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See detailEndogenous versus exogenous markers of adult neurogenesis in canaries and other birds: advantages and disadvantages.
Balthazart, Jacques ULg; Ball, Gregory F.

in The Journal of comparative neurology (2014), 522(18), 4100-20

Although the existence of newborn neurons had originally been suggested, but not broadly accepted, based on studies in adult rodent brains, the presence of an active neurogenesis process in adult ... [more ▼]

Although the existence of newborn neurons had originally been suggested, but not broadly accepted, based on studies in adult rodent brains, the presence of an active neurogenesis process in adult homoeothermic vertebrates was first firmly established in songbirds. Adult neurogenesis was initially studied with the tritiated thymidine technique, later replaced by the injection and detection of the marker of DNA replication 5-bromo-2'-deoxyuridine (BrdU). More recently, various endogenous markers were used to identify young neurons or cycling neuronal progenitors. We review here the respective advantages and pitfalls of these different approaches in birds, with specific reference to the microtubule-associated protein, doublecortin (DCX), that has been extensively used to identify young newly born neurons in adult brains. All these techniques of course have limitations. Exogenous markers label cells replicating their DNA only during a brief period and it is difficult to select injection doses that would exhaustively label all these cells without inducing DNA damage that will also result in some form of labeling during repair. On the other hand, specificity of endogenous markers is difficult to establish due to problems related to the specificity of antibodies (these problems can be, but are not always, addressed) and more importantly because it is difficult, if not impossible, to prove that a given marker exhaustively and specifically labels a given cell population. Despite these potential limitations, these endogenous markers and DCX staining in particular clearly represent a useful approach to the detailed study of neurogenesis especially when combined with other techniques such as BrdU. [less ▲]

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See detailEndogenous zinc modulates di-synaptic GABAergic transmission in the dentate gyrus
Grauert, A; Engel, Dominique ULg; Ruiz, AJ

Poster (2011)

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See detailEndokarsts and cryptokarsts in Cretaceous coarse and higly porous chalk at the Belgian-Dutch border
Willems, Luc ULg; Rodet, Joël

in Filippi, Michal; Bosák, Pavel (Eds.) Proceedings of the 16th International Congress of Speleology, July 21–28, Brno. Volume 3, p. 499. Czech Speleological Society. Praha. (2013, July 21)

Since 2003, the study of several quarries at the Belgian-Dutch border has made it possible to identify numerous karsts essentially developed in coarse chalk (calcarenites) of the Maastricht Formation ... [more ▼]

Since 2003, the study of several quarries at the Belgian-Dutch border has made it possible to identify numerous karsts essentially developed in coarse chalk (calcarenites) of the Maastricht Formation (Upper Cretaceous). This lithology is highly porous and is often considered unfavorable to karstification. However, caves, solution pipes, sponge networks, roof channel, pockets (alveoli) several meters in diameter developed inside without connection to fractures. These karsts belong to flooded karsts (caves and pockets) or to younger cryptokarsts (input karst type – thousands of solution pipes). When the endokarsts dewater, the high porosity of calcarenites inhibits closed caves from evolving. Tubular solution pipes are produced by the seepage water under fluvial terrace gravels and can exceed 30 m deep under the surface plateau. Sometimes, they encounter caves which are consequently filled and fossilized. By this process, they preserve caves from further collapsing inside a crumbly lithology. [less ▲]

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See detailThe endometrial hCG/LH receptor: quantification throughout the menstrual cycle
Tsampalas, M; Berndt, S; Gridelet, Virginie ULg et al

Conference (2010, March 04)

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See detailEndometrial laser interstitial hyperthermy: a potential modality for endometrial ablation.
Donnez, Jacques; Polet, Roland; Mathieu, Pierre-Emmanuel et al

in Obstetrics & Gynecology (1996), 87(3), 459-64

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were ... [more ▼]

This study was undertaken to evaluate the efficacy and safety of an intrauterine device designed for endometrial ablation by Nd-YAG laser interstitial hyperthermy. Eight hysterectomy specimens were treated in vitro with an output power of 30 W for 5 minutes; tissue temperatures, recorded by thermocouples, were plotted to draw time-temperature and time-distance curves. As a preliminary series, ten patients were treated, with the first five subjected to local temperature monitoring; all ten were followed-up for 6-17 months. Immediate and delayed (6 weeks) histologic data were obtained. The intramural temperature at 6 mm from the fibers ranged from 55-60C). In vivo, the cooling effect of the arterial blood flow lowered the serosal temperatures under 41C. The histologic data and the hysterographic pictures suggest that endometrial ablation was effective. This new device does not require distending medium, hysteroscopic control, or high-powered Nd-YAG laser machines. Preliminary long-term results suggest that the device could be used for endometrial ablation. [less ▲]

