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See detailGait analysis using a wearable accelerometer system: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(S2), 355

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See detailGait feature extraction in Parkinson's disease using low-cost accelerometers
Stamatakis, Julien; Cremers, Julien ULg; Maquet, Didier ULg et al

Poster (2011)

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling ... [more ▼]

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling, short steps, freezing of gait (FoG) and/or asymmetries in gait. There are currently no validated clinical instruments or device that allow a full characterization of gait disturbances in PD. As a step towards this goal, a four accelerometer-based system is proposed to increase the number of parameters that can be extracted to characterize parkinsonian gait disturbances such as FoG or gait asymmetries. After developing the hardware, an algorithm has been developed, that automatically epoched the signals on a stride-by-stride basis and quantified, among others, the gait velocity, the stride time,the stance and swing phases, the single and double support phases or the maximum acceleration at toe-off, as validated by visual inspection of video recordings during the task. The results obtained in a PD patient and an healthy volunteer are presented. The FoG detection will be improved using time-frequency analysis and the system is about to be validated with a state-of-the-art 3D movement analysis system. [less ▲]

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See detailGaius, professeur de droit et jurisconsulte
Gerkens, Jean-François ULg

in Revue de la Faculté de Droit de l'Université de Liège (2004), (2004/3), 443-449

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See detailGaius, professeur de droit et jurisconsulte
Gerkens, Jean-François ULg

in Van Orshoven, Paul; Geens, Koen; Lesaffer, Randall (Eds.) et al Ad amicissimum amici scripsimus. Vriendenboek Raf Verstegen (2004)

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See detailGalactic archaeology: mapping and dating stellar populations with asteroseismology of red-giant stars
Miglio, A.; Chiappini, C.; Morel, Thierry ULg et al

in Monthly Notices of the Royal Astronomical Society (2013), 429

Our understanding of how the Galaxy was formed and evolves is severely hampered by the lack of precise constraints on basic stellar properties such as distances, masses and ages. Here, we show that solar ... [more ▼]

Our understanding of how the Galaxy was formed and evolves is severely hampered by the lack of precise constraints on basic stellar properties such as distances, masses and ages. Here, we show that solar-like pulsating red giants represent a well-populated class of accurate distance indicators, spanning a large age range, which can be used to map and date the Galactic disc in the regions probed by observations made by the CoRoT and Kepler space telescopes. When combined with photometric constraints, the pulsation spectra of such evolved stars not only reveal their radii, and hence distances, but also provide well-constrained estimates of their masses, which are reliable proxies for the ages of the stars. As a first application, we consider red giants observed by CoRoT in two different parts of the Milky Way, and determine precise distances for ˜2000 stars spread across nearly 15 000 pc of the Galactic disc, exploring regions which are a long way from the solar neighbourhood. We find significant differences in the mass distributions of these two samples which, by comparison with predictions of synthetic models of the Milky Way, we interpret as mainly due to the vertical gradient in the distribution of stellar masses (hence ages) in the disc. In the future, the availability of spectroscopic constraints for this sample of stars will not only improve the age determination, but also provide crucial constraints on age-velocity and age-metallicity relations at different Galactocentric radii and heights from the plane. [less ▲]

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See detailThe Galactic halo. From globular clusters to field stars. Proceedings.
Noels-Grötsch, Arlette ULg; Magain, Pierre ULg; Caro, Denise ULg et al

Book (2000)

The following topics were dealt with: early galactic nucleosynthesis; chemical composition of metal-poor stars; metal-poor components of our Galaxy; HR diagrams of globular clusters; chemical and ... [more ▼]

The following topics were dealt with: early galactic nucleosynthesis; chemical composition of metal-poor stars; metal-poor components of our Galaxy; HR diagrams of globular clusters; chemical and dynamical evolution of globular clusters. [less ▲]

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See detailGalactose Alpha 1-3 Galactose and Anti-Alpha Galactose Antibody in Normal and Pathological Pregnancies
Christiane, Y.; Aghayan, M.; Emonard, H. et al

in Placenta (1992), 13(5, Sep-Oct), 475-87

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor ... [more ▼]

The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor cells, we have examined the possibility of their expression on human trophoblastic cells at different stages of placental implantation and in various pregnancy-associated conditions. Using immunohistochemical methods, Gal alpha 1-3 Gal was demonstrated on interstitial and vascular trophoblast during pregnancy. For villous trophoblast, the staining disappeared in second trimester pregnancies. The density of staining for Gal alpha 1-3 Gal was increased in highly invasive trophoblast (mole and choriocarcinoma) and decreased in poorly invasive specimens (spontaneous abortion, XO monosomia). No cells displaying Gal alpha 1-3 Gal at their surface were identified in some segments of spiral arteries from pre-eclamptic women. The anti-Gal antibody titer increased in the first trimester of pregnancy and in the sera of pre-eclamptic and eclamptic patients. These findings suggest that Gal alpha 1-3 Gal residues could be considered as markers for trophoblast invasive capacity and that the binding of maternal anti-Gal antibodies to the trophoblast could contribute to limit trophoblastic invasion and thus participate to the immunological control of implantation. [less ▲]

