Influence of environmental enrichment on cocaine vulnerability

Poster (2012)

Influence of Estrogen Replacement Therapy on Endogenous Calcitonin Production Rates

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (1992), 6(1), 65-71

Calcitonin is now a well-accepted therapy for inhibition of bone loss, both in the first years of menopause and in established osteoporosis. However, its exact role in the pathogenesis of that disease as ... [more ▼]

Calcitonin is now a well-accepted therapy for inhibition of bone loss, both in the first years of menopause and in established osteoporosis. However, its exact role in the pathogenesis of that disease as well as the interactions between calcitonin production and estrogen metabolism remain unsolved. In order to clarify the influence of estrogen replacement therapy (ERT) on calcitonin secretory capacity, we measured whole plasma immunoreactive calcitonin basal levels, metabolic clearance rates and production rates in a group of postmenopausal women, before and after a daily intake for 28 days of 0.625 mg/day of conjugated equine estrogens, and again 4 weeks after the withdrawal of that estrogen replacement therapy. No significant changes appeared in immunoreactive calcitonin or immunoreactive calcitonin metabolic clearance rate but the production rate significantly increased over the 28 days (mean +/- SEM, from 21.3 +/- 5.1 pg/ml to 25.2 +/- 5.9 pg/ml, p less than 0.05), and then decreased 4 weeks after therapy was withdrawn to the initial level (17.9 +/- 3.6 pg/ml). We concluded that estrogen replacement therapy significantly increases calcitonin secretory capacity. This confirms the interactions between calcitonin production and estrogen metabolism, and may provide an explanation concerning the mode of action of estrogen replacement therapy in prevention of postmenopausal bone loss. [less ▲]

Influence of evaporation and seepage on the convergence of a ventilated cavity

in Water Resources Research (2008), 44

In the design of nuclear waste disposals, an important topic concerns the development of an excavated damage zone, where permeability increases. A correct numerical prediction of the coupled processes ... [more ▼]

In the design of nuclear waste disposals, an important topic concerns the development of an excavated damage zone, where permeability increases. A correct numerical prediction of the coupled processes occurring during excavation is therefore needed. In this paper, a nonclassical hydraulic boundary condition is described. It mixes two modes of water exchanges in partial saturation: seepage and evaporation flows. Seepage flow avoids unphysical water inflow into the rock mass, which might be obtained with usual boundary condition in dilatant geomaterial. Evaporation flows enable the thermodynamical equilibrium between air relative humidity in the cavity and in the rock mass. The numerical modeling of a cavity excavation in dilatant geomaterial is carried out. The results show the influence of the hydraulic boundary condition on the convergence of the cavity. Depending on the value of the transfer coefficient, the proposed numerical model can recover the results obtained with an imposed atmospheric pressure or suction at the cavity wall. The determination of the mass transfer coefficient is thus needed and can be achieved through drying experiments or can be estimated thanks to in situ measurements. [less ▲]

Influence of exogenous oestrogen or (anti-) androgen administration on soluble transferrin receptor in human plasma.

in Journal of Endocrinology (2005), 186(1), 61-7

The objective of this investigation was to study the effects of sex steroids on levels of haemoglobin (Hb) and haematocrit (Hct) and to analyse whether these effects can be related to levels of the ... [more ▼]

The objective of this investigation was to study the effects of sex steroids on levels of haemoglobin (Hb) and haematocrit (Hct) and to analyse whether these effects can be related to levels of the soluble transferrin receptor (sTfR), a marker of erythropoietic activity. Nineteen male-to-female transsexuals were randomly assigned to either oral ethinyl oestradiol (EE) (n=12) or transdermal 17beta-oestradiol (E2) (n=7); both treatments included the anti-androgen cyproterone acetate (CA). Six male-to-female transsexuals were treated with CA only. Fifteen female-to-male transsexuals were treated with i.m. testosterone esters. The Hct, and levels of Hb, IGF-I, GH and sTfR were measured before and after 4 months of hormone administration. Androgen administration significantly increased the sTfR concentration by 31.5% (P=0.008) and increased levels of Hct, Hb and IGF-I. Both regimens of CA with oral EE and transdermal E2 reduced plasma testosterone similarly to castrate values and decreased Hb and Hct. The CA+oral EE combination induced a decrease in sTfR of 19.0% (P=0.002) which was not the case with CA+transdermal E2 (P=0.27). This cannot be explained by the profound decline in plasma testosterone which was similar with both regimens, but this difference could be related to the different effects of the two regimens on plasma IGF-I. This assumption is supported by the positive correlation that was found to exist between plasma sTfR and IGF-I after the interventions (P<0.05). [less ▲]

