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See detailGVHD chronique et effet anti-tumoral
Baron, Frédéric ULg; Beguin, Yves ULg

in Correspondance en Onco-Hématologie (2010), 5

It was demonstrated in 1981 that chronic GVHD was associated with a strong decrease of the relapse risk after conventional allogeneic hematopoietic cell transplantation (graf-versus-tumor effects). Recent ... [more ▼]

It was demonstrated in 1981 that chronic GVHD was associated with a strong decrease of the relapse risk after conventional allogeneic hematopoietic cell transplantation (graf-versus-tumor effects). Recent studies suggest that chronic GVHD might also been associated with improved progression-gree survival after allogeneic hematopoietic cell transplantation with reduced-intensity conditioning (RIC-allo), a transplant strategy based mainly on graft-versus-tumor effects for tumor eradication. Further, it has been demonstrated that elimination of leukemic cells after RIC-allo is due to donor T-cell cloones directed against multiple minor histocompatibility antigens (specific for the recipient) that are largely expressed not only by tumor cells but also by non-hematopoietic tissues, explaining the strong association between GVHD and graft-versus-tumor effects seen after RIC-allo. [less ▲]

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See detailGynaecological uses of a new class of steroids: the selective progesterone receptor modulators
Pintiaux, Axelle ULg; Chabbert-Buffet, N.; Foidart, Jean-Michel ULg

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2009), 25(2), 67-73

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on ... [more ▼]

Selective progesterone receptor modulators (SPRM) represent a new class of synthetic steroids, which can interact with the progesterone receptor (PR) and can exert agonist, antagonist or mixed effects on various progesterone target tissues in vivo. This review evaluates the actual and potential usefulness of SPRMs in gynaecology [less ▲]

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See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; FRANCHIMONT, Claudine ULg et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

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See detailLa gynécologie dans les papyrus grecs de médecine
Marganne, Marie-Hélène ULg

in Acta Belgica Historiae Medicinae (1994), 7(4), 207-217

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See detailGynogenesis induction and sex determination in the Eurasian perch, Perca fluviatilis
Rougeot, Carole ULg; Ngingo, J. V.; Gillet, Laurent ULg et al

in Aquaculture (2005), 243(1-4), 411-415

In the present study, we used meiotic gynogenesis, widely used in studies on sex determination, to confirm female homogamety in Eurasian perch, Perca fluviatilis. Sperm irradiated with UV for 400 s was ... [more ▼]

In the present study, we used meiotic gynogenesis, widely used in studies on sex determination, to confirm female homogamety in Eurasian perch, Perca fluviatilis. Sperm irradiated with UV for 400 s was used to artificially fertilized eggs. The diploid of the resulting embryos was restored by a heat shock (30 degreesC) applied to the eggs 5 min postfertilization, for 25 min. Fertilization (ranging between 45% and 75%) and survival rates at hatching (ranging between 3.4% and 46.6%) were not significantly different (P>0.05) between the diploid control and gynogenetics. The diploid controls and two batches of gynogenetics contained 100% diploid larvae, whereas two other batches of gynogenetics contained 6.7% and 10.0% triploid larvae. The sex ratios of the diploid controls were not significantly different from 1:1, whereas all gynogenetic families were 100% female. These results confirm female homogamety in Eurasian perch, demonstrated by the use of hormonally mascilinized breeders in a previous study. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailGypsum and bassanite in the bat guano deposit from the « dry » Cioclovina cave (Sureanu Mountains, Romania)
Dumitras, Delia; Hatert, Frédéric ULg; Bilai, E. et al

in Romanian Journal of Mineral Deposits (2004), 81

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See detailH NMR investigations on water dynamics during starch gels retrogradation.
Burtea, C.; Roch, A.; Pierart, Céline ULg et al

in Magnetic Resonance Materials in Biology, Physics and Medicine (2000), 11(Suppl. 1),

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See detailThe H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
Brabant, Christian ULg; Charlier, Yana ULg; Quertemont, Etienne ULg et al

in Behavioural Brain Research (2005), 160(1), 161-168

The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by ... [more ▼]

The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H-3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20 mg/kg, i.p.), an H-3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8 mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10 min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8 mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2 mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice. © 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailh- and a- Time-Domain Formulations for the Modelling of Thin Electromagnetic Shells
V Sabariego, Ruth ULg; Geuzaine, Christophe ULg; Dular, Patrick ULg et al

in Proceedings of the 7th International Conference on Computation in Electromagnetics (CEM2008) (2008, April)

