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See detailExploring brain connectivity: a new frontier in systems neuroscience
Ramnani, Narander; Lee, Lucy; Phillips, Christophe ULg et al

in Trends in Neurosciences (2002), 25(10), 496-497

Detailed reference viewed: 25 (1 ULg)
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See detailExploring Consumer Evaluations of e-Services: A Portal Site
Van Riel, Allard ULg; Liljander, Veronica

in International Journal of Service Industry Management (2001), 12(4), 359-377

Detailed reference viewed: 194 (2 ULg)
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See detailExploring EI in Belgium: a New Theoretical and Empirical Way to Deal with Environmental Conflicts in Urban Areas?
Lejeune, Zoé ULg

Conference (2013, September)

Environmental Inequalities (EI) –the unequal distribution of environmental goods and ‘bads’ among space and population– are a field of research at the crossroads of political science, socio-legal studies ... [more ▼]

Environmental Inequalities (EI) –the unequal distribution of environmental goods and ‘bads’ among space and population– are a field of research at the crossroads of political science, socio-legal studies, and urban research. Unlike US Environmental Justice movement, environmental inequalities are not seen by actors, or studied, as a specific frame for action and collective mobilisation in Belgium in environmental matters. Environmental conflicts are however numerous in urban areas in Belgium where industrial activities and housing cohabit. In this paper, I introduce the topic of environmental inequalities in Belgium and analyse the unequal consequences of urban policy in Belgium in terms of environmental quality and access to amenities, more precisely, of uneven access to ‘quality of life’ in a context of ‘anti-urban policy’. Environmental inequalities invite us to think about democracy in the cities (citizen participation, equal access to environmental quality of life) and about litigation and legal opportunities for individuals and groups in environmental conflicts. This paper questions the possibility of alternative modes of public regulation in a ‘social and environmental justice in the city’ perspective that could better integrate social and environmental issues. This paper explores (1) how environmental NGOs and individuals can mobilise the law to denounce environmental conflicts and inequalities providing insights into an environmental inequalities perspective on access to justice in environmental lawsuits. It then studies (2) how current urban policy in Belgium can contribute to explaining these inequalities. Empirical evidence relies, on the one hand, on legal texts, public policy analysis and litigation cases and, on the other hand, on exploratory interviews with stakeholders in Belgium –main political parties, environmental non-profit organizations, legal practitioners, trade unions and scientific institutions. [less ▲]

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See detailExploring Environmental Inequalities in Belgium: a New Theoretical and Empirical Way to Deal with Environmental Conflicts in Urban Areas?
Lejeune, Zoé ULg

Scientific conference (2013, June)

Environmental Inequalities (EI) – the unequal distribution of environmental goods and bads among space and population – are a field of research at the crossroads of political science, environmental ... [more ▼]

Environmental Inequalities (EI) – the unequal distribution of environmental goods and bads among space and population – are a field of research at the crossroads of political science, environmental studies, and urban studies. Unlike US Environmental Justice movement, EI are not seen by actors or studied as a specific frame for action and collective mobilisation in Belgium in environmental matters. Environmental conflicts are however numerous in urban areas in Belgium where industrial activities and housing cohabit. In this paper, I analyse the unequal consequences of urban policy in Belgium in terms of environmental quality and access to amenities, more precisely, of uneven access to “quality of life” in a context of “anti-urban policy”. EI invite us to think about democracy in the cities (citizen participation, equal access to environmental quality of life) and about litigation and legal opportunities for individuals and groups in environmental conflicts. This paper examines alternative modes of public regulation in a “social and environmental justice in the city” perspective that could better integrate social and environmental issues. After a general presentation of the doctoral research, this paper explores (1) how grassroots movements or individuals can mobilise the law to denounce environmental conflicts and inequalities providing insights into an environmental inequalities perspective. It then studies (2) how current urban and environmental policy in Belgium can contribute to explaining these inequalities. Empirical evidence relies, on the one hand, on legal texts, public policy analysis and litigation cases and, on the other hand, on exploratory interviews with stakeholders in Belgium – main political parties, environmental non-profit organizations, legal practitioners, unions and scientific public institutions. [less ▲]

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See detailExploring New Achievements in olefin metathesis catalysts. Part 1 - Highlights on N-heterocyclic carbene ruthenium complexes
Dragutan, Valerian; Dragutan, Ileana; Delaude, Lionel ULg et al

in Chimica Oggi = Chemistry Today (2009), 27(3), 9-12

Most important advances in ruthenium catalysts for olefin metathesis achieved during the last 4 years are briefly reviewed. The first part of the survey focuses on new catalytic precursors endowed with ... [more ▼]

