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See detailEffects of culture conditions on the synthesis of human chorionic gonadotropin by placental organ cultures.
Huot, R. I.; Foidart, Jean-Michel ULiege; Stromberg, K.

in In Vitro (1979), 15(7), 497-502

Culture conditions for maintaining first trimester human placenta in organ culture, which enhance the secretion of human chorionic gonadotropin (hCG), are described. Nutrient medium, oxygen tension and ... [more ▼]

Culture conditions for maintaining first trimester human placenta in organ culture, which enhance the secretion of human chorionic gonadotropin (hCG), are described. Nutrient medium, oxygen tension and Gelfoam support matrix influence the synthesis of hCG by these cultures. Placental tissue remained viable for the duration of experiments (12 days) as judged by the incorporation of tritiated thymidine into DNA and the lack of release of incorporated [125I]iododeoxyuridine. Optimal conditions for hCG synthesis in placental organ culture included an atmosphere of 95% air and 5% Co2 (approximately 20% O2), CMRL 1066 medium containing fetal human or bovine serum, insulin, hydrocortisone and retinal acetate. Multiple pieces of placenta could be cultured in the same dish with an additive effect on hCG secretion. The functional responsiveness of these placental cultures was demonstrated by modulation of hCG synthesis with theophylline and 3'5' dibutyryl cyclic AMP. [less ▲]

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See detailEffects of curing sodium nitrite additive and natural meat fat on growth control of Listeria monocytogenes by the bacteriocin-producing Lactobacillus curvatus strain CWBI-B28.
Kouakou, P.; Ghalfi, H.; Destain, Jacqueline ULiege et al

in Food Microbiology (2009), 26

In realistic model meat systems, the separate and combined effects of fat content and sodium nitrite on the antilisterial activity of the bacteriocin of Lactobacillus curvatus CWBI-B28 were studied. In ... [more ▼]

In realistic model meat systems, the separate and combined effects of fat content and sodium nitrite on the antilisterial activity of the bacteriocin of Lactobacillus curvatus CWBI-B28 were studied. In laboratory fermentations where Listeria monocytogenes was co-cultured at 4 C with bacteriocin-producing CWBIB28 in lean pork meat (fat content: 13%) without added nitrite, a strong antilisterial effect was observed after one week. The effect was maintained for an additional week, after which a slight and very gradual rebound was observed. Both added nitrite (20 ppm) and a high-fat content (43%) were found to antagonise this antilisterial effect, the Listeria cfu count reached after six weeks being 200 times as high in high-fat meat with added nitrite than in lean meat without nitrite. This antagonism could not be attributed to slower growth of the bacteriocin-producing strain, since CWBI-B28 grew optimally in fatrich meat with 20 ppm sodium nitrite. Bacteriocin activity was also measured in the samples. The observed activity levels are discussed in relation to the degree of antilisterial protection conferred [less ▲]

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See detailEffects of cyanamide and acetaldehyde accumulation on the locomotor stimulant and sedative effects of ethanol in mice
Tambour, Sophie ULiege; Closon, Catherine; Tirelli, Ezio ULiege et al

in Behavioural Pharmacology (2007), 18(8), 777-784

Ethanol administration induces both locomotor stimulant and sedative effects depending upon blood ethanol concentrations. Recent studies in rats and mice suggest that acetaldehyde, the first product of ... [more ▼]

Ethanol administration induces both locomotor stimulant and sedative effects depending upon blood ethanol concentrations. Recent studies in rats and mice suggest that acetaldehyde, the first product of ethanol metabolism, might be involved in the expression of both the stimulant and the sedative effects of ethanol. A number of studies have used the drug cyanamide in an attempt to clarify the role of acetaldehyde in the behavioral effects of ethanol. The results of such studies are, however, difficult to interpret because cyanamide is an inhibitor of the enzymes catalase and aldehyde dehydrogenase, two enzymes with opposite effects on brain acetaldehyde concentrations. This study was aimed at clarifying the effects of cyanamide on ethanol-induced locomotor stimulant and sedative effects in Swiss mice. The locomotor stimulant effects of ethanol were measured in standard activity boxes, whereas the sedative effects of ethanol were quantified using the loss of righting reflex procedure. Cyanamide prevented the locomotor stimulant effects of 2 g/kg ethanol, although this was mainly due to a potentiation of the inhibitory effects of ethanol as evidenced by a prolongation of ethanol-induced loss of righting reflex. Additionally, 4-methylpyrazole, an inhibitor of the enzyme alcohol dehydrogenase, prevented these effects of cyanamide. It is concluded that in vivo the effects of cyanamide are predominantly due to the inhibition of the enzyme aldehyde dehydrogenase, rather than to its effects on catalase. [less ▲]

