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See detailGaining speed in molecular dynamics simulations by implicit representation of water and membrane molecules
Steinhauer, Sven ULg; Crowet, Jean-Marc ULg; Brasseur, Robert ULg et al

Poster (2013, June 19)

Molecular dynamics (MD) is an appropriate method for investigation of peptide-membrane systems and helps in analyzing results from experiments. In many cases, the ability of viral fusion proteins and ... [more ▼]

Molecular dynamics (MD) is an appropriate method for investigation of peptide-membrane systems and helps in analyzing results from experiments. In many cases, the ability of viral fusion proteins and toxins for destabilizing the membrane is due to their hydrophobic profile, leading to particular membrane insertion. By now, many relevant processes for drug design, toxicological studies and other fields of application, are not feasible by MD simulations, when each atom is represented over time. Processes such as protein folding, often take place above the time scales reachable by MD simulations, which are of the order of micro seconds. The necessary time effort for carrying out such simulations stays considerable and depends mainly on (1) the complexity of the simulated system (2) the simulated time scale (3) the simulation method (4) the efficiency of used hardware and software algorithms. Nowadays, MD simulations can still take weeks of calculation on high end computers. Impala is an implicit water and lipids forcefield, initially developed by our laboratory. Implicit forcefields replace water and/or lipid molecules by a couple of simple and partially precalculable equations. Using this method, thousands of water and lipid molecules can be replaced in MD simulations using Gromacs software. This leads to a considerable reduction of system complexity. The original Impala algorithm based on the assumption of rigid peptides and used a Monte Carlo algorithm with the aim of finding the insertion characteristics of these molecules in membranes. Our current work is the integration of the Impala forcefield into Gromacs, a freely accessible MD software. Replacing the aqueous and lipid phase atomic description in Gromacs MD by an implicit forcefield is supposed to lead to a gain of speed compared to full atomistic simulations. A gain of precision compared to Impala is expected, too. This will be achieved by turning molecules flexible, when implementing Impala into Gromacs. [less ▲]

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See detailGains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 millions d’euros d’amendes pour avoir empêché l’accès d’entreprises concurrentes au marché de la distribution de colis aux particuliers
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2012), 4

Cour AELE, 18 avril 2012, Posten Norge/Autorité AELE, aff. E-15/10 Gains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 ... [more ▼]

Cour AELE, 18 avril 2012, Posten Norge/Autorité AELE, aff. E-15/10 Gains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 millions d’euros d’amendes pour avoir empêché l’accès d’entreprises concurrentes au marché de la distribution de colis aux particuliers. [less ▲]

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See detailGaio, l'insegnamento e il Belgio
Gerkens, Jean-François ULg

Conference (2012, June 11)

What was the impact of the discovery of the Veronese Palimpsest on the teaching methods in Belgium?

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See detailGait analysis during an original walking test
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg; Chapelier, Dominique et al

in Parkinsonism & Related Disorders (2008), 14

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See detailGait analysis during an original walking test: application in fibromyalgia syndrome
Maquet, Didier ULg; Chapelier, Dominique; Bouquegneau, Adeline ULg et al

in Journal of Rehabilitation Medicine Supplement (2008, June), 47

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See detailGait analysis during an original walking test: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(Suppl 2), 355

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See detailGait analysis in elderly adult patients with mild cognitive impairment and patients with mild Alzheimer’s disease: simple versus dual task: A preliminary report
Maquet, Didier ULg; Lekeu, Françoise ULg; Warzee, Emmanuelle ULg et al

in Clinical Physiology & Functional Imaging (2010), 30(1), 51-56

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly ... [more ▼]

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly subjects and mild Alzheimer s disease (AD) patients. Methods: We proposed a gait analysis to appreciate walking (simple task and dual task) in 14 MCI, 14 controls and six AD subjects who walked at their preferred speed. A 20-second period of stabilized walking was used to calculated stride frequency, stride length, symmetry and regularity. Speed walking was measured by electrical photocells. Results: Variables measured during simple and dual tasks showed an alteration of motor function as well in mild AD patients as in MCI patients. Conclusion: At the end of this preliminary study, we defined a specific gait pattern for each cognitive profile. Further researches appear necessary to enlarge the study cohort. [less ▲]

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See detailGait analysis using a wearable accelerometer system: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(S2), 355

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See detailGait feature extraction in Parkinson's disease using low-cost accelerometers
Stamatakis, Julien; Cremers, Julien ULg; Maquet, Didier ULg et al

Poster (2011)

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling ... [more ▼]

