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See detailGenetic variability in the Skyros pony and its relationship with other Greek and foreign horse breeds
Bömcke, Elisabeth ULg; Gengler, Nicolas ULg; Cothran, E Gus

in Genetics and Molecular Biology (2011), 34

In Greece, seven native horse breeds have been identified so far. Among these, the Skyros pony is outstanding through having a distinct phenotype. In the present study, the aim was to assess genetic ... [more ▼]

In Greece, seven native horse breeds have been identified so far. Among these, the Skyros pony is outstanding through having a distinct phenotype. In the present study, the aim was to assess genetic diversity in this breed, by using different types of genetic loci and available genealogical information. Its relationships with the other Greek, as well as foreign, domestic breeds were also investigated. Through microsatellite and pedigree analysis it appeared that the Skyros presented a similar level of genetic diversity to the other European breeds. Nevertheless, comparisons between DNA-based and pedigree-based results revealed that a loss of genetic diversity had probably already occurred before the beginning of breed registration. Tests indicated the possible existence of a recent bottleneck in two of the three main herds of Skyros pony. Nonetheless, relatively high levels of heterozygosity and Polymorphism Information Content indicated sufficient residual genetic variability, probably useful in planning future strategies for breed conservation. Three other Greek breeds were also analyzed. A comparison of these with domestic breeds elsewhere, revealed the closest relationships to be with the Middle Eastern types, whereas the Skyros itself remained isolated, without any close relationship, whatsoever. [less ▲]

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See detailGenetic variability of fatty acids in bovine milk
Soyeurt, Hélène ULg; Gengler, Nicolas ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(2), 203-210

Fatty acids composition of bovine milk influences the technological properties of butterfat and also presents some potential benefits for human health. Impact of feeding on fat composition is well ... [more ▼]

Fatty acids composition of bovine milk influences the technological properties of butterfat and also presents some potential benefits for human health. Impact of feeding on fat composition is well described in the literature; less information is available about the impact of genetics. Based on few studies, essentially conducted to isolate some feeding effect, the breed seemed to influence the fatty acids composition. The variation in the activity of δ-9 desaturase, key enzyme in the production of monounsaturated fatty acids and conjugated linoleic acids in milk, could explain these differences. Very few studies have been focussing on the estimation of genetic parameters of fatty acids composition. However, the moderate heritability estimates observed by these studies for the major fatty acids could suggest a potential genetic effect. [less ▲]

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See detailGenetic variability of lactoferrin content estimated by mid-infrared spectrometry in bovine milk
Soyeurt, Hélène ULg; Colinet, Frédéric ULg; Arnould, Valérie ULg et al

in Journal of Dairy Science (2007), 90(9), 4443-4450

The effects of lactoferrin (LF) on the immune system have already been shown by many studies. Unfortunately, the current methods used to measure LF levels in milk do not permit the study of the genetic ... [more ▼]

The effects of lactoferrin (LF) on the immune system have already been shown by many studies. Unfortunately, the current methods used to measure LF levels in milk do not permit the study of the genetic variability of lactoferrin or the performance of routine genetic evaluations. The first aim of this research was to derive a calibration equation permitting the prediction of LF in milk by mid-infrared spectrometry (MIR). The calibration with partial least squares on 69 samples showed a ratio of standard error of cross-validation to standard deviation equal to 1.98. Based on this value, the calibration equation was used to establish an LF indicator trait (predicted LF; pLF) on a large number of milk samples (n = 7,690). A subsequent study of its variability was conducted, which confirmed that stage of lactation and lactation number influence the overall pLF level. Small differences in mean pLF among 7 dairy breeds were also observed. The pLF content of Jersey milk was significantly higher than that in Holstein milk. Therefore, the choice of breed could change the expected LF level. Heritability estimated for pLF was 19.7%. The genetic and phenotypic correlations between somatic cell score and pLF were 0.04 and 0.26, respectively. As somatic cell score increases in presence of mastitis, this observation seems to indicate that pLF, or a function of observed pLF, compared with expected LF might have potential as an indicator of mastitis. The negative genetic correlation (−0.36) between milk yield and pLF could indicate an undesirable effect of selection for high milk production on the overall LF level. [less ▲]