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See detailGalanin Decreases the Activity of Locus Coeruleus Neurons in Vitro
Seutin, Vincent ULg; Verbanck, Paul; Massotte, Laurent ULg et al

in European Journal of Pharmacology (1989), 164(2), 373-6

A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the ... [more ▼]

A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging from 20 to 100% at 10(-7) M. Experiments performed in low-Ca2+, high-Mg2+ medium also showed a significant inhibition by galanin (10(-7) M) in three out of five neurons, which suggests that the peptide acts directly. [less ▲]

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See detailGalanin modulates GH secretion in prepubertal male lambs.
Saleri, Roberta; Baratta, Mario; Renaville, Robert ULg et al

in IV European Congress of Endocrinology (1998)

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See detailLas galas de la literatura: un análisis pragmático de "Poemas plagiados", de Esteban Peicovich
François, Jéromine ULg

Conference (2013, January 18)

Los Poemas plagiados demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del ... [more ▼]

Los Poemas plagiados demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del de la comunicación cotidiana. El autor argentino despliega todas las modalidades del humor y las aplica a los múltiples registros de los que se apodera, desde el lenguaje infantil hasta los tecnolectos más elaborados. Peicovich saca, en fin, poesía de donde no la hay, y avanza así rasgos que se han venido considerado definitorios de la literatura posterior al boom, tales como la hibridez genérica, la mezcla de niveles culturales, el lirismo narrativo o la mitificación de lo consuetudinario. [less ▲]

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See detailLas galas de la literatura: un análisis pragmático de _Poemas plagiados_, de Esteban Peicovich
Ceballos Viro, Alvaro ULg; François, Jéromine

Conference (2013, January 18)

En su _Introducción al camelo_, publicada en 1967, el escritor y periodista argentino Esteban Peicovich reunió una serie de textos no literarios y los presentó como si fueran poemas. El autor ampliaría ... [more ▼]

En su _Introducción al camelo_, publicada en 1967, el escritor y periodista argentino Esteban Peicovich reunió una serie de textos no literarios y los presentó como si fueran poemas. El autor ampliaría posteriormente el número de textos y los pondría bajo un nuevo título: _Poemas plagiados_. A pesar de que dicho volumen haya sido editado tres veces a ambas orillas del Atlántico desde el año 2000 —lo que resulta muy notable para un libro de poemas—, hasta ahora apenas ha sido desflorado por la crítica periodística, sin que la crítica académica se haya fijado todavía en él. Sin embargo, los _Poemas plagiados_ constituyen un objeto de estudio ideal en el que ensayar un análisis pionero de pragmática literaria: los poemas de Peicovich constituyen actos de habla falsificados en los que la función ilocutiva original de textos cotidianos es transformada, difuminada o simplemente suprimida; sus posibilidades perlocutivas, por el contrario, se multiplican. Peicovich dispone de una manera estudiada los elementos de cada poema (título, texto y fuente), lo que permite al lector escoger entre dos lecturas diferentes pero no excluyentes: la lectura poética, propiciada por una serie de transformaciones paratextuales, y la lectura referencial (conservada mediante la mención de la fuente original situada al final de cada texto). El resultado es una expresión poética espontánea que dignifica documentos cotidianos y aun prosaicos, y en la que el lector se ve ejercitado de continuo en un lúdico movimiento de ida y vuelta del proceso de interpretación. La aclaración final del origen del poema de hecho juega con su horizonte de expectativas y demuestra el carácter colectivo de la creación poética —resaltada por un Lautréamont— en la que quehacer artístico y recepción del espectador se complementan. Nuestra comunicación definirá, pues, la pragmática de los _Poemas plagiados_, destacando las estrategias que poetizan estos textos —fragmentación, versificación, títulos recontextualizadores, etc.—. Además situaremos la práctica del «poema plagiado» en la historia literaria, esbozando su genealogía y descendencia, en relación con el estatuto ambiguo que parece caracterizar la producción de otros autores sudamericanos contemporáneos, como Roberto Bolaño, Nicanor Parra o César Aira. No es tampoco una casualidad que Peicovich dedicase varios libros y entrevistas a Jorge Luis Borges, cuyas obras usurpan a veces los atuendos de la no ficción. Los _Poemas plagiados_ demuestran que, a pesar de lo tantas veces repetido durante todo el siglo XX, el carácter literario de un texto no procede del empleo de un código lingüístico especial, distinto del de la comunicación cotidiana. El autor argentino despliega todas las modalidades del humor y las aplica a los múltiples registros de los que se apodera, desde el lenguaje infantil hasta los tecnolectos más elaborados. Peicovich saca, en fin, poesía de donde no la hay, y avanza así rasgos que se han venido considerado definitorios de la literatura posterior al _boom_, tales como la hibridez genérica, la mezcla de niveles culturales, el lirismo narrativo o la mitificación de lo consuetudinario. [less ▲]