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See detailEffects of cyproterone acetate and vertically-transmitted microsporidia parasite on Gammarus pulex sperm production
Gismondi, Eric ULiege; Fivet, Adeline ULiege; Joaquim-Justo, Célia ULiege

in Environmental Science and Pollution Research (2017), 24(29), 2341723421

Endocrine disruption compounds (EDCs) and parasitism can both interfere with the reproduction process of organisms. The amphipod Gammarus pulex is the host of the vertically transmitted microsporidia ... [more ▼]

Endocrine disruption compounds (EDCs) and parasitism can both interfere with the reproduction process of organisms. The amphipod Gammarus pulex is the host of the vertically transmitted microsporidia Dictyocoela duebenum, and this work was devoted to the investigation of the effect of an exposure to the anti-androgen compound, cyproterone acetate (CPA), and/or of the presence of D. duebenum on the spermatozoa production and length. Significant reduction of the spermatozoa production was observed when G. pulex males were uninfected and exposed to CPA. There also appeared a lower number of spermatozoa when D. duebenum infects G. pulex, whatever the exposure condition. Moreover, we highlighted that CPA has no effect on spermatozoa production when males are infected by D. duebenum, and no treatment has impacted the spermatozoa length. Our results suggest CPA and D. duebenum could impact the endocrine system of G. pulex and especially processes close to the spermatozoa production (e.g., androgenic gland, androgen gland hormone released, gonad-inhibiting hormone synthesized by X-organ). However, as no mechanism of action was highlighted, further testing need to be performed to improve the understanding of their impacts. Finally, results confirm that vertically transmitted microsporidia could be a confounding factor in the endocrine disruption assessments in Gammaridae. [less ▲]

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See detailEffects of Dairy Products Consumption on Health: Benefits and Beliefs-A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases.
Rozenberg, Serge; Body, Jean-Jacques; Bruyère, Olivier ULiege et al

in Calcified Tissue International (2016), 98(1), 1-17

Dairy products provide a package of essential nutrients that is difficult to obtain in low-dairy or dairy-free diets, and for many people it is not possible to achieve recommended daily calcium intakes ... [more ▼]

Dairy products provide a package of essential nutrients that is difficult to obtain in low-dairy or dairy-free diets, and for many people it is not possible to achieve recommended daily calcium intakes with a dairy-free diet. Despite the established benefits for bone health, some people avoid dairy in their diet due to beliefs that dairy may be detrimental to health, especially in those with weight management issues, lactose intolerance, osteoarthritis, rheumatoid arthritis, or trying to avoid cardiovascular disease. This review provides information for health professionals to enable them to help their patients make informed decisions about consuming dairy products as part of a balanced diet. There may be a weak association between dairy consumption and a possible small weight reduction, with decreases in fat mass and waist circumference and increases in lean body mass. Lactose intolerant individuals may not need to completely eliminate dairy products from their diet, as both yogurt and hard cheese are well tolerated. Among people with arthritis, there is no evidence for a benefit to avoid dairy consumption. Dairy products do not increase the risk of cardiovascular disease, particularly if low fat. Intake of up to three servings of dairy products per day appears to be safe and may confer a favourable benefit with regard to bone health. [less ▲]

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See detailEffects of dark atom excitations
Cudell, Jean-René ULiege; Khlopov, Maxim; Wallemacq, Quentin ULiege

in Modern Physics Letters A (2014), 29

New stable quarks and charged leptons may exist and be hidden from detection, as they are bound by Coulomb interaction in neutral dark atoms of composite dark matter. This possibility leads to ... [more ▼]

