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See detailGenetique et environnement dans les maladies inflammatoires chroniques de l'intestin.
Louis, Edouard ULg; VAN KEMSEKE, Catherine ULg; LATOUR, Pascale ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 298-304

Inflammatory bowel diseases are both environmental and genetic illnesses. More than one hundred genes or loci involved in the regulation of innate or acquired immune response as well as intestinal mucosa ... [more ▼]

Inflammatory bowel diseases are both environmental and genetic illnesses. More than one hundred genes or loci involved in the regulation of innate or acquired immune response as well as intestinal mucosa homeostasis have been identified. Environmental studies have been less numerous up to now and only smoking and appendectomy have been validated, as protector for ulcerative colitis, while smoking is clearly associated with an increased risk and more severe forms of Crohn's disease. An important role is also currently suspected for the intestinal flora and the dysbiosis described in inflammatory bowel disease could contribute to the triggering or the persistence of the inflammation. New therapeutic strategies are currently studied, particularly aiming at targeting immune, inflammatory or homeostatic pathways corresponding to the predisposing gene variants. [less ▲]

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See detailGénétique moléculaire des récepteurs olfactifs
Parmentier, M.; Vanderhaeghen, P.; Schurmans, Stéphane ULg et al

in Medecine Sciences : M/S (1994), 10

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des ... [more ▼]

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des récepteurs à sept passages transmembranaires couplés, par l'intermédiaire de protéines G, à l'activation de l'adénylyl cyclase et de la phospholipase C. La grande diversité des récepteurs olfactifs réside surtout dans les domaines transmembranaires III, IV, V et VI, qui portent les sites de liaison des ligands, les molécules odorantes, et répond sans doute à la diversité des ligands [less ▲]

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See detailGeneva photometry of HD 129929 (Aerts+, 2004)
Aerts, C.; Waelkens, C.; Daszynska-Daszkiewicz, J. et al

in SIMBAD (2003), 341

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a ... [more ▼]

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a beating phenomenon is evident from the data. We find evidence for the presence of at least six frequencies, among which we see components of two frequency multiplets with an average spacing of ~0.0121c/d which points towards very slow rotation. This result is in agreement with new spectroscopic data of the star and also with previously taken UV spectra. We provide the amplitudes of the six frequencies in all seven photometric filters. The metal content of the star is Z=0.018+/-0.004. All these observational results will be used to perform detailed seismic modelling of this massive star in a subsequent paper. (1 data file). [less ▲]

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See detailGeneva photometry of HDE 318107 (Manfroid+, 2000)
Manfroid, Jean ULg; Mathys, G.

Report (2000)

File table1 contains the individual photometric measurements of HDE 318107 in the Geneva system. (1 data file).

Detailed reference viewed: 11 (1 ULg)
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See detailGénie des procédés chimiques et développement durable
Léonard, Angélique ULg

Conference given outside the academic context (2011)

Detailed reference viewed: 36 (9 ULg)
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See detailThe GENIE nulling experiment
Absil, Olivier ULg; Gondoin, Ph; den Hartog, R. et al

in Combes, F. (Ed.) SF2A-2002: Semaine de l'Astrophysique Francaise (2002, June)

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very ... [more ▼]

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very Large Telescope Interferometer (VLTI). The main objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer representative of the ESA IRSI-Darwin space mission. GENIE will prepare the Darwin science programme through a systematic search for exo-zodiacal dust clouds around Darwin candidate targets. GENIE also aims to perform Darwin related science including the detection of low-mass companions (if possible, hot Jupiters) around nearby stars. The prospective performances of some candidate configurations are presented in this paper. [less ▲]

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See detailLe « génie orienté produit » appliqué à l’élaboration de matrices poreuses pour l’ingénierie tissulaire.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Récents Progrès en Génie des Procédés (2013, October 08)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailGENIE, the Ground-based European Nulling Interferometry Experiment
Absil, Olivier ULg

Scientific conference (2002, May 15)

L’instrument GENIE (Ground-based European Nulling Interferometer Experiment), projet co-financé par l’ESA et l’ESO, est un interféromètre en frange noire qui sera installé vers mi-2006 sur le site du VLTI ... [more ▼]

L’instrument GENIE (Ground-based European Nulling Interferometer Experiment), projet co-financé par l’ESA et l’ESO, est un interféromètre en frange noire qui sera installé vers mi-2006 sur le site du VLTI. Cet instrument, actuellement en phase de définition, sera avant tout un démonstrateur technologique pour la mission spatiale Darwin. Mais il permettra aussi de détecter des disques de poussière zodiacale autour d’étoiles proches, de faire la spectroscopie des plus brillants d’entre eux, et probablement de détecter pour la première fois le rayonnement thermique de certains Jupiters chauds. Dans cet exposé, je discuterai les performances attendues de GENIE en fonction de la configuration instrumentale choisie, aussi bien pour la détection de disques que d’exoplanètes. [less ▲]

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See detailGENIE, the Ground-based European Nulling Interferometry Experiment
Absil, Olivier ULg

Scientific conference (2002, June 27)

