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See detailEffects of two PBDE congeners on the moulting enzymes of the freshwater amphipod Gammarus pulex.
Gismondi, Eric ULiege; Thomé, Jean-Pierre ULiege

Poster (2014, May)

Polybrominated diphenyl ethers (PBDEs) constitute a class of chemical compounds included to the composition of usual products such as plastics, textiles or electrical equipment, due to their flame ... [more ▼]

Polybrominated diphenyl ethers (PBDEs) constitute a class of chemical compounds included to the composition of usual products such as plastics, textiles or electrical equipment, due to their flame retardants properties. Since 2004, PBDEs were banned in Europe and listed as Priority Substances within the European Union Water Frame Work Directive. Unfortunately, the release of PBDEs always occurs in ecosystems due to their presence in products currently in use and new products manufactured using recycled PBDE-containing material. However, only few studies have investigated their impacts on freshwater invertebrates. This work aimed to study the effects of BDE-47 and BDE-99 congeners on the chitobiase and chitinolytic enzymes activities of the freshwater amphipod Gammarus pulex, according to gender, PBDE concentration and time of exposure. In addition, the bioaccumulation of BDE-47 and BDE-99 were measured. The results revealed that there was a dose-response relationship for the PBDE accumulation in G. pulex, whatever the gender and the PBDE congeners. Female G. pulex bioaccumulated more PBDE than males, and especially BDE-99 which was more accumulated than BDE-47. Moreover, PBDE exposures for 96hrs have caused the inhibition of chitobiase and chitinolytic enzymes activities. This study not only indicate the importance of taking into account various confounding factors (gender, congeners, concentration) to understand the PBDE effects, but underline also disruptions of enzymes activities involved in the molting process. These disturbances suggest effects on the gammarid development and reproduction, and consequently on the gammarid population. [less ▲]

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See detailEffects of U-46619 on Pulmonary Hemodynamics before and after Administration of Bm-573, a Novel Thromboxane A2 Inhibitor
Lambermont, Bernard ULiege; Kolh, Philippe ULiege; Dogné, Jean-Michel ULiege et al

in Archives of Physiology & Biochemistry (2003), 111(3), 217-23

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six ... [more ▼]

We studied the effects on pulmonary hemodynamics of U-46619, a thromboxane A2 (TXA2) agonist, before and after administration of a novel TXA2 receptor antagonist and synthase inhibitor (BM-573). Six anesthetized pigs (Ago group) received 6 consecutive injections of U-46619 at 30-min interval and were compared with six anesthetized pigs (Anta group) which received an increasing dosage regimen of BM-573 10 min before each U-46619 injection. Consecutive changes in pulmonary hemodynamics, including characteristic resistance, vascular compliance, and peripheral vascular resistance, were continuously assessed during the experimental protocol using a four-element Windkessel model. At 2 mg/kg, BM-573 completely blocked pulmonary hypertensive effects of U-46619 but pulmonary vascular compliance still decreased. This residual effect can probably be explained by a persistent increase in the tonus of the pulmonary vascular wall smooth muscles sufficient to decrease vascular compliance but not vessel lumen diameter. Such molecule could be a promising therapeutic approach in TXA2 mediated pulmonary hypertension as it is the case in pulmonary embolism, hyperacute lung rejection and endotoxinic shock. [less ▲]

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See detailEffects of Unfractionated and Fractionated Heparins on Myeloperoxidase Activity and Interactions with Endothelial Cells: Possible Effects on the Pathophysiology of Equine Laminitis
de la Rebière de Pouyade, Geoffroy ULiege; Franck, Thierry ULiege; Dupont, Ginette ULiege et al

in Veterinary Journal (2007), 178(1), 62-69

As heparins are sometimes used to prevent equine laminitis, the interactions between equine neutrophil myeloperoxidase (MPO), unfractionated (UFH) and fractionated low molecular weight (LMWH) heparins and ... [more ▼]

As heparins are sometimes used to prevent equine laminitis, the interactions between equine neutrophil myeloperoxidase (MPO), unfractionated (UFH) and fractionated low molecular weight (LMWH) heparins and digital endothelium have been investigated. The effects of the heparins on purified equine MPO activity were tested by immunocapture followed by enzymatic detection. Endothelium-MPO interactions were assessed by measuring total and active MPO uptake by arterial and venous digital endothelial cells in culture with or without the addition of heparins. A dose-dependent MPO inhibition by UFH and LMWH was seen, with the greatest reduction in MPO activity noted with the highest concentration of LMWH. The MPO capture was greater in arterial cells, but heparins better inhibited MPO capture in venous cells. The activity of cell-bound MPO was almost completely suppressed by the heparins, and no differences were observed between UFH and LMWH. The results confirm the anti-inflammatory properties of heparins and allow a better understanding of the potential role of MPO in laminitis. [less ▲]

