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See detailFacile Microwave-Assisted Synthesis of Cyclic Amidinium Salts
Aidouni, Adila; Bendahou, Soufiane; Demonceau, Albert ULg et al

in Journal of Combinatorial Chemistry (2008), 10(6), 886-892

The cyclization of N,N '-dialkyl or diaryl ethane-1,2-diamines or propane-1,3-diamines with inorganic ammonium salts and orthoesters proceeds briskly under microwave irradiation to afford the ... [more ▼]

The cyclization of N,N '-dialkyl or diaryl ethane-1,2-diamines or propane-1,3-diamines with inorganic ammonium salts and orthoesters proceeds briskly under microwave irradiation to afford the corresponding imidazolinium or tetrahydropyrimidinium salts. The transformation is highly versatile and tolerates a wide range of substituents and counterions. It could be scaled from 1 to 50 mmol without any difficulty. Because the workup is equally rapid and straightforward, this experimental procedure provides fast and convenient access to an important class of heterocyclic compounds that have found numerous applications as N-heterocyclic carbene precursors, organocatalysts, and ionic liquids. [less ▲]

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See detailFacilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.
Kuijpers, Marijke; Schulte, V.; Oury, Cécile ULg et al

in Journal of Physiology (2004)

This work indicates that, under physiological conditions of flow, both adhesive receptors GPIb and alphaIIbbeta3 facilitate GPVI-mediated PS exposure by stabilizing platelet binding to collagen. Hence ... [more ▼]

This work indicates that, under physiological conditions of flow, both adhesive receptors GPIb and alphaIIbbeta3 facilitate GPVI-mediated PS exposure by stabilizing platelet binding to collagen. Hence, these glycoproteins have an assistant procoagulant role in collagen-dependent thrombus formation, which is most prominent at reduced GPVI activity and is independent of the presence of thrombin. [less ▲]

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See detailFacilitating studies of cell proliferation in chronic lymphocytic leukemia
Macallan, Derek C.; Defoiche, Julien; Willems, Luc ULg

in Leukemia Research (2010), 34

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See detailFacilitation of Responses to Motor Cortex Stimulation: Effects of Isometric Voluntary Contraction
Maertens De Noordhout, Alain ULg; PEPIN, Jean-Louis ULg; GERARD, Pascale ULg et al

in Annals of Neurology (1992), 32(3), 365-70

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over ... [more ▼]

In 7 normal subjects we compared the facilitatory effect of isometric contraction of the tibialis anterior on the size of electromyographic responses evoked in this muscle by electric stimuli applied over the cervical column and by electric and magnetic percutaneous stimulation of the motor cortex. No significant difference was found between the degrees of facilitation of the responses to any of the stimuli. Using collision techniques, we also showed that the pyramidal fibers activated by spinal and cortical stimuli are the same. Facilitation induced by isometric contraction (20% maximum) was of similar or greater magnitude than that found with constant vibration of the tendon of the target muscle. In cases where vibration and contraction had equal facilitatory effects, there was no further facilitation of the responses when both conditions were applied together. These findings indicate that the facilitatory effect of isometric contraction of the target muscle essentially originates at a spinal level rather than in the motor cortex. [less ▲]

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See detailFacilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice
Bernaerts, P.; Tirelli, Ezio ULg

in Behavioural Brain Research (2003), 142(1-2), 41-52

The still unknown contribution of the D4 receptors to memory consolidation was studied examining the memory effects of the dopamine D4 agonist PD168,077, the putative dopamine D4 antagonist L745,870 ... [more ▼]