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See detailGalaxies statistics around highly luminous quasars: the ESO Sample
van Drom, E.; Surdej, Jean ULg; Magain, Pierre ULg et al

in Surdej, Jean; Fraipont-Caro, Denise; Gosset, Eric (Eds.) et al The proceedings of the 31st Liège International Astrophysical Colloquium "Gravitational lenses in the Universe" (1993)

We present observational evidence on the correlation between the positions of Highly Luminous Quasars and those of galaxies for a sample of 136 objects, observed under good seeing conditions.

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See detailGalaxy counterparts of intervening high-z sub-DLAs/DLAs and Mg ii absorbers towards gamma-ray bursts
Schulze, steve; Letawe, Géraldine ULg

in Astronomy and Astrophysics (2012), 546(A20),

We present the first search for galaxy counterparts of intervening high-z (2 < z < 3.6) sub-damped Lyα absorbers (sub-DLAs) and DLAs towards gamma-ray bursts (GRBs). Our final sample comprises five ... [more ▼]

We present the first search for galaxy counterparts of intervening high-z (2 < z < 3.6) sub-damped Lyα absorbers (sub-DLAs) and DLAs towards gamma-ray bursts (GRBs). Our final sample comprises five intervening sub-DLAs and DLAs in four GRB fields. To identify candidate galaxy counterparts of the absorbers we used deep optical- and near-infrared imaging, and low-, mid- and high-resolution spectroscopy acquired with 6-m to 10-m class telescopes, the Hubble and the Spitzer Space Telescopes. Furthermore, we used the spectroscopic information and spectral-energy-distribution fitting techniques to study them in detail. Our main result is the detection and spectroscopic confirmation of the galaxy counterpart of the intervening DLA at z = 3.096 in the field of GRB 070721B (zGRB = 3.6298) as proposed by other authors. We also identify good candidates for the galaxy counterparts of the two strong Mg ii absorbers at z = 0.6915 and 1.4288 towards GRB 050820A (zGRB = 2.615). The properties of the detected DLA galaxy are typical for Lyman-break galaxies (LBGs) at similar redshifts; a young, highly star-forming galaxy that shows evidence for a galactic outflow. This supports thehypothesis that a DLA can be the gaseous halo of an LBG. In addition, we report a redshift coincidence of different objects associated with metal lines in the same field, separated by 130–161 kpc. The high detection rate of three correlated structures on a length scale as short as ~150 kpc in two pairs of lines of sight is intriguing. The absorbers in each of these are most likely not part of the same gravitationally bound structure. They more likely represent groups of galaxies. [less ▲]

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See detailGale auriculaire du lapin et des carnivores domestiques : efficacité d’un gel phyto-aromatique
Mignon, Bernard ULg

in Action Vétérinaire (1995), suppl 1343

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See detailLa gale psoroptique bovine. Une maladie éradicable ?
Mignon, Bernard ULg; Lonneux, J. F.; Losson, Bertrand ULg

in Sillon Belge (1996), 20.12.1996

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See detailGalectin expression in the multiple myeloma microenvironment
Muller, Joséphine ULg; CAERS, Jo ULg; Binsfeld, Marilène ULg et al

in Belgian Journal of Hematology (2014)

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See detailGalectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin
van den Brule, Frédéric; Califice, Stéphane; Garnier, Frédérique et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2003), 83(3), 377-386

Galectin-1 (gal-1) is a 14-kDa laminin-binding galectin involved in several biologic events including regulation of cancer cell proliferation and adhesion to the matrix. In this study, we examined gal-1 ... [more ▼]