Dual time-domain magnetodynamic finite element formulations taking into account thin conductive magnetic shells are presented. The interface conditions are expressed in terms of the average flux and ... [more ▼]

Dual time-domain magnetodynamic finite element formulations taking into account thin conductive magnetic shells are presented. The interface conditions are expressed in terms of the average flux and current density together with higher-order components. [less ▲]

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See detailh- and a-Formulations for the Time-Domain Modelling of Thin Electromagnetic Shells
V Sabariego, Ruth ULg; Geuzaine, Christophe ULg; Dular, Patrick ULg et al

in IET Science, Measurement & Technology (2008), 2(6), 402-408

Thin conductive magnetic shells are accounted for by means of two different time-domain magnetodynamic finite-element formulations, namely the magnetic field formulation and the magnetic vector potential ... [more ▼]

Thin conductive magnetic shells are accounted for by means of two different time-domain magnetodynamic finite-element formulations, namely the magnetic field formulation and the magnetic vector potential formulation. Both approaches are an extension of the classical linear frequency-domain thin-shell approximation. The interface conditions for the magnetic field formulation and the vector potential formulation are expressed in terms of the average current density and the average flux density, respectively, together with a number of higher-order components of these quantities. The proposed time-domain thin-shell approaches are validated by means of a 3D magnetodynamic problem. The results are shown to agree well with those obtained with a fine model, whereas the computation time is significantly reduced. [less ▲]

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See detailh- and b-conform finite element perturbation techniques for nondestructive eddy current testing
V Sabariego, Ruth ULg; Dular, Patrick ULg

in COMPEL (2008), 27(1), 319-327

Purpose - The aim of the present paper is to compare the performances of a finite-element perturbation technique applied either to the h- conform magnetodynamic formulation or to its b-conform counterpart ... [more ▼]

Purpose - The aim of the present paper is to compare the performances of a finite-element perturbation technique applied either to the h- conform magnetodynamic formulation or to its b-conform counterpart in the frame of nondestructive eddy-current testing problems. Design/methodology/approach - In both complementary perturbation techniques, the computation is split into a computation without defect (unperturbed problem) and a computation of the field distorsion due to its presence (perturbation problem). The unperturbed problem is conventionally solved in the complete domain. The source of the perturbation problem is then determined by the projection of the unperturbed solution in a relatively small region surrounding the defect. The discretisation of this reduced domain is chosen independently of the dimensions of the excitation probe and the specimen under study and is thus well adapted to the size of the defect. Findings - The accuracy of the perturbation model is evidenced by comparing the results of the two counterpart formulations to those achieved in the conventional way for different dimensions of the reduced domain. The size of the reduced domain increases with the size of the defect at hand. This proposed sub-domain approach eases considerably the meshing process and speeds-up the computation for different probe positions. Originality/value - At a discrete level, the impedance change due to the defect is efficiently and accurately computed by integrating only over the defect itself and a layer of elements in the reduced domain that touches its boundary. Therefore, no integration of any flux variation in the coils is required. [less ▲]

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See detailH-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase
Damblon, Christian ULg; Prosperi, Christelle ULg; Lian, L. Y. et al

in Journal of the American Chemical Society (1999), 121(49), 11575-11576

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See detailH-band thermal emission from the 19-h period planet WASP-19b
Anderson, D. R.; Gillon, Michaël ULg; Maxted, P. F. L. et al

in Astronomy and Astrophysics (2010), 513

We present the first ground-based detection of thermal emission from an exoplanet in the H-band. Using HAWK-I on the VLT, we observed an occultation of WASP-19b by its G8V-type host star. WASP-19b is a ... [more ▼]

We present the first ground-based detection of thermal emission from an exoplanet in the H-band. Using HAWK-I on the VLT, we observed an occultation of WASP-19b by its G8V-type host star. WASP-19b is a Jupiter-mass planet with an orbital period of only 19 h, and thus, being highly irradiated, is expected to be hot. We measure an H-band occultation depth of 0.259[SUP]+0.046[/SUP][SUB]-0.044[/SUB]%, which corresponds to an H-band brightness temperature of T[SUB]H[/SUB] = 2580 ± 125 K. A cloud-free model of the planet's atmosphere, with no redistribution of energy from day-side to night-side, under predicts the planet/star flux density ratio by a factor of two. As the stellar parameters, and thus the level of planetary irradiation, are well-constrained by measurement, it is likely that our model of the planet's atmosphere is too simple. Based on data collected with the VLT/HAWKI instrument at ESO Paranal Observatory, Chile (programs 083.C-0377(A)).The photometric time-series used in this work are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via <A href="http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/513/L3">http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/513/L3</A> [less ▲]