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See detailEndometrial laser intrauterine thermo-therapy (ELITT™): a revolutionary new approach to the elimination of menorrhagia
Donnez, Jacques; Polet, Roland; Squifflet, Jean et al

in Current Opinion in Obstetrics & Gynecology (1999), 11(4), 363-70

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is ... [more ▼]

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is low-dose laser radiation of the endometrium with the diode source, which is characterized by the highest incidence of amenorrhea. [less ▲]

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See detailEndometrial laser intrauterine thermotherapy: the first series of 100 patients observed for 1 year
Donnez, Jacques; Polet, Roland; Rabinovitz, Rafi et al

in Fertility and Sterility (2000), 74(4), 791-6

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in ... [more ▼]

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in the management of dysfunctional uterine bleeding. Design: Prospective study. Setting: University hospital. Patient(s): 100 premenopausal women with dysfunctional uterine bleeding were observed for 1 year. Intervention(s): Intrauterine laser thermotherapy with a diode laser. Main Outcome Measurement(s): Amenorrhea rate after 1 year. Result(s): The amenorrhea rate after 1 year of follow-up was 71%, and the rate of amenorrhea/severe hypomenorrhea rate was >90%; these rates are much higher than those in the literature after such procedures as electrosurgery or intrauterine thermal balloon therapy. The ELITT procedure is an inherently safe and simple alternative, providing controlled and effective treatment of the entire endometrium. In contrast to traditional endometrial ablation using a neodymium yttrium-aluminum-garnet laser, the ELITT procedure does not require intensive training or hysteroscopic control; it is also far less risky, because the power used per unit area is 1,000 times lower. Conclusion(s): The ELITT procedure is a new nonhysteroscopic technique for endometrial ablation. The technique is very safe and offers the highest amenorrhea rate to date in the literature. [less ▲]

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See detailEndometrial thickness in different cut-off points for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding
To, Hong ULg

in Ultrasound in Medicine & Biology (2011, August 26), 37(8S), 118

Purpose: The aim of this study is to find the suitable cutoff point of endometrial thickness (ET) for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding (PMB). Material ... [more ▼]

Purpose: The aim of this study is to find the suitable cutoff point of endometrial thickness (ET) for predicting abnormal endometrium in Vietnamese women with postmenopausal bleeding (PMB). Material & Methods: A prospective study was carried out during 2 years. 308 women, who did not use any hormone therapy, were suffered from PMB. All of them were measured ET by transvaginal sonography before an endometrial biopsy. Dilation and curettage (D&C) was indicated in women with ET ≥ 3 mm to diagnose an abnormal endometrium (hyperplasia atypia or cancer). We compared the sensitivity and false-negative rate at each 1-mm interval cutoff point of ET for detecting these histopathologies. Results: 292 women gave their consent to perform an endometrial biopsy (D&C). Their mean age was 59.4 ± 9.3 years. The median time of amenorrhea was 5 years (range 2-13 years); 12.67% (95%CI 9.10-17.04) of cases were diagnosed an abnormal ET in which the mean of endometrial thickness found was 4.0±1.7 mm (95% CI 3.8-11.8). In comparison to seven cutoff points, the ET at 4 mm showed the highest detection rate of abnormal endometrium in women with PMB (95% of sensitivity for 4% false-negative rate) Conclusion: The ET at 4 mm is the most suitable cutoff point for predicting an abnormal endometrium in Vietnamese women with PMB. [less ▲]

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See detailEndometrial vessel maturation in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time
Ravet, Stéphanie ULg; Labied, Soraya ULg; Blacher, Silvia ULg et al

in Human Reproduction (2007), 22(12), 3084-3091

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document ... [more ▼]

BACKGROUND: Levonorgestrel-releasing intrauterine system (LNG-IUS), although inserted to reduce heavy menstruation, causes irregular early transient bleeding. The objective of the study was to document quantitative changes in endometrial vessels of short- (< or =3 months) and long-term (> or =12 months) LNG users. The area, density and maturation of endometrial vessels were quantified in 19 endometrial biopsies of women with LNG-IUS and in 10 normally ovulating patients during mid-luteal phase. METHODS: Vessel maturation was evaluated by double immunostaining using anti-von Willebrand factor (endothelial cell marker) and anti-alpha Smooth Muscle Actin (vascular smooth muscle cells) antibodies. Vessel area, number and density were quantified with a novel computer-assisted image analysis system. RESULTS: Endometrium exposed to LNG-IUS for 1-3 months displayed a 11.5-fold increase in small naked vessel number. The partially mature vessel (alphaSMA partially positive) number increased six times. After long-term LNG-IUS treatment, the immature and partially mature vessel number remained four times higher than in the control group. Vessel area and density also increased dramatically in a time-dependent pattern with LNG-IUS use. CONCLUSIONS: Levonorgestrel affects blood vessel number, area, density and maturation in a time-dependent pattern that may explain the early transient increase in breakthrough bleeding with the LNG-IUS. [less ▲]