Galectin-1 (gal-1) is a 14-kDa laminin-binding galectin involved in several biologic events including regulation of cancer cell proliferation and adhesion to the matrix. In this study, we examined gal-1 expression in 30 human epithelial ovary carcinoma samples by Western and Northern blotting and by immunohistochemistry. Gal-1 mRNA levels were increased in more than 95% of the examined ovary carcinoma samples, compared with a wedge resection of a normal ovary. Immunohistochemical analysis of the samples demonstrated gal-1 expression in cancer epithelial cells from 17 of 30 samples, with a cytoplasmic pattern. Gal-1 immunostaining was significantly increased in the stroma associated with carcinoma cells compared with the normal, noninvaded stroma (p = 0.003). This pattern of expression was confirmed by examination of 12 other frozen epithelial ovary carcinomas, using in situ hybridization. Immunohistochemical staining of the specimens demonstrated colocalization of gal-1, laminin-1, and fibronectin. In vitro experiments were conducted to elucidate the potential biologic role of gal-1 in ovarian cancer progression. Gal-1 protein expression and release was detected in AZ364, SK-OV-3, and AZ224, but not in OVCAR-3, AZ419, and AZ382, human ovary carcinoma cell lines. Incubation of 84BR fibroblasts with conditioned media harvested from the ovary carcinoma cell lines induced an increased expression of gal-1 in the cultured fibroblasts in all cases except AZ419 and SK-OV-3. High concentrations of gal-1 (100 mug/ml) induced significantly decreased cell proliferation in all cell lines, as defined by bromodeoxyuridine incorporation. Additionally, recombinant gal-1 induced a dose-dependent increase in in vitro adhesion of AZ224, SK-OV-3, and AZ382 cells to laminin-1; adhesion to fibronectin was increased by gal-1 in OVCAR-3, AZ224, and SK-OV-3. No effect was observed in the other cases. Our data contribute to define a role for gal-1 during the interactions between human ovary carcinoma cells and host fibroblasts. [less ▲]

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See detailGalectin-1 Expression in Prostate Tumor-Associated Capillary Endothelial Cells Is Increased by Prostate Carcinoma Cells and Modulates Heterotypic Cell-Cell Adhesion
Clausse, Nathalie; van den Brule, Frédéric; Waltregny, David ULg et al

in Angiogenesis (1999), 3(4), 317-25

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host ... [more ▼]

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host immune cells. Galectin-1, a soluble human lectin, is involved in numerous biological functions including cell-cell and cell-substrate interactions. In addition, galectin-1 is able to induce apoptosis of activated T-lymphocytes. In this study, we have examined galectin-1 expression in capillaries associated to the carcinoma cells or present in the remote non-tumoral stroma of 100 human prostate carcinoma samples by immunoperoxidase staining. Galectin-1 was expressed by endothelial cells from capillaries infiltrating the tumor tissue in 64% (64/100) of the cases. On the contrary, endothelial cells in the adjacent non-tumoral stroma expressed galectin-1 in very few cases (7/100). Increased frequency of galectin-1-positive capillaries in the tumor-associated compared to the tumor-free areas was observed in 63% of the cases. This striking contrast led us to set up an in vitro model to test whether tumor cells could induce galectin-1 expression by endothelial cells. Incubation of human umbilical vein endothelial cells with conditioned media from PC-3 or DU 145 prostate carcinoma cells led to a significant increase of galectin-1 protein expression (+32.97% and 37.91% P < 0.01 and P < 0.05, respectively). PC-3 conditioned medium also induced increased adhesion values of PC-3 cells to the endothelial cells (53.4 +/- 4.7 vs. 38.5 +/- 3.5 after 30 min; 66.6 +/- 7.8 vs. 46.2 +/- 6.4 after 60 min). An anti-galectin-1 antiserum abolished this modulation, and recombinant galectin-1 also induced increased adhesion values in a dose-dependent fashion. This effect was specific as no such modulations were observed using normal lymphocytes instead of PC-3 cells. Preferential galectin-1 expression in the endothelial cells close to the cancer cells could provide these latter with increased abilities to interact with the endothelial cells as well as a defense against the host immune system. [less ▲]

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See detailGalectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes.
Mathieu, V.; de Lassalle, Elisabeth Martin; Toelen, J. et al

in Journal of Investigative Dermatology (2012)

Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted ... [more ▼]

Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted by both cancer and endothelial cells stimulates proliferation and angiogenesis. This study first shows that gal-1 is more highly expressed at both mRNA and protein levels than its congeners in melanomas and particularly in advanced lesions. The roles of gal-1 were further investigated in vivo in the highly proliferating and vascularized pseudometastatic B16F10 mouse melanoma model using stable knockdown B16F10 cells and wild-type versus gal-1 knockout mice, and then in vitro in B16F10 tumoral and lung microvascular cells. Gal-1 depletion in the B16F10 tumor cells but not in the tumor-bearing mice significantly increased melanoma-bearing mice survival. Tumor-derived gal-1 thus seems to have more critical roles than the host-derived one. In fact, gal-1 displays distinct effects on the H-Ras-dependent p53/p21 pathways: in primary lung microvessel endothelial cells, gal-1 seems to be involved in the maintenance of senescent status through the induction of both p53 and p21 while it stimulates B16F10 cancer cell proliferation through a p53/p21 decrease. Altogether, these data point to gal-1 as a potential target to combat melanomas.Journal of Investigative Dermatology advance online publication, 24 May 2012; doi:10.1038/jid.2012.142. [less ▲]

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