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very ... [more ▼]

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very Large Telescope Interferometer (VLTI). The main objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer representative of the ESA IRSI-Darwin space mission. GENIE will prepare the Darwin science programme through a systematic search for exo-zodiacal dust clouds around Darwin candidate targets. GENIE also aims to perform Darwin related science including the detection of low-mass companions (if possible, hot Jupiters) around nearby stars. The prospective performances of some candidate configurations are presented in this paper. [less ▲]

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See detailGENIE: a Ground-Based European Nulling Instrument at ESO Very Large Telescope Interferometer
Gondoin, P.; den Hartog, R.; Fridlund, M. et al

in Richichi, A.; Delplancke, F.; Paresce, F. (Eds.) et al The Power of Optical/IR Interferometry: Recent Scientific Results and 2nd Generation Instrumentation (2008)

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars, to analyze the ... [more ▼]

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars, to analyze the composition of their atmospheres and to assess their ability to sustain life as we know it. Darwin is conceived as a space ``nulling interferometer'' which makes use of on-axis destructive interferences to extinguish the stellar light while keeping the off-axis signal of the orbiting planet. Within the frame of the Darwin program, definition studies of a Ground based European Nulling Interferometry Experiment, called GENIE, were completed in 2005. This instrument built around the Very Large Telescope Interferometer (VLTI) in Paranal will test some of the key technologies required for the Darwin Infrared Space Interferometer. GENIE will operate in the L' band around 3.8 microns as a single Bracewell nulling interferometer using either two Auxiliary Telescopes (ATs) or two 8m Unit Telescopes (UTs). Its science objectives include the detection and characterization of dust disks and low-mass companions around nearby stars. [less ▲]

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See detailGENIE: a ground-based precursor for Darwin
Absil, Olivier ULg

Scientific conference (2003, November 21)

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See detailGENIE: a ground-based precursor for the IRSI-Darwin mission
Absil, Olivier ULg

in Aime, Claude; Soummer, Rémi (Eds.) Astronomy with High Contrast Imaging (2003)

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and ... [more ▼]

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and hot Jupiter detection. Their expected performances have been computed in light of the measured or expected performances of the VLTI sub-systems. A simple Bracewell nulling interferometer, formed of two Unit Telescopes and working in the L' or N bands, has been identified as a good candidate configuration for exozodiacal cloud detection. External or internal chopping, fringe tracking and intensity matching will be critical issues for this configuration. In the case of hot Jupiter detection, a double Bracewell with internal modulation in the L' band seems well appropriate, and should allow to carry out low resolution spectroscopy on a few bright exoplanets. The basic assumptions and computations which have lead to these candidate configurations are described in this paper. [less ▲]

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See detailGENIE: High-Resolution Study of Debris Disks
Absil, Olivier ULg; Augereau, Jean-Charles; Den Hartog, Roland et al

in Richichi, A.; Delplancke, F.; Paresce, F. (Eds.) et al The Power of Optical/IR Interferometry: Recent Scientific Results and 2nd Generation Instrumentation (2008)

GENIE, the Ground-based European Nulling Interferometer Experiment, will combine the lights collected in the L’ band by two VLT telescopes in a destructive way, thereby revealing the thermal and/or ... [more ▼]

GENIE, the Ground-based European Nulling Interferometer Experiment, will combine the lights collected in the L’ band by two VLT telescopes in a destructive way, thereby revealing the thermal and/or scattered emission of faint objects in the close neighbourhood of the target star. A prime scientific goal for GENIE thus consists in the detection and characterization of debris disks around nearby Vega-type stars. Thanks to its high angular resolution and operating wavelength (3.8 µm), GENIE will be particularly sensitive to the thermal emission from the warm dust standing within a few AU from the star, a part of the disks which is not accessible with current detection methods (IR photometric excesses, sub-millimeter imaging, …). In this paper, we investigate the capabilities of GENIE to detect and characterize the physical parameters of the debris disk around zeta Leporis, a prototypical Vega-type star suspected to harbour a warm dust component in its debris disk (Fajardo-Acosta et al., AJ 115, 2101). This study is then extended to the detection of faint exozodiacal disks around typical Darwin/TPF targets, thereby demonstrating the very high potential of GENIE in the field of high-contrast imaging. [less ▲]

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See detailGENIE: un précurseur pour Darwin
Absil, Olivier ULg

Scientific conference (2003, October 09)

L'instrument GENIE, un projet commun de l'ESA (Agence Spatiale Européenne) et de l'ESO (Observatoire Européen Austral), sera installé en 2007 sur le site du VLTI (Paranal, Chili). Cet instrument ... [more ▼]

