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See detailFracture prevention in osteoporosis: assessing risks, providing solutions.
Reginster, Jean-Yves ULg; Brandi, M. L.

in Osteoporosis International (2010), 21 Suppl 2

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See detailFracture prevention in postmenopausal women
Bruyère, Olivier ULg; Edwards, John; Reginster, Jean-Yves ULg

in Clinical Evidence (2005), 13

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See detailFracture prevention in postmenopausal women
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Clinical Evidence (2001), 6

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See detailFracture prevention in postmenopausal women.
Bruyère, Olivier ULg; Edwards, John; Reginster, Jean-Yves ULg

in Clinical Evidence (2002), 8

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See detailFracture prevention in postmenopausal women.
Bruyère, Olivier ULg; Edwards, John; Reginster, Jean-Yves ULg

in Clinical Evidence (2003), 9

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See detailFracture prevention. New topic
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Clinical Evidence (2000), 4

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See detailFracture risk and zoledronic acid therapy in men with osteoporosis
Boonen, S.; REGINSTER, Jean-Yves ULg; Kaufman, J.-M. et al

in New England Journal of Medicine (2012), 367(18), 1714-1723

BACKGROUND: Fractures in men are a major health issue, and data on the antifracture efficacy of therapies for osteoporosis in men are limited. We studied the effect of zoledronic acid on fracture risk ... [more ▼]

BACKGROUND: Fractures in men are a major health issue, and data on the antifracture efficacy of therapies for osteoporosis in men are limited. We studied the effect of zoledronic acid on fracture risk among men with osteoporosis. METHODS: In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1199 men with primary or hypogonadism-associated osteoporosis who were 50 to 85 years of age to receive an intravenous infusion of zoledronic acid (5 mg) or placebo at baseline and at 12 months. Participants received daily calcium and vitamin D supplementation. The primary end point was the proportion of participants with one or more new morphometric vertebral fractures over a period of 24 months. RESULTS: The rate of any new morphometric vertebral fracture was 1.6% in the zoledronic acid group and 4.9% in the placebo group over the 24-month period, representing a 67% risk reduction with zoledronic acid (relative risk, 0.33; 95% confidence interval, 0.16 to 0.70; P = 0.002). As compared with men who received placebo, men who received zoledronic acid had fewer moderate-to-severe vertebral fractures (P = 0.03) and less height loss (P = 0.002). Fewer participants who received zoledronic acid had clinical vertebral or nonvertebral fractures, although this difference did not reach significance because of the small number of fractures. Bone mineral density was higher and bone-turnover markers were lower in the men who received zoledronic acid (P<0.05 for both comparisons). Results were similar in men with low serum levels of total testosterone. The zoledronic acid and placebo groups did not differ significantly with respect to the incidence of death (2.6% and 2.9%, respectively) or serious adverse events (25.3% and 25.2%). CONCLUSIONS: Zoledronic acid treatment was associated with a significantly reduced risk of vertebral fracture among men with osteoporosis. (Funded by Novartis Pharma; ClinicalTrials.gov number, NCT00439647.) Copyright © 2012 Massachusetts Medical Society. [less ▲]

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See detailFracture risk in women ≥ 65 years with once-monthly oral bisphosphonate compared with weekly bisphosphonates: subanalysis from the evaluation of ibandronate efficacy (VIBE) database study.
Siverman, S.; Poston, S.; Blumenthals, W. et al

in Osteoporosis International (2009, March), 20(Suppl.1), 153

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See detailFracture risk reduction during treatment with teriparatide is independent of pretreatment bone turnover
Delmas, P. D.; Licata, A. A.; Reginster, Jean-Yves ULg et al

in BONE (2006), 39(2), 237-243

Introduction: Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. Methods: The primary purpose of this ... [more ▼]