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See detailGenetic variability of milk components based on mid-infrared spectral data.
Soyeurt, Hélène ULg; Misztal, I.; Gengler, Nicolas ULg

in Journal of Dairy Science (2010), 93(4), 1722-1728

The aim of this study was to estimate the genetic parameters of the mid-infrared (MIR) milk spectrum represented by 1,060 data points per sample. The dimensionality of traits was reduced by principal ... [more ▼]

The aim of this study was to estimate the genetic parameters of the mid-infrared (MIR) milk spectrum represented by 1,060 data points per sample. The dimensionality of traits was reduced by principal components analysis. Therefore, 46 principal components describing 99.03% of the phenotypic variability were used to create 46 new traits. Variance components were estimated using canonical transformation. Heritability ranged from 0 to 0.35. Twenty-five out of 46 studied traits showed a permanent environment variance greater than genetic variance. Eight traits showed heritability greater than 0.10. Variances of original spectral traits were obtained by back transformation. Heritabilities for each spectral data points ranged from 0.003 to 0.42. In particular, 3 MIR regions showing moderate to high heritability estimates were of potential genetic interest. Heritabilities for specific wave numbers, linked with common milk traits (e.g., lipids, lactose), were similar to those estimated for these traits. This research confirms the genetic variability of the MIR milk spectrum and, therefore, the genetic variation of milk components. The objective of this study was to better understand the genetics of milk composition and, maybe in the future, to select animals to improve milk quality. [less ▲]

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See detailGenetic variability of milk fatty acids.
Arnould, Valérie ULg; Soyeurt, Hélène ULg

in Journal of Applied Genetics (2009), 50(1), 29-39

The milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. The natural sources of variation, such as feeding or genetics, could be used to increase the ... [more ▼]

The milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. The natural sources of variation, such as feeding or genetics, could be used to increase the concentrations of unsaturated fatty acids. The impact of feeding is well described. However, genetic effects on the milk FA composition begin to be extensively studied. This paper summarizes the available information about the genetic variability of FAs. The greatest breed differences in FA composition are observed between Holstein and Jersey milk. Milk fat of the latter breed contains higher concentrations of saturated FAs, especially short-chain FAs. The variation of the delta-9 desaturase activity estimated from specific FA ratios could explain partly these breed differences. The choice of a specific breed seems to be a possibility to improve the nutritional quality of milk fat. Generally, the proportions of FAs in milk are more heritable than the proportions of these same FAs in fat. Heritability estimates range from 0.00 to 0.54. The presence of some single nucleotide polymorphisms could explain partly the observed individual genetic variability. The polymorphisms detected on SCD1 and DGAT1 genes influence the milk FA composition. The SCD1 V allele increases the unsaturation of C16 and C18. The DGAT1 A allele is related to the unsaturation of C18. So, a combination of the molecular and quantitative approaches should be used to develop tools helping farmers in the selection of their animals to improve the nutritional quality of the produced milk fat. [less ▲]

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See detailGenetic variability of test-day stearoyl coenzyme-A desaturase 9 activity
Arnould, Valérie ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

Conference (2009, July)

Milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. Different natural sources of variation such as feeding or genetics could be used to modify the contents of ... [more ▼]

Milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. Different natural sources of variation such as feeding or genetics could be used to modify the contents of unsaturated fatty acids. The impact of feeding is well described; however, genetics effects on the milk FA composition are not well studied. Increasing the unsaturated fatty acids contents of bovine milk could have the potential to raise the nutritive and therapeutic values of dairy products. The stearoyl Coenzyme-A desaturase 9 (delta-9) gene was identified as a potential functional candidate gene affecting milk fat composition in dairy cattle. The objective of this research was to study the genetic variability on this enzyme activity across lactations. A total of 199,977 test-day records were obtained from 29,603 Holstein cows in first lactation, 154,267 records from 23,453 Holstein cows in second lactation, and 173,244 records from 75,887 Holstein cows in third and later lactations. The used model was a multiple-trait random regressions test-day model. Fixed effects were: herd × date of test, and class of age. Random effects were: herd × year of calving, permanent environmental, additive genetic, and residual effects. The studied traits were milk yield, protein content, percentage of fat, monounsaturated fatty acids estimated by mid-infrared spectrometry, and the ratios reflecting the delta-9 activity. Obtained heritability estimates of delta-9 as well as the genetic and phenotypic correlations varied across lactations. These results suggest potential improvements of milk fat composition based on delta-9 activity using animal selection and appropriate management practices. [less ▲]

