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See detailLes évêques de Tongres-Maastricht-Liège sous Charlemagne
Rolland, Jean-Noël ULg

Conference (2015, October 20)

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See detailEverolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial.
Andre, Fabrice; O'Regan, Ruth; Ozguroglu, Mustafa et al

in The lancet oncology (2014)

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to ... [more ▼]

BACKGROUND: Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited women with HER2-positive, trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy. Eligible patients were randomly assigned (1:1) using a central patient screening and randomisation system to daily everolimus (5 mg/day) plus weekly trastuzumab (2 mg/kg) and vinorelbine (25 mg/m2) or to placebo plus trastuzumab plus vinorelbine, in 3-week cycles, stratified by previous lapatinib use. The primary endpoint was progression-free survival (PFS) by local assessment in the intention-to-treat population. We report the final analysis for PFS; overall survival follow-up is still in progress. This trial is registered with ClinicalTrials.gov, number NCT01007942. FINDINGS: Between Oct 26, 2009, and May 23, 2012, 569 patients were randomly assigned to everolimus (n=284) or placebo (n=285). Median follow-up at the time of analysis was 20.2 months (IQR 15.0-27.1). Median PFS was 7.00 months (95% CI 6.74-8.18) with everolimus and 5.78 months (5.49-6.90) with placebo (hazard ratio 0.78 [95% CI 0.65-0.95]; p=0.0067). The most common grade 3-4 adverse events were neutropenia (204 [73%] of 280 patients in the everolimus group vs 175 [62%] of 282 patients in the placebo group), leucopenia (106 [38%] vs 82 [29%]), anaemia (53 [19%] vs 17 [6%]), febrile neutropenia (44 [16%] vs ten [4%]), stomatitis (37 [13%] vs four [1%]), and fatigue (34 [12%] vs 11 [4%]). Serious adverse events were reported in 117 (42%) patients in the everolimus group and 55 (20%) in the placebo group; two on-treatment deaths due to adverse events occurred in each group. INTERPRETATION: The addition of everolimus to trastuzumab plus vinorelbine significantly prolongs PFS in patients with trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer. The clinical benefit should be considered in the context of the adverse event profile in this population. FUNDING: Novartis Pharmaceuticals Corporation. [less ▲]

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See detailEverolimus Plus Exemestane Versus Everolimus or Capecitabine Monotherapy in Breast Cancer : BOLERO-6
Ejlertsen, Bent; JERUSALEM, Guy ULg; Hurvitz, Sara et al

Poster (2013, March)

The data from this trial will provide insight into the safety and efficacy of the combination of EVE and EXE versus EVE or capecitabine monotherapy in women with ER+, HER2- ABC progressing on/after prior ... [more ▼]

The data from this trial will provide insight into the safety and efficacy of the combination of EVE and EXE versus EVE or capecitabine monotherapy in women with ER+, HER2- ABC progressing on/after prior LET or ANA. [less ▲]

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See detailEverybody knows what IRT is... (really?)
Magis, David ULg

Conference (2012, March 27)

Item response theory (IRT) is not only a famous acronym, it also covers a broad range of statistical and psychometric models, methods, and applications in psychology and educational science. However, IRT ... [more ▼]

Item response theory (IRT) is not only a famous acronym, it also covers a broad range of statistical and psychometric models, methods, and applications in psychology and educational science. However, IRT looks somewhat misunderstood or even esoteric to the non-statisticians and non-psychometricians. The main goal of this talk is to briefly and clearly present the main aspects of traditional IRT: objectives, assumptions, basic models, and basic estimation methods. As a secondary purpose, extensions of IRT to more complex situations (polytomous data, multidimensional and hierarchical models, computerized adaptive testing, differential item functioning, nonparametric IRT) are briefly outlined. This talk will be as little technical as possible, focusing on the main concepts and applications of this theory. [less ▲]

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See detail“Everything was losing definition and outline”: Re-membering Trauma Fiction in Gail Jones’s Sorry
Belleflamme, Valérie-Anne ULg

Conference (2016, March 18)

In an article, Australian novelist and essayist Gail Jones confesses of her novel Sorry that it has “a political-allegorical aspect – as one would expect, claiming such a title” (2008, 79). Published in ... [more ▼]

