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See detailExtracellular amygdala taurine can be conditioned to stimuli associated with ethanol
Quertemont, Etienne ULg; de Neuville, Jessica; De Witte, Philippe

in Alcoholism, Clinical & Experimental Research (1996), 20

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See detailExtracellular catalase production by Aspergillus phoenicis.
Kacem-Chaouche, N.; Meraihi, Z.; Destain, Jacqueline ULg et al

Poster (2004, May)

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See detailThe extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species
Kumita, Janet R.; Poon, Stephen; Caddy, Gemma L. et al

in Journal of Molecular Biology (2007), 369

We have studied the effects of the extracellular molecular chaperone, clusterin, on the in vitro aggregation of mutational variants of human lysozyme, including one associated with familial amyloid ... [more ▼]

We have studied the effects of the extracellular molecular chaperone, clusterin, on the in vitro aggregation of mutational variants of human lysozyme, including one associated with familial amyloid disease. The aggregation of the amyloidogenic variant I56T is inhibited significantly at clusterin to lysozyme ratios as low as 1:80 (i.e. one clusterin molecule per 80 lysozyme molecules). Experiments indicate that under the conditions where inhibition of aggregation occurs, clusterin does not bind detectably to the native or fibrillar states of lysozyme, or to the monomeric transient intermediate known to be a key species in the aggregation reaction. Rather, it seems to interact with oligomeric species that are present at low concentrations during the lag (nucleation) phase of the aggregation reaction. This behavior suggests that clusterin, and perhaps other extracellular chaperones, could have a key role in curtailing the potentially pathogenic effects of the misfolding and aggregation of proteins that, like lysozyme, are secreted into the extracellular environment. [less ▲]

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See detailExtracellular enveloped vaccinia virus is resistant to complement because of incorporation of host complement control proteins into its envelope
Vanderplasschen, Alain ULg; Mathew, E.; Hollinshead, M. et al

in Proceedings of the National Academy of Sciences of the United States of America (1998), 95

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See detailExtracellular enveloped vaccinia virus. Entry, egress, and evasion
Smith, G. L.; Vanderplasschen, Alain ULg

in Advances in Experimental Medicine and Biology (1998), 440

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See detailExtracellular Matrix in Testicular Differentiation
Pelliniemi, L. J.; Paranko, J.; Grund, S. K. et al

in Annals of the New York Academy of Sciences (1984), 438

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See detailExtracellular matrix proteins and basement membrane identification in bovine ovaries and significance for the attachment of cultured preantral follicles
Figueiredo, J. R.; Hulshof, S. C. J.; Thiry, Marc ULg et al

in Theriogenology (1995), 43(5), 845-858

Described in the present paper is the immunolocalization of the extracellular matrix proteins (e.g., fibronectin, collagen Types I and III) in the bovine ovary, with special attention to preantral ... [more ▼]

Described in the present paper is the immunolocalization of the extracellular matrix proteins (e.g., fibronectin, collagen Types I and III) in the bovine ovary, with special attention to preantral follicles. In addition, we have shown, histochemically and ultrastructurally, that mechanically isolated bovine preantral follicles are surrounded by an intact basement membrane. After 24 h of culture in serum-free medium, only 20.4% of these follicles attached to a plastic substrate. We showed that covering the plastic with extracellular matrix proteins (i.e., fibronectin, collagen Type I and matrigel) significantly increased the percentage of attached follicles to 76.0, 65.2 and 80.4%, respectively, while laminin had no effect (18.6%). When preantral follicles were embedded within three-dimensional collagen gels, no loss of follicles was observed. Restoring surface interactions between preantral follicles and the extracellular matrix in vitro, either in a two- or a three-dimensional system, might be important for maintaining follicular viability and growth in the future. [less ▲]

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See detailExtracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression.
Tennenbaum, T.; Yuspa, S. H.; Grover, A. et al

in Cancer Research (1992), 52(10), 2966-76

Interaction of cells with the basement membrane is important for cell proliferation and differentiation. Disruption of the basement membrane is an early event during progression of benign tumors to cancer ... [more ▼]