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See detailGenetic variability of test-day stearoyl coenzyme-A desaturase 9 activity
Arnould, Valérie ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Journal of Dairy Science (2009), 92(E-suppl.1), 353-354

Milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. Different natural sources of variation such as feeding or genetics could be used to modify the contents of ... [more ▼]

Milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. Different natural sources of variation such as feeding or genetics could be used to modify the contents of unsaturated fatty acids. The impact of feeding is well described; however, genetics effects on the milk FA composition are not well studied. Increasing the unsaturated fatty acids contents of bovine milk could have the potential to raise the nutritive and therapeutic values of dairy products. The stearoyl Coenzyme-A desaturase 9 (delta-9) gene was identified as a potential functional candidate gene affecting milk fat composition in dairy cattle. The objective of this research was to study the genetic variability on this enzyme activity across lactations. A total of 199,977 test-day records were obtained from 29,603 Holstein cows in first lactation, 154,267 records from 23,453 Holstein cows in second lactation, and 173,244 records from 75,887 Holstein cows in third and later lactations. The used model was a multiple-trait random regressions test-day model. Fixed effects were: herd × date of test, and class of age. Random effects were: herd × year of calving, permanent environmental, additive genetic, and residual effects. The studied traits were milk yield, protein content, percentage of fat, monounsaturated fatty acids estimated by mid-infrared spectrometry, and the ratios reflecting the delta-9 activity. Obtained heritability estimates of delta-9 as well as the genetic and phenotypic correlations varied across lactations. These results suggest potential improvements of milk fat composition based on delta-9 activity using animal selection and appropriate management practices. [less ▲]

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See detailGenetic variability of the mid-infrared prediction of lactoferrin content in milk for Walloon Holstein first-parity cows
Leclercq, Gil ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg et al

in Livestock Science (2013), 151(2-3), 158-162

The objective of this study was to assess the genetic variability of the mid-infrared prediction of lactoferrin content in milk (pLF) in Holstein first-parity cows. Variance components were estimated by ... [more ▼]

The objective of this study was to assess the genetic variability of the mid-infrared prediction of lactoferrin content in milk (pLF) in Holstein first-parity cows. Variance components were estimated by Average Information Restricted Maximum Likelihood using a single-trait test-day random regression animal model. The dataset included 395,287 test-day records from 67,178 cows in 1190 herds from the Walloon Region of Belgium. Average pLF was 164.89. mg/L and the standard deviation was 76.07. mg/L. Frequency distribution for pLF was slightly asymmetrical, and pLF seemed to increase almost linearly all along the first lactation after a sharp decrease in early lactation. Genetic variance of pLF increased with days in milk within lactation while the permanent environmental variance was the highest in early lactation, then decreased to become lower than genetic variance at 50 days in milk, and finally increased in the last lactation stages. The pLF was a moderately heritable trait. Daily heritability of pLF was the lowest at 5 days in milk (0.19), then increased to reach a maximum at 260 days in milk (0.44), and finally decreased for the last stages of lactation (0.35 at 365 days in milk). Results from this study indicated that pLF is variable and heritable over the lactation and therefore it could be changed by genetic selection. © 2012 Elsevier B.V. [less ▲]

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See detailGenetic variability of the Skyros pony breed and its relationship with other Greek and foreign horse breeds
Bömcke, Elisabeth ULg; Gengler, Nicolas ULg; Cothran, E. G.

in Book of Abstracts of the 59th Annual Meeeting of the European Association for Animal Production (EAAP) (2008, August)

