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See detailGlomerular matrix proteins in nodular glomerulosclerosis in association with light chain deposition disease and diabetes mellitus.
Bruneval, P.; Foidart, Jean-Michel ULg; Nochy, D. et al

in Human Pathology (1985), 16(5), 477-84

The diagnosis of light chain deposition nephropathy is based on the immunohistochemical demonstration of monoclonal light chain deposits within connective tissue matrix and on the presence at the ... [more ▼]

The diagnosis of light chain deposition nephropathy is based on the immunohistochemical demonstration of monoclonal light chain deposits within connective tissue matrix and on the presence at the ultrastructural level of electron-dense granular deposits along glomerular and tubular basement membranes. A nodular glomerulopathy characterized by amorphous periodic acid-Schiff-positive and argyrophilic widened mesangium and nodules is described in three patients with light chain deposition nephropathy. Light microscopic examination did not allow discrimination between the glomerular changes found in these specimens and the nodular glomerulosclerosis described in four patients with well-documented diabetes mellitus. Electron microscopic examination revealed microtubular fibrils 10 to 12 nm thick in mesangial areas in both groups. Such microfibrils could be glycoproteins. Immunofluorescence localization of matrix proteins, by staining with affinity-purified antibodies to types I, III, IV, and V (A, B) collagens, fibronectin, laminin, and heparan sulfate-containing proteoglycans, showed similar distributions in the two conditions. The mechanism of this abnormal accumulation of mesangial and glomerular basement membrane matrix proteins in two different conditions remains unknown. [less ▲]

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See detailLa glomérulonéphrite fibrillaire non amyloïde : une cause rare de syndrome néphrotique
GROSCH, Stéphanie ULg; VAN OVERMEIRE, Lionel ULg; Krzesinski, Jean-Marie ULg et al

in Néphrologie & Thérapeutique (2011), 7

La glomérulonéphrite fibrillaire non amyloïde est une pathologie glomérulaire à dépôts fibrillaires, non amyloïdes, composés principalement d'immunoglobulines G polyclonales. Il s'agit d'une ... [more ▼]

La glomérulonéphrite fibrillaire non amyloïde est une pathologie glomérulaire à dépôts fibrillaires, non amyloïdes, composés principalement d'immunoglobulines G polyclonales. Il s'agit d'une glomérulopathie idiopathique responsable de protéinurie sévère, souvent néphrotique et d'insuffisance rénale arrivant à un stade terminal dans 40% des cas à cinq ans. Elle peut prendre différents aspects anatomopathologiques déterminants en terme de pronostic rénal. La négativité des dépôts en coloration rouge Congo et l'épaisseur des fibrilles en microscopie électronique permettent le diagnostic différentiel avec les dépôts amyloïdes. Il n'y a pas de traitement efficace. Après transplantation rénale, la récidive est fréquente avec un pronostic rénal cependant moins péjoratif. [less ▲]

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See detailLes glomérulonéphrites
Krzesinski, Jean-Marie ULg

Conference (2007, December 11)

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See detailGlossaire
Hoffsummer, Patrick ULg; Touzé, Rachel

in Hoffsummer, Patrick (Ed.) Les charpentes du XIe au XIe au XIXe siècle: Grand Ouest de la France: typologie et évolution: analyse de la documentation de la Médiathèque de l'architecture et du patrimoine (2011)

This french glossay is a complement to these published in and 2009 in Archiectura mediiaevi 3

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See detailGlossaire
Hoffsummer, Patrick ULg; Prévet, Alain

in Hoffsummer, Patrick (Ed.) Les charpentes du XIe au XIXe siècle: typologie et évolution en France du Nord et en Belgique (2002)

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See detailUn glossaire naturaliste au second degré ? À propos de La Flore pornographique d’Ambroise Macrobe
Saint-Amand, Denis ULg

in Cahiers Naturalistes : Bulletin officiel de la Société Littéraire des Amis d'Emile Zola (2013), 87