In an article, Australian novelist and essayist Gail Jones confesses of her novel Sorry that it has “a political-allegorical aspect – as one would expect, claiming such a title” (2008, 79). Published in 2007, that is, one year prior to the formal apology delivered by the Australian government to the Aborigines and Torres Strait Islanders, Sorry engages in a reflection on the ethics of reconciliation. Written in response to Jones’s wish to acknowledge the debt to the Stolen Generations, the novel also offers new possibilities of ethical mourning, allowing the dead to return and the voiceless to speak. My paper will seek to explore the ways in which Jones draws on trauma fiction to bypass not only the unsayable dimension of Australia’s history and what she elsewhere criticises as the trauma model’s “transferential gesture of victim surrogacy” symptomatic of postcolonising settler cultures (2004, 162) but also the representational difficulties inherent in trauma. Moreover, it is by introducing into her novel the concept of traumatic time, “a time that is broken, and […] recursive” (qtd. in Block 2008) and which mirrors on the level of form and structure the effects that trauma exerts on its victims, that Jones she recreates a narrative model that echoes an Australian discourse pre-dating the Bringing Them Home report – that is tinged with amnesia, fragmented memories, and silence –, against which she will assert her own counter-discourse. Works Cited: - Block, Summer. 09 May 2008. “Interview: Gail Jones.” Interview. January Magazine. Web. 16 Jan. 2013. - Jones, Gail. 2004. “Sorry-in-the-Sky: Empathetic Unsettlement, Mourning, and the Stolen Generations.” In Imagining Australia: Literature and Culture in the New New World, edited by Judith Ryan and Chris Wallace-Crabbe, 159-171. Cambridge, MA: Harvard University Press. - Jones, Gail. 2007. Sorry. London: Harvill Secker. - Jones, Gail. 2008. “Speaking Shadows: Justice and the Poetic.” In Just Words?: Australian Authors Writing for Justice, edited by Bernadette Brennan, 76-86. St Lucia: University of Queensland Press. [less ▲]

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See detailHet everzwijn en het geheimzinnige eiland
Gerkens, Jean-François ULg

Scientific conference (2009, March 19)

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See detailEvi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation.
Van Campenhout, Claude; Nichane, Massimo; Antoniou, Aline et al

in Developmental Biology (2006), 294(1), 203-19

The ecotropic viral integration site 1 (Evi1) and related MEL1 (MDS1/Evi1-like gene 1) genes are zinc finger oncogenic transcription factors involved in myeloid leukaemia. Here, we show that in Xenopus ... [more ▼]

The ecotropic viral integration site 1 (Evi1) and related MEL1 (MDS1/Evi1-like gene 1) genes are zinc finger oncogenic transcription factors involved in myeloid leukaemia. Here, we show that in Xenopus, Evi1 and MEL1 have partially overlapping restricted embryonic expression profiles. Within the pronephros, Evi1 and MEL1 are sequentially expressed within the distal tubule and duct compartments, Evi1 transcription being detected prior to any sign of pronephric morphogenesis. In the pronephros of zebrafish embryos, Evi1 expression is restricted to the posterior portion of the duct, the anterior portion having characteristics of proximal tubules. In the Xenopus pronephros, Evi1 expression is upregulated by retinoid signaling and repressed by overexpression of xWT1 and by Notch signaling. Overexpression of Evi1 from late neurula stage specifically inhibits the expression of proximal tubule and glomus pronephric markers. We show that the first zinc finger and CtBP interaction domains are required for this activity. Overexpression of a hormone-inducible Evi1-VP16 antimorphic fusion with activation at neurula stage disrupts distal tubule and duct formation and expands the expression of glomus markers. Although overexpression of this construct also causes in many embryos a reduction of proximal tubule markers, embryos with expanded and ectopic staining have been also observed. Together, these data indicate that Evi1 plays a role in the proximo-distal patterning of the pronephros and suggest that it may do so by functioning as a CtBP dependent repressor. [less ▲]

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See detailEVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells.
De Weer, An; Van der Meulen, Joni; Rondou, Pieter et al

in British Journal of Haematology (2011), 154(3), 337-48

Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated with poor prognosis. In this study, we assessed the role ... [more ▼]