On the basis of phenotypes and genotypes, seven native breeds were identified in Greece. The Skyros pony is the more distinctive of these breeds. Using blood group and microsatellite loci, the aim of this ... [more ▼]

On the basis of phenotypes and genotypes, seven native breeds were identified in Greece. The Skyros pony is the more distinctive of these breeds. Using blood group and microsatellite loci, the aim of this study was to assess the genetic diversity of Skyros breed, using also available genealogical information, and to investigate its relationships with the other Greek and foreign horse breeds. Results showed that the Skyros breed presented similar level of genetic diversity to other European breeds. Comparisons between DNA-based and pedigree-based results showed that the loss of genetic diversity has probably occurred before the beginning of breed registration. However, the relatively high levels of heterozygosity and Polymorphism Information Content values indicated still sufficient residual genetic variability that could be useful for planning future breeding strategies for the breed conservation. Relationship study showed no association between genetic variation of native Greek breed and population size or degree of geographic isolation. Compared to other domestic breeds, most of the Greek breed showed closest relationships with Middle Eastern breeds, while the Skyros breed clustered surprisingly with Lithuanian horses. [less ▲]

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See detailGenetic variance in environmental sensitivity for milk and milk quality in Walloon Holstein cattle
Vandenplas, Jérémie ULg; Bastin, Catherine ULg; Gengler, Nicolas ULg et al

in Book of Abstracts of the 63rd Annual Meeting of the European Federation of Animal Science (2012)

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See detailGenetic variance in environmental sensitivity for milk and milk quality in Walloon Holstein cattle
Vandenplas, Jérémie ULg; Bastin, Catherine ULg; Gengler, Nicolas ULg et al

Conference (2012, August 27)

Animals that are robust to environmental changes are desirable in the current dairy industry. This difference in environmental sensitivity can be studied through the heterogeneity of residual variance ... [more ▼]

Animals that are robust to environmental changes are desirable in the current dairy industry. This difference in environmental sensitivity can be studied through the heterogeneity of residual variance while homogeneous residual variance between animals is usually assumed homogeneous in traditional genetic evaluations. The aim of this study was to study genetic heterogeneity of residual variance by the estimation of variance components in residual variance for 5 milk and milk quality traits. 146,027 test-day records from 26,887 Walloon Holstein first-parity cows in 747 herds were available. All cows had at least 3 records and had a known sire. These sires had at least 10 cows with records and each herd x test-day had at least 5 cows. Five traits, milk yield, somatic cell score, and content in milk (g/dL) of oleic acid (C18:1 cis-9), monounsaturated and unsaturated fatty acids, were analyzed separately. Estimation of variance components was performed by running iteratively Expectation Maximization-Restricted Maximum Likelihood algorithm by the implementation of double hierarchical generalized linear models. For all traits, the genetic standard deviation in residual variance (i.e. approximately the genetic coefficient of variation of residual variance) was low and ranged between 0.12 and 0.17. The standard deviations due to herd x test day and permanent environment in residual variance ranged between 0.35 and 0.44 for herd x test-day effect and between 0.55 and 0.96 for permanent environmental effect. This study shows the heterogeneity of residual variance and the existence of some genetic variance in environmental sensitivity for all studied traits in the Walloon Holstein dairy cattle. [less ▲]

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See detailGenetic variance in micro-environmental sensitivity for milk and milk quality in Walloon Holstein cattle
Vandenplas, Jérémie ULg; Bastin, Catherine ULg; Gengler, Nicolas ULg et al

in Journal of Dairy Science (2013), 96

Animals that are robust to environmental changes are desirable in the current dairy industry. Genetic differences in micro-environmental sensitivity can be studied through heterogeneity of residual ... [more ▼]

