the “artificial timing” bias and delivers particularly encouraging results on a sample of 1,413 U.S. mutual funds selected for an empirical analysis. Unlike alternative approaches proposed in the literature, most of positive market timers seem to be rewarded for the convexity they add to their portfolio, while negative market timers are penalized, and a correlation between abnormal performance and the convexity parameter is found. [less ▲]

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See detailEvaluating product temperature during thin bed drying.
Bera, François ULg

in Berichte Der Bundesforschungsanstalt Für Ernährung (1987, February)

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See detailEvaluating radical conservation futures: strategies for assessing the potential for Eurasian lynx in the Benelux countries
Bouyer, Yaëlle ULg; Poncin, Pascal ULg; Beudels-Jamar, Roseline et al

Poster (2011, July 08)

Tolerance of anthropic environment has allowed large carnivores to recolonize and to be reintroduced within Europe in the last forty years. This indicates that, even in areas where the return of large ... [more ▼]

Tolerance of anthropic environment has allowed large carnivores to recolonize and to be reintroduced within Europe in the last forty years. This indicates that, even in areas where the return of large carnivores seems unlikely, their presence and establishment is possible, even in highly modified environments. In the current context of the return of large carnivores in Europe, there is a need for scientific conservation tools to assess the full potential and consequences of the return of large carnivores in Europe, and in particular to evaluate potential impact on game and livestock. Today, the return of the Eurasian Lynx (Lynx lynx) in areas where it has been absent for long periods is becoming increasingly probable, and this requires further investigations. Three main lines of research will be particularly important: the use of habitat by Eurasian Lynx, the effect of habitat on predation behavior, and potential sources of conflict with human populations. The research project will address fine scale habitat use, the effect of prey‘s spatial variation on Lynx predation behavior, the use of different statistical methods to estimate Lynx‘s viability in various habitats and landscape, and a review of current conflicts throughout Europe. Results should allow better understanding of the Lynx redeployment potentials in lowland Western Europe [less ▲]

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See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

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See detailEvaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]

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See detailEvaluating somatic cell scores with a Bayesian Gaussian linear state-space model.
Detilleux, Johann ULg; Theron, Léonard ULg; Reding, E. et al

in Animal (2014), 8(3), 477-83

Because accurate characterization of health state is important for managing dairy herds, we propose to validate the use of a linear state-space model (LSSM) for evaluating monthly somatic cell scores ... [more ▼]

Because accurate characterization of health state is important for managing dairy herds, we propose to validate the use of a linear state-space model (LSSM) for evaluating monthly somatic cell scores (SCSs). To do so, we retrieved SCS from a dairy database and collected reports on clinical mastitis collected in 20 farms, during the period from January 2008 to December 2011 in the Walloon region of Belgium. The dependent variable was the SCS, and the independent variables were the number of days from calving, year of calving and parity. The LSSM also incorporated an error-free underlying variable that described the trend across time as a function of previous clinical and subclinical status. We computed the mean sum of squared differences between observed SCS and median values of the posterior SCS distribution and constructed the receiver operating characteristic (ROC) curve for SCS thresholds going from 0 to 6. Our results show SCS estimates are close to observed SCS and area under the ROC curve is higher than 90%. We discuss the meaning of the parameters in light of our current knowledge of the disease and propose methods to incorporate, in LSSM, this knowledge often expressed in the form of ordinary differential equations. [less ▲]

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See detailEvaluating the attainment of LOGO objectives in a constructivist approach
Denis, Brigitte ULg

in Schuyten, Gilberte (Ed.) Proceedings : Second European LOGO conference, Gent, August 1989 (1989)

Detailed reference viewed: 38 (1 ULg)