Introduction: Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. Methods: The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absolute and relative fracture risks after adjusting for baseline femoral neck BMD, number of prevalent vertebral fractures, and age. Because femoral neck BMD is commonly attained in the assessment of patients at risk for osteoporosis, we examined the ability of a multivariate assessment including pretreatment BTM concentration and femoral neck BMD to predict future fracture risk after adjusting for the number of prevalent vertebral fractures. We examined data from the Fracture Prevention Trial, a study designed to determine the effect of teriparatide 20 mcg/day and teriparatide 40 mcg/day on vertebral and nonvertebral fracture risk in postmenopausal women with osteoporosis. BTM were analyzed in two subsets of women within the Fracture Prevention Trial, and included serum bone-specific alkaline phosphatase (BSAP), serum carboxyterminal extension peptide of procollagen type I (PICP), serum amino-terminal extension peptide of procollagen type I (PINP), urinary free deoxypyridinoline (DPD), and urinary N-terminal telopeptide (NTX). Results: Teriparatide significantly reduced the risk of fracture [four BTM subset (n = 520), placebo = 14.3%, teriparatide = 5.8%, P < 0.05; PINP subset (n = 771), placebo = 17.7%, teriparatide = 5.5%, P < 0.05]. Subjects with the highest pretreatment BTM concentrations had the greatest fracture risk. Teriparatide-mediated absolute risk reduction was greatest for women with high pretreatment bone turnover; however, the relative fracture risk reduction was independent of pretreatment bone turnover. After adjusting for pretreatment BTM and number of prevalent vertebral fractures, baseline femoral neck BMD was not a significant predictor of fracture risk. Conclusion: Teriparatide-mediated relative fracture risk reduction was independent of pretreatment bone turnover, demonstrating that this therapy offers clinical benefit to patients across a range of disease severity. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailThe fracture studies of polycrystalline silicon based MEMS
Mulay, Shantanu Shashikant ULg; Becker, Gauthier; Vayrette, Renaud et al

Scientific conference (2012, November 24)

The advantages of micro-electro-mechanical system (MEMS), such as low power requirement, miniature sizes and costs reduction, has already made significant impact in many technological fields. MEMS are now ... [more ▼]

The advantages of micro-electro-mechanical system (MEMS), such as low power requirement, miniature sizes and costs reduction, has already made significant impact in many technological fields. MEMS are now widely used as accelerometers, pressure sensors, and resonators. However, the determination of mechanical properties of MEMS devices with high accuracy is still a challenging task due to their miniature size. For example, the crystal size and orientation may have a significant effect on the fracture strength of MEMS microstructure. Among several important materials used for the development of MEMS devices, polycrystalline silicon plays a key role in various applications. Thus, an understanding of the relationship between poly-silicon manufacturing processes, and the resulting mechanical behaviour and durability of micro-fabricated structures is needed to allow rational design of MEMS devices. This work focuses on the modelling and simulation of the fracture of MEMS, made up of polycrystalline silicon, by discontinuous Galerkin (DG) formulation combined with an extrinsic cohesive law. The problem is solved as plane-stress type. All the elements are discontinuous in the DG method, and inter-element continuity is weakly enforced by having recourse to interface elements. When a fracture criterion is reached, an extrinsic cohesive law is activated on the already existing interface elements. The cracks can be initiated, merged or propagated, in this method. The fracture properties of material can be considered different along crystal interfaces and inside crystal bulk, and can account for crystal orientation. Moreover this method avoid drawbacks of usual cohesive method (no modification of the structure stiffness and no complex implementation in parallel) allowing for accurate large scale simulation. Polycrystalline silicon is an orthotropic material, i.e., it has different material properties, such as Young’s modulus, Poisson’s ratio, fracture strength, along different crystal lattice planes. These properties are also symmetric for a cubic crystal, i.e., the lattice planes perpendicular to each other have similar properties. This symmetric nature is well captured in the proposed work by a new formulation to compute effective fracture strength along any plane of interest based on the known values of the same along (1 0 0), (1 1 0), and (1 1 1) lattice planes. The effect of thickness of MEMS is also included by computing the effective stress on interface elements at different vertical angles. These formulations are analyzed by sample simulation results. The efficiency and accuracy of the method are assessed by experiments involving on-chip fracture tests, providing the fracture stress, and supplemented by the characterization of the test specimen. The characterization consists of the measurement of grain size and crystallographic orientation by electron back scattering diffraction, and the determination of crack path. An important point is the analysis of the competition between inter-granular versus trans-granular crack path with respect to the grain orientation. [less ▲]

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See detailThe fracture studies of polycrystalline silicon based MEMS
Mulay, Shantanu Shashikant ULg; Becker, Gauthier; Vayrette, Renaud et al

in EUROSIME 2013 (2013)

The advantages of micro-electro-mechanical systems (MEMS), such as low power requirement, miniaturized sizes and costs reduction, have already made significant impact in many technological fields. MEMS ... [more ▼]

The advantages of micro-electro-mechanical systems (MEMS), such as low power requirement, miniaturized sizes and costs reduction, have already made significant impact in many technological fields. MEMS are now widely used as accelerometers, pressure sensors, and resonators etc. However, the determination of the mechanical properties of MEMS devices with high accuracy is still a challenging task due to their small dimensions and often anisotropic behaviour. This paper focuses on the modelling and simulation of the fracture of a key MEMS component, which is a polycrystalline silicon beam, by discontinuous Galerkin (DG) formulation combined with an extrinsic cohesive law (ECL) to describe the fracture process. As the beam is modelled by plane-stress 2D elements, an analytical equation to compute the effective fracture strength and the effective critical strain energy release rate in terms of the through-the-thickness fracture mode and of the orientation of the facet with respect to the crystal is also developed. At the end, a model is simulated, and the results are verified as per the physics of the problem and experiments. [less ▲]

