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Peer Reviewed
See detailExploration of perceptual and motor inhibition in children with traumatic brain injury
Catale, Corinne ULg; Lejeune, Caroline ULg; Meulemans, Thierry ULg

Poster (2010)

Inhibitory control, which is commonly considered as one of the essential components of executive functions (Barkley, 1997; Miyake et al., 2000), is not considered as an unitary construct (for example ... [more ▼]

Inhibitory control, which is commonly considered as one of the essential components of executive functions (Barkley, 1997; Miyake et al., 2000), is not considered as an unitary construct (for example, Friedman & Miyake, 2004; Nassauer & Halperin, 2003). In this study, perceptual and motor inhibition were studied in 12 children who had sustained a moderate to severe traumatic brain injury and in 24 matched control children, with the Conflict Resolution task (Nassauer & Halperin, 2003). The perceptual inhibition task required the children to respond to the direction of an arrow while ignoring the conflicting arrow location. In the motor inhibition task, the subject had to press a key corresponding to the opposite direction of a centrally located arrow. Direct comparisons of inhibition performances between traumatic brain injury children and matched controlled subjects showed a specific and disproportionate impairment for motor inhibition (compared to perceptive inhibition) in the traumatic brain injury children, suggesting that inhibition processes might be differentially impaired after traumatic brain injury in children. Interestingly, impairments in behavioural inhibition in day-to-day activities (as reported by the parents), was found to strongly correlate with both types of inhibition. [less ▲]

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See detailExploration of serial structure procedural learning in children with language impairment.
Gabriel, Audrey ULg; Maillart, Christelle ULg; Guillaume, mélody et al

in Journal of the International Neuropsychological Society (2011), 17

Recent studies on specific language impairment (SLI) have suggested that language deficits are directly associated with poor procedural learning abilities. Findings from our previous work are contrary to ... [more ▼]

Recent studies on specific language impairment (SLI) have suggested that language deficits are directly associated with poor procedural learning abilities. Findings from our previous work are contrary to this hypothesis; we found that children with SLI were able to learn eight-element-long sequences as fast and as accurately as children with normal language (NL) on a serial reaction time (SRT) task. A probabilistic rather than a deterministic SRT paradigm was used in the current study to explore procedural learning in children with SLI to mimic real conditions of language learning. Fifteen children with or without SLI were compared on an SRT task including a probabilistic eight-element-long sequence. Results show that children with SLI were able to learn this sequence as fast and as accurately as children with NL, and that similar sequence-specific learning was observed in both groups. These results are novel and suggest that children with SLI do not display global procedural system deficits. (JINS, 2011, 17, 1-8). [less ▲]

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See detailExploration of the chemical space of novel naphthalene-sulfonamide and anthranilic acid-based inhibitors of penicillin-binding Proteins
Sosic, Izidor; Turk, Samo; Sinreih, Masa et al

in Acta Chimica Slovenica (2012), 59(2), 380-388

Penicillin-binding proteins are a well established, validated and still a very promising target for the design and development of new antibacterial agents. Based on our previous discovery of several ... [more ▼]

Penicillin-binding proteins are a well established, validated and still a very promising target for the design and development of new antibacterial agents. Based on our previous discovery of several noncovalent small-molecule inhibitor hits for resistant PBPs we decided to additionally explore the chemical space around these compounds. In order to clarify their structure-activity relationships for PBP inhibition two new series of compounds were synthesized, characterized and evaluated biochemically: the derivatives of anthranilic acid and naphthalene-sulfonamide derivatives. The target compounds were tested for their inhibitory activities on three different transpeptidases: PBP2a from methicillin-resistant Staphylococcus aureus (MRSA) strains, PBP5fm from Enterococcus faecium strains, and PBP1b from Streptococcus pneumoniae strains. The most promising results for both of these series of compounds were obtained against the PBP2a enzyme with the IC50 values in the micromolar range. Although these results do not represent a significant breakthrough in the field of noncovalent PBP inhibitors, they do provide useful structure-activity relationship data, and thus a more solid basis for the design of potent and noncovalent inhibitors of resistant PBPs. [less ▲]

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See detailExploration of the mechanisms underlying the ISPC effect: Evidence from behavioral and neuroimaging data
Grandjean, Julien; D'Ostilio, Kevin ULg; Fias, Wim et al

in Neuropsychologia (2013), 51

The item-specific proportion congruent (ISPC) effect in a Stroop task – the observation of reduced interference for color words mostly presented in an incongruent color – has attracted growing interest ... [more ▼]

The item-specific proportion congruent (ISPC) effect in a Stroop task – the observation of reduced interference for color words mostly presented in an incongruent color – has attracted growing interest since the original study by Jacoby (2003). Two mechanisms have been proposed to explain the effect: associative learning of contingencies and item-specific control through word reading modulation. Both interpretations have received empirical support from behavioral data. Therefore, the aim of this study was to investigate the responsible mechanisms of the ISPC effect with the classic two-item sets design using fMRI. Results showed that the ISPC effect is associated with increased activity in the anterior cingulate (ACC), dorsolateral prefrontal (DLPFC), and inferior and superior parietal cortex. Importantly, behavioral and fMRI analyses specifically addressing the respective contribution of associative learning and item-specific control mechanisms brought support for the contingency learning account of the ISPC effect. Results are discussed in reference to task and procedure characteristics that may influence the extent to which item-specific control and/or contingency learning contribute to the ISPC effect. [less ▲]

