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Peer Reviewed
See detailEpithelial to mesenchymal transition (EMT) and carcinoma invasion.
Gilles, Christine ULg; Polette, M; Piette, J et al

Poster (1996, April 20)

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailEpithelial to mesenchymal transition in HPV-33-transfected cervical keratinocytes associates with increased invasiveness.
Gilles, Christine ULg; Polette, M; Piette, J et al

Poster (1994, September 28)

Detailed reference viewed: 13 (0 ULg)
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See detailEpithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions.
Ullmann, U.; In'T Veld, P.; Gilles, Christine ULg et al

in Molecular Human Reproduction (2007), 13(1), 21-32

Feeder-free human embryonic stem cell (hESC) culture is associated with the presence of mesenchymal-like cells appearing at the periphery of the colonies. The aim of this study was to identify this early ... [more ▼]

Feeder-free human embryonic stem cell (hESC) culture is associated with the presence of mesenchymal-like cells appearing at the periphery of the colonies. The aim of this study was to identify this early differentiation process. Long-term feeder-free hESC cultures using matrigel and conditioned medium from mouse and from human origin revealed that the appearance of mesenchymal-like cells was similar regardless of the conditioned medium used. Standard characterization confirmed the preservation of hESC properties, but the feeder-free cultures could not be maintained longer than 37 passages. The early differentiation process was characterized in the short term after switching hESCs cultured on feeders to feeder-free conditions. Transmission electron microscopy showed an epithelium-like structure inside the hESC colonies, whereas the peripheral cells revealed the acquisition of a rather mesenchymal-like phenotype. Immunochemistry analysis showed that cells at the periphery of the colonies had a negative E-cadherin expression and a positive Vimentin expression, suggesting an epithelial–mesenchymal transition (EMT). Nuclear staining of ß-catenin, positive N-cadherin and negative Connexin 43 expression were also found in the mesenchymal-like cell population. After RT–PCR analysis, Slug and Snail, both EMT-related transcription factors, were detected as up-regulated in the mesenchymal-like cell population. Taken together, our data suggest that culturing hESCs in feeder-free conditions enhances an early differentiation process identified as an EMT. [less ▲]

Detailed reference viewed: 33 (2 ULg)
Peer Reviewed
See detailEpithelial-to-mesenchymal transition (EMT)-regulated soluble factors mediate tumor angiogenesis and myeloid cell recruitment
Suarez-Carmona; Bourcy, Morgane ULg; Lesage, J et al

Conference (2015, October 13)

Detailed reference viewed: 27 (4 ULg)
Peer Reviewed
See detailEpithelial-to-Mesenchymal Transition in Hpv-33-Transfected Cervical Keratinocytes Is Associated with Increased Invasiveness and Expression of Gelatinase A
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1994), 59(5), 661-6

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on ... [more ▼]

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on collagen rafts. Cell lines from the first group reconstituted CINIII-like lesions, whereas cell lines from the second group reconstituted epithelia comparable to micro-invasive carcinomas. They were thus postulated to represent distinct stages of cervical carcinogenesis. The present results have shown that lines from group I, which have conserved an epithelial morphology in monolayer, (i) could not invade matrigel when tested in a modified Boyden chamber assay, (ii) produced solely gelatinase B and (iii) were unable to activate exogenous gelatinase A. On the other hand, lines from group II associated epithelial-to-mesenchymal transition (acquisition of elongated morphology, vimentin positivity) with high in vitro invasive potential and with the ability both to produce and to activate gelatinase A. These results strongly support the hypothesis that the epithelial-to-mesenchymal transition and the associated events might be implicated in the progression to the metastatic phenotype. [less ▲]

Detailed reference viewed: 16 (0 ULg)
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See detailEpithelial-to-mesenchymal transition: contribution to human mammary epithelial cell migration
Gilles, Christine ULg; Polette, M; Zahm, JM et al

Conference (2000, March 13)

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailEpithelial-to-Mesenchymal Transitions (EMT) and the metastatic progression.
Gilles, Christine ULg

Conference (2011, February 05)

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailEpithelial-to-Mesenchymal Transitions and Circulating Tumor Cells
Gilles, Christine ULg

Conference (2011, February 23)

Detailed reference viewed: 19 (1 ULg)
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Peer Reviewed
See detailEpithelial-to-mesenchymal transitions and circulating tumor cells.
Bonnomet, A.; Brysse, Anne ULg; Tachsidis, A. et al

in Journal of Mammary Gland Biology & Neoplasia (2010), 15(2), 261-73

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological ... [more ▼]

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival. [less ▲]

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See detailEpithelial-to-mesenchymal transitions and the metastatic spread
Gilles, Christine ULg

Conference (2015, May 14)

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See detailEpithelial-to-Mesenchymal Transitions modulate interactions between Circulating Tumor Cells and the coagulation system: implication for the metastatic spread.
Bourcy, M; Suarez-Carmona, M; Francart, ME et al

Conference (2015, May 13)

Detailed reference viewed: 14 (3 ULg)
Peer Reviewed
See detailEpithelio-mesenchymal interface and fibronectin in the differentiation of the rat mesonephric and paramesonephric ducts.
Paranko, J.; Pelliniemi, L. J.; Foidart, Jean-Michel ULg

in Differentiation : Research in Biological Diversity (1984), 27(3), 196-204

The distribution of fibronectin and the morphological differentiation of the genital ducts was studied in rat fetuses at ages from 15 to 21 days. Fibronectin was localized with the peroxidase ... [more ▼]

The distribution of fibronectin and the morphological differentiation of the genital ducts was studied in rat fetuses at ages from 15 to 21 days. Fibronectin was localized with the peroxidase-antiperoxidase and avidin-biotin method at the electron- and light-microscope level. In 15-day-old male and female fetuses, fibronectin was localized as a continuous lamella around the mesonephric duct and as a discontinuous lamella around the paramesonephric duct. During the differentiation of the female paramesonephric duct, the fibronectin layer became continuous and remained so after the age of 16 days. The fibronectin layer of the male mesonephric duct remained continuous at all ages. The accumulation of mesenchymal cells on the outer surface of the female mesonephric duct and the concomitant detachment of the fibronectin layer around the duct suggests that mesenchymal regulation plays a role in the regression of the mesonephric duct. In the regressing male paramesonephric duct fibronectin was simultaneously lost in the condensed periductal mesenchyme, the places of epithelio-mesenchymal contact, and the epithelial cytoplasmic protrusions towards the mesenchyme. Ultrastructurally, fibronectin was localized in the basal laminae, on the cell membrane in contact with the extracellular material, and on the surface of the fibrillar and flocculent extracellular material. In addition to auto- and heterophagy, epithelio-mesenchymal interactions seem to play an important role in the regression of the genital ducts, although in different ways in males and females. The present results give additional support to the theory of the possible migration of epithelial cells into the surrounding mesenchyme during the regression of the paramesonephric duct. [less ▲]

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See detailEpithelioid Cell Histiocytoma: A Report of Two Cases
Dezfoulian, Bita ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 349-350

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and ... [more ▼]

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and immunohistochemical features. [less ▲]

Detailed reference viewed: 23 (0 ULg)
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See detailÉpithètes cultuelles et interprétation philosophique. À propos d'Aphrodite Ourania et Pandémos à Athènes
Pirenne-Delforge, Vinciane ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1988), 57

Detailed reference viewed: 80 (5 ULg)