New stable quarks and charged leptons may exist and be hidden from detection, as they are bound by Coulomb interaction in neutral dark atoms of composite dark matter. This possibility leads to fundamentally new types of indirect effects related to the excitation of such dark atoms followed by their electromagnetic de-excitation. Stable -2 charged particles, bound to primordial helium in O-helium (OHe) atoms, represent the simplest model of dark atoms. Here we consider the structure of OHe atomic levels which is a necessary input for the indirect tests of such composite dark matter scenarios, and we give the spectrum of electromagnetic transitions from the levels excited in OHe collisions. [less ▲]

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See detailThe effects of daylength and light intensiy on the reproductive development of Lolium temulentum
Périlleux, Claire ULiege; Kinet, Jean-Marie; Bernier, Georges ULiege

in Archives internationales de Physiologie et de Biochimie (1988), 96

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See detailEffects of defatting combined or not to heating of Jatropha curcas kernel meal on feed intake and growth performance in broiler chickens and chicks in Senegal
Nesseim, Thierry ULiege; Dieng, Abdoulaye; Mergeai, Guy ULiege et al

in Tropicultura (2017), 35(3), 149-157

Jatropha curcas is a tropical drought-resistant plant belonging to the Euphorbiaceae family that has gained importance for the production of biodiesel. The kernel of the seed contains approximately 55 ... [more ▼]

Jatropha curcas is a tropical drought-resistant plant belonging to the Euphorbiaceae family that has gained importance for the production of biodiesel. The kernel of the seed contains approximately 55% lipid in dry matter and the meal obtained could be an exceptional source of protein for family poultry farming, after treatments to remove toxic and anti-nutritional compounds. The ingestion and the growth performance of J. curcas kernel meal (JKM), obtained after partial physico chemical de-oiling combined or not with heating was evaluated in broiler chickens and chicks. Sixty unsexed broiler chickens, 30 day-old, divided into three groups as well as twenty broiler chicks, 1 day-old, divided into two groups were obtained for two experiments. In experiment 1, jatropha kernel was de-oiled and incorporated into a control fattening feed at 40 and 80g/kg (diets 4JKM1 and 8JM1). In experiment 2, jatropha kernel meal obtained in experiment 1 was heat treated and incorporated into a growing diet at 80g/kg (diet 8JKM2). Daily dietary intakes as well as weight gain of the animals were affected by the incorporation of jatropha kernel meal in the ration. In experiment 1, average daily feed intake (ADFI1) of 139.2, 55.2 and 23.4g/day/animal and also average daily weight gain (ADWG1) of 61.9, 18.5 and -7.7g/animal were obtained respectively for the groups fed with diets 0JKM1, 4JKM1 and 8JKM1. In experiment 2, Average daily feed intake (ADFI2) of 18.7 and 3.1g/day/animal and also average daily weight gain (ADWG2) of 7.1 and 1.9g/animal were obtained respectively for the groups fed with diets 0JKM2 and 8JKM2. In both experiment, feed conversion ratio (FCR) was also affected by the dietary treatments and the overall mortality rate showed an increase according to levels of jatropha kernel meal in diet. Keywords: broiler chickens, broiler chicks, Jatropha curcas, ingestion, growth performance [less ▲]

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See detailEffects of delayed introduction of calcineurin inhibitor on GFR in liver transplant: 12 month data from a multi-centre randomised controlled study
Pirenne, J.; Boon, N.; Colle, I. et al

in Acta Gastro-Enterologica Belgica (2009, January), 72(1), 30

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See detailEffects of desert dust on air quality and human health. What do we know about West Africa compared to other regions?
De Longueville, Florence ULiege; Henry, Sabine; Ozer, Pierre ULiege

Conference (2009, February 24)

The main source of atmospheric mineral dust is the Sahara and its desertified margins that produce about half of the yearly global mineral dust. Saharan dust is often transported far away to the sources ... [more ▼]