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See detailEffects of User IT Capabilities and Organized Big Data Analytics on Competitive Advantage
Kamioka, Taro; Hosoya, Ryuichi; Tapanainen, Tommi ULiege

in Proceedings of the Pacific-Asian Conference on Information Systems (PACIS) (2017, July 20)

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have ... [more ▼]

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have received attention in many ways, we note that the capability literature has focused more on the IT supply side. We argue that user capabilities have moved to an integral position in firm competitive advantage, and call them “User IT Capabilities” (UIC). A survey was conducted to collect data from Japanese organizations, and a total valid sample of 1,170 respondents involved in big data use was extracted. The findings show the effect of UIC on the performance of big data analytics and firm competitiveness, mediated by the variable of organized big data analytics (OBDA). The direct effects are shown to be valid irrespective of company size, although the levels of UIC and OBDA are higher in larger firms. [less ▲]

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See detailEffects of vaccination with live or inactivated aqueous-suspension NDV vaccine in pigeons previously infected with paramyxovirus type 1
Duchatel, Jean-Pierre ULiege

in Vlaams Diergeneeskundig Tijdschrift (1987), 56(2), 135-140

The authors compared the effects of vaccination of previously PMV1 infected pigeons, either with live-NDV-LaSota strain or with the inactivated aqueous-suspension vaccine (Colombovac PMV). Young ... [more ▼]

The authors compared the effects of vaccination of previously PMV1 infected pigeons, either with live-NDV-LaSota strain or with the inactivated aqueous-suspension vaccine (Colombovac PMV). Young susceptible pigeons were inoculated by intramuscular injectionwith pigeon PMV1 and vaccinated 4 days later ocularly/intranasally with live-LaSota strain or by subcutaneous injection of one 0.2 ml dose of Colombovac PMV. Cumulative nervous signs/mortality rates reached 95% in the live-LaSota vaccinated group, 70% in the control group and 60% in the Colombovac PMV vaccinated group. As compared to the control group, vaccination with Colombovac PMV had no beneficial but no disadvantageous effects on the disease while vaccination with live-LaSota significantly increased viral excretion in the faeces and number of pigeons with polyuria at the beginning of the clinical phase of infection. Consequently, percentages of pigeons having developed polyuria and cumulative percentages of nervous signs/mortality were significantly lower in the Colombovac PMV vaccinated group than in the live LaSota vaccinated group. In conclusion, when first symptoms are appearing in a PMV1 infected pigeon-house, vaccinated with Colombovac PMV may be attempted without heightening the disease while vaccination with live-Lasota increases the severity of the disease. [less ▲]

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, Sylvie ULiege; Scholsem, Martin; LEGRAIN, Caroline ULiege et al

Poster (2006, November)

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, Sylvie ULiege; Scholsem, Martin; LEGRAIN, Caroline ULiege et al

in Book of Abstracts of the 36th Annual Meeting Society for Neuroscience (Oct 2006) (2006, October)

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See detailEffects of vagal nerve stimulation in the rat orofacial formalin model of pain
Multon, S.; Scholsem, M.; Legrain, C. et al

Conference (2006, November 10)

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See detailEffects of valve replacement for aortic stenosis on mitral regurgitation.
Unger, Philippe; Plein, Daniele; Van Camp, Guy et al

in American Journal of Cardiology (2008), 102(10), 1378-82

We aimed to prospectively and quantitatively assess the effects of aortic valve replacement (AVR) for aortic stenosis (AS) on mitral regurgitation (MR) and to examine the determinants of the changes in MR ... [more ▼]

We aimed to prospectively and quantitatively assess the effects of aortic valve replacement (AVR) for aortic stenosis (AS) on mitral regurgitation (MR) and to examine the determinants of the changes in MR. Fifty-two patients with AS scheduled for AVR were included if holosystolic MR not being considered for replacement or repair was detected. MR was quantified using the proximal isovelocity surface area method before and 8 +/- 4 days after surgery. Mitral valvular deformation parameters did not change significantly, but the mitral effective regurgitant orifice (ERO) and regurgitant volume decreased from 11 +/- 6 mm(2) to 8 +/- 6 mm(2) and from 20 +/- 10 ml to 11 +/- 9 ml, respectively (both p <0.0001). Using multiple linear regression analysis, preoperative severity of MR, mitral leaflet coaptation height, and end-diastolic volume decrease were independently associated with postoperative reduction in MR, whereas changes in mitral valve morphology after surgery were not. MR etiology did not predict the reduction in MR. In conclusion, the decrease in MR observed in most patients after AVR is associated with the magnitude of acute left ventricular reverse remodeling. As the reduction in left ventricular systolic pressure contributes to the decrease in regurgitant volume, the preoperative quantitative assessment of MR should best be performed by measurement of the ERO. [less ▲]