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See detailEndométriose : pourquoi se développe-telle ?
BELIARD, Aude ULg; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Références en Gynécologie Obstétrique (2012), 14

Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the ... [more ▼]

Endometriosis is an estrogen-dependent disorder that can result in substantial morbidity, including multiple operations, and pelvic pain. New findings on the genetics, the possible roles of the environment, the immune system, and the inflammation have given insight into the pathogenesis of this disorder and serve as the background for new treatments and new diagnostic approach. [less ▲]

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See detailL'endométriose en 2009: place respective du traitement médical et du traitement chirurgical.
Cheruy, Charlotte ULg; Nervo, Patricia ULg; Dequesne, J. et al

in Gunaïkeia (2009), 14(3), 69-73

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See detailL'endometriose extragenitale
Nisolle, Michelle ULg; Pasleau, Françoise ULg; Foidart, Jean-Michel ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2007), 36(2), 173-8

Parietal, appendiceal, pleuropulmonary and diaphragmatic endometriosis represent 5% of endometriosis cases. Diagnosis and management of these extra-genital localisations are described according to the ... [more ▼]

Parietal, appendiceal, pleuropulmonary and diaphragmatic endometriosis represent 5% of endometriosis cases. Diagnosis and management of these extra-genital localisations are described according to the literature. Parietal endometriosis usually requires large resection of the tumor. Appendiceal endometriosis is frequently observed in cases of digestive endometriosis. Induration or rigidity of the appendix due to the presence of deep infiltrating endometriosis justifies appendicectomy. Thoracic and diaphragmatic endometriosis is characterized by the presence of typical symptoms during the perimenstrual periode. Medical treatment obtaining therapeutic amenorrhea is firstly administered and surgery is indicated in cases of symptoms recurrence. [less ▲]

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See detailEndométriose minime et légère: quel impact sur la fertilité?
BRICHANT, Géraldine ULg; AUDEBERT, Alain; NISOLLE, Michelle ULg

in Revue Médicale de Liège (2016), 71(5), 236-241

L’endométriose minime ou légère (stades I/II) est fréquemment identifiée chez les femmes hypofertiles, surtout en cas de stérilité inexpliquée. L’impact de ces lésions sur la fertilité est controversé ... [more ▼]

L’endométriose minime ou légère (stades I/II) est fréquemment identifiée chez les femmes hypofertiles, surtout en cas de stérilité inexpliquée. L’impact de ces lésions sur la fertilité est controversé, certains les considérant comme paraphysiologiques. Elles sont hétérogènes dans leur étendue, leur activité biologique, l’inflammation qui les caractérise ou les adhérences qu’elles peuvent induire. La diminution de la qualité ovocytaire, et de la mobilité des spermatozoïdes ainsi que les altérations endométriales apparaissent comme les mécanismes les plus pertinents pour expliquer l’hypofertilité. La fécondité spontanée des femmes présentant une endométriose minime ou légère est diminuée en comparaison avec celle des femmes pour lesquelles le diagnostic de stérilité inexpliquée a été posé. L’insémination intra-utérine avec stimulation de l’ovulation améliore la fertilité des femmes traitées. L’ablation coelioscopique des lésions endométriosiques améliore de façon modeste la fécondité, conduisant à recommander cette pratique compte tenu de ses faibles risques. La fécondation in vitro (FIV) est le moyen le plus efficace permettant d’obtenir des résultats similaires ou légèrement inférieurs à ceux observés chez les femmes témoins présentant une infertilité tubaire. L’impact des endométrioses minimes et légères sur la fertilité apparaît très probable, au moins pour certaines lésions qui demandent à être identifiées. [less ▲]

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See detailEndometriose stade I et II: implications physiopathologiques, cliniques et therapeutiques
Nisolle, Michelle ULg; Nervo, Patricia ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2003), 32(8, Pt 2), 11-4

Stage I and II endometriosis is defined by a r-AFS score respectively ranging from 1 to 5 and from 6 to 15. This mild, superficial endometriosis is a very common pathology occurring in infertile women ... [more ▼]

