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See detailGenetic Relationships between Bovine Herpesvirus 4 and the Gammaherpesviruses Epstein-Barr Virus and Herpesvirus Saimiri
Bublot, M.; Lomonte, P.; Lequarré, Anne-Sophie ULg et al

in Virology (1992), 190(2), 654-65

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least ... [more ▼]

The overall arrangement of genes in the unique central part of the bovine herpesvirus type 4 (BHV-4) genome has been deduced by analysis of short DNA sequences. Twenty-three genes conserved in at least one of the completely sequenced herpesviruses have been identified and localized. All of these genes encoded amino acid sequences with higher similarity to proteins of the gammaherpesviruses Epstein-Barr virus (EBV) and herpesvirus saimiri (HVS) than to the homologous products of the alphaherpesviruses varicella-zoster virus and herpes simplex virus type 1 or the betaherpesvirus human cytomegalovirus. The genome organization of BHV-4 had also an overall colinearity with that of the gammaherpesviruses EBV and HVS. Furthermore, the BHV-4 genes content and arrangement were more similar to those of HVS than to those of EBV, suggesting that BHV-4 and HVS are evolutionarily more closely related to each other than either are to EBV. BHV-4 DNA sequences were generally deficient in CpG dinucleotide. This CpG deficiency is characteristic of gammaherpesvirus genomes and suggests that the BHV-4 latent genome is extensively methylated. Despite several biological features similar to those of betaherpesviruses, BHV-4 displays the molecular characteristics of the representative members of the gammaherpesvirinae subfamily. [less ▲]

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See detailGenetic Resources of Togo
Mergeai, Guy ULg

in Plant Genetic Resources Newsletter (Rome, Italy : 1979) (1986), (66), 6-13

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See detailGenetic Risk in Natural and Medically Assisted Procreation
Koulischer, Lucien ULg; Verloes, Alain ULg; Lesenfants, S. et al

in Early Pregnancy (1997), 3(3), 164-71

Current in vitro fertilization techniques (IVF) including intracytoplasmic sperm injection (ICSI), microepididymal sperm aspiration (MESA) or testicular sperm extraction (TESE) clearly prevent any ... [more ▼]

Current in vitro fertilization techniques (IVF) including intracytoplasmic sperm injection (ICSI), microepididymal sperm aspiration (MESA) or testicular sperm extraction (TESE) clearly prevent any spontaneous choice of ova or spermatozoa. According to the widely admitted concept of gamete selection, pregnancies following IVF, when compared to natural fertilization, could therefore present a higher risk of genetic anomalies. However, no increased fetal or newborn abnormalities are noticed with IVF, except perhaps for sex chromosome aneuploidies. Data from the literature support the view that the uterus is, indeed, the organ where selection mechanisms occur (when they do so), as suggested by Carr in 1971. This selection concerns mainly autosome imbalances; unbalanced conceptuses are aborted. Sex chromosome aneuploidies, apparently, are less prone to natural abortion, but their higher rate of occurrence, as reported in a few series of studies, does not seem to be associated with the IVF procedures. [less ▲]

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See detailGenetic risk profiling and prediction of disease course in Crohn's disease patients.
Henckaerts, Liesbet; Van Steen, Kristel ULg; Verstreken, Isabel et al

in Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of The American Gastroenterological Association (2009), 7(9), 972-9802

BACKGROUND & AIMS: Clinical presentation at diagnosis and disease course of Crohn's disease (CD) are heterogeneous and variable over time. Early introduction of immunomodulators and/or biologicals might ... [more ▼]