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See detailEffects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays.
Xhauflaire, Emmanuelle ULiege; Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Journal of Cosmetic Dermatology (2008), 7(3), 194-8

BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the ... [more ▼]

BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the effects of various concentrations of glycolic acid on the stratum corneum and collagen fibers using two selected bioassays. METHODS: Corneoxenometry was performed to test the effects on human stratum corneum. Collaxenometry was similarly designed to quantify the effect on sheets of collagen fibers. Different glycolic acid concentrations ranging from 5% to 70% in alcohol were tested, respectively, for 3- and 10-min exposure times. RESULTS: Both bioassays showed consistent reactivities with a dose-effect relationship when using a 3-min exposure time. By contrast, the tests appeared unreliable or uninformative for the 10-min exposure time. CONCLUSION: Corneoxenometry and collaxenometry appear useful for in vitro testing peeling agents during short exposure times. [less ▲]

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See detailEffects of various design parameters on system-level fire fragility functions for steel buildings
Elhami Khorasani, Negar; Gernay, Thomas ULiege; Garlock, Maria

Conference (2017, April 07)

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be ... [more ▼]

The existing literature in fire engineering is mostly based on single component study of structures, as opposed to system level building performance. In current practice, fire does not need to be considered as part of the structural design of the building. The required fire protection for steel components in a building is based on prescriptive design guidelines, which are based on standard fire tests on individual structural members. In addition, the fire-structure engineering has primary focused on deterministic analysis, while the field is moving towards performance-based design in recent years. Meanwhile, the scenarios leading to a fire event and the performance of the structure at elevated temperatures involve a great level of uncertainty. This work focuses on fire-structure interaction with the objective of developing fire fragility functions that capture fire damage uncertainty for the entire building (i.e., at the system-level). A fragility function provides the probability of exceeding a damage state for a given intensity measure of a given hazard. Fire fragility functions can be developed to measure the expected losses based on performance of a building structural system, rather than a single component. Different functions can be developed for buildings with different typologies (e.g. high-rise steel building with moment resisting frame, low rise steel building with bracing). This presentation derives fragility functions based on stochastic analyses of prototype buildings. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response should be considered; but such a large number of random variables adds to the complexity of analysis and the computational time. Based on a sensitivity analysis for steel gravity frames, this work identifies the most important input parameters to be considered as random variables when developing fire fragility functions for an entire building. The sensitivity analysis for a multi-story steel building prototype is completed considering uncertainties at the compartment and building levels. At the compartment level, uncertainty in the fire scenario, compartment geometry, applied load, thermal and mechanical properties of steel and insulating materials are considered. At the building level, the influence of fire-resistance rating, building height, and occupancy type are studied. The results of this study identify the local and global parameters needed as part of deriving system-level fire fragility functions for a steel building. [less ▲]

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See detailEffects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: Results from two randomized trials.
Van Damme, Pierre; Leroux-Roels, Geert; Simon, Philippe et al

in Vaccine (2014)

BACKGROUND: A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized ... [more ▼]

BACKGROUND: A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized, controlled studies were conducted to compare the immunogenicity and safety of investigational tetravalent HPV L1 virus-like particle (VLP) vaccines, containing VLPs from two additional oncogenic genotypes, with the licensed HPV-16/18 AS04-adjuvanted vaccine (control) in healthy 18-25 year-old women. METHODS: In one trial (NCT00231413), subjects received control or one of 6 tetravalent HPV-16/18/31/45 AS04 vaccine formulations at months (M) 0,1,6. In a second trial (NCT00478621), subjects received control or one of 5 tetravalent HPV-16/18/33/58 vaccines formulated with different adjuvant systems (AS04, AS01 or AS02), administered on different schedules (M0,1,6 or M0,3 or M0,6). RESULTS: One month after the third injection (Month 7), there was a consistent trend for lower anti-HPV-16 and -18 geometric mean antibody titers (GMTs) for tetravalent AS04-adjuvanted vaccines compared with control. GMTs were statistically significantly lower for an HPV-16/18/31/45 AS04 vaccine containing 20/20/10/10mug VLPs for both anti-HPV-16 and anti-HPV-18 antibodies, and for an HPV-16/18/33/58 AS04 vaccine containing 20/20/20/20mug VLPs for anti-HPV-16 antibodies. There was also a trend for lower HPV-16 and -18-specific memory B-cell responses for tetravalent AS04 vaccines versus control. No such trends were observed for CD4+ T-cell responses. Immune interference could not always be overcome by increasing the dose of HPV-16/18 L1 VLPs or by using a different adjuvant system. All formulations had acceptable reactogenicity and safety profiles. Reactogenicity in the 7-day post-vaccination period tended to increase with the introduction of additional VLPs, especially for formulations containing AS01. CONCLUSIONS: HPV-16 and -18 antibody responses were lower when additional HPV L1 VLPs were added to the HPV-16/18 AS04-adjuvanted vaccine. Immune interference is a complex phenomenon that cannot always be overcome by changing the antigen dose or adjuvant system. [less ▲]