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See detailH. Rickert, Les deux voies de la théorie de la connaissance (1909)
Dewalque, Arnaud ULg

Book published by Vrin (2006)

First published in the "Kant-Studien" (1909), Rickert's "two ways of the theory of knowledge" is a master-piece of the debate between neo-Kantianism and Husserl's phenomenology. In this text, Rickert ... [more ▼]

First published in the "Kant-Studien" (1909), Rickert's "two ways of the theory of knowledge" is a master-piece of the debate between neo-Kantianism and Husserl's phenomenology. In this text, Rickert - with Windelband and Lask one of the main representatives of the Heidelberg neo-Kantian school - presents in a clear and synthetic way the principles of his critical philosophy. The French translation of the German Text is here accompanied by a substantive commentary (100 p.) on the Rickert-Husserl relationship. Discussed topics include: antipsychologism and normative logic, theory of obviousness, nature of judgement and truth, heterological relation between subject and object, etc. Those topics are examined from the methodological distinction between "noetical analysis" (or act-analysis) and "noematical analysis" (content-analysis), which can be regarded at some extend as common to Husserl and Rickert. [less ▲]

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See detailH. Rickert, Les tâches d'une logique de l'histoire (1902)
Dewalque, Arnaud ULg

in Etudes Philosophiques (2010), 1

French translation of a polemical article by the neo-Kantian philosopher Heinrich Rickert. The article has originally been published in the "Archiv für systematische Philosophie" (1902). It is a response ... [more ▼]

French translation of a polemical article by the neo-Kantian philosopher Heinrich Rickert. The article has originally been published in the "Archiv für systematische Philosophie" (1902). It is a response to some objections coming from the philosopher Ferdinand Tönnies, but also a clear exposition of Rickert's logical and methodological distinction between historical and natural sciences. [less ▲]

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See detailH1N1 vaccines in a large observational cohort of patients with inflammatory bowel disease treated with immunomodulators and biological therapy.
Rahier, Jean-Francois; Papay, Pavol; Salleron, Julia et al

in Gut (2011), 60(4), 456-62

BACKGROUND: Safety data are lacking on influenza vaccination in general and on A (H1N1)v vaccination in particular in patients with inflammatory bowel disease (IBD) receiving immmunomodulators and/or ... [more ▼]

BACKGROUND: Safety data are lacking on influenza vaccination in general and on A (H1N1)v vaccination in particular in patients with inflammatory bowel disease (IBD) receiving immmunomodulators and/or biological therapy. AIMS AND METHODS: The authors conducted a multicentre observational cohort study to evaluate symptoms associated with influenza H1N1 adjuvanted (Pandemrix, Focetria, FluvalP) and non-adjuvanted (Celvapan) vaccines and to assess the risk of flare of IBD after vaccination. Patients with stable IBD treated with immunomodulators and/or biological therapy were recruited from November 2009 until March 2010 in 12 European countries. Harvey-Bradshaw Index and Partial Mayo Score were used to assess disease activity before and 4 weeks after vaccination in Crohn's disease (CD) and ulcerative colitis (UC). Vaccination-related events up to 7 days after vaccination were recorded. RESULTS: Of 575 patients enrolled (407 CD, 159 UC and nine indeterminate colitis; 53.9% female; mean age 40.3 years, SD 13.9), local and systemic symptoms were reported by 34.6% and 15.5% of patients, respectively. The most common local and systemic reactions were pain in 32.8% and fatigue in 6.1% of subjects. Local symptoms were more common with adjuvanted (39.3%) than non-adjuvanted (3.9%) vaccines (p < 0.0001), whereas rates of systemic symptoms were similar with both types (15.0% vs 18.4%, p = 0.44). Among the adjuvanted group, Pandemrix more often induced local reactions than FluvalP and Focetria (51.2% vs 27.6% and 15.4%, p < 0.0001). Solicited adverse events were not associated with any patient characteristics, specific immunomodulatory treatment, or biological therapy. Four weeks after vaccination, absence of flare was observed in 377 patients with CD (96.7%) and 151 with UC (95.6%). CONCLUSION: Influenza A (H1N1)v vaccines are well tolerated in patients with IBD. Non-adjuvanted vaccines are associated with fewer local reactions. The risk of IBD flare is probably not increased after H1N1 vaccination. [less ▲]

