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See detailFolipidine, a new type quinoline alkaloid from plants of the Haplophyllum genus
Akhmedzhanova, V. I.; Rasulova, K. A.; Bessonova, I. A. et al

in Chemistry of Natural Compounds (2005), 41(1, JAN-FEB), 60-64

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC ... [more ▼]

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity. [less ▲]

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See detailLe folk-lore [sic] et les sociétés historiques
Kurth, Godefroid ULg

in Kurth, Godefroid (Ed.) Le folk-lore [sic] et les sociétés historiques (1888)

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See detailFollicle Stimulating Hormone -Secreting Pituitary adenomas
Beckers, Albert ULg; Stevenaert, Achille ULg; Mashiter, K. et al

in Journal of Clinical Endocrinology and Metabolism (1985), 61(3), 525-528

This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH ... [more ▼]

This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH levels. LH levels were normal in 5 and slightly elevated in 1. Testosterone levels were low in 2 patients and within normal limits in 2 others. Sexual impotency had developed from 6 months to 1 yr before surgery in all patients. Primary hypogonadism could be eliminated on clinical grounds (recent onset of hypogonadism, previous fertility of 5 of the 6, and postoperative improvement). After transsphenoidal adenomectomy, FSH levels returned to normal values in all, and clinical recovery occurred in most patients. Tumor tissue obtained at operation stained positively for the gonadotropins, but was negative for other pituitary hormones in all patients. The most probable explanation for these findings was that the tumors were responsible for the elevated FSH secretion. This explanation is supported by the immunocytochemical identification of gonadotropin-containing cells in the tumors. We conclude that these 6 men frm a series of 40 patients who presented with pituitary tumor but no GH, PRL, or ACTH hypersecretion had primary gonadotropinomas. [less ▲]

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See detailA follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine.
Abs, R.; Beckers, Albert ULg; De Longueville, M.

in Journal of Endocrinological Investigation (1990), 13

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See detailFollicular dendritic cells act as accessory cells
Heinen, Ernst ULg; Cormann, N.; Lesage, F. et al

in Progress in Leukocyte Biology (1988), 7

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See detailFollicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.
Kranich, Jan; Krautler, Nike Julia; Heinen, Ernst ULg et al

in Journal of Experimental Medicine (2008), 205(6), 1293-302

The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis ... [more ▼]

The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis). Impairment of this process can contribute to autoimmunity. We show that Mfge8 is identical to the mouse follicular dendritic cell (FDC) marker FDC-M1. In bone-marrow chimeras between wild-type and Mfge8(-/-) mice, all splenic Mfge8 was derived from FDCs rather than TBMphis. However, Mfge8(-/-) TBMphis acquired and displayed Mfge8 only when embedded in Mfge8(+/+) stroma, or when situated in lymph nodes draining exogenous recombinant Mfge8. These findings indicate a licensing role for FDCs in TBMphi-mediated removal of excess B cells. Lymphotoxin-deficient mice lacked FDCs and splenic Mfge8, and suffer from autoimmunity similar to Mfge8(-/-) mice. Hence, FDCs facilitate TBMphi-mediated corpse removal, and their malfunction may be involved in autoimmunity. [less ▲]

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See detailFollicular Dendritic Cells Do Not Produce Tnf-Alpha nor its Receptor
Mancini, I.; Bosseloir, A.; Hooghe-Peters, E. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailFollicular dendritic cells in lymph nodes after x-irradiation.
Kinet-Denoel, C.; Heinen, Ernst ULg; Radoux, Dominique ULg et al

in International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine (1982), 42(2), 121-30

Follicular dendritic cells (FDC), non lymphoid cells present in lymph follicles, are characterized by numerous cytoplasmic processes retaining antigen-antibody complexes. Their origin, nature and function ... [more ▼]