Publié en 1883, La Flore pornographique. Glossaire de l’école naturaliste se présente comme un outil destiné à livrer les clefs d’une littérature recourant fréquemment à la « langue verte » pour mieux en ... [more ▼]

Publié en 1883, La Flore pornographique. Glossaire de l’école naturaliste se présente comme un outil destiné à livrer les clefs d’une littérature recourant fréquemment à la « langue verte » pour mieux en dénoncer l’obscénité. Cet article tente d’apporter un éclairage neuf sur ce cas particulier, en en interrogeant la structure et les logiques et en cherchant à mesurer s’il ne convient pas de le lire en réalité comme une satire de la critique antinaturaliste. [less ▲]

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See detailGlossaire toponymique de la commune de Saint-Léger
Kurth, Godefroid ULg

in Fédération archéologique et historique de Belgique (Ed.) Compte rendu des travaux du congrès (1887)

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See detailGlossaires pour rire ou Le lexique comme style.
Saint-Amand, Denis ULg

Conference (2010, March 20)

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See detailLes glossaires toponymiques
Kurth, Godefroid ULg

in Fédération archéologique et historique de Belgique (Ed.) Compte rendu des travaux du congrès (1887)

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See detailGlossary for the English Edition
Alcock, Nathaniel W.; Courtenay, Lynn T.; Currie, Christopher et al

in Hoffsummer, Patrick (Ed.) Roof Frames from the 11th to the 19th Century: Typology and Development in Northern France and in Belgium: Analysis of CRMH Documetnation (2009)

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See detailGlossematica e semiotica: loro espansioni
Galassi, Romeo; Zorzella, Cristina; Cigana, Lorenzo ULg

Book published by ZeL Edizioni (2012)

Collection of contribution on Hjelmslev's Glossematics

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See detailGlossopharyngeal neuralgia triggered by non-noxious stimuli at multiple cephalic and extracephalic sites.
ter Berg, J. W. M.; Dupont, P.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2009), 29(11), 1174-9

Glossopharyngeal neuralgia (GN) triggered by non-noxious stimuli at multiple cephalic and extracephalic sites with positron emission tomography (PET) evidence for involvement of the upper brainstem has ... [more ▼]

Glossopharyngeal neuralgia (GN) triggered by non-noxious stimuli at multiple cephalic and extracephalic sites with positron emission tomography (PET) evidence for involvement of the upper brainstem has never been reported. We present such a patient, a 73-year-old man who since the age of 50 had suffered from GN with a high recurrence rate and very severe unilateral, non-familial GN episodes with very easy trigger zones widely extending beyond the n IX territory. Extensive neuroimaging and neurophysiological tests detected no precise underlying cause. PET scan revealed activation in the upper brainstem on extracephalic triggers. Single-fibre electromyography data will be discussed. We hypothesize that deficient inhibition as seen in trigeminal nociceptive reflexes on the level of brainstem interneurons, a functional lesion in the primary somatosensory cortex-sensory thalamic nuclei circuit and the dorsal column-thalamic pathway both activated by light touch may in part be involved in the extracephalic triggering. [less ▲]

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See detailGlottoplasty for Male-to-Female Transsexualism: Voice Results
Remacle, Marc; Matar, Nayla; Morsomme, Dominique ULg et al

in Journal of Voice (2010), 25(1), 120-3

Summary: Objectives. The aim of this study was to evaluate the objective voice results ofWendler’s glottoplasty in male-to-female transsexuals. Method. We retrospectively reviewed our patients treated ... [more ▼]