The still unknown contribution of the D4 receptors to memory consolidation was studied examining the memory effects of the dopamine D4 agonist PD168,077, the putative dopamine D4 antagonist L745,870, their mutual combination, and the combination of the D4 agonist with representative compounds acting as agonist or antagonist on the D1, D2 and the D3 receptors. Memory consolidation was assessed in C57BL/6J mice using the one-trial step-through inhibitory avoidance task, the compounds being injected immediately after training (foot-shock) and performance measured 24h later. PD168,077 (0.5-10mg/kg) dose-dependently improved memory performance and L745,870 (0.05-5mg/kg) at doses lower than 1mg/kg increased and at doses higher than 1mg/kg impaired memory performance. PD168,077 did not affect the paradoxical promnesic effect of low doses (0.1-0.5mg/kg) of L745,870, but antagonised the memory-impairing effect induced by 5mg/kg L745,870. The D1 antagonist SCH23390 (0.025-0.05 mg/kg) and the D2 antagonist eticlopride (0.01-0.05 mg/kg) antagonised the promnesic effects of PD168,077, which attenuated the decreasing effect on memory consolidation of both D1 and D2 antagonists. Accordingly, the D1 agonist SKF38393 (5-20mg/kg) and the D2 agonist quinelorane (0.1-1 mg/kg) both synergistically magnified the memory-improving effects of the D4 agonist. The dopamine D3 antagonist U99194A (2.5-10mg/kg) did not affect the promnesic effects induced by the D4 agonist, which nevertheless abolished the U99194A-induced promnesic effects. Additionally, the amnesic effects produced by the D3 agonist 7-OH-DPAT (0.01-1 microg/kg) was attenuated by PD168,077. These results suggest a potential role of dopamine D4 receptors in memory consolidation, which would be similar to that of the D1 and D2 receptors and probably opposite to that of the D3 receptors. [less ▲]

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See detailFacilitatory effects of chronically administered citicoline on learning and memory processes in the dog.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (1998), 22(1), 115-28

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment ... [more ▼]

1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differential reinforcement of response duration schedule in normal dogs. 3. The effects of citicoline on a stabilized performance were also measured in order to be able to differentiate specific memory effects from non specific influences on the motor, neuro-vegetative and motivational systems. 4. The results demonstrate that citicoline can exert facilitatory effects on learning and memory but also on retrieval processes. The complete absence of effects on the stabilized performance and on the motor, neuro-vegetative and motivational systems constitutes arguments in favour of a selectivity of action on the memory processes. [less ▲]

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See detailFacilités de paiement, demande amiable et rééchelonnement
Biquet, Christine ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2013), (11-12), 681-683

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See detailFacility location via fuzzy modeling and simulation
Rezaei Sadrabadi, Mahmood ULg; Fazel Zarandi, M. H.

in Applied Soft Computing (2011), 11(8), 5330-5340

This paper presents a continuous facility location model with fuzzy methodology. The developments concern mainly to some drawbacks in the initial model which takes it far from being used in practice. A ... [more ▼]

This paper presents a continuous facility location model with fuzzy methodology. The developments concern mainly to some drawbacks in the initial model which takes it far from being used in practice. A fuzzy modeling method is proposed to estimate the required functions in the initial model. Structure identification in the proposed fuzzy modeling method is carried out using subtractive clustering, and parameter identification is conducted via some heuristics as well as an optimization problem. Furthermore, a simulation method along with some heuristic relations is used for implementation and evaluation of the modified model. Efficiency of the proposed method to fuzzy modeling as well as the proposed simulation method is presented by a numerical example. [less ▲]

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See detailFacing the problem of the bis(acetylacetonato)cobalt(II)-mediated radical polymerization of acrylates
Hurtgen, Marie ULg; Debuigne, Antoine ULg; Jérôme, Christine ULg et al

Poster (2010, July 13)

Cobalt-Mediated Radical Polymerization (CMRP) is an efficient tool for polymerizing acrylates and vinyl esters. However, a challenge in CMRP remains in controlling the polymerization of both types of ... [more ▼]

Cobalt-Mediated Radical Polymerization (CMRP) is an efficient tool for polymerizing acrylates and vinyl esters. However, a challenge in CMRP remains in controlling the polymerization of both types of monomers with the same cobalt complex. Here, we show how Co(acac)2, efficient for unconjugated vinyl monomers, can also cope with acrylates. [less ▲]

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See detailFacing towards epidermal stem cells (Review).
Schreder, Anelaure; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2010), 26(2), 171-4

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation ... [more ▼]

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development. [less ▲]

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See detailFacing up to the imperceptible perspiration. Modulatory influences by diabetic neuropathy, physical exercise and antiperspirant.
Xhauflaire-Uhoda, E.; Mayeux, G.; Quatresooz, Pascale ULg et al

in Skin Research & Technology (2011)

