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See detailGefitinib monotherapy in advanced non-small cell lung cancer (NSCLC): Experience from a large, Western community implementation study
van Puijenbroek, R.; Bosquee, Léon ULg; Meert, A. P. et al

in European Respiratory Journal (2007, June), 29(1), 128-133

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See detailGefitinib monotherapy in advanced nonsmall cell lung cancer: a large Western community implementation study
van Puijenbroek, R.; Bosquee, Léon ULg; Meert, A. P. et al

in European Respiratory Journal (2007), 29(1), 128-133

Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent ... [more ▼]

Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent previous clinical trial experience matches large-scale Western community implementation of this treatment. In the Belgian expanded access programme, the data from 513 patients with advanced or metastatic NSCLC, not suitable for further chemotherapy and receiving oral gefitinib 250 mg center dot day(-1) until disease progression, death or unacceptable toxicity, were analysed. The median (range) duration of gefitinib treatment was 2.3 months (0.0-32.7). Its use was predominantly in second- or third-line treatment. The overall response and disease control rates were 8.9 and 41.2%, respectively. In univariate analysis, response was more common in females and never-smokers. In multivariate analysis, female sex was the only significant predictive factor (odds ratio (OR) (95% confidence interval (Cl)) 0.329 (0.129-0.839)). Symptom improvement was reported in 108 patients of whom 32 (29.6%) had an objective response, 66 (61.1%) experienced disease stabilisation and 10 (9.3%) progressed. Gefitinib was well tolerated; only 7.8% of the patients reported grade 3 or 4 toxicity. The overall median survival was 4.7 months, with a 1-yr survival rate of 21%. Survival was strongly influenced by a better performance status (PS) (good PS: hazard ratio (HR) (95%Cl) 0.110 (0.077-0.157)) and adenocarcinoma with bronchioloalveolar carcinoma features histology (HR (95%Cl) 0.483 (0.279-0.834)). In conclusion, the activity of gefitinib was confirmed in the present large Western community implementation study. Response, present in a small subgroup, led to a rewarding survival and could be predicted by sex only. Baseline performance status and adenocarcinoma with bronchioloalveolar carcinoma features histology were significant factors for survival. [less ▲]

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See detailGefühlskulturen: Überlegungen zu einer kontrastiven Poetik der Affekte am Beispiel des ridicule.
Pontzen, Alexandra ULg

in Sieburg, Heinz; Dieter Heimböckel, Dieter (Eds.) Zwischen Provokation und Usurpation. Interkulturalität als (un)vollendetes Projekt der Literatur- und Sprachwissenschaften (2010)

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See detail"Gefühltes Komma - richtiges Komma?"
Münzberg, Franziska ULg

Scientific conference (2014, April 11)

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See detail"Gegenwart und Vergangenheit in eins" : Hugo von Hofmannsthals Gedächtnis-Konzept und seine mediale Realisierung während und nach dem Ersten Weltkrieg.
Viehöver, Vera ULg

in Krumeich, Gerd; Witte, Bernd; Borsò, Vittoria (Eds.) Medialität und Gedächtnis : Interdisziplinäre Beiträge zur kulturellen Verarbeitung europäischer Krisen (2001)

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See detailEin ‘geheimer Faden.’ E.T.A. Hoffmanns Roman "Die Elixiere des Teufels" und Goethes "Wahlverwandtschaften"
Küpper, Achim ULg

in Germanistische Mitteilungen (2005), (62), 79-97

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See detailDie Geheimnisse der Schrift: Heinrich von Kleists Poetik der Verschlossenheit und das Prinzip der Verschiebung in seinen Texten
Küpper, Achim ULg

in Brittnacher, Hans Richard; von der Lühe, Irmela (Eds.) Risiko – Experiment – Selbstentwurf. Kleists radikale Poetik (2013)

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See detailGehlenite from three occurrences of high-temperature skarns, Romania: new mineralogical data
Marincea, Stefan ULg; Dumitras, Delia; Ghinet, C. et al

in Canadian Mineralogist (2011), 49

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See detailHet geïntegreerde contrastieve onderzoeksdesign onder de loep
Hiligsmann, Philippe; Rasier, Laurent ULg

in Rasier, Laurent; Van Heuven, Vincent; Defrancq, Bart (Eds.) et al Nederlands in het perspectief van uitspraakverwerving en contrastieve taalkunde (2011)

