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See detailEstrategias sociopreventivas del hooliganismo
Comeron, Manuel ULg

in Colome, Gabriel (Ed.) Politica y Deporte (2001)

Une analyse comparative en Europe (Angleterre, Belgique, France, Espagne): évolution des politiques sportives, le sport et l'Etat, la lutte contre le hooliganisme, les stratégies préventives, le sport ... [more ▼]

Une analyse comparative en Europe (Angleterre, Belgique, France, Espagne): évolution des politiques sportives, le sport et l'Etat, la lutte contre le hooliganisme, les stratégies préventives, le sport comme spectacle médiatique. [less ▲]

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See detailEstrogen activation revisited: control of local metabolism in the brain
Charlier, Thierry ULg

Scientific conference (2012)

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See detailEstrogen and pain: a study in aromatase knock-out mice using the formalin model.
Multon, Sylvie ULg

Conference (2004, September)

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See detailEstrogen Receptor β Activation Rapidly Modulates Male Sexual Motivation through the Transactivation of Metabotropic Glutamate Receptor 1a
Seredynski, Aurore L; Balthazart, Jacques ULg; Ball, Gregory F et al

in Journal of Neuroscience (2015), 35(38), 13110-23

In addition to the transcriptional activity of their liganded nuclear receptors, estrogens, such as estradiol (E2), modulate cell functions, and consequently physiology and behavior, within minutes ... [more ▼]

In addition to the transcriptional activity of their liganded nuclear receptors, estrogens, such as estradiol (E2), modulate cell functions, and consequently physiology and behavior, within minutes through membrane-initiated events. The membrane-associated receptors (mERs) underlying the acute effects of estrogens on behavior have mostly been documented in females where active estrogens are thought to be of ovarian origin. We determined here, by acute intracerebroventricular injections of specific agonists and antagonists, the type(s) of mERs that modulate rapid effects of brain-derived estrogens on sexual motivation in male Japanese quail. Brain aromatase blockade acutely inhibited sexual motivation. Diarylpropionitrile (DPN), an estrogen receptor β (ERβ)-specific agonist, and to a lesser extent 17α-estradiol, possibly acting through ER-X, prevented this effect. In contrast, drugs targeting ERα (PPT and MPP), GPR30 (G1 and G15), and the Gq-mER (STX) did not affect sexual motivation. The mGluR1a antagonist LY367385 significantly inhibited sexual motivation but mGluR2/3 and mGluR5 antagonists were ineffective. LY367385 also blocked the behavioral restoration induced by E2 or DPN, providing functional evidence that ERβ interacts with metabotropic glutamate receptor 1a (mGluR1a) signaling to acutely regulate male sexual motivation. Together these results show that ERβ plays a key role in sexual behavior regulation and the recently uncovered cooperation between mERs and mGluRs is functional in males where it mediates the acute effects of estrogens produced centrally in response to social stimuli. The presence of an ER-mGluR interaction in birds suggests that this mechanism emerged relatively early in vertebrate history and is well conserved. Significance statement: The membrane-associated receptors underlying the acute effects of estrogens on behavior have mostly been documented in females, where active estrogens are thought to be of ovarian origin. Using acute intracerebroventricular injections of specific agonists and antagonists following blockade of brain aromatase, we show here that brain-derived estrogens acutely facilitate male sexual motivation through the activation of estrogen receptor β interacting with the metabotropic glutamate receptor 1a. This behavioral effect occurring within minutes provides a mechanistic explanation of how an estrogen receptor not intrinsically coupled to intracellular effectors can signal from the membrane to govern behavior in a very rapid fashion. It suggests that different subtypes of estrogen receptors could regulate the motivation versus performance aspects of behavior. [less ▲]

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See detailEstrogen Receptor-Beta in Quail: Cloning, Tissue Expression and Neuroanatomical Distribution
Foidart, Agnès ULg; Lakaye, Bernard ULg; Grisar, Thierry ULg et al

in Journal of Neurobiology (1999), 40(3), 327-42

A partial estrogen receptor-beta (ERbeta) cDNA had been previously cloned and sequenced in Japanese quail. The 3'- and 5'-rapid amplification of cDNA ends techniques were used here to identify a cDNA ... [more ▼]