Most important advances in ruthenium catalysts for olefin metathesis achieved during the last 4 years are briefly reviewed. The first part of the survey focuses on new catalytic precursors endowed with inventive N-heterocyclic carbene ligands which have proved highly proficient in a diversity of applications based on metathesis reactions. Part two extends the progress in other types of Ru initiators. [less ▲]

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See detailExploring new achievements in olefin metathesis catalysts. Part 2 - Compelling innovations in ruthenium complexes
Dragutan, Ileana; Dragutan, Valerian; Delaude, Lionel ULg et al

in Chimica Oggi = Chemistry Today (2009), 27(3), 13-16

This part of the survey introduces recent developments on de novo designed types of ruthenium complexes used as promoters in olefin metathesis reactions. Encompassing diversity-oriented initiators not ... [more ▼]

This part of the survey introduces recent developments on de novo designed types of ruthenium complexes used as promoters in olefin metathesis reactions. Encompassing diversity-oriented initiators not illustrated in Part 1, in this second part of the review emphasis is placed on the leading role played by distinct ligands in an exquisite control of metathesis reactions. [less ▲]

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See detailExploring new dimensions in cadaveric decomposition odour analysis
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn; Lloyd, Rebecca et al

in Analytical Methods (2015), 7

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound ... [more ▼]

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound analysis in the forensic sciences. High-resolution mass spectral data provided higher confidence in analyte identification. GC×GC-HRTOFMS will be valuable for future studies of decomposition odour and other complex volatile matrices. [less ▲]

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See detailExploring PNS in Fabry disease
WANG, François-Charles ULg; BOUQUIAUX, Olivier ULg

Scientific conference (2013, November 19)

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See detailExploring self-defining memories in schizophrenia.
Raffard, Stephane; D'Argembeau, Arnaud ULg; Lardi, Claudia et al

in Memory (2009), 17(1), 26-38

Previous studies have shown that patients with schizophrenia are impaired in recalling specific events from their personal past. However, the relationship between autobiographical memory impairments and ... [more ▼]

Previous studies have shown that patients with schizophrenia are impaired in recalling specific events from their personal past. However, the relationship between autobiographical memory impairments and disturbance of the sense of identity in schizophrenia has not been investigated in detail. In this study the authors investigated schizophrenic patients' ability to recall self-defining memories; that is, memories that play an important role in building and maintaining the self-concept. Results showed that patients recalled as many specific self-defining memories as healthy participants. However, patients with schizophrenia exhibited an abnormal reminiscence bump and reported different types of thematic content (i.e., they recalled less memories about past achievements and more memories regarding hospitalisation and stigmatisation of illness). Furthermore, the findings suggest that impairments in extracting meaning from personal memories could represent a core disturbance of autobiographical memory in patients with schizophrenia. [less ▲]

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See detailExploring Structure and Reformulations in Different Integer Programming Algorithms
Louveaux, Quentin ULg

Doctoral thesis (2004)

In this thesis we consider four topics all related to using problem reformulations in order to solve integer programs, i.e. optimization problems in which the decision variables must be integer. We first ... [more ▼]

In this thesis we consider four topics all related to using problem reformulations in order to solve integer programs, i.e. optimization problems in which the decision variables must be integer. We first consider the polyhedral approach. We start by addressing the ques- tion of lifting valid inequalities, i.e. finding a valid inequality for a set Y from the knowledge of a valid inequality for a lower-dimensional restriction X of Y . We simplify and clarify the presentation of the procedure. This allows us to derive conditions under which the computation of the lifting is tractable. The second topic is the study of valid inequalities for the single node flow set. The single node flow set is the problem obtained by considering one node of a fixed charge network flow problem. We derive valid inequalities for this set and various generalizations. Our approach is a systematic procedure using only basic tools of integer programming: fixing and complementing variables, mixed- integer rounding and lifting. The method allows us to explain and generate a large range of inequalities describing the convex hull of such sets. The last two topics are based on non-standard approaches for integer pro- gramming. We first show how the group relaxation approach can be used to provide reformulations for the integral basis method. This is based on a study of extended formulations for the group problem. We present four extended for- mulations and show that the projections of three of these formulations provide the convex hull of the original group problem. Initial computational tests of the approach are also reported. Finally we consider a problem that is difficult for the standard branch-and- bound approach even for small instances. A reformulation based on lattice basis reduction is known to be more effective. However the step to compute the re- duced basis is O(n4) and becomes a bottleneck for small to medium instances. By using the structure of the problem, we show that we can decompose the problem and obtain the basis by taking the kronecker product of two smaller bases easier to compute. Furthermore, if the two small bases are reduced, the kronecker product is also reduced up to a reordering of the vectors. Computa- tional results show the gain from such an approach. [less ▲]

