The interplay of two single nucleotide polymorphisms in the CACNA1A gene may contribute to migraine susceptibility.

in Neuroscience Letters (2009), 453(1), 12-5

Migraine is a common disorder with a significant genetic component. Mutations in the CACNA1A gene are found in hemiplegic migraine (HM). Basilar-type (BM), another subtype of migraine with aura, differs ... [more ▼]

Migraine is a common disorder with a significant genetic component. Mutations in the CACNA1A gene are found in hemiplegic migraine (HM). Basilar-type (BM), another subtype of migraine with aura, differs from HM only by the absence of motor deficits. BM and HM may thus share common genetic features. In the present study, two single nucleotide polymorphisms (SNPs) of the CACNA1A gene were characterized in a population of migraine patients and healthy controls. The polymorphisms, E918D, predicting a glutamic acid-to-aspartic acid substitution at codon 918 and E993V, predicting a glutamic acid-to-valine substitution at codon 993, were frequently detected among patients and controls. Seven BM, 10 SHM, 5 FHM, 57 migraine with typical aura, 32 migraine without aura patients and 107 healthy controls were screened. The E918D and E993V SNPs were found in 30/117 (25.6%) and 32/117 (27.3%) migraine patients, respectively. The prevalence of these SNPs taken separately was not significantly different from that of control subjects (n=28/107, 26.2% for E918D; n=29/107 for E993V, 27.1%) neither for the total migraine population nor for the various migraine subtypes. By contrast, coexistence of both SNPs was more frequent in migraineurs (25/117, 21%) than in healthy controls (12/107, 11%; p=0.048), a difference that was significant for every migraine subtype. This result suggests that the interplay of minor genetic variants such as single nucleotide polymorphisms may influence the P/Q-type calcium channel function in several subtypes of migraine. [less ▲]

Interpolymer radical coupling: A toolbox complementary to controlled radical polymerization

in Progress in Polymer Science (2012), 37(7), 1004-1030

The current review focuses on the relevance and practical benefit of interpolymer radical coupling methods. The latter are developing rapidly and constitute a perfectly complementary macromolecular ... [more ▼]

The current review focuses on the relevance and practical benefit of interpolymer radical coupling methods. The latter are developing rapidly and constitute a perfectly complementary macromolecular engineering toolbox to the controlled radical polymerization techniques (CRP). Indeed, all structures formed by CRP are likely to be prone to radical coupling reactions, which multiply the available synthetic possibilities. Basically, the coupling systems can be divided in two main categories. The first one, including the atom transfer radical coupling (ATRC), silane radical atom abstraction (SRAA) and cobalt-mediated radical coupling (CMRC), relies on the recombination of macroradicals produced from a dormant species. The second one, including atom transfer nitroxide radical coupling (ATNRC), single electron transfer nitroxide radical coupling (SETNRC), enhanced spin capturing polymerization (ESCP) and nitrone/nitroso mediated radical coupling (NMRC), makes use of a radical scavenger in order to promote the conjugation of the polymer chains. More than a compilation of macromolecular engineering achievements, the present review additionally aims to emphasize the particularities, synthetic potential and present limitations of each system. [less ▲]

Interpretation and modelling of multi-tracer tests in heterogeneous geological media

in Peters, N. E.; Coudrain-Ribstein, A. (Eds.) Hydrochemistry (Proc. of the Rabat Symposium) (1997)

Interprétation d'une photo aérienne de Campine

in La Géographie (1969), (82), 157-164

Présentation d'une région géographique belge au départ d'une photo aérienne en vue d'un cours dans l'enseignement secondaire

Interprétation de l'index IgG et du diagramme de Reiber par Protis 2 dans les maladies inflammatoires du système nerveux central

in Immuno-Analyse & Biologie Spécialisée [=IBS] (2009), (24), 135-147

L'interprétation des clauses d'une police d'assurance en cas de doute

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

Interprétation des données GPS TRIMBLE 4000 SLD

Report (1989)

Interprétation des résultats d’évaluation en EAD - Pratiques du LabSET-ULg

Conference (2004, January 20)

Interprétation du levé photogrammétrique

in Les fouilles de la place Saint-Lambert à Liège, 1 (1984)

Interprétation géométrique de la régression

in Notes de Statistique et d'Informatique (2003), (2), 1-28