Stage I and II endometriosis is defined by a r-AFS score respectively ranging from 1 to 5 and from 6 to 15. This mild, superficial endometriosis is a very common pathology occurring in infertile women. Nevertheless, these women with stage I/II endometriosis have usually few pelvic pain. This review summarizes the recent literature concerning new data on the pathogenesis of peritoneal endometriosis and its clinical management. Retrograde menstruation, peritoneal adhesion of shed endometrial tissue, and outgrowth of endometrial cells, glands and stroma, are essential elements in the pathogenesis of endometriosis according to Sampson's classic implantation theory. Nevertheless, exact pathophysiology of endometriosis remains unknown. Superficial endometriotic lesions observed by laparoscopy have to be treated. Surgical procedure is not difficult for stage I and II of endometriosis. Surgical procedure remains controversial. Carbon dioxide (CO2) Laser can be used for laparoscopic destruction of endometriosis. Newer procedures, such as SurgiTouch (Lumenis), are more effective in vaporization and decrease the risk thermal damage of contiguous structures. The monopolar scissors can also be used in order to excise the peritoneal endometriotic lesions. Medical treatment may be usefull if surgical treatment is not complete or if the pelvic cavity is hypervascularized. In these cases, Gonadotropin-Releasing Hormone agonists (Gn-RHa) are the most common and effective treatment. [less ▲]

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See detailEndometriosis by adolescence
CLOSON, François ULg; BRICHANT, Géraldine ULg; TEBACHE, Linda ULg et al

in Médecine de la Reproduction, Gynécologie Endocrinologie (2013), 15(3), 228-33

Endometriosis is a chronic disease usually diagnosed at adult age, even the symptoms begin at adolescence. The medical history could help for the diagnosis and could select the patients for medical or ... [more ▼]

Endometriosis is a chronic disease usually diagnosed at adult age, even the symptoms begin at adolescence. The medical history could help for the diagnosis and could select the patients for medical or surgical treatment. The main criterion is the description of severe dysmenorrhea necessitating the prescription of oral contraceptive pill early after the menarcha. The early diagnosis is a major issue in the evolution of the disease which is caracterized by physical, psyco-social and sexual repercussions. [less ▲]

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See detailEndometriosis-associated infertility: evaluation of preoperative use of danazol, gestrinone, and buserelin.
Donnez, J.; NISOLLE, Michelle ULg; Casanas-Roux, F.

in International Journal of Fertility (1990), 35(5), 297-301

In order to assess adequately the effectiveness of danazol, Gestrinone, and Buserelin, a prospective nonrandomized study was initiated in 126 patients with laparoscopically confirmed ovarian endometriosis ... [more ▼]

In order to assess adequately the effectiveness of danazol, Gestrinone, and Buserelin, a prospective nonrandomized study was initiated in 126 patients with laparoscopically confirmed ovarian endometriosis. After hormonal therapy, laparotomy with microsurgical resection of endometriotic cysts was carried out. Regression (greater than 25%) of ovarian endometriosis was noted in 30%, 34%, and 73% of cases after danazol, Gestrinone, and Buserelin, respectively. The pregnancy rate in moderate endometriosis (53%) differed significantly from the rate obtained in severe endometriosis (45%). The highest percentages were found after Buserelin therapy. In conclusion, Buserelin emerged superior to danazol or Gestrinone treatment. Nevertheless, hormonal treatment leads to an incomplete suppression of ovarian endometriotic implants and this suggests the necessity of surgically removing invasive ovarian endometriosis. [less ▲]

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See detailEndometriosis: from research to clinical practice
Nisolle, Michelle ULg; Alvarez Gonzalez, Maria-Luz ULg; Colombo, M. et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2007), 162(5-6), 263-72

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynaecological ... [more ▼]

Endometriosis, defined by the development of endometrial tissue outside the uterus, is a benign disease responsible for infertility and pelvic pain. The diagnosis based on a detailed gynaecological history and a careful clinical examination should be done as early as possible in order to treat patients correctly. Medical treatment is not appropriate in all cases and surgical treatment should be proposed but morbidity is related to the severity of the lesion. Ectopic implantation of endometrial cells needs complex interactions between host tissue and epithelial endometrial cells. The conditions for the development of endometriosis are oestrogeno-dependent growth of endometrial cells, induction of angiogenesis and lymphangiogenesis. Principal cellular and molecular factors of angiogenesis, lymphangiogenesis and fibrosis should be identified in order to develop new therapeutic strategies of endometriosis. [less ▲]

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