Follicular dendritic cells (FDC), non lymphoid cells present in lymph follicles, are characterized by numerous cytoplasmic processes retaining antigen-antibody complexes. Their origin, nature and function are unknown. Mice inguinal lymph nodes after 4.5 or 7.5 Gy X-irradiation were depleted of lymphoid cells. Ultrastructural observations during the first few days post-irradiation show that FDC are unaltered and possess dendritic processes enveloping dense material. Furthermore, they show intense metabolic activity. A lamina densa, never observed so well-developed in other lymph node cells, was detected around the nuclear envelope. The localization of junctions between FDC was analysed. FDC preserve their typical cytoplasmic processes even if lymphoid cells are rare. The latter thus seem not to be responsible for the maintenance of FDC integrity or their development. The possible role of this for antibody production is discussed. Irradiated lymph nodes of lymphoid cells are highly convenient for studying FDC. Isolation of FDC from irradiated lymph organs would seem to be possible. [less ▲]

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See detailThe follicular dendritic cells in normal and pathological conditions
Heinen, Ernst ULg

Book published by Springer (1995)

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See detailFollicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells.
Tsunoda, R.; Heinen, Ernst ULg; Sugai, N.

in Cell & Tissue Research (2000), 299(3), 395-402

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular ... [more ▼]

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular dendritic cells (FDC) are capable of regulating the susceptibility to apoptosis of GC B cells, we constructed a GC model in vitro: emperipolesis of tonsillar B cells by FDC. We then analyzed the expressions of apoptosis-related proteins (Bcl-2 and Fas) on the cells by three-color flow cytometry. B cells nonentrapped by FDC decreased rapidly in number owing to early apoptosis in vitro, whereas entrapped B cells were rescued for at least 18 h and showed peculiar regulation of Fas and Bcl-2. GC founder cells (CD38+, IgD+; GCFC) and GC B cells (CD38+, IgD-) showed approximately a twofold increased expression of Fas; in contrast, mantle zone B cells (CD38-, IgD+) and memory B cells (CD38-, IgD-) showed no changes. Bcl-2 expression in mantle zone and memory B cells was reduced by approximately one-half; however, GCFC and GC B cells continued to express little Bcl-2 and this did not change. Our findings strongly suggest that FDC play a part in the modulation of the susceptibility to apoptosis on B cells within GC. [less ▲]

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See detailFollicular dendritic cells innervation within spleen of five mouse strains with different incubation periods after intraperitoneal BSE inoculation.
Demonceau, C.; Marshall, A.; Sales, J. et al

Poster (2005, February)

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See detailFollicular dendritic cells isolated from human tonsils.
Kinet-Denoel, C.; Heinen, Ernst ULg; Radoux, D. et al

in Advances in Experimental Medicine and Biology (1985), 186

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See detailFollicular dendritic cells related to nerve fibres and cellular prion protein expression in ileal and jejunal Peyer’s patches of cows and calves
Defaweux, Valérie ULg; Antoine, Nadine ULg; Dorban, G. et al

Poster (2005, February)

Prion pathogenesis following oral exposure is thought to involve gut-associated lymphoid tissue, which includes Peyer’s patches (PP). Before neuroinvasion, early accumulation of infectious prion protein ... [more ▼]

Prion pathogenesis following oral exposure is thought to involve gut-associated lymphoid tissue, which includes Peyer’s patches (PP). Before neuroinvasion, early accumulation of infectious prion protein (PrPsc) takes place on follicular dendritic cells (FDC) which are resident cells in germinal centres. The strain, the infection pathway and the lesions in the central nervous system are similar between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt Jakob diseases. But in BSE, the agent tropism differs from lymphoid organs. Only bovine ileal PP are infectious. In order to study the replication and the possible ways of neuroinvasion of PrPsc in bovine PP, we studies the expression of cellular prion protein (PrPc), necessary for PrPsc accumulation, and compared the innervation of germinal centres related to FDC on ileal and jejunal PP of cows and calves. We performed classical immunoperoxydase staining and double immunofluorescence staining analyzed with a confocal microscopy. Differences in the innervation of germinal centres and expression of PrPc were evident. More contacts between FDC and nerve fibres are observed in calves PP. PrPc expression, carried out with different anti-PrPc antibodies, highlighted a heterogeneous labelling between calves and cows PP. Such results permit us to show that the innervation of PP is a dynamic process which could influence the first way of neuroinvasion in prion diseases. Moreover differences in the affinity of some antibody for PrPc allow us to postulate that PrPc glycoforms differ with age of bovines and thus could interfere with PrPsc tropism. [less ▲]