Animals that are robust to environmental changes are desirable in the current dairy industry. Genetic differences in micro-environmental sensitivity can be studied through heterogeneity of residual variance between animals. However, residual variance between animals is usually assumed homogeneous in traditional genetic evaluations. The aim of this study was to investigate genetic heterogeneity of residual variance by estimating variance components in residual variance for milk yield, somatic cell score, contents in milk (g/dL) of two groups of milk fatty acids (i.e. saturated fatty acids and unsaturated fatty acids) and the content in milk of one individual fatty acid (i.e. the oleic acid, C18:1 cis-9), for first-parity Holstein cows in the Walloon Region of Belgium. A total of 146,027 test-day records from 26,887 cows in 747 herds were available. All cows had at least three records and had a known sire. These sires had at least 10 cows with records and each herd x test-day had at least five cows. The five traits were analyzed separately based on fixed lactation curve and random regression test-day models for the mean. Estimation of variance components was performed by running iteratively Expectation Maximization-Restricted Maximum Likelihood algorithm by the implementation of double hierarchical generalized linear models. Based on fixed lactation curve test-day mean models, heritability for residual variances ranged between 1.01*10-3 and 4.17*10-3 for all traits. The genetic standard deviation in residual variance (i.e. approximately the genetic coefficient of variation of residual variance) ranged between 0.12 and 0.17. Therefore, some genetic variance in micro-environmental sensitivity existed in the Walloon Holstein dairy cattle for the five studied traits. The standard deviations due to herd x test-day and permanent environment in residual variance ranged between 0.36 and 0.45 for herd x test-day effect and between 0.55 and 0.97 for permanent environmental effect. Therefore, non-genetic effects also contributed substantially to the micro-environmental sensitivity. Results also showed that the addition of random regressions to the mean model did not reduce heterogeneity in residual variance and that genetic heterogeneity of residual variance was not simply an effect of an incomplete mean model. [less ▲]

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See detailGenetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.
Sandor, Cynthia ULg; Li, Wanbo ULg; Coppieters, Wouter ULg et al

in PLoS Genetics (2012), 8(7), 1002854

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL ... [more ▼]

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage. [less ▲]

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See detailGenetic variation among the geographic population of the grain aphid, Sitobion avenae (Hemiptera: Aphididae) in China inferred from mitochondrial COI gene sequence
Xu, Zhao-Huan; Chen, Julian; Cheng, Deng-Fa et al

in Agricultural Sciences in China (2011), 10(7), 1041-1048

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See detailGenetic variation and evolution in the genus Apodemus (Muridae : Rodentia)
Filippucci, M. G.; Macholan, M.; Michaux, Johan ULg

in Biological Journal of the Linnean Society (2002), 75(3), 395-419

Genetic variation was studied using protein electrophoresis of 28-38 gene loci in 1347 specimens of Apodemus agrarius, A. peninsulac, A. flavicollis, A. sylvaticus, A. alpicola, A. uralensis, A. cf ... [more ▼]

Genetic variation was studied using protein electrophoresis of 28-38 gene loci in 1347 specimens of Apodemus agrarius, A. peninsulac, A. flavicollis, A. sylvaticus, A. alpicola, A. uralensis, A. cf. hyrcanicus, A. hermonensis, A. m. mystacinus and A. in. epimelas, representing 121 populations from Europe, the Middle East, and North Africa. Mean values of heterozygosity per locus for each species ranged from 0.02 to 0.04. Mean values of Nei's genetic distance (D) between the taxa ranged from 0.06 (between A. flavicollis and A. alpicola) to 1.34 (between A. uralensis and A. agrarius). The highest values of D were found between A. agrarius and other Apodemus species (0.62-1.34). These values correspond to those generally observed between genera in small mammals. Our data show that A. agrarius and A. peninsulae are sister species, well-differentiated from other taxa. High genetic distance between A. m. mystacinus and A. m. epimelas leads us to consider them distinct species and sister taxa to other Western Palaearctic species of the subgenus Sylvaemus. The data also suggest a recent separation of members of the latter group from a common ancestor, and subsequent rapid radiation, making it difficult to infer phylogenetic relationships. Some taxonomic implications of the results are discussed further. (C) 2002 The Linnean Society of London. [less ▲]

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See detailGenetic variation in heat stress tolerance of Holsteins producing under a continental temperate environment
Hammami, Hedi ULg; Arnould, Valérie ULg; Bormann, Jeanne et al

Poster (2012)

Under projected climate changes, considerations for heat stress tolerance but also for genotype by environment interactions should enter breeding decisions, both for importing, but also exporting ... [more ▼]