Chromosomal rearrangements involving the MECOM (MDS1 and EVI1 complex) locus are recurrent genetic events in myeloid leukaemia and are associated with poor prognosis. In this study, we assessed the role of MECOM locus protein EVI1 in the transcriptional regulation of microRNAs (miRNAs) involved in the leukaemic phenotype. For this, we profiled expression of 366 miRNAs in 38 MECOM-rearranged patient samples, normal bone marrow controls and MECOM (EVI1) knock down/re-expression models. Cross-comparison of these miRNA expression profiling data showed that MECOM rearranged leukaemias are characterized by down regulation of MIR449A. Reconstitution of MIR449A expression in MECOM-rearranged cell line models induced apoptosis resulting in a strong decrease in cell viability. These effects might be mediated in part by MIR449A regulation of NOTCH1 and BCL2, which are shown here to be bona fide MIR449A targets. Finally, we confirmed that MIR449A repression is mediated through direct promoter occupation of the EVI1 transcriptional repressor. In conclusion, this study reveals MIR449A as a crucial direct target of the MECOM locus protein EVI1 involved in the pathogenesis of MECOM-rearranged leukaemias and unravels NOTCH1 and BCL2 as important novel targets of MIR449A. This EVI1-MIR449A-NOTCH1/BCL2 regulatory axis might open new possibilities for the development of therapeutic strategies in this poor prognostic leukaemia subgroup. [less ▲]

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See detailEvidence and analysis of 2012 Greenland records from spaceborne observations, a regional climate model and reanalysis data
Tedesco, M.; Fettweis, Xavier ULg; Mote, T. et al

in Cryosphere (The) (2013), 7

A combined analysis of remote sensing observations, regional climate model (RCM) outputs and reanalysis data over the Greenland ice sheet provides evidence that multiple records were set during summer ... [more ▼]

A combined analysis of remote sensing observations, regional climate model (RCM) outputs and reanalysis data over the Greenland ice sheet provides evidence that multiple records were set during summer 2012. Melt extent was the largest in the satellite era (extending up to ∼97% of the ice sheet) and melting lasted up to ∼2 months longer than the 1979–2011 mean. Model results indicate that near surface temperature was ∼3 standard deviations (σ) above the 1958–2011 mean, while surface mass balance (SMB) was ∼3σ below the mean and runoff was 3.9σ above the mean over the same period. Albedo, exposure of bare ice and surface mass balance also set new records, as did the total mass balance with summer and annual mass changes of, respectively, −627 Gt and −574 Gt, 2σ below the 2003–2012 mean. We identify persistent anticyclonic conditions over Greenland associated with anomalies in the North Atlantic Oscillation (NAO), changes in surface conditions (e.g., albedo, surface temperature) and preconditioning of surface properties from recent extreme melting as major driving mechanisms for the 2012 records. Less positive if not increasingly negative SMB will likely occur should these characteristics persist. [less ▲]

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See detailEvidence and purification of a novel bacterial dehydrogenase : a vanillin : NAD (P) oxydoreductase.
Bare, G.; Moukil, M.; Swiatkowski, Th. et al

Poster (1996, August)

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See detailEvidence based medicine - Tendon and platelet-rich plasma (PRP)
Kaux, Jean-François ULg

in Annual Congress RSBPRM (2014, December 06)

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines ... [more ▼]

Platelets have known roles in coagulation, inflammatory processes, and immunity modulation; they also have ‘‘restorative’’ properties. Indeed, during degranulation, platelets release different cytokines and growth factors (VEGF, PDGF, TGF-B, IGF-I, and HGF) that promote angiogenesis, tissue remodeling (bone, skin, muscle, tendon, etc.), and wound healing. PRP is obtained by centrifuging autologous blood to obtain a concentration of platelets, usually between 3 and 10 times that of whole blood, depending on the isolation method. For this reason, different PRP preparation techniques cannot provide a consistently identical final product, but there is currently no international consensus on this issue. Overall, PRP could be an attractive therapeutic option for treating chronic musculoskeletal conditions, such as tendinopathy or plantar fasciitis. Tendons do not have a high metabolic index. Growth factors released by platelets promote tenocyte proliferation, stimulate angiogenesis and have analgesic properties. Thus it could stimulate and accelerate tissue regeneration in animal models. In addition to PRP, optimal tissue quality requires the application of mechanical loads. PRP should be considered for chronic tendinopathies. Indeed, the goal is to initiate an acute inflammatory reaction that quickly moves on to the proliferative phase that involves collagen synthesis. The latter is necessary for appropriate tendon healing. PRP should therefore not be used for acute tendinitis or tenosynovitis. Even if most of the preclinical studies showed that PRP stimulates the tendon healing process, clinical series remain more controversial. Based on literature and our clinical experience, we suggest some ideas for improving this treatment. Optimization of the technique for collecting the PRP is paramount. Different risk factors must be corrected before infiltration, and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely necessary. Standardisation of the use of PRP remains necessary in order to optimise the results. [less ▲]