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See detailFollicular dendritic cells: isolation procedures, short and long term cultures.
Heinen, Ernst ULg; Tsunoda, R.; Marcoty, C. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailFollicular Dendritic Cells: Origin and Function
Heinen, Ernst ULg; Bosseloir, A.; Bouzahzah, F.

in Current Topics in Microbiology and Immunology (1995), 201

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See detailFollicular dendritic cells: whose children?
Heinen, Ernst ULg; Bosseloir, A.

in Immunology Today (1994), 15(5), 201-4

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological ... [more ▼]

At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological conditions such as lymphoproliferative diseases and AIDS. Here, Ernst Heinen and Alain Bosseloir report on this fascinating field. [less ▲]

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See detailFollicular status and embryo production in Ouled Djellal (Algeria) ewes breed pretreated with a GnRH agonist
Gharbi, I; Ferrouk, M; Dechicha, A et al

in Asian Journal of Animal and Veterinary Advances (2012), 7(2), 117-127

Variability in ovulation rate and number of embryos in response to superovulation is the main limiting factor in small ruminants transfer programs. The objective of this study was to evaluate the ovarian ... [more ▼]

Variability in ovulation rate and number of embryos in response to superovulation is the main limiting factor in small ruminants transfer programs. The objective of this study was to evaluate the ovarian follicular status and in vivo embryo production in Ouled djellal ewes following a pre-treatment with a Gonadotropin Releasing Hormone (GnRH) agonist. Twenty (n = 20) cycling ewes were allotted into two groups, the first (n = 10) received subcutaneously a daily injection of 40 micrograms buserelin for 14 days prior to superovulatory treatment (pretreated group) while the second group (n = 10) did not receive GnRH agonist before superovulatory treatment (control group). Before batching, the ovarian follicular population was assessed by laparoscopy numbering of the ovarian follicles. In the pretreated ewes, a significant increase in small follicles (8.50±1.64 vs. 15.50±2.74, p<0.01) and a suppression of large follicles (≥4 mm) (4, 3±0.76 vs. 0.0, p<0.001) was observed after treatment with Buserelin. In addition to the pretreated group, the number of small follicles prior to porcine Follicle-Stimulating Hormone (pFSH) treatment was higher and the number of large follicles smaller than the control group. The ovulatory response and the number of transferable embryos per ewe treated was significantly higher in ewes pretreated than in control ewes (ovulatory response: 17,8±1,56 vs. 9,1±1,11; p<0.001) (transferable embryos: 10.2±1.87 vs. 4.1±0.40, p≤0.01). Compared to the pretreated group a higher percentage of degenerated embryos was recorded in the control group (control: 20.40 vs. 7.27 pretreated, p<0.05). The pre-treatment with a GnRHa to the superovulation protocol improve embryo production in Ouled Djellal ewes, in allowing the terminal follicular growth inhibition and increasing of small follicles number at the start of p FSH treatment. [less ▲]

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See detailFolliculogenèse et transplantation embryonnaire chez les ruminants
Beckers, Jean-François ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1989), 144(12), 607-620

In ruminant embryo transfer development, the limiting step remains the superovulation of the donor: using both PMSG and pituitary extracts, the superovulatory response is variable. In our research unit ... [more ▼]

In ruminant embryo transfer development, the limiting step remains the superovulation of the donor: using both PMSG and pituitary extracts, the superovulatory response is variable. In our research unit, FSH and LH were purified until homogeneity. Superovulatory treatment includes the administration of pure FSH the day following the preovulatory LH pulse and an administration of an LH/FSH mixture in the middle cycle. This biphasic of folliculogenesis allows superovulatroy response with more and higher embryos. [less ▲]

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