L'instrument GENIE, un projet commun de l'ESA (Agence Spatiale Européenne) et de l'ESO (Observatoire Européen Austral), sera installé en 2007 sur le site du VLTI (Paranal, Chili). Cet instrument interférométrique recombinera de façon destructive la lumière infrarouge collectée par deux ou plusieurs Very Large Telescopes, permettant ainsi d'étudier l'environnement d'objets brillants avec une haute résolution angulaire. Son objectif principal est de valider le concept du "nulling interferometer", de gagner de l'expérience dans le design et l'opération d'un tel instrument, et de tester certaines des nouvelles technologies nécessaires pour Darwin. GENIE préparera aussi le programme scientifique de Darwin en détectant et caractérisant d'éventuels disques de poussière autour des étoiles cibles de Darwin. Cette étude permettra d'écarter les cibles inappropriées pour la recherche de planètes habitables. GENIE obtiendra également des spectres basse résolution pour le rayonnement thermique de quelques exoplanètes géantes. [less ▲]

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See detailGENIEsim: the GENIE Science Simulator
Absil, Olivier ULg

Master of advanced studies dissertation (2003)

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See detailGENIEsim: the GENIE simulation software
Absil, Olivier ULg; den Hartog, R.; Erd, C. et al

in Fridlund, Malcolm; Henning, Thomas (Eds.) Towards Other Earths: DARWIN/TPF and the Search for Extrasolar Terrestrial Planets (2003, October 01)

GENIEsim, the GENIE simulation software, is an IDL-based code to simulate future observations with the Ground-based European Nulling Interferometer Experiment, which should be commissioned on the Very ... [more ▼]

GENIEsim, the GENIE simulation software, is an IDL-based code to simulate future observations with the Ground-based European Nulling Interferometer Experiment, which should be commissioned on the Very Large Telescope Interferometer (VLTI) in 2007. The code simulates operation in the mid-infrared (L' and N bands) and includes all major noise sources. The atmospheric turbulence is described by a Kolmogorov power spectrum, from which random time series are computed for perturbations to the optical paths. The effect of turbulence is reduced by means of control loops, which are either included in the VLTI facility (MACAO, PRIMA) or specific to the GENIE instrument. The output of GENIEsim is a time series of fluxes computed by integration of a source field multiplied by the GENIE transmission map, projected onto the plane of the sky. Simulations have already allowed to identify critical points in the design of the instrument, such as OPD and dispersion control, calibration of stellar leakage and background subtraction. [less ▲]

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See detailGenital re-excretion of Murid gammaherpesvirus 4 following intranasal infection
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

Poster (2010, November 18)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections of immunocompetent hosts. Thus, infected individuals simultaneously both elicit antiviral protective immune response and secrete infectious virions. The best studied gammaherpesviruses are Human herpesvirus 4 and Human herpesvirus 8. As these viruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4), a virus that has originally been isolated from bank voles (Myodes glareolus). Although MuHV-4 has not been isolated from house mice (Mus musculus), infection of inbred laboratory mouse strains is commonly accepted as a good model for studying gammaherpesviruses in vivo. To date, it has however never been possible to monitor viral reexcretion and virus transmission in this species suggesting that this model could be imperfect. In order to identify potential re-excretion sites, intranasally infected mice were followed through global luciferase imaging for up to six months after infection. By this technique, we were able to detect appearance of viral replication in mice genital tract at various times post-infection. Typically, it firstly occurred between days 20 to 30 after infection, a period at which it is admitted that latency is established. Ex vivo imaging, quantitative PCR and immunohistochemistry helped us to determine that virus genomes were present in high quantity in the vaginal tissue and that viral replication occurred mainly at the vaginal external border. Finally, we highlighted the presence of free infectious viruses in the vaginal cavity at the moment of the observation of viral replication. In conclusion, we experimentally indentified for the first time a reexcretion site for MuHV-4 in mice that had been intranasaly infected. It therefore suggests potential genital transmission, either horizontal or vertical, of this virus in mice populations. In the future, these results could help us to better understand the biology of gammaherpesviruses but should also allow us to develop vaccinal strategies that could prevent the spread of these viruses in natural populations. [less ▲]

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See detailGenital re-excretion of Murid gammaherpesvirus 4 following intranasal infection
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

in Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (2011, December 09)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4) in inbred laboratory mouse strains which are commonly accepted as a good model for studying gammaherpesviruses in vivo. To date, it has however never been possible to monitor viral reexcretion and virus transmission in this species. In order to identify potential re-excretion sites, intranasally infected mice were followed through global luciferase imaging for up to six months after infection. Surprisingly, we detected transient viral replication in mice genital tract at various times after latency establishment. Ex vivo imaging, quantitative PCR and immunohistochemistry revealed that virus genomes were present in high quantity in the vaginal tissue and that viral replication occurred mainly at the vaginal external border. Moreover, we highlighted the presence of free infectious viruses in the vaginal cavity at the moment of the observation of viral replication. As this ephemeral viral reexcretion could reveal a link with reproductive cycle, we compared reexcretion in normal and ovariectomized mice. Interestingly, no viral reactivation was observed in absence of hormonal cycle. In conclusion, we experimentally indentified for the first time a reexcretion site for MuHV-4 in mice that had been intranasaly infected. In the future, these results could help us to better understand the biology of gammaherpesviruses but should also allow us to develop strategies that could prevent the spread of these viruses in natural populations. [less ▲]

Detailed reference viewed: 42 (15 ULg)