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See detailEORTC Radiation Oncology Group quality assurance platform: Establishment of a digital central review facility
Fairchild, A.; Aird, E.; Fenton, P. A. et al

in Radiotherapy & Oncology (2012), 103(3), 279-286

Objective: Quality assurance (QA) in clinical trials is essential to ensure treatment is safely and effectively delivered. As QA requirements have increased in complexity in parallel with evolution of ... [more ▼]

Objective: Quality assurance (QA) in clinical trials is essential to ensure treatment is safely and effectively delivered. As QA requirements have increased in complexity in parallel with evolution of radiation therapy (RT) delivery, a need to facilitate digital data exchange emerged. Our objective is to present the platform developed for the integration and standardization of QART activities across all EORTC trials involving RT. Methods: The following essential requirements were identified: secure and easy access without on-site software installation; integration within the existing EORTC clinical remote data capture system; and the ability to both customize the platform to specific studies and adapt to future needs. After retrospective testing within several clinical trials, the platform was introduced in phases to participating sites and QART study reviewers. Results: The resulting QA platform, integrating RT analysis software installed at EORTC Headquarters, permits timely, secure, and fully digital central DICOM-RT based data review. Participating sites submit data through a standard secure upload webpage. Supplemental information is submitted in parallel through web-based forms. An internal quality check by the QART office verifies data consistency, formatting, and anonymization. QART reviewers have remote access through a terminal server. Reviewers evaluate submissions for protocol compliance through an online evaluation matrix. Comments are collected by the coordinating centre and institutions are informed of the results. Conclusions: This web-based central review platform facilitates rapid, extensive, and prospective QART review. This reduces the risk that trial outcomes are compromised through inadequate radiotherapy and facilitates correlation of results with clinical outcomes. © 2012 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailEORTC-ROG expert opinion: Radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach
Matzinger, O.; Gerber, E.; Bernstein, Z. et al

in Radiotherapy & Oncology (2009), 92(2), 164-175

Purpose: The Gastro-Intestinal Working Party of the EORTC Radiation Oncology Group (GIWP-ROG) developed guidelines for target volume definition in neoadjuvant radiation of adenocarcinomas of the ... [more ▼]

Purpose: The Gastro-Intestinal Working Party of the EORTC Radiation Oncology Group (GIWP-ROG) developed guidelines for target volume definition in neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction (GEJ) and the stomach. Methods and materials: Guidelines about the definition of the clinical target volume (CTV) are based on a systematic literature review of the location and frequency of local recurrences and lymph node involvement in adenocarcinomas of the GEJ and the stomach. Therefore, MEDLINE was searched up to August 2008. Guidelines concerning prescription, planning and treatment delivery are based on a consensus between the members of the GIWP-ROG. Results: In order to support a curative resection of GEJ and gastric cancer, an individualized preoperative treatment volume based on tumour location has to include the primary tumour and the draining regional lymph nodes area. Therefore we recommend to use the 2nd English Edition of the Japanese Classification of Gastric Carcinoma of the Japanese Gastric Cancer Association which developed the concept of assigning tumours of the GEJ and the stomach to anatomically defined sub-sites corresponding respectively to a distinct lymphatic spread pattern. Conclusion: The GIWP-ROG defined guidelines for preoperative irradiation of adenocarcinomas of the GEJ and the stomach to reduce variability in the framework of future clinical trials. © 2009 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailEosiniphilic bronchopulmonary disease in dogs (EBP): a clinical analysis of 25 cases.
Clercx, Cécile ULg; Snaps, Frédéric ULg; Peeters, Dominique ULg et al

in Proceedings of the 8th Annual Congress of the ESVIM (1998)

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See detailEosinophile Bronchopneumonie
Clercx, Cécile ULg

in Proceedings of the 34. Internationaler Fortbildungskurs Kleintierkrankheiten : “Thorax – Herz- und Lungenerkrankungen" - Flims -Switzerland (2013, February)

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See detailEosinophilic Bronchopneumopathy
Clercx, Cécile ULg

in Proceedings 35 Internationaler Fortbildungskurs Kleintierkrankheiten (2014)

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See detailEosinophilic Bronchopneumopathy in Dogs
Clercx, Cécile ULg; Peeters, Dominique ULg; Snaps, Frédéric ULg et al

in Journal of Veterinary Internal Medicine (2000), 14(3, May-Jun), 282-91

Eosinophilic bronchopneumopathy was diagnosed in 23 young dogs. Clinical signs included cough, gagging, and retching in all dogs, dyspnea in 21 dogs (91%), and nasal discharge in 12 dogs (52%). The most ... [more ▼]