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See detailA gel retardation assay system for studying protein binding to simple repetitive DNA sequences.
Maueler, W.; Muller, Marc ULg; Kohne, A. C. et al

in Electrophoresis (1992), 13(1-2), 7-10

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC ... [more ▼]

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC-DRB genes for long evolutionary times, including such distant animals as artiodactyla and man. We describe herein an unsophisticated method which reveals that at least certain simple repetitive (gt)n(ga)m sequences bind nuclear proteins and show characteristics of a specific DNA-protein interaction via gel retardation. [less ▲]

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See detailGel-casted porous Al2O3 ceramics by use of natural fibres as pore developers
Gaydardzhiev, Stoyan ULg; Gusovius, Hans; Wilker, Viola et al

in Journal of Porous Materials (2007)

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See detailGelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy.
Polette, M.; Gilbert, N.; Stas, I. et al

in Virchows Archiv : An International Journal of Pathology (1994), 424

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is ... [more ▼]

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is some controversy about its origin. Gelatinase A was localized by immunohistochemistry using confocal microscopy in 15 human mammary carcinomas. In addition, the cells responsible for the synthesis of this enzyme were detected by in situ hybridization. Most invasive and non-invasive tumour cells were labelled by immunohistochemistry. Of particular interest was the pattern observed in some pre-invasive areas. Gelatinase A was found in fibroblasts in close contact with pre-invasive tumour clusters. Confocal observation allowed a more precise localization of gelatinase A to the periphery of tumour clusters along the basement membranes and in peritumour fibroblasts. The malignant epithelial cells were negative by immunohistochemistry in these areas. By in situ hybridization, mRNAs encoding gelatinase A were detected only in fibroblasts in close contact with pre-invasive and well differentiated tumour clusters. These findings support the hypothesis that peritumour fibroblasts produce gelatinase A and that breast cancer cells may bind this enzyme to their cell surface and/or internalize it. [less ▲]

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See detailGeldanamycin inhibits tyrosine phosphorylation-dependent NF-kB activation
Crèvecoeur, Julie ULg; Piette, Jacques ULg; Gloire, Geoffrey ULg

in Biochemical Pharmacology (2008), 75(11), 2183-2191

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using ... [more ▼]

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using the Hsp90 ATPase inhibitor Geldanamycin (GA), an anti-tumour drug. Hsp90 inhibition blocks the synthesis and activation of the IKK complex, the major kinases complex responsible for IκBα phosphorylation on serine 32 and 36, a key step for its degradation and the nuclear translocation of NF-κB. However, the effect of GA on other IκBα kinases, including tyrosine kinases, is unknown. In the present study, we investigated the effect of GA on NF-κB activation induced by sodium pervanadate (PV), a tyrosine phosphatase inhibitor triggering c-Src-mediated tyrosine phosphorylation of IκBα. We reporte for the first time that GA inhibits PV-induced IκBα tyrosine phosphorylation and degradation. Using an in vitro kinase assay, we demonstrated that GA inhibits the activity of c-Src as an IκBα tyrosine kinase, but not its cellular expression. As a result, GA blocked PV-induced NF-κB DNA binding activity on an exogenous κB element and on the endogenous iκbα promoter, thereby inhibiting IκBα transcription. Finally, we demonstrated that, despite NF-κB inhibition, pre-treatment with GA does not potentiate PV-induced apoptosis. We conclude that c-Src requires Hsp90 for its tyrosine kinase activity, and its inhibition by GA blocks c-Src-dependent signalling pathways, such as NF-κB activation induced by sodium pervanadate. The effect of GA on PV-induced apoptosis is discussed in the light of recent publications in the literature. [less ▲]

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See detailGellert und die empfindsame Aufklärung : Vermittlungs-, Austausch- und Rezeptionsprozesse in Wissenschaft, Kunst und Kultur.
Viehöver, Vera ULg; Schönborn, Sibylle

Book published by Erich Schmidt (2009)