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See detailExploration of the neural substrates of executive functioning by functional neuroimaging
Collette, Fabienne ULg; Hogge, Michaël; Salmon, Eric ULg et al

in Neuroscience (2006), 139(1), 209-221

This review presents neuroimaging studies that have explored the cerebral substrates of executive functioning. These studies have demonstrated that different executive functions not only recruit various ... [more ▼]

This review presents neuroimaging studies that have explored the cerebral substrates of executive functioning. These studies have demonstrated that different executive functions not only recruit various frontal areas but also depend upon posterior (mainly parietal) regions. These results are in accordance with the hypothesis that executive functioning relies on a distributed cerebral network that is not restricted to anterior cerebral areas. However, there exists an important heterogeneity in the cerebral areas associated with these different processes, and also between different tasks assessing the same process. Since these discrepant results could be due to the paradigms used (subtraction designs), recent results obtained with conjunction and interaction analyses are presented, which confirm the role of parietal areas in executive functioning and also demonstrate the existence of some specificity in the neural substrates of the executive processes of updating, shifting and inhibition. Finally, functional magnetic resonance imaging studies show that the activity in cerebral areas involved in executive tasks can be transient or sustained. Consequently, to better characterize the functional role of areas associated with executive functioning, it is important to take into account not only the localization of cerebral activity but also the temporal pattern of this activity. [less ▲]

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See detailExploration of the neurocognitive mecanisms of memory awareness in Alzheimer’s disease (AD).
Genon, Sarah ULg

Scientific conference (2012, December 17)

Detailed reference viewed: 22 (3 ULg)
Peer Reviewed
See detailExploration of the neuronal substrates of Directed Forgetting with fMRI
Feyers, Dorothée ULg; Hogge, Michaël; Salmon, Eric ULg et al

Conference (2007, June 01)

Detailed reference viewed: 11 (4 ULg)
See detailExploration of the neuronal substrates of Directed Forgetting with fMRI.
Feyers, Dorothée ULg; Hogge, Michaël; Salmon, Eric ULg et al

Conference (2007, June 26)

Detailed reference viewed: 5 (2 ULg)
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Peer Reviewed
See detailAn exploration of the relationships between short-term memory for serial order information, item information and new word learning in adults
Majerus, Steve ULg; Poncelet, Martine ULg; Elsen, B. et al

in European Journal of Cognitive Psychology (2006), 18(6), 848-873

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See detailExploration of unitization processes in episodic memory in Alzheimer's disease
Delhaye, Emma ULg; Salmon, Eric ULg; Bastin, Christine ULg

in Frontiers in Human Neuroscience (2014)

Detailed reference viewed: 33 (8 ULg)
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See detailExploration of volumetric cerebral changes, with de micro-MRi, due to psychomotor exercise in mice
Moës, Florian ULg; Plenevaux, Alain ULg; Becker, Guillaume ULg et al

Poster (2015, January 27)

It's well know that exercise is good for health .In addition exercise has postive effects on cognition ,neurodegenerative disease and on mood. Some studies show that exercise has effect on brain so the ... [more ▼]

It's well know that exercise is good for health .In addition exercise has postive effects on cognition ,neurodegenerative disease and on mood. Some studies show that exercise has effect on brain so the aim of this study is to see if there are volumetric changes due to exercise or not. [less ▲]

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Peer Reviewed
See detailExploration on structure activity relation of natural, self-assembling cyclic lipodepsipeptides
Geudens, Niels; Feher, Kristina; De Vleeschouwer, Matthias et al

Poster (2014, February)

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See detailL'exploration robotique de la Lune - Formation, structure et évolution
Nazé, Yaël ULg

in Jaminon, Martine; richelle, jean; thomas, jean-marcel (Eds.) Éclats de Lune. Entre science et imaginaire (2013)

Detailed reference viewed: 14 (0 ULg)
See detailL’exploration scientifique.
Vandersmissen, Jan ULg

in Halleux, Robert; Vandersmissen, Jan; Despy-Meyer, Andrée (Eds.) et al Histoire des sciences en Belgique 1815-2000 (2001)

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Peer Reviewed
See detailExplorations algo-fonctionnelles comparatives entre populations fibromyalgique et lombalgique chronique
Demoulin, Christophe ULg; Maquet, Didier ULg; Delcourt, D. et al

in Revue du Rhumatisme (2007), 74(10-11), 982

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See detailLes explorations de la grotte de Remouchamps
Courtois, Henri; Courtois, Jean; Denoël, René et al

in Parcs Nationaux (1969), XXIV(1), 19-29

Remouchamps Cave, already inhabited at the very end of Paleolithic time, was explored since 1828. Recent explorations extended the known parts since 1958. A map of the explorations and a map of successive ... [more ▼]

Remouchamps Cave, already inhabited at the very end of Paleolithic time, was explored since 1828. Recent explorations extended the known parts since 1958. A map of the explorations and a map of successive plans are presented. [less ▲]

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See detailExplorations et géographies coloniales: le Congo Belge
Poncelet, Marc ULg

Scientific conference (2011, November 29)

The Geographic Movement in Belgium was strongly and exclusively linked with the exploration of Congo, conquest and colonial rule in Central Africa. The paper deals with the institutionalization of ... [more ▼]

The Geographic Movement in Belgium was strongly and exclusively linked with the exploration of Congo, conquest and colonial rule in Central Africa. The paper deals with the institutionalization of overseas knowledge in belgian universities and sciences. [less ▲]

Detailed reference viewed: 28 (2 ULg)