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See detailExploring The Active Site Cavity Of Human Pancreatic Lipase
Colin, Damien Yann; Deprez-Beauclair, Paule; Allouche, Maya et al

in Biochemical and Biophysical Research Communications (2008), 370(3), 394-8

Within the scope of improving the efficiency of pancreatic enzyme replacement therapy in cystic fibrosis, the feasibility of shifting the pH-activity profile of pancreatic lipase toward acidic values was ... [more ▼]

Within the scope of improving the efficiency of pancreatic enzyme replacement therapy in cystic fibrosis, the feasibility of shifting the pH-activity profile of pancreatic lipase toward acidic values was investigated by site specific mutagenesis in different regions of the catalytic cavity. We have shown that introducing a negative charge close to the catalytic histidine induced a shift of the pH optimum toward acidic values but strongly reduced the lipase activity. On the other hand, a negative charge in the entrance of the catalytic cleft gives rise to a lipase with improved properties and twice more active than the native enzyme at acidic pH. [less ▲]

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See detailExploring the Antarctic soil metagenome as a source of novel cold-adapted enzymes and genetic mobile elements
Berlemont, Renaud ULg; Pipers; Delsaute, Maud ULg et al

in Revista Argentina de Microbiologia (2011)

Metagenomic library PP1 was obtained from Antarctic soil samples. Both functional and genotypic metagenomic screening were used for the isolation of novel cold-adapted enzymes with potential applications ... [more ▼]

Metagenomic library PP1 was obtained from Antarctic soil samples. Both functional and genotypic metagenomic screening were used for the isolation of novel cold-adapted enzymes with potential applications, and for the detection of genetic elements associated with gene mobilization, respectively. Fourteen lipase/esterase-, 14 amylase-, 3 protease-, and 11 cellulase-producing clones were detected by activity-driven screening, with apparent maximum activities around 35 °C for both amylolytic and lipolytic enzymes, and 35-55 °C for cellulases, as observed for other cold-adapted enzymes. However, the behavior of at least one of the studied cellulases is more compatible to that observed for mesophilic enzymes. These enzymes are usually still active at temperatures above 60 °C, probably resulting in a psychrotolerant behavior in Antarctic soils. Metagenomics allows to access novel genes encoding for enzymatic and biophysic properties from almost every environment with potential benefits for biotechnological and industrial applications. Only intI- and tnp-like genes were detected by PC R, encoding for proteins with 58-86%, and 58-73% amino acid identity with known entries, respectively. Two clones, BAC 27A-9 and BAC 14A-5, seem to present unique syntenic organizations, suggesting the occurrence of gene rearrangements that were probably due to evolutionary divergences within the genus or facilitated by the association with transposable elements. The evidence for genetic elements related to recruitment and mobilization of genes (transposons/integrons) in an extreme environment like Antarctica reinforces the hypothesis [less ▲]

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See detailExploring the cultural politics of labour in South China
Florence, Eric ULg

Scientific conference (2013, June 20)

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See detailExploring the Diversity of Fair Trade Social Enterprises
Huybrechts, Benjamin ULg; Defourny, Jacques ULg

E-print/Working paper (2010)

Fair trade (FT) organisations have been quite early taken as examples of social enterprises (SE) and have contributed to the shaping of the SE concept. The goal of this article is to examine more deeply ... [more ▼]

Fair trade (FT) organisations have been quite early taken as examples of social enterprises (SE) and have contributed to the shaping of the SE concept. The goal of this article is to examine more deeply, both at a conceptual and at an empirical level, to what extent FT organisations can be considered as social enterprises. First, we introduce different theoretical frameworks of SE and examine FT in the context of each of these frameworks. In a second step, we use an empirical study on fair trade social enterprises (FTSEs) across four European countries to illustrate and deepen the links between FT and SE, focusing on the goals and the governance structures of FTSEs. It appears that all FTSEs combine in some way economic, social and sometimes also political goals. FTSEs are thus in line with the "hybrid-goal" nature of SEs. FTSEs' governance is also quite specific and often innovative in terms of organisational architecture and stakeholders' involvement. Some FTSEs are closer to the European – participatory – approach of social enterprise, while others are closer to US – individual – approaches. Finally, the governance structures of FTSEs seem to reflect quite well their goal mix. This article provides a more solid basis for the often implicit link between FT and SE. Future researches could use our work to explore specific topics of the SE literature (e.g. stakeholders' involvement) in the context of FT. The FT example could also be used to examine further the shifting boundaries of the SE reality. The originality of this article is to apply the SE concept to a specific field and to show how, within this field, there is at the same time (1) a diversity of organisations, reflecting the diversity of SE approaches and (2) a range of specific features (especially in terms of goal mix and governance) distinguishing SEs from other types of organisations operating in the same field. [less ▲]

