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See detailFibrine
Fredericq, Léon ULg

in Richet, Charles (Ed.) Dictionnaire de physiologie. 006. Tome VI (1904)

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See detailFibrinogène
Fredericq, Léon ULg

in Richet, Charles (Ed.) Dictionnaire de physiologie. 006. Tome VI (1904)

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See detailFibrinolyse intra-artérielle in situ des membres inférieurs
Van Damme, Hendrik ULg; Trotteur, Geneviève ULg; Jamblain, P. et al

in Revue Médicale de Liège (1992), 47(1), 25-41

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See detailFibroblasts Induce the Assembly of the Macromolecules of the Basement Membrane
Delvoye, Pierre ULg; Piérard, D.; Noël, Agnès ULg et al

in Journal of Investigative Dermatology (1988), 90(3), 276-82

The mechanism regulating the deposition of basement membrane components (BMCs) in a polymeric structure at the junction with the connective tissues is not yet understood. Cultures and cocultures of ... [more ▼]

The mechanism regulating the deposition of basement membrane components (BMCs) in a polymeric structure at the junction with the connective tissues is not yet understood. Cultures and cocultures of epithelial BMC-producing cells (L2 or PER cells) and fibroblasts were prepared in several experimental conditions and the organization of BMCs was studied by immunofluorescence. The pattern of BMCs in pure cultures of L2 or pulmonary epithelial rat (PER) cells consisted of intra- and extracellular granular deposits. At very high density, the cell contours were also underlined by a disrupted network of BMC deposits. A different fibrillar plexus--containing laminin, collagen type IV, and heparan-sulfate proteoglycan resistant to deoxycholate treatment and distant from the cell membrane--was observed in cocultures of L2 or PER cells with fibroblasts. Fibrils of fibronectin and/or collagen type I were most often dissociated from this plexus of BMCs. Similar results were obtained by adding a conditioned medium of L2 or PER cells to confluent fibroblasts, even when the cells were killed. Pure laminin also bound to the fibroblast layer. A coated film of fibronectin or polymeric collagen type I was unable to bind BMC provided by a conditioned medium. It is suggested that molecule(s) synthesized by fibroblasts and deposited in the pericellular matrix are involved in the assembly of BMCs. [less ▲]

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See detailFibromes cutanés.
PIERARD, Gérald ULg; Franchimont, Claudine ULg

in Fondation René Touraine (Ed.) Thérapeutique Dermatologique (2012)

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See detailFibromuscular dysplasia of the external iliac artery. A case report.
ADANT, JEAN-PHILIPPE; SakalihasanN, Natzi ULg; Dekoster, Guy ULg et al

in Vascular Surgery (1992), 26

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See detailFibromuscular dysplasia of the internal carotid artery. Personal experience with 13 cases and literature review.
VAN DAMME, Hendrik ULg; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1999), 99(4), 163-8

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two ... [more ▼]

From January 1990 to December 1997, the authors observed 13 cases of fibromuscular dysplasia of the internal carotid artery. Four patients presented transient ischemic attacks, one amaurosis fugax, two suffered from a minor stroke, four had non-focalized ischemic cerebral symptoms and two were asymptomatic. At angiography, all patients showed a typical image of "string of beads". Seven patients were operated on. Six had endoluminal graduated dilatation, with rigid dilators up to 4.5 mm, associated with thrombendarterectomy of the bifurcation in three and to correction of a kink in one case. In one case a venous interposition graft was done to exclude a saccular microaneurysm of the dysplasic internal carotid artery. In another case, backflow was insufficient after endoluminal dilatation, and a long venous patch allowed to restitute a normal vascular lumen. There was neither postoperative mortality nor stroke. Six patients, asymptomatic or with non focalized symptoms, were treated medically. During a mean follow-up of 47 months, only one of the 13 patients developed a transient ischemic attack; the patient had not been operated on and received only medical treatment. Prevalence, etiopathology, diagnosis and management of fibromuscular dysplasia of the internal carotid artery are discussed. Fibromuscular dysplasia is a rare cause of cerebral ischemia. For asymptomatic lesions, a conservative approach seems appropriate. Surgery is only to be considered for symptomatic lesions. Surgical graduated endoluminal dilatation, where necessary combined with standard endarterectomy of the carotid bifurcation, is a safe, efficient and durable operation. Some complex cases of fibromuscular dysplasia may necessitate patch insertion or excision and graft interposition. [less ▲]

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detailLa fibromyalgie : exploration fonctionnelle musculaire
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Demoulin, Christophe ULg et al

in Abstract book des Mardis de la Kinésithérapie 2003 (2003, February)