Eosinophilic bronchopneumopathy was diagnosed in 23 young dogs. Clinical signs included cough, gagging, and retching in all dogs, dyspnea in 21 dogs (91%), and nasal discharge in 12 dogs (52%). The most common radiographic findings were a moderate to severe bronchointerstitial pattern (68%, 13 of 19 dogs). Bronchoscopic findings included the presence of abundant yellow-green mucus or mucopurulent material (70%, 16 of 23 dogs) and severe mucosal thickening with an irregular or polypoid appearance (52%, 12 of 23 dogs), with partial airway closure during expiration in 3 dogs (13%). Peripheral blood eosinophilia was noted in 14 of 23 dogs (61%). Inflammatory cells in brush or bronchoalveolar lavage fluid cytologic preparations comprised more than 50% eosinophils in 14 of 23 dogs (61%), and 20-50% eosinophils in 6 dogs (26%). Eosinophilic infiltration of the bronchial mucosa was observed in biopsies from 19 dogs and was graded as mild (37%, 7 dogs), moderate (32%, 6 dogs), or severe (32%, 6 dogs). The mean serum immunoglobulin A concentration was almost double that of a population of 20 healthy dogs of various breeds. Oral glucocorticoids were administered on alternate days with progressive tapering of the dose; the dosage at maintenance varied between 0.1 and 1.0 mg/kg every other day. No relationship was found between the duration of clinical signs and the maintenance dosage or the cytologic and histopathologic grades. [less ▲]

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See detailEosinophilic bronchopulmonary disease in dogs : clinical characteristics, treatment and follow-up
Clercx, Cécile ULg

in 15th Veterinary Respiratory Symposium - Liège - Belgique (1997)

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See detaileosinophilic esophagitis
Leclercq, Philippe ULg; Marting, Audrey; Gast, Pierrette ULg

in New England Journal of Medicine [=NEJM] (2007), 357(14),

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See detailEosinophilic pulmonary diseases
Clercx, Cécile ULg; Peeters, Dominique ULg

in Bonagura, John; Twedt, David (Eds.) Kirk's Current Veterinary Therapy (2014)

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See detailEotaxin polymorphisms and serum total IgE levels in children with asthma
Raby, B. A.; Van Steen, Kristel ULg; Lazarus, R. et al

in Journal of Allergy and Clinical Immunology (The) (2006), 117(2), 298-305

BACKGROUND: Eotaxin (chemokine, CC motif, ligand; CCL11) is a potent eosinophil chemoattractant strongly implicated in the pathobiology of asthma. Genetic variation at the CCL11 locus has been correlated ... [more ▼]

BACKGROUND: Eotaxin (chemokine, CC motif, ligand; CCL11) is a potent eosinophil chemoattractant strongly implicated in the pathobiology of asthma. Genetic variation at the CCL11 locus has been correlated with serum total IgE, blood eosinophil counts, and circulating eotaxin protein levels in several case-control asthma studies. Family-based association studies of CCL11 genetic variants have not been reported to date. OBJECTIVE: To evaluate 9 common CCL11 single nucleotide polymorphisms (SNPs) in nuclear families ascertained through patients with asthma participating in the Childhood Asthma Management Program study. METHODS: Single nucleotide polymorphism genotyping was performed by using minisequencing and probe hybridization platforms. Family-based association analysis for asthma and 4 asthma-related intermediate quantitative phenotypes was performed by using FBAT. RESULTS: One SNP, -384A>G, was associated with asthma among African American families (P = .01). CCL11 SNPs and haplotypes were not associated with asthma among white or Hispanic families. Two low-frequency alleles in strong pairwise linkage disequilibrium, -426C and IVS2+199A, were associated with lower serum total IgE levels (P = .0006 and P = .009, respectively) in white families, whereas 2 more common variants, -576C and g.4438C, were associated with higher IgE levels in African American families (P = .01-.04). Haplotype analysis in the white cohort provided additional evidence of association with serum total IgE, implicating 2 haplotypes. No single SNP or haplotype associations were observed with blood eosinophil levels, FEV(1), or airway responsiveness. CONCLUSION: These findings provide further evidence that genetic variation at the CCL11 locus is an important determinant of serum total IgE levels among patients with asthma. [less ▲]

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See detailL'eotaxine, une chemokine importante dans l'asthme.
Hemelaers, L.; Louis, Renaud ULg

in Revue Médicale de Liège (2006), 61(4), 223-6

We know that the eosinophil plays an important role in asthma pathogenesis. This polynuclear cell is attracted into the airways by several chemokines. Eotaxin is one of them. Endothelial cells, smooth ... [more ▼]

We know that the eosinophil plays an important role in asthma pathogenesis. This polynuclear cell is attracted into the airways by several chemokines. Eotaxin is one of them. Endothelial cells, smooth muscle cells, epithelial cells, alveolar macrophages and eosinophils can produce eotaxin. In asthmatic airways, eotaxin production is increased in bronchial airway lumen and mucosa. Eotaxine actively participates in asthma pathogenesis by activating eosinophil recruitment. [less ▲]