The main source of atmospheric mineral dust is the Sahara and its desertified margins that produce about half of the yearly global mineral dust. Saharan dust is often transported far away to the sources and causes air quality deterioration impacting northwards the Mediterranean and Europe, westwards crossing the Atlantic Ocean to the United States, the Caribbean and South America, and southwards to the Gulf of Guinea. Saharan dust storms can lead to particulate levels that exceed internationally recommended levels and transport allergens, including bacteria and fungi. Therefore special attention is paid to dust storms as such mineral particulate matter air pollution may be a serious health threat in various regions of the world because it may promote respiratory infection, cardiovascular disease and other ailments. [less ▲]

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See detailEffects of design and kinematic parameters of rotary cultivators on soil structure
Destain, Marie-France ULiege; Houmy, K.

in Soil & Tillage Research (1990), 17(3-4), 291-301

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary ... [more ▼]

In comparison with drawn implements, rotary cultivators are of particular interest in final seedbed preparation. In this paper, a quantitative basis for the description of soil structure created by rotary tillers is given. Undisturbed Ap horizon samples were collected, impregnated with polyester resin, sectioned by sawing and analysed by means of image analysis. Total porosity, area and size of pores are related to the design and kinematic parameters of the rotary cultivator, arising from an analysis based upon the location of instant centres of velocity. It is shown that using a rotary cultivator with a higher ratio of peripheral to forward velocity leads to a smaller total mean porosity which is more homogeneous. [less ▲]

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See detailEffects of Dexamethasone on the Profile of Cytokine Secretion in Human Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULiege; Dewé, Walthère ULiege et al

in Regulatory Peptides (1998), 73(1), 59-65

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit ... [more ▼]

EXPERIMENTAL OBJECTIVES: The interaction between the endocrine and immune systems is a very intriguing area. Endogenous glucocorticoids, as end-effectors of the hypothalamo-pituitary-adrenal axis, inhibit the immune and inflammatory responses and are used as immunosuppressive drugs in many inflammatory, autoimmune and allergic diseases. The aims of this study were to investigate the effects of dexamethasone on the profile of cytokine secretion in whole blood cell cultures from healthy subjects and to analyse the gender-related sensitivity to dexamethasone on each cytokine secretion. RESULTS: There was a significant inhibition by dexamethasone (from 1 to 100 nM) on the secretion of monokines (IL-1beta, IL-6, IL-8 and TNF alpha) and lymphokines (IL-2, IL-4, IL-10 and IFN gamma), either after LPS or PHA stimulation (P < 0.01). Interleukin 4 and IL-10 were less inhibited than IFN gamma (P < 0.05 at 1 nM, P < 0.01 at 10 nM and P < 0.001 from 100 nM to 10 microM). No gender difference was observed in the rate of inhibition of the secretion of each cytokine. CONCLUSION: This study shows that the inhibition of cytokine secretion by dexamethasone is more marked on Th1-type cytokines than on Th2-type cytokines. These data support the idea that glucocorticoids may induce a shift from the Th1 to Th2 profile of cytokine secretion. [less ▲]

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See detailEffects of dexamethasone treatment on growth performances, sexual axis and hormonal status in finishing bulls
Renaville, Robert ULiege; Massart, Serge; Devolder, Anne et al

Poster (1993)

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See detailEffects of dexamethasone treatment on growth performances, sexual axis and hormonal status in finishing bulls
Renaville, Robert ULiege; Massart, Serge; Devolder, Anne et al

in Journal of Animal Science (1993), 71(suppl 1), 232

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See detailEffects of diazoxide, benzothiadiazine and benzopyrane derivatives on mitochondrial proton and electron leaks of cardiomyocytes (H9C2 cell line).
Mouithys-Mickalad, Ange ULiege; Ceusters, Justine ULiege; Charef, M et al

Poster (2013)

Background: Mitochondria are double membrane- organelles that play a central role in cellular metabolism, calcium homeostasis and redox signaling. They have been also considered as main producers of ... [more ▼]