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See detailLa fibromyalgie en l'an 2000
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Revue Médicale de Liège (2000), 55(11), 991-7

Musculoskeletal pain is common in the population. Several pathologies like fibromyalgia (FM), chronic fatigue syndrome (CFS) or spasmophilia are associated with functional myalgia. The etiology of FM ... [more ▼]

Musculoskeletal pain is common in the population. Several pathologies like fibromyalgia (FM), chronic fatigue syndrome (CFS) or spasmophilia are associated with functional myalgia. The etiology of FM remains elusive, but the diagnosis is well established. The criteria for the classification are widespread pain combined with tenderness at 11 or more of the 18 specific tender points sites. The prevalence is 2% in the general population. This article reviews recent data on the pathophysiology and treatment of FM. [less ▲]

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See detailFibromyalgie et lombalgie chronique : étude des facteurs invalidants et facteurs facilitateurs à la réinsertion et au maintien professionnel
CELENTANO, Jessica; PALMARICCIOTTI, Valérie ULg; Nyssen, Anne-Sophie ULg et al

in Douleur et Analgésie (2011), 24(1), 46-49

The aim of this research is to explore the invalidating and facilitating factors related to return to work and/or to maintain work perceived by two groups of patients with chronic diseases: fibromyalgia ... [more ▼]

The aim of this research is to explore the invalidating and facilitating factors related to return to work and/or to maintain work perceived by two groups of patients with chronic diseases: fibromyalgia or chronic back pain. Indeed, the current studies generally examined either return to work or maintaining work; their approach is rarely supported by an integrated view. Our study revealed similarities and differences between the two perspectives but also between the two groups of patients. This will help with the development of future initiatives for returning chronic pain patients to employment. [less ▲]

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See detailFibromyalgie et performances musculaires
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Renard, Cécile ULg et al

in Revue du Rhumatisme [Ed Fr] (2002), 69(3), 518-525

Objectifs. Évaluer la fonction musculaire d’un groupe de patientes fibromyalgiques et la comparer à celle d’une population féminine de référence. Méthodes. Seize patientes fibromyalgiques et 87 sujets ... [more ▼]

Objectifs. Évaluer la fonction musculaire d’un groupe de patientes fibromyalgiques et la comparer à celle d’une population féminine de référence. Méthodes. Seize patientes fibromyalgiques et 87 sujets sains féminins sédentaires ou sportifs de loisir ont exécuté un protocole expérimental composé de quatre épreuves. La première évaluait le moment de force isocinétique concentrique maximum des muscles extenseurs et fléchisseurs du genou dominant. Un dynamomètre de Colin autorisait une mesure de la force manuelle isométrique. La résistance musculaire à la fatigue s’appréciait lors d’une épreuve isocinétique de flexion–extension des genoux : le sujet enchaînait 30 contractions concentriques d’intensité maximale à la vitesse angulaire de 180 °/s. La dernière épreuve évaluait l’endurance musculaire statique à l’aide de tests exigeant le maintien d’une position donnée. Résultats. Toutes les variables musculaires apparaissaient réduites chez les sujets fibromyalgiques. Ce déficit, déjà manifeste pour les efforts anaérobiques, s’accentuait lors des efforts en aérobie. Le déficit moyen correspondait à 39 % (p < 0,001) pour la force musculaire, 40 % (p < 0,0001) pour la résistance musculaire à la fatigue et 81 % (p < 0,0001) pour l’endurance musculaire statique. Les perceptions nociceptives au cours de l’effort, évaluées à l’aide d’une échelle visuelle analogique, étaient supérieures chez les patientes fibromyalgiques. Conclusion. L’exploration combinée des trois filières énergétiques confirme l’altération générale de la fonction musculaire du sujet fibromyalgique. Cette étude suggère cependant une perturbation préférentielle des composantes oxydatives. [less ▲]

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See detailFibromyalgie post-traumatique : mythe ou réalité ?
Crielaard, Jean-Michel ULg; Maquet, Didier ULg

in Lucas, Pierre; Stehman, Michel (Eds.) Les troubles somatoformes (2014)

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See detailFibromyalgie: un syndrome d'Ehlers-Danlos de type hypermobile qui s'ignore?
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg; Angenot, Ph

in Revue Médicale de Liège (2013), 68(1), 22-4

Some patients suffering from fibromyalgia present with clinical signs and alterations in the histopathology, immunohistochemistry and ultrastructure of the dermis similar to the Ehlers-Danlos syndrome ... [more ▼]