Interaction of cells with the basement membrane is important for cell proliferation and differentiation. Disruption of the basement membrane is an early event during progression of benign tumors to cancer. Using the techniques of immunohistochemistry and immunofluorescence, we show that cell-matrix interactions via the cell surface integrin receptors alpha 3 beta 1, alpha 5 beta 1, alpha 6 beta 4, the Mr 67,000 laminin receptor (67LR) laminin-binding protein, and the secreted matrix protein laminin are strictly regulated during differentiation of mouse epidermis. While alpha 6 beta 4 and alpha 5 beta 1 are polarized to the basal surface of basal cells in contact with the basement membrane, alpha 3 beta 1 and the non-integrin 67LR are primarily detected in the cell periphery of suprabasal cells, where cell to cell contacts are found. Sequential changes in expression of matrix receptors occur following multistage carcinogenesis of mouse skin. In an analysis of benign and malignant skin tumors induced by chemical carcinogens or oncogene transduction, we found that alpha 3 beta 1 and alpha 5 beta 1 as well as the non-integrin 67LR are sequentially down-regulated in the progression from benign to malignant, while alpha 6 beta 4 is the predominant receptor expressed in the carcinomas. Tumor expression of alpha 6 beta 4 is not polarized and is dissociated from its colocalized normal partner bullous pemphigoid antigen, which remains restricted to the basement membrane. The changes in matrix receptors are linked to appearance of keratin 13 in suprabasal regions, but always in alpha 6 beta 4 negative cells. The predominance of alpha 6 beta 4 in the proliferating cells during progression is associated with decreased expression of keratin 13 in carcinomas. These results suggest that matrix interactions with its receptors are important determinants of ordered differentiation in normal skin and show characteristic alterations during carcinogenesis that parallel changes in differentiation of the tumors. [less ▲]

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

in Frontiers in Plant Science (2015), 6(37),

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]

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See detailExtracellular, penicillin-resistant DD-carboxypeptidase from Streptomyces SP [abstract]
Leyh-Bouille, Mélina; Ghuysen, Jean-Marie ULg; Bonaly, R. et al

in Xe Congresso Internacional de Microbiologica - Resumenes - abstracts - résumés (1970)

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See detailExtracting a common high frequency signal from Northern Quebec black spruce tree-rings with a Bayesian hierarchical model
Boreux, Jean-Jacques ULg; Naveau, P.; Guin, O. et al

in Climate of the Past (2009), 5

One basic premise of dendroclimatology is that tree rings can be viewed as climate proxies, i.e. rings are assumed to contain some hidden information about past climate. From a statistical perspective ... [more ▼]

One basic premise of dendroclimatology is that tree rings can be viewed as climate proxies, i.e. rings are assumed to contain some hidden information about past climate. From a statistical perspective, this extraction problem can be understood as the search of a hidden variable which represents the common signal within a collection of tree-ring width series. Classical average-based techniques used in dendrochronology have been applied to estimate the mean behavior of this latent variable. Still, depending on tree species, regional factors and statistical methods, a precise quantification of uncertainties associated to the hidden variable distribution is difficult to assess. To model the error propagation throughout the extraction procedure, we propose and study a Bayesian hierarchical model that focuses on extracting an inter-annual high frequency signal. Our method is applied to black spruce (Picea mariana) tree-rings recorded in Northern Quebec and compared to a classical average-based techniques used by dendrochronologists. [less ▲]

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See detailExtracting explicit and implicit causal relations from sparse, domain-specific texts
Ittoo, Ashwin ULg; Bouma, Gosse

in Lecture Notes in Computer Science (2011)

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See detailExtracting high resolution records of deformation from well-imaged sections
Suppe, J; Gonzalez-Mieres, R; Hubert, Aurelia ULg

in Abstracts with Programs - Geological Society of America (2006, October), 38(7), 132

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See detailExtracting Intra-Domain Topology from mrinfo Probing
Pansiot, Jean-Jacques; Mérindol, Pascal; Donnet, Benoît ULg et al

in 11th international Conference on Passive and active Measurement (2010, April)

Activeandpassivemeasurementsfortopologydiscoveryhave known an impressive growth during the last decade. If a lot of work has been done regarding inter-domain topology discovery and modeling, only a few ... [more ▼]

Activeandpassivemeasurementsfortopologydiscoveryhave known an impressive growth during the last decade. If a lot of work has been done regarding inter-domain topology discovery and modeling, only a few papers raise the question of how to extract intra-domain topologies from measurements results. In this paper, based on a large dataset collected with mrinfo, a multicast tool that silently discovers all interfaces of a router, we provide a mechanism for retrieving intra-domain topologies. The main challenge is to assign an AS number to a border router whose IP addresses are not mapped to the same AS. Our algorithm is based on probabilistic and empirical IP allocation rules. The goal of our pool of rules is to converge to a consistent router to AS mapping. We show that our router-to-AS algorithm results in a mapping in more than 99% of the cases. Furthermore, with mrinfo, point-to-point links between routers can be distinguished from multiple links attached to a switch, providing an accurate view of the collected topologies. Finally, we provide a set of large intra-domain topologies in various formats. [less ▲]

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See detailExtracting laws of decay in the femto-picosecond range from autocorrelation functions
Remacle, Françoise ULg; Desouter, Michèle ULg; Lorquet, Jean-Claude

in Journal of Chemical Physics (1989), 91

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See detailExtracting Meronymy Relationships from Domain-Specific, Textual Corporate Databases
Ittoo, Ashwin ULg; Bouma, Gosse; Maruster, Laura et al

in Lecture Notes in Computer Science (2010)

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See detailExtraction and characterisation of a dietary fibre concentrate from date pulp
Roiseux, O.; Blecker, Christophe ULg; Besbes, S. et al

Poster (2006, June)

Detailed reference viewed: 15 (2 ULg)