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See detailFractures de fatigue
Kaux, Jean-François ULg

Learning material (2014)

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See detailLes fractures de la base du crâne.
Martin, Didier ULg

Conference (2003, December 12)

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See detailFractures in osteoporosis: the challenge for the new millennium
Reginster, Jean-Yves ULg; Sarlet, Nathalie ULg; Lecart, Marie-Paule ULg

in Osteoporosis International (2005), 16(Suppl. 1), 1-3

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See detailFractures osseuses et ostéodensitométrie chez l'hémodialysé
Fontaine, Marie-Anne; Zandona, R; Geavlete, E et al

Conference (1995, December 04)

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See detailFractures vertébrales ostéoporotiques et raloxifène (Evista°).
Reginster, Jean-Yves ULg

in Patient Care (2004), 27

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See detailDie Frage nach der Identität: Uwe Johnson und Max Frisch
Letawe, Céline ULg

Conference (2006, October 02)

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See detailFragile Symbiose
Paques, Frédéric ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2006)

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See detailThe Fragile-X syndrome : what about the deficit in the pragmatic component ?
Comblain, Annick ULg; Elbouz, Mouna

in Journal of Cognitive Education and Psychology (2002), 2(3), 3-22

Language profile of fragile-X syndrome people looks like the one of Down syndrome people, except for phonological and pragmatic abilities. It's this last aspect that we want to study and describe. If the ... [more ▼]

Language profile of fragile-X syndrome people looks like the one of Down syndrome people, except for phonological and pragmatic abilities. It's this last aspect that we want to study and describe. If the pragmatic aspect of language is relatively preserve (excepting referential communication) in Down syndrome, it is one of the most impaired language component in fragile-X syndrome. Discourse of fragile-X persons generally contains a lot of repetitions, perseverations and stereotypy. Echolalia is also very frequent. These behaviors are well documented in the literature but, we do not know, for now, the reasons of these repetitions and perseverations. Are they the consequence of a real pragmatic disorder or the consequence of motor difficulties ? Another aspect of the pragmatic component of language remains almost unexplored in this pathology : the common ground management and the organisation of the old and the new information in conversation. It's this last point that we want to explore. Studying this topic in fragile-X syndrome allow is the continuity of our previous work on referential communication abilities in Down syndrome. Having data on both pathologies will lead to interesting theorical, practical and clinical comparisons. We decided to work with 6 to 12 years-old fragile-X boys. Groups of two boys will work together on referential communication tasks. We will propose traditional experimental situations (speaker and receptor with another child or with an adult) and more original situations in which we allow or not visual contact between the participants during the experimentation. By this, we want to see if, as certain researches claim it, visual contact will modify the nature, the quantity and the quality of verbal output in fragile-X syndrome children. [less ▲]

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See detailThe fragileX syndrome : What about the deficit innthe pragmatic component of language ?
Comblain, Annick ULg; Elbouz, Mouna

in Journal of Cognitive Education and Psychology (2002), 2(3), 29-58

Language profile of fragile-X syndrome individuals looks like the one of Down syndrome individuals, except for phonological and pragmatic abilities. If the pragmatic aspect of language is relatively ... [more ▼]

Language profile of fragile-X syndrome individuals looks like the one of Down syndrome individuals, except for phonological and pragmatic abilities. If the pragmatic aspect of language is relatively preserve in Down syndrome, it is one of the most impaired language component in fragile-X syndrome. Discourse of fragile X persons generally contains of repetitions, perseverations and stereotypies. These behaviors are well documented in the literature but, we do not know, for now, the reasons of these repetitions and perseverations. Are they the consequence of a real pragmatic disorder or the consequence of motor difficulties ? Another aspect of the pragmatic component of language remains almost unexplored in this pathology : the common ground management and the organization of the old and the new information in conversation. It is this last point that we want to explore. We decided to conduct a preliminary study with four fragile-X boys aged from 6 to 12 years-old. Groups of two boys work together on referential communication tasks. We proposed traditional experimental situations in a non-eye contact condition between participants. We compare the results of our subjects with those of typically developing children matched on the lexical age. Fragile-X boys are less efficient than typically developing children when the message to give or receive contains spatial terms or "ordinal" attributes. They also manage less efficiently with an incomplete message especially when it is given by an adult. [less ▲]

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