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling, short steps, freezing of gait (FoG) and/or asymmetries in gait. There are currently no validated clinical instruments or device that allow a full characterization of gait disturbances in PD. As a step towards this goal, a four accelerometer-based system is proposed to increase the number of parameters that can be extracted to characterize parkinsonian gait disturbances such as FoG or gait asymmetries. After developing the hardware, an algorithm has been developed, that automatically epoched the signals on a stride-by-stride basis and quantified, among others, the gait velocity, the stride time,the stance and swing phases, the single and double support phases or the maximum acceleration at toe-off, as validated by visual inspection of video recordings during the task. The results obtained in a PD patient and an healthy volunteer are presented. The FoG detection will be improved using time-frequency analysis and the system is about to be validated with a state-of-the-art 3D movement analysis system. [less ▲]

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See detailGaius, professeur de droit et jurisconsulte
Gerkens, Jean-François ULg

in Revue de la Faculté de Droit de l'Université de Liège (2004), (2004/3), 443-449

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See detailGaius, professeur de droit et jurisconsulte
Gerkens, Jean-François ULg

in Van Orshoven, Paul; Geens, Koen; Lesaffer, Randall (Eds.) et al Ad amicissimum amici scripsimus. Vriendenboek Raf Verstegen (2004)

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See detailGalactic archaeology: mapping and dating stellar populations with asteroseismology of red-giant stars
Miglio, A.; Chiappini, C.; Morel, Thierry ULg et al

in Monthly Notices of the Royal Astronomical Society (2013), 429

Our understanding of how the Galaxy was formed and evolves is severely hampered by the lack of precise constraints on basic stellar properties such as distances, masses and ages. Here, we show that solar ... [more ▼]

Our understanding of how the Galaxy was formed and evolves is severely hampered by the lack of precise constraints on basic stellar properties such as distances, masses and ages. Here, we show that solar-like pulsating red giants represent a well-populated class of accurate distance indicators, spanning a large age range, which can be used to map and date the Galactic disc in the regions probed by observations made by the CoRoT and Kepler space telescopes. When combined with photometric constraints, the pulsation spectra of such evolved stars not only reveal their radii, and hence distances, but also provide well-constrained estimates of their masses, which are reliable proxies for the ages of the stars. As a first application, we consider red giants observed by CoRoT in two different parts of the Milky Way, and determine precise distances for ˜2000 stars spread across nearly 15 000 pc of the Galactic disc, exploring regions which are a long way from the solar neighbourhood. We find significant differences in the mass distributions of these two samples which, by comparison with predictions of synthetic models of the Milky Way, we interpret as mainly due to the vertical gradient in the distribution of stellar masses (hence ages) in the disc. In the future, the availability of spectroscopic constraints for this sample of stars will not only improve the age determination, but also provide crucial constraints on age-velocity and age-metallicity relations at different Galactocentric radii and heights from the plane. [less ▲]

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See detailThe Galactic halo. From globular clusters to field stars. Proceedings.
Noels-Grötsch, Arlette ULg; Magain, Pierre ULg; Caro, Denise ULg et al

Book (2000)

The following topics were dealt with: early galactic nucleosynthesis; chemical composition of metal-poor stars; metal-poor components of our Galaxy; HR diagrams of globular clusters; chemical and ... [more ▼]

The following topics were dealt with: early galactic nucleosynthesis; chemical composition of metal-poor stars; metal-poor components of our Galaxy; HR diagrams of globular clusters; chemical and dynamical evolution of globular clusters. [less ▲]

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See detailGalactose Alpha 1-3 Galactose and Anti-Alpha Galactose Antibody in Normal and Pathological Pregnancies
Christiane, Y.; Aghayan, M.; Emonard, H. et al

in Placenta (1992), 13(5, Sep-Oct), 475-87

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor ... [more ▼]

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor cells, we have examined the possibility of their expression on human trophoblastic cells at different stages of placental implantation and in various pregnancy-associated conditions. Using immunohistochemical methods, Gal alpha 1-3 Gal was demonstrated on interstitial and vascular trophoblast during pregnancy. For villous trophoblast, the staining disappeared in second trimester pregnancies. The density of staining for Gal alpha 1-3 Gal was increased in highly invasive trophoblast (mole and choriocarcinoma) and decreased in poorly invasive specimens (spontaneous abortion, XO monosomia). No cells displaying Gal alpha 1-3 Gal at their surface were identified in some segments of spiral arteries from pre-eclamptic women. The anti-Gal antibody titer increased in the first trimester of pregnancy and in the sera of pre-eclamptic and eclamptic patients. These findings suggest that Gal alpha 1-3 Gal residues could be considered as markers for trophoblast invasive capacity and that the binding of maternal anti-Gal antibodies to the trophoblast could contribute to limit trophoblastic invasion and thus participate to the immunological control of implantation. [less ▲]