Background: Mitochondria are double membrane- organelles that play a central role in cellular metabolism, calcium homeostasis and redox signaling. They have been also considered as main producers of adenosine triphosphate (ATP) and reactive oxygen species (ROS). In many cancer cells those organelles become dysfunctional leading to a shift of energy metabolism from oxidative phosphorylation to active glycolysis and an increase of ROS generation. According to Warberg’ theory, cancer damage might occur at the mitochondrial level, affecting tiny structures within each cell implicated in the energy production through ATP. New insight is that mitochondria might be a good therapeutic target for metabolic syndromes, ischemia/reperfusion injury and organs transplantation. Therefore, search for novel molecules able to keep mitochondria functional are of relevant interest. Methodology: Cardiomyocytes (H9C2 cells) were from ATCC (USA) and grown till confluence. The basal cellular respiratory rate, proton and electron leaks as well as ATP production were measured with the High Resolution Oxygraphy (Oroboros, Austria). All compounds: diazoxide (DIAZ), diazoxide –related analogs (1: BPDZ-259, 2: BPDZ-444), and benzopyran derivatives (3: BPDZ-490, 4: BPDZ-711) were tested at final concentration of 10-5 M, except when specified and compared to control samples (cells with or without DMSO). Results and conclusion: The basal respiratory rate of H9C2 cells (5x106/mL) was changed depending on the chemical structure of the tested compounds: e.g. compound 3 strongly enhanced the routine respiration, while 4 displayed a marked lowering effect. In contrast, the addition of similar concentration of benzothiadiazin derivatives (1, 2) had no effect on routine respiration but also on the other respiratory parameters such as oligomycin-induced leak and ATP production. Similar profile was obtained with the reference molecule: diazoxide. Overall, our findings indicate that both diazoxide-like analogues (1 and 2) and diazoxide were without significant effect on basal respiration, ATP production, even on maximal respiration. Interestingly, two derivatives show opposite effects: compound 3 behaves as a uncoupling agent and the other one (4) exhibits a real lowering effect on respiration but that was reversible. The latter effect might be of interest if this kind of molecules could be used for further use as an agent for organ conservation during transplantation. Our results also demonstrate that diazoxide, a well-known Mito-KATP opener, did not exert its effect beside of clinical situation like ischemia/reperfusion injury. [less ▲]

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See detailEffects of dibutyryl cyclic AMP on cultured brain cells from chick embryos of different ages.
Moonen, Gustave ULiege; Sensenbrenner, M.

in Experientia (1976), 32(1), 40-42

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See detailEffects of dietary A-lipoic-acid on feed intake and hypothalamic AMPK activity of young broiler chicks
Wang, Y.; Willems, E.; Franssens, L et al

in Proceedings of the 6th Combined Workshop on Fundamental Physiology and Perinatal Development in Poultry (2013)

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See detailEffects of dietary carbohydrate composition on rumen fermentation, plasma hormone and metabolites in growing fattening bull
Van Eenaeme, Christian ULiege; Istasse, Louis ULiege; Gabriel, Annick ULiege et al

in Animal Production (1990), 50

A finishing diet containing barley and sugarbeet pulp 500:200 or 200:500 g/kg was given to 12 bulls twice daily at 08.00 and 16.00 h. The high-pulp diet increased rumen acetic and butyric acids and ... [more ▼]

A finishing diet containing barley and sugarbeet pulp 500:200 or 200:500 g/kg was given to 12 bulls twice daily at 08.00 and 16.00 h. The high-pulp diet increased rumen acetic and butyric acids and decreased propionic acid compared with the high-barley diet. The diurnal patterns over a 24-h period of rumen pH, volatile fatty acids, glucose and ammonia were characterized by 2 cycles. The high-pulp induced more even fermentations as indicated by flatter curves with less extreme values than those produced by high-barley diet. Ammonia concentration was high before feeding and decreased subsequently during 4 to 6 h after the meal. No typical patterns were observed in plasma concentrations of glucose and alpha-amino nitrogen. Plasma urea concentration increased 2 h after feeding and dropped during the following 6 to 8 h. There were no effects of dietary carbohydrate composition on growth hormone concentration but plasma insulin was significantly reduced with the high-pulp diet. Furthermore, the insulin profile showed peaks after each meal with the high-barley diet but only after the afternoon feeding with the high-pulp diet. [less ▲]

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