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See detailGellerts Spur in Leopold Mozarts 'Versuch einer gründlichen Violinschule'
Viehöver, Vera ULg

in Viehöver, Vera; Schönborn, Sibylle (Eds.) Gellert und die empfindsame Aufklärung : Vermittlungs-, Austausch- und Rezeptionsprozesse um 1750 (2009)

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See detailGelling properties of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Deroanne, C.

in Journal of Food Science (2000), 65(4), 561-563

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least ... [more ▼]

The effect of residual fat hydrolysis upon the gelation of whey protein concentrate (WPC) was studied. Gelling properties of a commercial WPC and lipase-treated WPC were evaluated on the basis of least concentration endpoint gelation, penetration test, texture profile analysis and water-holding capacity. Heat treatment of lipase-treated WPC led to gels with the highest hardness, springiness, cohesiveness and water retention. Such transformed WPC could be advantageously used to help improve texture in formulated meat, bakery, and confectionery products. [less ▲]

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See detailDas Gelobte Land: Erez Israel von der Antike bis zur Gegenwart in Quellen und Darstellungen
Pontzen, Alexandra ULg; Stähler, Axel

Book published by rowohlt enzyklopädie (2003)

Die Auseinandersetzung um die Existenz-Bedingungen und die territoriale Ausdehnung des Staates Israel steht seit Jahrzehnten im Zentrum des Nahost-Konflikts. Grundlegend für die Landfrage ist die ... [more ▼]

Die Auseinandersetzung um die Existenz-Bedingungen und die territoriale Ausdehnung des Staates Israel steht seit Jahrzehnten im Zentrum des Nahost-Konflikts. Grundlegend für die Landfrage ist die Tradition von "Erez Israel", dem "Land Israel" als gottbestimmter, legitimierter Heimat der Juden. Auf diese für Religion, Geschichte und Kultur des Judentums zentrale Tradition beruft sich auch der heutige jüdische Staat. Er versteht sich als Erfüllung des Traums von der "Erlösung Israels". Die Proklamationsurkunde von 1948 erklärt das "natürliche und historische Recht des jüdischen Volkes", den jüdischen Staat "auf den Boden des Heimatlandes" zu gründen: in Palästina. Textzeugnisse unterschiedlicher Herkunft und Gattung aus der Zeit zwischen 600 v. Chr. bis 2000 n. Chr. dokumentieren die Idee von verheißenem Land und die Kopplung von Religion und Land in Tradition von "Erez Israel". Kommentare und Erläuterungen von Wissenschaftlern verschiedener Disziplinen liefern Hintergrundinformationen und einen historischen Überblick. Sie ermöglichen es dem allgemein-politisch wie dem fachwissenschaftlich interessierten Leser, sich ein eigenes Urteil zu bilden. [less ▲]

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See detailDas „Gelobte Land“ von den Anfängen bis zur Gegenwart – ein Überblick
Pontzen, Alexandra ULg; Bertrams, Oliver; Stähler, Axel

Part of book (2003)

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See detailLa "Geltung" de Lotze et l'a priori matériel
Dewalque, Arnaud ULg

Conference (2011, December 16)

Je me propose de réévaluer un certain aspect de l’héritage de Lotze, à savoir sa théorie de la validité (Geltung). En m’inspirant notamment d’une remarque de Georg Misch, qui fut l’éditeur de la troisième ... [more ▼]

Je me propose de réévaluer un certain aspect de l’héritage de Lotze, à savoir sa théorie de la validité (Geltung). En m’inspirant notamment d’une remarque de Georg Misch, qui fut l’éditeur de la troisième édition du système de Lotze en 1912, et de certaines déclarations de Husserl, je défendrai la thèse suivante : la théorie lotzéenne de la validité appartient à une tradition qui se caractérise par la découverte de propositions aprioriques d’un certain genre, à savoir des relations of ideas (au sens de Hume), des lois aprioriques matérielles (au sens de Husserl) ou des axiomes objectifs, régionaux ou matériels (au sens de Stumpf). Ce que je voudrais suggérer, en un mot, c’est qu’il y a une connexion étroite entre le concept lotzéen de validité et la découverte de l’a priori matériel. [less ▲]

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