Some patients suffering from fibromyalgia present with clinical signs and alterations in the histopathology, immunohistochemistry and ultrastructure of the dermis similar to the Ehlers-Danlos syndrome, hypermobile type (EDSH). Some types of fibromyalgia possibly represent an undiagnosed EDSH. [less ▲]

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See detailFibronectin mediates the retraction of type I collagen fibers by breast cancer cells.
Castronovo, Vincenzo ULg; Paye, M.; Courtois, R. et al

in Evaluation du Risque de Cancer Mammaire. Chimiothérapie Première ? (1985)

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See detailFibronectin presence in native collagen fibrils of human fibroblasts: immunoperoxidase and immunoferritin localization.
Furcht, L. T.; Smith, D.; Wendelschafer-Crabb, G. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1980), 28(12), 1319-33

Fibronectin is a major constituent of the fibroblast extracellular matrix. Fibronectin binds to collagen, mediates fibroblast adhesion to collagen, and is synthesized and secreted into the medium of ... [more ▼]

Fibronectin is a major constituent of the fibroblast extracellular matrix. Fibronectin binds to collagen, mediates fibroblast adhesion to collagen, and is synthesized and secreted into the medium of cultured fibroblasts. Affinity-purified antibodies to fibronectin and collagen were localized using the peroxidase-antiperoxidase method or with ferritin-coupled secondary antibodies. Using human fibroblasts cultured under routine conditions, fibronectin and procollagen I react in a nonperiodic manner with: 1) approximately 10 nm extracellular fibrils, 2) cell membrane, and 3) membrane-associated vesicles. All fibrils react with both antibodies, suggesting some form of codistribution of fibronectin and collagen in these fibrils. Treatment with ascorbate leads to the development of a larger diameter extracellular fibril, approximately 40 nm in diameter. These large diameter fibrils are clearly collagen fibrils as documented by the procollagen antibody reaction. Importantly, fibronectin is bound to or a constituent of these "native" or cellular made collagen fibrils. Fibronectin and procollagen antibodies localized with the peroxidase-antiperoxidase method have a 70 nm axial repeat of reaction product on ascorbate-treated fibroblasts. Localization of antibodies with ferritin-labeled secondary antibodies is less satisfactory, but supports the basic observations made with the unlabeled antibody enzyme method. This observation rules out any potential criticisms. Although it is more difficult to observe with immunoferritin, there is an indication that antibodies to fibronectin react with an axial periodicity on cellular produced collagen fibrils. [less ▲]

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See detailFibronectin Promotes Lung Colony Formation in the Mouse by B16 Melanoma Cells Spheroids
Coucke, P.; De Pauw-Gillet, Marie-Claire ULg; de Leval, Laurence ULg et al

in In Vivo (Athens, Greece) (1992), 6(5, Sep-Oct), 481-6

By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of ... [more ▼]

By microscopical observation and using an original method of automatic image analysis, we studied on histological sections the rate of lung colony formation after intravenous injection into the mouse of B16 melanoma cells previously cultivated in vitro as pure or mixed spheroids (B16 + 3T3 fibroblasts). The preincubation in vitro of pure spheroids with fibronectin significantly increased the percentages of lung section area occupied by tumors and the relative number of internal lung colonies. This effect of fibronectin was even more obvious when mixed spheroids were injected. [less ▲]

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See detailFibronectin promotes rat Schwann cell growth and motility
Baron-Van Evercooren, Anne; Kleinman, Hinda K.; Seppa, H. E. et al

in Journal of Cell Biology (1982), 93(1), 211-216

Techniques are now available for culturing well characterized and purified Schwann cells. Therefore, we investigated the role of fibronectin in the adhesion, growth, and migration of cultured rat Schwann ... [more ▼]

Techniques are now available for culturing well characterized and purified Schwann cells. Therefore, we investigated the role of fibronectin in the adhesion, growth, and migration of cultured rat Schwann cells. Double-immunolabeling shows that, in primary cultures of rat sciatic nerve, Schwann cells (90%) rarely express fibronectin, whereas fibroblasts (10%) exhibit a granular cytoplasmic and fibrillar surface-associated fibronectin. Secondary cultures of purified Schwann cells do not express fibronectin. Exogenous fibronectin has a small effect on promoting the adhesion of Schwann cells to the substrate and does not significantly affect cell morphology, but it produced a surface fibrillar network on fibronectin on the secondary Schwann cells. Tritiated thymidine autoradiography revealed that addition of fibronectin to the medium, even at low concentrations, markedly stimulates Schwann cell proliferation, in both primary and secondary cultures. In addition, when cell migration was measured in a Boyden chamber assay, fibronectin was found to moderately, but clearly, stimulate directed migration or chemotaxis. [less ▲]

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