BACKGROUND & AIMS: Clinical presentation at diagnosis and disease course of Crohn's disease (CD) are heterogeneous and variable over time. Early introduction of immunomodulators and/or biologicals might be justified in patients at risk for disease progression, so it is important to identify these patients as soon as possible. We examined the influence of recently discovered CD-associated susceptibility loci on changes in disease behavior and evaluated whether a genetic risk model for disease progression could be generated. METHODS: Complete medical data were available for 875 CD patients (median follow-up time, 14 years; interquartile range, 7-22). Fifty CD-associated polymorphisms were genotyped. Kaplan-Meier survival analyses, multiple logistic regression, and generalized multifactor dimensionality reduction analyses (GMDR) were performed, correcting for follow-up time. RESULTS: Homozygosity for the rs1363670 G-allele in a gene encoding a hypothetical protein near the IL12B gene was independently associated with stricturing disease behavior (odds ratio [OR], 5.48; 95% confidence interval [CI], 1.60-18.83; P = .007) and with shorter time to strictures (P = .01), especially in patients with ileal involvement (P = .0002). Male patients carrying at least one rs12704036 T-allele in a gene desert had the shortest time to non-perianal fistula (P < .0001). The presence of a C-allele at the CDKAL1 single nucleotide polymorphism rs6908425 and the absence of NOD2 variants were independently associated with development of perianal fistula (OR, 8.86; 95% CI, 1.13-69.78; P = .04 and OR, 0.56; 95% CI, 0.38-0.83; P = .004, respectively), particularly when colonic involvement and active smoking were present. CONCLUSIONS: CD-associated polymorphisms play a role in disease progression and might be useful in identifying patients who could benefit from an early top-down treatment approach. [less ▲]

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See detailGenetic screening for AIP mutations in Young patients with sporadic and Familial Pituitary Macroadenomas
Yaneva, M.; Elenkova, A.; Daly, Adrian ULg et al

in Endocrinologia = Endokrinologiia (2011), 16(1), 41-48

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See detailGenetic screening in pituitary patients
Beckers, Albert ULg

Scientific conference (2014, May 04)

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See detailGenetic selection: Evaluation and methods
Wiggans, George R.; Gengler, Nicolas ULg

in Fuquay, J. W.; Fox, P. F.; McSweeney, P. L. H. (Eds.) Encyclopedia of Dairy Sciences (2011)

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See detailGenetic selection: Evaluation and methods
Wiggans, George R.; Gengler, Nicolas ULg

in Roginski, H.; Fuquay, J. W.; Fox, P. F. (Eds.) Encyclopedia of Dairy Science (2002)

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See detailGenetic spatial structure of European common hamsters (Cricetus cricetus)--a result of repeated range expansion and demographic bottlenecks.
Neumann, K.; Michaux, Johan ULg; Maak, S. et al

in Molecular Ecology (2005), 14(5), 1473-83

The spatial genetic structure of common hamsters (Cricetus cricetus) was investigated using three partial mitochondrial (mt) genes and 11 nuclear microsatellite loci. All marker systems revealed ... [more ▼]

The spatial genetic structure of common hamsters (Cricetus cricetus) was investigated using three partial mitochondrial (mt) genes and 11 nuclear microsatellite loci. All marker systems revealed significant population differentiation across Europe. Hamsters in central and western Europe belong largely to two allopatric mitochondrial lineages south and northwest of the Carpathian and Sudetes. The southern group, 'Pannonia', comprises populations inside the Carpathian basin (Czech Republic, Hungary) while the second group, 'North', includes hamsters from Belgium, the Netherlands, France, and Germany. Isolation of the lineages is maintained by a combination of geographical and ecological barriers. Both main phylogeographical groups show signs of further subdivision. North is separated into highly polymorphic central German and less polymorphic western populations, which most likely split during late glacial expansion (15,000-10,000 bp). Clock estimates based on haplotype distributions predict a divergence of the two major lineages 85,000-147,000 bp. Expansion times fall during the last glaciation (115,000-10,000 bp) corroborating fossil data, which identify Cricetus cricetus as characteristic of colder climatic phases. Despite the allopatry of mt haplotypes, there is an overlap of nuclear microsatellite alleles between phylogeographical units. Although there are strong evidence that Pannonian hamsters have persisted inside the Carpathian basin over the last 50,000 years, genetic differentiation among European hamsters has mainly been caused by immigration from different eastern refugia. Possible source populations are likely to be found in the Ukrainian and the southern Russian plains--core areas of hamster distribution. From there, hamsters have repeatedly expanded during the Quaternary. [less ▲]

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See detailGenetic structuralism, psychological sociology and pragmatic social actor theory, Proposals for a convergence of French sociologies
Frère, Bruno ULg

in Theory, Culture & Society (2004), 21(3), 85-99

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other ... [more ▼]