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See detailEvidence based policies?
Blad, John; Lauwaert, Katrien ULg

in Vanfraechem, Inge; Aertsen, Ivo (Eds.) Restorative Justice Realities. Empirical Research in a European Context (2010)

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See detailEvidence Based Practice
Bruyère, Olivier ULg

Learning material (2011)

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See detailEvidence for a differentiated chromosomal race north of classical south European refuge areas in the garden dormouse Eliomys quercinus
Libois, Roland ULg; Ramalhinho, Maria da Graça; Rosoux, René

in Acta Theriologica (2012), 57(4), 313-320

The dormouse Eliomys quercinus is a forest rodent undergoing long periods of winter hibernation. The species presents a surprisingly large diversity of chromosomal races, which geographic distribution was ... [more ▼]

The dormouse Eliomys quercinus is a forest rodent undergoing long periods of winter hibernation. The species presents a surprisingly large diversity of chromosomal races, which geographic distribution was shown recently to predate the Pleistocene glaciations. Previously reported data on the karyotypes of the garden dormouse in France come from the northeast of the country, where the 2N050 race occurs. New data are presented from specimens trapped near the Atlantic coast (departments of Vendée and Charente-Maritime), in the Pyrenees, the Alps and in the Massif Central. The French Alpine chain, close to the Italian border, is inhabited by the 2N054 race. A karyotype with 2N048 chromosomes, of Iberian type, is found north of the Pyrenees, near the central Atlantic coast and also in the south of the Massif Central, whereas the 2N050 race occurs in the north of the massif. A hybrid between these two races (2N049) was found in Vendée. These facts reveal that neither the Pyrenees nor the Alps constitute a biogeographic barrier to the dormouse and strongly suggest that the present population of northern France derives from a postglacial recolonisation movement initiated in the southernmost regions of France or in the Rhône valley. [less ▲]

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See detailEvidence for a global access deficit to the meaning of numerical symbols in people with Williams syndrome.
Rousselle, Laurence ULg; Noel, Marie-Pascale

Poster (2014)

Recent studies suggest that patients with Williams syndrome (WS) present specific deficit in processing numerical magnitude (Krajcsi et al., 2009; O’Hearn & Landau, 2007; Paterson et al., 2006 ... [more ▼]

Recent studies suggest that patients with Williams syndrome (WS) present specific deficit in processing numerical magnitude (Krajcsi et al., 2009; O’Hearn & Landau, 2007; Paterson et al., 2006). Contradictory evidence has nevertheless been reported about a possible impairment of their subitizing abilities (Ansari et al., 2007; O’Hearn et al., 2005, 2011). As patients with WS were always tested in the visual modality, it remains unclear whether their deficit is specific to the processing of numerical magnitude or result from their basic visuo-spatial impairment (main characteristic of the WS cognitive phenotype). A first set of results supported the second hypothesis as people with WS were shown to have lower numerical acuity only in numerical tasks with high visuo-spatial processing requirements (i.e. comparing two lengths or two arrays of elements but not when comparing two durations or two sequences of flash in a single location; Rousselle & Noël, 2013). Recently, we tested whether a similar dissociation would be observed in processing the meaning of numerical symbols. Patients with WS were asked to compare the numerical magnitude of two Arabic numbers vs two spoken verbal numerals. They also had to enumerate sets of 1 to 7 dots shown for 250 ms to explore their subitizing abilities. Participants with WS were compared to two groups of children, one matched on verbal and the other matched on nonverbal mental abilities. Our results indicate that people with WS have difficulties in accessing the meaning of numerical symbols whatever the format and present smaller subitizing range. [less ▲]

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