A partial estrogen receptor-beta (ERbeta) cDNA had been previously cloned and sequenced in Japanese quail. The 3'- and 5'-rapid amplification of cDNA ends techniques were used here to identify a cDNA sequence of the quail ERbeta that contains a complete open reading frame. For the first time in an avian species, this cDNA sequence and the corresponding amino acid sequence are described. They are compared with the known ERbeta sequences previously described in mammals and with the ERalpha sequences identified in a selection of mammalian and avian species. The analysis by Northern blotting of the ERbeta mRNA expression in the brain and kidneys revealed the presence of several transcripts. The presence of ERbeta identified by reverse transcriptase-polymerase chain reaction demonstrated a widespread distribution quite different from the distribution of ERalpha. The complete neuroanatomical distribution of ERbeta mRNA as determined by in situ hybridization with 35S- and 33P-labeled oligoprobes is also presented. Transcripts are present in many nuclei implicated in the control of reproduction such as the medial preoptic nucleus, the nucleus striae terminalis, and the nucleus taeniae, the avian homologue of the amygdala. These data demonstrate the presence of ERbeta in a nonmammalian species and indicate that the (neuro)-anatomical distribution of this receptor type has been conserved in these two classes of vertebrates. The role of this receptor in the control of reproduction and other physiological processes should now be investigated. [less ▲]

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See detailEstrogen replacement therapy and inhibition of bone resorption
Reginster, Jean-Yves ULg; Sarlet, N; Albert, Adelin ULg et al

in Revue du Rhumatisme et des Maladies Osteo-Articulaires (1992), 59

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See detailEstrogen-deficient female but not male aromatase knockout (ArKO) mice exhibit "depressive-like" symptoms
Bakker, Julie ULg; Dalla, C.; Antoniou, K. et al

in Hormones & Behavior (2004, June), 46(1), 127

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See detailEstrogenic components for use in the treatment of neurological disorders
Foidart, Jean-Michel ULg; Tskitishvili, Ekaterine ULg

Patent (2013)

The invention relates to the prophylactic and therapeutic applications of certain estrogenic components such as estetrol in neurological disorders such as neonatal hypoxic-ischemic encephalopathy (HIE).

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See detailEstrogenic Evaluation and Organochlorine Identification in Blubber of North Sea Harbour Porpoise (Phocoena phocoena) Stranded on the North Sea Coast
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Jauniaux, Thierry ULg et al

in BioMed Research International (2015), Volume 2015(Article ID 438295), 13

Thirteen individual organochlorine compounds at 3 concentrations (80, 400, and 2000 ng/mL culture medium), as well as mixtures, were assayed for the estrogen receptor (ER) activation or inhibition, using ... [more ▼]

Thirteen individual organochlorine compounds at 3 concentrations (80, 400, and 2000 ng/mL culture medium), as well as mixtures, were assayed for the estrogen receptor (ER) activation or inhibition, using a luciferase reporter gene assay (RGA). None of the PCB 138, 153, or 180 or their mixture induced a response in the RGA. o,p'-DDT was the most potent xenoestrogen fromthe DDT group, inducing a response already at 80 ng/mL. From the HCH and HCB group, only 𝛽-HCH (at 400 and 2000 ng/mL) and 𝛿-HCH (at 2000 ng/mL) displayed estrogenic activities.These 13 organochlorines were determined by GC-MS in 12 samples of North Sea harbor porpoise blubber. The PCBs were the main contaminants. Within each group, PCB 153 (6.0 × 102∼4.2 × 104 𝜇g/kg), p,p'- DDE (5.1 × 102∼8.6 × 103 𝜇g/kg), and HCB (7.6 × 101∼1.5 × 103 𝜇g/kg) were the compounds found in highest concentrations.The hormonal activity of the porpoise blubber samples was also assayed in RGA, where two samples showed estrogenic activity, seven samples showed antiestrogenic activity, and one sample showed both estrogenic and antiestrogenic activity. Our results suggest that the 13 POPs measured by GC-MS in the samples cannot explain alone the estrogenicity of the extracts. [less ▲]

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See detailEstrogens and neonatal neuroprotection
Pequeux, Christel ULg; Tskitishvili, Ekaterine ULg

Scientific conference (2014, November 27)

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See detailEstrogens and pain : a study in aromatase knock-out mice using the formalin model
Multon, Sylvie ULg; Mosen, Jeanine; Wouters, Murielle ULg et al

Poster (2004, July)

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See detailEstrogens and tumor microenvironment
Pequeux, Christel ULg

Conference (2013)

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See detailEstrogens control female sexual motivation and receptivity in quail.
de Bournonville, Catherine ULg; Ball, Gregory, F.; Balthazart, Jacques ULg et al

Poster (2013, November 10)

Detailed reference viewed: 20 (5 ULg)