Summary: Objectives. The aim of this study was to evaluate the objective voice results ofWendler’s glottoplasty in male-to-female transsexuals. Method. We retrospectively reviewed our patients treated with Wendler’s technique with minor modifications. Glottoplasty consisted in CO2-laser epithelial ablation of the anterior commissure and the two vocal folds in anterior third, suturing of the two vocal folds with two stitches of 3.0 resorbable thread, and application of fibrin sealant to strengthen the suture. Voice assessment was based mainly on fundamental frequency (F0), frequency range, jitter, maximum phonation time, phonation quotient, estimated subglottic pressure (ESGP) grade of dysphonia (G), and voice handicap index (VHI). These measures were taken before surgery and on the last follow-up visit. Results. Our series included 15 patients with a mean age of 36 years. The mean follow-up period was 7.2 months.We did not observe any early complications related to the technique. The comparison between the preoperative and the postoperative measurements, using Wilcoxon signed rank test, showed a significant improvement of median F0 from 139 to 191 Hz (P ¼ 0.006) with an increase in the grade of dysphonia (Gpre ¼ 0.2, Gpost ¼ 1, P ¼ 0.013) and ESGP (ESGPpre ¼ 8.1 ± 3.2, ESGPpost ¼ 12.0 ± 3.8, P ¼ 0.002). Other measurements, including VHI, did not show any significant differences pre- and postoperatively. Conclusion. Wendler’s glottoplasty can contribute to feminize the voice. [less ▲]

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See detailGLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician?
SCHEEN, André ULg

in Annales d'Endocrinologie (2013)

Pharmacological treatment of type 2 diabetes has been enriched during recent years, with the launch of incretin therapies targeting glucagon-like peptide-1 (GLP-1). Such medications comprise either GLP-1 ... [more ▼]

Pharmacological treatment of type 2 diabetes has been enriched during recent years, with the launch of incretin therapies targeting glucagon-like peptide-1 (GLP-1). Such medications comprise either GLP-1 receptor agonists, with short (one or two daily injections: exenatide, liraglutide, lixisenatide) or long duration (one injection once weekly: extended-released exenatide, albiglutide, dulaglutide, taspoglutide); or oral compounds inhibiting dipeptidyl peptidase-4 (DPP-4), the enzyme that inactives GLP-1, also called gliptins (sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin). Although both pharmacological approaches target GLP-1, important differences exist concerning the mode of administration (subcutaneous injection versus oral ingestion), the efficacy (better with GLP-1 agonists), the effects on body weight and systolic blood pressure (diminution with agonists versus neutrality with gliptins), the tolerance profile (nausea and possibly vomiting with agonists) and the cost (higher with GLP-1 receptor agonists). Both agents may exert favourable cardiovascular effects. Gliptins may represent a valuable alternative to a sulfonylurea or a glitazone after failure of monotherapy with metformin while GLP-1 receptor agonists may be considered as a good alternative to insulin (especially in obese patients) after failure of a dual oral therapy. However, this scheme is probably too restrictive and modalities of using incretins are numerous, in almost all stages of type 2 diabetes. Physicians may guide the pharmacological choice based on clinical characteristics, therapeutic goals and patient's preference. [less ▲]

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See detailLe glucagon-like peptide-1 (GLP-1), nouvelle cible dans le traitement du diabete de type 2.
Scheen, André ULg

in Revue Médicale de Liège (2007), 62(4), 217-21

Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted in response to the ingestion of a meal. It exerts various favourable metabolic effects among which a glucose-dependent stimulation of insulin ... [more ▼]

Glucagon-like peptide-1 (GLP-1) is a gut hormone secreted in response to the ingestion of a meal. It exerts various favourable metabolic effects among which a glucose-dependent stimulation of insulin secretion, an inhibition of glucagon secretion, a slow down of gastric emptying, and a central anorectic effect. In rodents, a protective effect, or even a trophic effect, on B cell has also been reported. Interestingly, GLP-1 secretion is decreased in patients with type 2 diabetes. This observation stimulated the pharmaceutical research with the aim of restoring appropriate GLP-1 circulating levels able to exert the numerous positive effects of the hormone. One of the main objectives was to solve the problem due to the very short half-life of GLP-1. We here briefly describe the main two proposed approaches : ether to subcutaneously inject an incretinomimetic agent closed to GLP-1 (exenatide) or a long-acting GLP-1 analogue (liraglutide), both being partially resistant to the action of dipeptidylpeptidase-IV (DPP-IV), either to orally administer a selective DPP-IV inhibitor, an enzyme metabolising endogenous GLP-1 (sitagliptin, vildagliptin, .... These new drugs offer the advantage of improving blood glucose control of type 2 diabetic patients, without inducing severe hypoglycaemia and without promoting weight gain (instead a weight reduction is generally observed). These agents should occupy a key place in the overall pharmacological strategy of type 2 diabetes in a near future, especially if the additional favourable effects on B cells are confirmed in clinical practice. [less ▲]