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See detailGalanin Decreases the Activity of Locus Coeruleus Neurons in Vitro
Seutin, Vincent ULg; Verbanck, Paul; Massotte, Laurent ULg et al

in European Journal of Pharmacology (1989), 164(2), 373-6

A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the ... [more ▼]

A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging from 20 to 100% at 10(-7) M. Experiments performed in low-Ca2+, high-Mg2+ medium also showed a significant inhibition by galanin (10(-7) M) in three out of five neurons, which suggests that the peptide acts directly. [less ▲]

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See detailGalanin modulates GH secretion in prepubertal male lambs.
Saleri, Roberta; Baratta, Mario; Renaville, Robert ULg et al

in IV European Congress of Endocrinology (1998)

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See detailLas galas de la literatura: un análisis pragmático de "Poemas plagiados", de Esteban Peicovich
François, Jéromine ULg

Conference (2013, January 18)

Los Poemas plagiados demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del ... [more ▼]

Los Poemas plagiados demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del de la comunicación cotidiana. El autor argentino despliega todas las modalidades del humor y las aplica a los múltiples registros de los que se apodera, desde el lenguaje infantil hasta los tecnolectos más elaborados. Peicovich saca, en fin, poesía de donde no la hay, y avanza así rasgos que se han venido considerado definitorios de la literatura posterior al boom, tales como la hibridez genérica, la mezcla de niveles culturales, el lirismo narrativo o la mitificación de lo consuetudinario. [less ▲]

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See detailLas galas de la literatura: un análisis pragmático de _Poemas plagiados_, de Esteban Peicovich
Ceballos Viro, Alvaro ULg; François, Jéromine

Conference (2013, January 18)

En su _Introducción al camelo_, publicada en 1967, el escritor y periodista argentino Esteban Peicovich reunió una serie de textos no literarios y los presentó como si fueran poemas. El autor ampliaría ... [more ▼]

En su _Introducción al camelo_, publicada en 1967, el escritor y periodista argentino Esteban Peicovich reunió una serie de textos no literarios y los presentó como si fueran poemas. El autor ampliaría posteriormente el número de textos y los pondría bajo un nuevo título: _Poemas plagiados_. A pesar de que dicho volumen haya sido editado tres veces a ambas orillas del Atlántico desde el año 2000 —lo que resulta muy notable para un libro de poemas—, hasta ahora apenas ha sido desflorado por la crítica periodística, sin que la crítica académica se haya fijado todavía en él. Sin embargo, los _Poemas plagiados_ constituyen un objeto de estudio ideal en el que ensayar un análisis pionero de pragmática literaria: los poemas de Peicovich constituyen actos de habla falsificados en los que la función ilocutiva original de textos cotidianos es transformada, difuminada o simplemente suprimida; sus posibilidades perlocutivas, por el contrario, se multiplican. Peicovich dispone de una manera estudiada los elementos de cada poema (título, texto y fuente), lo que permite al lector escoger entre dos lecturas diferentes pero no excluyentes: la lectura poética, propiciada por una serie de transformaciones paratextuales, y la lectura referencial (conservada mediante la mención de la fuente original situada al final de cada texto). El resultado es una expresión poética espontánea que dignifica documentos cotidianos y aun prosaicos, y en la que el lector se ve ejercitado de continuo en un lúdico movimiento de ida y vuelta del proceso de interpretación. La aclaración final del origen del poema de hecho juega con su horizonte de expectativas y demuestra el carácter colectivo de la creación poética —resaltada por un Lautréamont— en la que quehacer artístico y recepción del espectador se complementan. Nuestra comunicación definirá, pues, la pragmática de los _Poemas plagiados_, destacando las estrategias que poetizan estos textos —fragmentación, versificación, títulos recontextualizadores, etc.—. Además situaremos la práctica del «poema plagiado» en la historia literaria, esbozando su genealogía y descendencia, en relación con el estatuto ambiguo que parece caracterizar la producción de otros autores sudamericanos contemporáneos, como Roberto Bolaño, Nicanor Parra o César Aira. No es tampoco una casualidad que Peicovich dedicase varios libros y entrevistas a Jorge Luis Borges, cuyas obras usurpan a veces los atuendos de la no ficción. Los _Poemas plagiados_ demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del de la comunicación cotidiana. El autor argentino despliega todas las modalidades del humor y las aplica a los múltiples registros de los que se apodera, desde el lenguaje infantil hasta los tecnolectos más elaborados. Peicovich saca, en fin, poesía de donde no la hay, y avanza así rasgos que se han venido considerado definitorios de la literatura posterior al _boom_, tales como la hibridez genérica, la mezcla de niveles culturales, el lirismo narrativo o la mitificación de lo consuetudinario. [less ▲]

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