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See detailExploring the effect of action familiarity on SPTs recall performance in Alzheimer's disease
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Moonen, Gustave ULg et al

in Journal of Clinical & Experimental Neuropsychology (2002), 24(8), 1057-1069

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and ... [more ▼]

This study examined the performance of normal controls (NC) and Alzheimer's disease (AD) patients on free recall, semantic cued recall and object cued recall of both subject-performed tasks (SPTs) and verbal descriptions of actions, by controlling familiarity of actions associated to objects. The results showed that both groups performed better after SPT encoding than after verbal encoding. in all three types of recall. In addition, this SPT advantage was greater for AD patients than for NC in the object cued recall test, emphasizing AD patients' sensibility to the congruence of cues between encoding and retrieval conditions. Following verbal encoding. NC showed a better recall for less familiar actions than for highly familiar actions, whereas AD patients exhibited the opposite pattern. These results reflect that AD patients did not benefit from a distinctiveness effect at encoding for improving subsequent retrieval of verbal information, probably due to a reduced level of elaboration during encoding. However, there was no effect of action familiarity on recall performance by both groups following SPT encoding. These results suggest that memory for verbal actions and SPTs is governed by different principles. In addition. they demonstrate the robustness of the SPT effect in AD patients, who were able to improve memory performance in the SPT condition not only with highly familiar actions but also with less familiar actions. [less ▲]

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See detailExploring the Formation Pathways of DNA G-Quadruplex Architectures
Rosu, Frédéric ULg; Poncelet, Harmonie; Teulade-Fichou, Marie-Paule et al

Conference (2007, September 07)

Guanine-rich DNA strands can form the so-called G-quadruplex architectures due to the formation of quartets of guanines linked by 8 hydrogen bonds. G-quadruplexes are further stabilized by the inclusion ... [more ▼]

Guanine-rich DNA strands can form the so-called G-quadruplex architectures due to the formation of quartets of guanines linked by 8 hydrogen bonds. G-quadruplexes are further stabilized by the inclusion of cations between the G-quartets. The abundance of G-rich regions throughout the genome and their very presence in telomeric regions made G-quadruplexes interesting targets. NMR and crystallographic studies of G-quadruplex structures revealed amazing variety in the G-quadruplex topologies. The next challenge will be to understand the rules governing the formation of the various topologies, in order to predict relevant G-quadruplexes in the genome, and in order to act rationally on their formation or disruption. To date, only few experimental [1] or theoretical [2] studies have been devoted to investigating the mechanisms of G-quadruplex formation. We report here a detailed investigation of DNA G-quadruplex formation pathways using electrospray mass spectrometry (ESI-MS). The sequences TGnT (n = 3-6) were purchased from Eurogentec (Seraing, Beliugm). ESI-MS experiments were performed in the negative ion mode on a Q-TOF Ultima Global (Waters, Manchester, UK). The cation used was ammonium (up to 150 mM). Experiments were performed in the presence and absence of methanol (up to 20%) as co-solvent. ESI-MS allows counting both the number of strands and the number of cations in each intermediate. We could confirm the presence of transient dimer and trimer intermediates in low abundance. More unexpectedly, ESI-MS also reveals unambiguously the formation of pentamers which contain ammonium cations. The pentamers slowly convert into tetramers. Counting the number of included cations also revealed that, in the case of (TG6T)4, inclusion of four ammonium cations is fast, while the inclusion of the last ammonium ion is very slow. We also found that the addition of methanol (initially added to obtain higher ion intensities) significantly increases the rate of G-quadruplex formation. Finally, we also investigated the role of G-quadruplex ligands in the rate of formation of G-quadruplexes. We could classify the ligands according to their increase of G-quadruplex formation kinetics, and distinguish the intermediates. Interestingly, one ligand showed formation of a higher-order structure by bridging two G-quadruplexes. Acknowledgement: The authors thank the FRS-FNRS for their support. References: [1] J. Gros et al., Nucleic Acids Res., 2007, doi:10.1093/nar/gkm111. [2] R. Stefl et al., Biophys. J., 2003, 85(3), 1787-1804. [less ▲]

Detailed reference viewed: 9 (0 ULg)