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See detailEffects of visual cortex activation on the nociceptive blink reflex in healthy subjects.
Sava, Simona L.; de Pasqua, Victor; MAGIS, Delphine ULiege et al

in PloS one (2014), 9(6), 100198

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not ... [more ▼]

Bright light can cause excessive visual discomfort, referred to as photophobia. The precise mechanisms linking luminance to the trigeminal nociceptive system supposed to mediate this discomfort are not known. To address this issue in healthy human subjects we modulated differentially visual cortex activity by repetitive transcranial magnetic stimulation (rTMS) or flash light stimulation, and studied the effect on supraorbital pain thresholds and the nociceptive-specific blink reflex (nBR). Low frequency rTMS that inhibits the underlying cortex, significantly decreased pain thresholds, increased the 1st nBR block ipsi- and contralaterally and potentiated habituation contralaterally. After high frequency or sham rTMS over the visual cortex, and rMS over the right greater occipital nerve we found no significant change. By contrast, excitatory flash light stimulation increased pain thresholds, decreased the 1st nBR block of ipsi- and contralaterally and increased habituation contralaterally. Our data demonstrate in healthy subjects a functional relation between the visual cortex and the trigeminal nociceptive system, as assessed by the nociceptive blink reflex. The results argue in favour of a top-down inhibitory pathway from the visual areas to trigemino-cervical nociceptors. We postulate that in normal conditions this visuo-trigeminal inhibitory pathway may avoid disturbance of vision by too frequent blinking and that hypoactivity of the visual cortex for pathological reasons may promote headache and photophobia. [less ▲]

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See detailEffects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial.
Passerieux, Emilie; Hayot, Maurice; Jaussent, Audrey et al

in Free radical biology & medicine (2015), 81

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative ... [more ▼]

Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative stress may contribute to FSHD pathology, antioxidants that might modulate or delay oxidative insults could help in maintaining FSHD muscle function. Our primary objective was to test whether oral administration of vitamin C, vitamin E, zinc gluconate, and selenomethionine could improve the physical performance of patients with FSHD. Adult patients with FSHD (n=53) were enrolled at Montpellier University Hospital (France) in a randomized, double-blind, placebo-controlled pilot clinical trial. Patients were randomly assigned to receive 500 mg vitamin C, 400mg vitamin E, 25mg zinc gluconate and 200 mug selenomethionine (n=26), or matching placebo (n=27) once a day for 17 weeks. Primary outcomes were changes in the two-minute walking test (2-MWT), maximal voluntary contraction, and endurance limit time of the dominant and nondominant quadriceps (MVCQD, MVCQND, TlimQD, and TlimQND, respectively) after 17 weeks of treatment. Secondary outcomes were changes in the antioxidant status and oxidative stress markers. Although 2-MWT, MVCQ, and TlimQ were all significantly improved in the supplemented group at the end of the treatment compared to baseline, only MVCQ and TlimQ variations were significantly different between groups (MVCQD: P=0.011; MVCQND: P=0.004; TlimQD: P=0.028; TlimQND: P=0.011). Similarly, the vitamin C (P<0.001), vitamin E as alpha-tocopherol (P<0.001), vitamin C/vitamin E ratio (P=0.017), vitamin E gamma/alpha ratio (P=0.022) and lipid peroxides (P<0.001) variations were significantly different between groups. In conclusion, vitamin E, vitamin C, zinc, and selenium supplementation has no significant effect on the 2-MWT, but improves MVCQ and TlimQ of both quadriceps by enhancing the antioxidant defenses and reducing oxidative stress. This trial was registered at clinicaltrials.gov (number: NCT01596803). [less ▲]

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See detailEffects of vitamin D in the elderly population : current status and perspectives
Bruyère, Olivier ULiege; CAVALIER, Etienne ULiege; Souberbielle, JC et al

in Archives of Public Health (2014), 72

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support ... [more ▼]

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case–control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated. [less ▲]

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