Influence of experimental parameters on properties and microstructure of the steel X210CrW12 in the semi-solid state

in Solid State Phenomena (2006), 116-117

This paper deals with the examination of the steel grade X210CrW12 and its suitability for Thixoforming. In the semi-solid state, the microstructure of this steel consists of a homogeneous distribution of ... [more ▼]

This paper deals with the examination of the steel grade X210CrW12 and its suitability for Thixoforming. In the semi-solid state, the microstructure of this steel consists of a homogeneous distribution of globular particles surrounded by liquid. Additionally, carbides are stabile up to fraction liquid contents of approximately 40%. After quenching, this steel reveals a globular austenitic microstructure with eutectic (former liquid phase) at the grain boundaries. Compression tests permit to determine the influence of different process parameters on the properties and the material behaviour in the semi-solid state. Their influence on the microstructure was investigated but not yet highlighted. Further investigations on this steel allow a fine-tuning to establish optimal process windows of the different thixoforming- and rheoforming-routes. [less ▲]

Influence Of Extrusion On Ruminal And Intestinal Disappearance In Sacco Of Pea (Pisum-Sativum) Proteins And Starch

in Animal Feed Science & Technology (1992), 38(1), 43-55

Influence of facial expression on memory for facial identity: effects of visual features or emotional meaning?

in Emotion (2011), 11

INFLUENCE OF FATIGUE ON THE STRIDE CHARACTERISTICS DURING AN INTENSE ENDURANCE RUNTEST

in Abstract book of 17th ECSS Congress (2012, July)

The Influence of Fetal and Postnatal Growth on Heart Rate Variability in Young Infants

in Cardiology (2001), 95(2), 80-3

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in ... [more ▼]

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in the programming of later cardiovascular disease. HRV data were collected during a night session in 546 healthy infants at 5-12 weeks of adjusted age, and statistical associations with fetal and postnatal growth indices were established. A significant positive correlation between birth weight, the ratio of neonatal weight to head circumference and postnatal weight gain, and HRV indices mostly influenced by sympathetic activity was demonstrated in 11- and 12-week-old infants. A slight correlation (p > 0.05) was also found in younger infants. These data suggest the influence of fetal and postnatal growth on the programming of the autonomic nervous system beyond the neonatal period. This influence may be one of the important mechanisms that link impaired growth in fetal and infant life to high blood pressure and other cardiovascular disease during childhood and adulthood (the Barker hypothesis). [less ▲]

The influence of follicular dendritic cells on B-cell proliferation depends on the activation of B cells and the mitogen used.

in Scandinavian Journal of Immunology (1996), 43(1), 23-30

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of ... [more ▼]

Follicular dendritic cells (FDC) are unique non-lymphoid cells found only in lymph follicles. They play a part in the survival, proliferation and differentiation of B cells. To analyse the influence of FDC on B-lymphocyte proliferation, we isolated them from human tonsils on albumin gradients and treated them with mitomycin C to prevent the multiplication of lymphoid cells harboured in their cytoplasmic evaginations. FDC cultured for 12-16 h remained attached to the substrate; non-adherent cells were carefully eliminated by washing. Purified B cells cultured alone or with contaminant-cleared FDC were maintained for 2 days in the presence or absence of various stimulants, after which tritiated thymidine uptake by these cells was measured. In the absence of activators, FDC did not induce B-cell multiplication. B cells cultured in the presence of FDC exhibited increased 3H-TdR uptake when activated with anti-CD40 MoAb, anti-immunoglobulin MoAb or transferrin, but not when stimulated with Staphylococcus aureus strain Cowan I (SAC) at a given concentration. In the latter case, B-cell proliferation clearly decreased. In control cocultures where mitomycin-C-treated non-adherent cells were used instead of FDC in the presence of the different stimulants, no increase in B-cell proliferation was observed. The results suggest that, inside the germinal centres, FDC modulation of B-cell proliferation depends on the activation state of the B cells and on the stimulant encountered. [less ▲]