Under projected climate changes, considerations for heat stress tolerance but also for genotype by environment interactions should enter breeding decisions, both for importing, but also exporting countries. Most studies concerning the breeding strategies on heat stress tolerance used the temperature humidity index (THI) to assess the thermal stress in a given environment and assumed a specific threshold to each studied population with the same response to each individual above this threshold. Recently new comprehensive thermal indices (TI) integrating radiation solar, wind speed, in addition to temperature and relative humidity were developed. Therefore, the aim of this study is advanced modelling of milk yield trait to evaluate the genetic variation in heat stress tolerance of Holsteins in a temperate environment using random regressions models and six new comprehensive TI. A total of 107,350 test day milk records were available for 12,099 primiparous Holsteins calving from 2000 to 2010. Test-day milk records were merged with meteorological data from 14 public weather stations across Luxembourg. Daily values of 6 new comprehensive TI (3 THI and 3 apparent temperature indices) were calculated by averaging hourly TI over 24 hours. The average distance between herds and their meteorological reference station was of 16 km. Sensitivity of cows to the climate environmental conditions was modelled by applying a reaction norm for each animal, representing its EBV for milk yield on values of the TI on the day in milk (DIM). Six separate random regression models were applied using time-dependent (DIM) and specific TI-dependent covariates. Random effects were additive genetic, permanent environmental, and herd year modelled with Legendre polynomials of order 2 for both DIM and TI. Genetic variances of the different TI evaluated in this study represent 27 to 30% of their correspondent variances for DIM effect. Permanent environmental and genetic variances of TI effect were in the same range. Additive genetic variances and heritabilities for daily milk yield slightly decreased with increasing degrees of the different THI and apparent temperature indices. The average daily milk heritability overall the lactation at the mean of each of the six TI was of 0.28. Genetic correlations between adjacent points across the lactation were > 0.90. Correlations between extreme distant DIM (e.g. early and late lactation stage) were reduced at 0.38 to 0.52. The overall genetic correlations between the different values of each TI remain high (> 0.85). EBV’s summing regular additive effect (DIM effect) and tolerance to heat stress (TI effect) were computed for several combinations of DIM and TI values. Ranking for sires and cows did not change among the 6 heat stress indicators. The correlations between EBVs estimated with the six models were greater than 0.90. In conclusion, the different models depicted genetic variation of milk yield among combinations of DIM and TI levels without defining thresholds in advance. Genetic variation was slightly lower when TI values exceed the thermoneutral zone. Breeding for reduced thermal sensitivity using any of the six indicators of heat stress evaluated in this study is possible. The indicator TI2 representing the adjusted THI for radiation solar and wind speed is favoured because it was the indicator that did identify the highest yearly milk losses under this continental temperate environment. [less ▲]

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See detailGenetic variation in PLAG1 associates with early life body weight and peripubertal weight and growth in Bos taurus.
Littlejohn, M.; Grala, T.; Sanders, K. et al

in Animal Genetics (2012), 43(5), 591-4

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy ... [more ▼]

Variation at the pleiomorphic adenoma gene 1 (PLAG1) locus has recently been implicated in the regulation of stature and weight in Bos taurus. Using a population of 942 outbred Holstein-Friesian dairy calves, we report confirmation of this effect, demonstrating strong association of early life body weight with PLAG1 genotype. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype. Growth rate per kilogram of body weight, daily feed intake, gross feed efficiency and residual feed intake were not significantly associated with PLAG1 genotype. This study supports the status of PLAG1 as a key regulator of mammalian growth. Further, the data indicate the utility of PLAG1 polymorphisms for the selection of animals to achieve enhanced weight gain or conversely to aid the selection of animals with lower mature body weight and thus lower maintenance energy requirements. [less ▲]

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See detailGenetic variation in the autophagy gene ULK1 and risk of Crohn's disease
Henckaerts, Liesbeth; Cleynen, Isabelle; Brinar, Marko et al

in Inflammatory Bowel Diseases (2011), 17(6), 1392-1397

Detailed reference viewed: 25 (5 ULg)