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Peer Reviewed
See detailEnacting political games in organizational transformation projects: panoptic vs polyphonic styles of management
Pichault, François ULiege

Conference (2011, July)

Resistance to change and micro-politics around change processes have been studied by many social scientists. In the managerial field, numerous authors plead for the adoption of participative methods in ... [more ▼]

Resistance to change and micro-politics around change processes have been studied by many social scientists. In the managerial field, numerous authors plead for the adoption of participative methods in order to overcome such phenomena but few of them seriously document the way in which the so-called “human factor” may be really taken into consideration in the management of change projects. Is there a direct relation between the managerial ability to cope with power games and the final results of a change project? Does a participatory strategy necessarily lead to a successful change? What are the conditions under which the enactment of micropolitics may contribute to an effective organizational transformation? We will here focus on change processes occurring in the public sphere: the NPM school of thought led to a large range of organizational reforms in which the civil servants’ engagement and motivation appear to play a crucial role. Our research questions will be discussed through the presentation of two cases studies of Belgian public organizations concerned with the implementation of an electronic document management system (DMS). The first case is located in the Federal Police department while the second occurs in a regional administration. Both are issued from action-researches undertaken with my research team during the last decade. They have been selected in order to contrast the different ways in which power games and end-users resistances may be enacted by senior management. They will help us to distinguish two management styles and to explore their respective impact on the change process itself. [less ▲]

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See detailEnantiomer separation of N-protected amino acids by non-aqueous capillary electrophoresis and high-performance liquid chromatography with tert.-butyl carbamoylated quinine in either the background electrolyte or the stationary phase
Piette, Véronique; Lammerhofer, M.; Lindner, W. et al

in Journal of Chromatography. A (2003), 987(1-2), 421-427

A non-aqueous CE method was developed for evaluating the chiral discrimination potential of cinchona alkaloids and different kinds of carbamoylated derivatives of quinine and quinidine type chiral ... [more ▼]

A non-aqueous CE method was developed for evaluating the chiral discrimination potential of cinchona alkaloids and different kinds of carbamoylated derivatives of quinine and quinidine type chiral selectors towards acidic analytes, in particular a series of various Bz (benzoyl), DNB (3,5-dinitrobenzoyl) and DNZ (3,5-dinitrobenzyloxycarbonyl) amino acid derivatives. In this study, the enantioselectivity values obtained in non-aqueous CE with tert-butyl carbamoylated quinine as chiral additive have been compared with the values found for the same series of selectands in HPLC using the same selector immobilized onto silica as chiral stationary phase. Similarly to the background electrolyte used in CE an ethanol-methanol mixture (60:40, v/v) containing 100 mM octanoic acid and 12.5 mM ammonia has been selected as HPLC mobile phase. Under these conditions, a good correlation (r=0.954) between the enantioselectivities observed with the two techniques has been obtained. Thus the non-aqueous CE method can be applied as a screening tool for the rapid evaluation of the chiral discrimination potential of a large set of newly developed chiral selectors derived from quinine and related alkaloids. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEnantiomeric separaiton of sotalol and other B-blockers on a chiral-AGP column using aliphatic carboxylic acids as ionic modifiers
Ceccato, Attilio ULiege; Hubert, Philippe ULiege; Streel, B. et al

in Journal de Pharmacie de Belgique (1995), 50

Detailed reference viewed: 12 (1 ULiège)
Peer Reviewed
See detailEnantiomeric separation of acidic and basic drugs by capillary electrophoresis using neutral and anionic cyclodextrins
Fillet, Marianne ULiege; Bechet, I.; Schomburg, G. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailEnantiomeric separation of acidic compounds using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis
Fradi, Inès; Servais, Anne-Catherine ULiege; Pedrini, Matteo et al

in Electrophoresis (2006), 27(17), 3434-3442

The enantiomeric separation of a series of acidic pharmaceuticals (mostly nonsteroidal anti-inflammatory drugs) has been investigated in NACE systems using single-isomer amino beta-CD derivatives. The ... [more ▼]

The enantiomeric separation of a series of acidic pharmaceuticals (mostly nonsteroidal anti-inflammatory drugs) has been investigated in NACE systems using single-isomer amino beta-CD derivatives. The first part of this study consisted of the selection of the basic experimental conditions to separate efficiently the enantiomers of acidic drugs. Several parameters, such as the nature of the ionic BGE components, were studied and a methanolic solution of ammonium acetate containing the cationic CD was selected as BGE. A D-optimal design with 20 experimental points was then applied and the nature and concentration of the CD were found to have a significant effect on the enantiomeric resolution for all studied compounds. Resolution (R(s)) values were always higher with 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta-CD (PA-beta-CD) compared to those obtained with 6-monodeoxy-6-mono(2-hydroxy)propylamino-beta-CD (IPA-beta-CD). However, the latter led to shorter migration times. Generic NACE conditions were then selected by means of the multivariate approach in order to obtain the highest R(s) values in a minimum amount of time. Finally, dependence of separation selectivity, resolution, as well as mobility difference on chiral selector concentration was discussed and binding constants with PA-beta-CD were estimated for the two enantiomers of one of the model compounds, suprofen in these NACE systems. [less ▲]

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See detailEnantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.
Piette, Véronique; Fillet, Marianne ULiege; Lindner, W. et al

in Biomedical Chromatography : BMC (2000), 14(1), 19-21

Enantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.

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See detailEnantiomeric separation of aminoglutethimide by capillary electrophoresis using native cyclodextrins in single and dual systems
Abushoffa, A. M.; Fillet, Marianne ULiege; Marini Djang'Eing'A, Roland ULiege et al

in Journal of Separation Science (2003), 26(6-7), 536-542

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A ... [more ▼]

Aminoglutethimide (AGT) is one of the few examples of chiral drugs that can be enantioseparated by capillary electrophoresis using any of the three native cyclodextrins: alpha-, beta-, or gamma-CD. A complete resolution of the enantiomers of this compound in cationic form could be achieved with each of the three CDs, using a pH 3 phosphoric acid-triethanolamine buffer. Affinity constants for AGT enantiomers with the three native CDs were determined, confirming that the highest selectivity was given by gamma-CD while the strongest complexation was obtained with beta-CD. However, an opposite affinity pattern was observed with the latter. Selectivity was lower for AGT enantiomers in dual CD systems, compared to that obtained with a single selector at its optimal concentration, which confirms that dual systems are of more limited interest when the two selectors have a similar effect on the analyte mobility. These results are in good agreement with those predicted using recently developed mathematical models. [less ▲]

Detailed reference viewed: 30 (5 ULiège)