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See detailEP-1420 ADAPTIVE CLINICAL COMMISSIONING OF MONACO VMAT: MAXIMIZING EFFICACY WITHOUT SACRIFICING SAFETY
GULYBAN, Akos ULg; Oltenau, A. M. L.; Vercauteren, T. et al

in Radiotherapy & Oncology (2012), 103

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See detailÉpaisseur d’image : profondeur(s) paradoxale(s). Sur Long Live the New Flesh de Nicolas Provost
Thonon, Jonathan ULg

in Cinéma & Cie : International Film Studies Journal (2013)

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See detailEpaisseur d’images : profondeurs paradoxales. Sur "Long Live The New Flesh » de Nicolas Provost
Thonon, Jonathan ULg

in Cinéma: immersivité, surface, exposition (2012, March 25)

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See detailL’épanchement péricardique chez le chien : approche clinique et diagnostic étiologique
Lemaitre, Pierre ULg

in Point Vétérinaire (2013), (338), 67-72

Pericardial effusion mainly affects middle-aged and large-breed dogs. The clinical signs are more or less those of right heart failure, which aids diagnosis. This is confirmed by echocardiography. Several ... [more ▼]

Pericardial effusion mainly affects middle-aged and large-breed dogs. The clinical signs are more or less those of right heart failure, which aids diagnosis. This is confirmed by echocardiography. Several tests are used to assess the impact on cardiac function and clarify the aetiology, including radiography, echocardiography, histopathology, measurement of cardiac troponin I and cardiac magnetic resonance imaging. The most common causes of pericardial effusion are haemangiosarcoma and idiopathic pericardial effusion, followed by mesothelioma. The prognosis is strongly influenced by the aetiology and treatment option chosen. [less ▲]

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See detailÉpanchement péricardique récidivant chez un golden retriever
Lemaitre, Pierre ULg

in Point Vétérinaire (2013), (338), 62-66

A 7 1/2-year old Golden retriever presented for recurrent pericardial effusion with signs of right-sided heart failure. Pericardial fenestration was performed. Idiopathic pericardial effusion was ... [more ▼]

A 7 1/2-year old Golden retriever presented for recurrent pericardial effusion with signs of right-sided heart failure. Pericardial fenestration was performed. Idiopathic pericardial effusion was diagnosed, which carries a favourable prognosis after surgery. [less ▲]

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See detailL’épandage d’engrais de ferme avant le semis d’une culture intermédiaire (CIPAN) présente-t-il un risque important de lixiviation de nitrate ?
Vandenberghe, Christophe ULg; De Toffoli, Marc; Lambert, Richard et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2),

Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the ... [more ▼]

Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the sowing of a catch crop. Objectives. This paper aims to assess whether the spreading of a manure before sowing a catch crop is more risky for groundwater quality than planting a cereal followed by another crop without any action being implemented between the harvesting of the cereal and the sowing (winter or spring) of the next crop. Method. This study is based on measurements of the nitrate nitrogen content of soils, at the beginning of the leaching period, performed on reference parcels and on controlled parcels. Results. Three thousand six hundred soil analyses performed in relation to controlled parcels between 2008 and 2013 showed that the presence of a catch crop (information about the possible application of a manure was not known) led to a nitrate nitrogen content (median) lower (with a very highly significant difference) than in a situation where no action was implemented between the two main crops. For the same period, the analysis of 600 results in reference parcels led to the same conclusion. Moreover, no significant difference was found between the two kinds of manure (“fast action”, such as pig slurry or “low action”, such as bovine manure). Conclusions. After the harvesting of a cereal, the spreading of a manure before sowing a catch crop creates no higher risk for water quality than the succession of a cereal by a crop sowed in the autumn. [less ▲]

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See detailEpargne sanguine : aspects préopératoires
LARBUISSON, Robert ULg

Scientific conference (2013, May 24)

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See detailEpargne sanguine en chirurgie cardiaque : Etude rétrospective des pratiques
ERPICUM, Marie ULg; DEFRAIGNE, Jean ULg; LARBUISSON, Robert ULg

Report (2013)

Cette étude rétrospective s’inscrit dans le cadre des recherches de la thèse de doctorat sur l’épargne sanguine à travers l’itinéraire clinique du patient opéré cardiaque. Son objectif est de dresser un ... [more ▼]

Cette étude rétrospective s’inscrit dans le cadre des recherches de la thèse de doctorat sur l’épargne sanguine à travers l’itinéraire clinique du patient opéré cardiaque. Son objectif est de dresser un état des lieux de la prise en charge des patients opérés cardiaques au CHU de Liège, des pratiques d’épargne sanguine qui y sont employées et de leur impact sur le recours à la transfusion, les durées de séjour et la mortalité. Cet audit devrait permettre de 1) mettre en évidence les éléments pouvant être améliorés dans l’organisation actuelle de la prise en charge de ces patients afin de concourir aux objectifs d’épargne sanguine 2) servir de base à l’élaboration d’un itinéraire clinique du patient opéré cardiaque. [less ▲]

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See detailL'Epargne sanguine en Chirurgie Cardio-vasculaire et Thoracique
ERPICUM, Marie ULg

Conference (2013, May 24)

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