Background: Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants. Methods: Skin temperature, skin surface water loss (SSWL), the Corneometer((R)) average capacitance ... [more ▼]

Background: Sweating is variably altered by physical exercise, diabetic neuropathy and antiperspirants. Methods: Skin temperature, skin surface water loss (SSWL), the Corneometer((R)) average capacitance (CMAC) and skin capacitance mapping (SCM) were measured before and after moderate physical exercise in 20 healthy subjects. The effect of 5% aluminium chloride hexahydrate (ACH) in a water solution was similarly tested. The same assessments were performed in 20 diabetic patients at rest. Results: Diabetic neuropathy appeared at rest as an increased (compensatory) SCM on the forearms without obvious modification on the hypohidrotic legs. On ACH sites after exercise, SCM revealed both a lowered number of active sweat glands and a lighter stratum corneum (SC) (dryness). In addition, CMAC and SSWL were decreased on ACH sites at rest and at completion of exercise. Conclusion: In diabetic neuropathy, the compensatory hyperhidrosis is more easily disclosed than the hypohidrosis. ACH affects both sweat excretion and the SC hydration. [less ▲]

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See detailLes facio-craniostenoses
Castermans, A.; Stevenaert, Achille ULg; Born, J. et al

in Acta Chirurgica Belgica (1988), 88(2, Mar-Apr), 89-94

Facio-craniostenosis. Facio-craniostenosis is associated with premature stenosis of one or several cranial sutures. The clinical variety is defined by the affected suture. In the complex forms, major ... [more ▼]

Facio-craniostenosis. Facio-craniostenosis is associated with premature stenosis of one or several cranial sutures. The clinical variety is defined by the affected suture. In the complex forms, major disturbances of the anterior fossa of the cranial base are observed. Intracranial hypertension sometimes observed may lead to impairment of the function of the brain or the eyes. The authors have observed 73 children with craniostenosis and have operated upon 49 of them. Three types of methods have been used. The stress is made on the latest one combining advancement of the orbito-frontal "bandeau" and the regularization of the vault. Operating early is essential for prevention of functional sequellae. The optimal age for surgical treatment seems to be between 3 and 6 months. Complications have been remarkable benign. [less ▲]

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See detailFaciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer.
Ayala, Inmaculada; Giacchetti, Giada; Caldieri, Giusi et al

in Cancer Research (2009), 69(3), 747-52

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling ... [more ▼]

Invadopodia are proteolytically active membrane protrusions that extend from the ventral surface of invasive tumoral cells grown on an extracellular matrix (ECM). The core machinery controlling invadopodia biogenesis is regulated by the Rho GTPase Cdc42. To understand the upstream events regulating invadopodia biogenesis, we investigated the role of Fgd1, a Cdc42-specific guanine nucleotide exchange factor. Loss of Fgd1 causes the rare inherited human developmental disease faciogenital dysplasia. Here, we show that Fgd1 is required for invadopodia biogenesis and ECM degradation in an invasive cell model and functions by modulation of Cdc42 activation. We also find that Fgd1 is expressed in human prostate and breast cancer as opposed to normal tissue and that expression levels matched tumor aggressiveness. Our findings suggest a central role for Fgd1 in the focal degradation of the ECM in vitro and, for the first time, show a connection between Fgd1 and cancer progression, proposing that it might function during tumorigenesis. [less ▲]

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See detailFaçonnement du lit dans deux rivières à charge de fond et à régime différents
Petit, François ULg

in First International conference in Geomorphology (1985)

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See detailFact sheet: Using mutual information to infer causal relationships Catharina
Olsen, Catharina; Meyer, Patrick ULg; Bontempi, Gianluca

in JMLR: Workshop and Conference Proceedings-NIPS 2008 workshop on causality (2008)

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See detailLe facteur humain dans les aménagements forestiers intégrés
Vermeulen, Cédric ULg; Feteke, R.

in Parcs & Réserves (2007), 62(2), 32-39

Detailed reference viewed: 39 (11 ULg)