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See detailH2O retrievals from Jungfraujoch infrared spectra: some spectroscopic problems.
Demoulin, Philippe ULg; Trabelsi, Samy; Mahieu, Emmanuel ULg et al

in Proceedings of the 8th Atmospheric Spectroscopy Applications Meeting (2008)

Since 1949, solar absorption spectra have been acquired at the Jungfraujoch observatory (Swiss Alps, 46.5°N, 8.0°E, 3580 m a.s.l.), first with grating spectrometers, then with Fourier transform infrared ... [more ▼]

Since 1949, solar absorption spectra have been acquired at the Jungfraujoch observatory (Swiss Alps, 46.5°N, 8.0°E, 3580 m a.s.l.), first with grating spectrometers, then with Fourier transform infrared (FTIR) spectrometers. Most observations collected with these instruments encompass water vapor absorptions, even the narrow spectral domains regularly recorded with the grating instruments to monitor the evolution of important atmospheric constituents. The aim of this work is to analyze all available spectra containing usable H2O absorption lines, to derive a long-term record of its total column in the atmosphere above the Jungfraujoch. In addition, more recent FTIR broadband spectra, with better signal-to-noise ratio and resolution, will be analyzed with state of the art algorithm, in order to derive information on the vertical distribution of H2O. [less ▲]

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See detailH3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.
Bado, A.; Moizo, L.; Laigneau, J. P. et al

in Yale Journal of Biology and Medicine (The) (1994), 67(3-4), 113-121

We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin ... [more ▼]

We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent of basal; p < .01), and maximal inhibition of SR (-62 +/- 9 percent under basal; p < .01) were obtained with 1 micron carbachol. Neither (R)alpha-MeHA nor Thiop, up to 10 microns, affected GR. However, SR was dose-dependently enhanced by Thiop (25 +/- 8 percent for 10 microns). Carbachol stimulation of GR was strongly inhibited by Thiop (30 +/- 7 percent for 100 nM and 73 +/- 14 percent for 1 microgram), whereas it was potentiated by (R)alpha-MeHA. Carbachol inhibition of SR was reversed by Thiop and (R)alpha-MeHA. However, the reversal effect of (R)alpha-MeHA was prevented by the CCKB/gastrin receptor antagonist PD134308. These results support H3-receptor regulation of basal and cholinergically-stimulated GR and SR. [less ▲]

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See detailH4 Histamine Receptors Mediate Cell Cycle Arrest in Growth Factor-Induced Murine and Human Hematopoietic Progenitor Cells
Petit-Bertron, Anne France; Machavoine, François; Defresne, Marie-Paule ULg et al

in PLoS ONE (2009), 4(8), 1-13

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See detailH50, estimateur d’indice de productivité
Perin, Jérôme ULg; De Thier, Olivier ULg

Computer development (2014)

H50 est un outil qui permet l’estimation de l’indice de productivité de divers peuplements purs équiennes, tant résineux que feuillus. Il intègre, au sein d’une interface simple d’utilisation, les modèles ... [more ▼]

H50 est un outil qui permet l’estimation de l’indice de productivité de divers peuplements purs équiennes, tant résineux que feuillus. Il intègre, au sein d’une interface simple d’utilisation, les modèles de productivité les plus récents développés par les scientifiques de Gembloux Agro-Bio Tech pour l’épicéa, le douglas, les mélèzes, le bouleau verruqueux, le merisier, l’érable sycomore, les chênes indigènes et le robinier. Les données nécessaires à son utilisation sont l’essence, une mesure de hauteur dominante et l’âge du peuplement au moment de la mesure. L’outil se présente sous la forme d’une feuille de calcul qui permet le traitement simultané de données issues de plusieurs peuplements de diverses essences. Il est également possible de directement y copier-coller des données issues de documents encodés sous Microsoft Access ou Excel par exemple. Cet outil a été développé avec l’appui des Services Publics de Wallonie (Département de la Nature et des Forêts, Accord-Cadre Recherche et Vulgarisation forestières). [less ▲]

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