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other currents, which have emerged in French Sociology in the last few years, and were developed by L. Boltanski and L. Thevenot, on the one hand, and B. Lahire, on the other. Although they do not make it explicit, the advocates of these two currents have nevertheless been influenced by Wittgenstein and Freud. Thus Boltanski has drawn on Wittgenstein to develop a sociology which gives primacy to the social actor's interpretation of his or her situation through lay theorising. Lahire's work clearly pays a debt to Freud with his psychological sociology. It would therefore be interesting, in the first instance, to tease out how Wittgenstein and Freud, respectively, have influenced these two systems to demonstrate that they can indeed be used to generate new sociological currents, other than Bourdieu's own. This would then allow us to explore how they could be used to fill any gaps in Bourdieu's work, thus giving the latter renewed relevance and staunching its stagnating tendencies. But, ultimately, this analysis aims to show how Wittgenstein’s and Freud's theoretical influences can lead the way towards a theoretical synthesis between Bourdieu's critical sociology, Boltanski's social actor theory and Lahire's psychological sociology. Currently, these three currents operate independently of each other, without any kind of dialogue. And yet, far from being incompatible, these sociologies offer opportunities for exploring how they might complement each other and for mutual enrichment. [less ▲]

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailGenetic structure of Barn swallow (Hirundo rustica).
Dardenne, Sophie ULg; Stevens, Virginie ULg; Hollander, F. et al

Poster (2009)

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See detailGenetic Structure Of Quinoa (Chenopodium Quinoa Willd.) From The Bolivian Altiplano As Revealed By Rapd Markers
Del Castillo, C.; Winkel, T.; Mahy, Grégory ULg et al

in Genetic Resources and Crop Evolution (2007), 54(4), 897-905

Quinoa (Chenopodium quinoa Willd.) is a pseudocereal originated from the Andes important for small farmers’ food security as well as for commercial production. Recently, it has been claimed that in ... [more ▼]

Quinoa (Chenopodium quinoa Willd.) is a pseudocereal originated from the Andes important for small farmers’ food security as well as for commercial production. Recently, it has been claimed that in Bolivia genetic erosion could result from the marginalization of the crop in the north and from its commercial standardization in the south. The aim of this study was to quantify the hierarchical structure of the genetic variation present in eight quinoa field populations, consisting of cultivated and weedy individuals, representative of the altiplano and interandean valleys of Bolivia. Randomly amplified polymorphic DNA markers show that quinoa has a strong population structure and a high intra-population variation. An effect of geographical structure of the populations was highlighted, due to population isolation, not simply linked to distance but more probably to climatic and orographic barriers present in the studied zone. The population structure is also reinforced by the limited seed exchanges among farmers as revealed by field interviews. This population structure appears related to three major biogeographic zones: the northern and central altiplano, the interandean valley, and the southern Salar. Intrapopulation genetic diversity was higher than that expected for a mainly autogamous species, and higher than that reported in anterior studies based on germplasm collections. These results are commented in view of current knowledge on phylogeny and reproductive biology of the species, and their implications regarding genetic resources management are discussed. [less ▲]

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See detailGenetic susceptibility in pituitary adenomas : from pathogenesis to clinical implications
Jaffrain-Rea, Marie-Lise; Daly, Adrian ULg; Angelini, Mariolina et al

in Expert Review of Endocrinology & Metabolism (2011)

Pituitary adenomas (PA) usually present sporadically, with a multifactorial pathogenesis including somatic mutational events in cancer-related genes. Genetic predisposition implies the presence of ... [more ▼]

Pituitary adenomas (PA) usually present sporadically, with a multifactorial pathogenesis including somatic mutational events in cancer-related genes. Genetic predisposition implies the presence of germline DNA alterations with a variety of impacts on pituitary cell biology, translating into a variable penetrance of the disease. Genetic causes must be considered in the presence of specific clinical settings, such as familial occurrence of PA, with or without extrapituitary diseases, and may also be suspected in young patients with macroadenomas. We <br />review the clinical implications of genetic predisposition, with special attention to Multiple Endocrine Neoplasia type 1 (MEN1), Carney’s complex (CNC) and FIPA (Familial Isolated Pituitary Adenoma), and the scenario of genetic screening in selected patients with an apparently sporadic disease is discussed. [less ▲]

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See detailGenetic transformation of Anthemis nobilis L. (Roman chamomille)
Jaziri, M.; Fauconnier, Marie-Laure ULg; Guo, Y. W. et al

in Bajaj, Y. P. S. (Ed.) Transgenic Medicinal Plants (1999)

Detailed reference viewed: 8 (2 ULg)