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See detailThe glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity
Nalda, Asunción M; Martial, Joseph ULg; Muller, Marc ULg

in Molecular & Cellular Endocrinology (1997), 134(2), 129-37

Glucocorticoids have been shown to inhibit the activity of the human prolactin (hPRL) promoter. Using transient expression experiments in rat pituitary cells, we located the sequence conferring ... [more ▼]

Glucocorticoids have been shown to inhibit the activity of the human prolactin (hPRL) promoter. Using transient expression experiments in rat pituitary cells, we located the sequence conferring glucocorticoid inhibition to a region which contains Pit-1 binding sites, responsible for pituitary-specific expression, but does not seem to contain a glucocorticoid receptor (GR) binding site. Co-transfection experiments in non-pituitary cell lines, using expression vectors for Pit-1 and different mutants of the human GR show that inhibition of the hPRL gene is seen only in the presence of Pit-1 and GR, and that the DNA binding function of the receptor is not required. Immunoprecipitation studies show that either anti-GR or anti-Pit-1 antibodies are able to co-precipitate GR and Pit-1, suggesting an interaction between these factors. We conclude that the activated GR functionally interferes with the pituitary specific factor Pit-1, thereby leading to the observed transcriptional repression. [less ▲]

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See detailThe glucocorticoid receptor.
Muller, Marc ULg; Renkawitz, R.

in Biochimica et Biophysica Acta (1991), 1088

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See detailGlucocorticoid receptors bound to the antagonist RU486 are not downregulated despite their capacity to interact in vitro with defined gene regions
Rajpert, E. J.; Lemaigre, F. P.; Eliard, P. H. et al

in Journal of Steroid Biochemistry (1987), 26(5), 513-20

Modulation of gene expression by glucocorticoids involves interaction of these hormones with an intracellular receptor followed by 'transformation' of the hormone-receptor complex into a nuclear binding ... [more ▼]

Modulation of gene expression by glucocorticoids involves interaction of these hormones with an intracellular receptor followed by 'transformation' of the hormone-receptor complex into a nuclear binding form. The molecular basis for the antiglucocorticoid action of high-affinity steroid analogues such as RU486 remains controversial. The effects of dexamethasone and RU486 on in vitro and in vivo properties of the receptor were compared using human lymphoblastoid IM-9 cells. In these cells, RU486 fully antagonized the glucocorticoid-specific induction of 5'-nucleotidase activity by dexamethasone. In vitro, however, RU486-bound receptor could be transformed and shown to interact specifically with cloned DNA fragments containing glucocorticoid response elements. These fragments included one from the mouse mammary tumour virus and two from the human growth hormone gene. In vivo, RU486-bound receptor did not behave like dexamethasone-bound receptor. While receptor downregulation, a property of the transformed receptor, was achieved by dexamethasone, this did not occur with RU486. Likewise, RU486 did not affect receptor half-life under conditions when this was shortened by dexamethasone. These seemingly contradictory results can be reconciled by proposing that receptor transformation by agonists involves dissociation of the receptor oligomer to reveal a DNA-binding site that pre-exists on this protein. Although cell-free receptor dissociation and therefore DNA binding can occur even when the receptor is bound to RU486, this steroid maintains receptors in the untransformed state in the intact cell and therefore behaves a glucocorticoid antagonist in vivo. [less ▲]

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See detailLes glucocorticoïdes, de puissants immunomodulateurs naturels
Geenen, Vincent ULg

Conference given outside the academic context (2008)

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