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See detailAn essential role for gamma-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle.
Palmeira, Leonor; Sorel, Océane ULg; Van Campe, Willem et al

in Proceedings of the National Academy of Sciences of the United States of America (2013)

Wildebeests carry asymptomatically alcelaphine herpesvirus 1 (AlHV-1), a gamma-herpesvirus inducing malignant catarrhal fever (MCF) to several ruminant species (including cattle). This acute and lethal ... [more ▼]

Wildebeests carry asymptomatically alcelaphine herpesvirus 1 (AlHV-1), a gamma-herpesvirus inducing malignant catarrhal fever (MCF) to several ruminant species (including cattle). This acute and lethal lymphoproliferative disease occurs after a prolonged asymptomatic incubation period after transmission. Our recent findings with the rabbit model indicated that AlHV-1 infection is not productive during MCF. Here, we investigated whether latency establishment could explain this apparent absence of productive infection and sought to determine its role in MCF pathogenesis. First, whole-genome cellular and viral gene expression analyses were performed in lymph nodes of MCF-developing calves. Whereas a severe disruption in cellular genes was observed, only 10% of the entire AlHV-1 genome was expressed, contrasting with the 45% observed during productive infection in vitro. In vivo, the expressed viral genes included the latency-associated nuclear antigen homolog ORF73 but none of the regions known to be essential for productive infection. Next, genomic conformation analyses revealed that AlHV-1 was essentially episomal, further suggesting that MCF might be the consequence of a latent infection rather than abortive lytic infection. This hypothesis was further supported by the high frequencies of infected CD8+ T cells during MCF using immunodetection of ORF73 protein and single-cell RT-PCR approaches. Finally, the role of latency-associated ORF73 was addressed. A lack of ORF73 did not impair initial virus replication in vivo, but it rendered AlHV-1 unable to induce MCF and persist in vivo and conferred protection against a lethal challenge with a WT virus. Together, these findings suggest that a latent infection is essential for MCF induction. [less ▲]

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See detailEssential role of sirtuins in the pathogenesis of allergic airway inflammation
Legutko, Agnieszka ULg; Marichal, Thomas ULg; Fievez, Laurence ULg et al

in Short book of the Annual Congress of the European Respiratory Society (ERS), Vienne (2009)

Detailed reference viewed: 31 (6 ULg)
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See detailThe essential role of the plastidial glyceraldehyde- 3-phosphate dehydrogenase in viable pollen development in Arabidopsis
Muñoz-Bertomeu, Jesús; Cascales - Miñana, Borja ULg; Anoman, Armand D. et al

Poster (2010, July)

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See detailEssentials of actions
Cerfontaine, Benjamin ULg; Collin, Frédéric ULg; Denoël, Vincent ULg et al

Learning material (2015)

This document deals with the philosophy of safety in civil engineering structures, including loads and load combinations to be applied when designing a structure. It contains general concepts that are ... [more ▼]

This document deals with the philosophy of safety in civil engineering structures, including loads and load combinations to be applied when designing a structure. It contains general concepts that are presented and discussed as well as values for some important input data that can be used as order of magnitude in the initial phase of a project. [less ▲]

Detailed reference viewed: 107 (34 ULg)
See detailEssere uomini di “lettere”: segretari e politica culturale nel Cinquecento
Geremicca, Antonio ULg; Miesse, Hélène ULg

Book published by Franco Cesati - 1re éd. (in press)

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See detailL'essor de l'industrie belge du zinc (1800-1880)
Peters, Arnaud ULg

in Parcs & Réserves (2011), 66(3), 4-11

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See detailL'essor de l'industrie belge du zinc et la prise en compte de l'environnement
Peters, Arnaud ULg

in Parmentier, Isabelle (Ed.) La recherche en histoire de l'environnement : Belgique, Luxembourg, Congo, Rwanda, Burundi, Actes PREBel, Namur, décembre 2008 (2010)

Detailed reference viewed: 58 (14 ULg)
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See detailL'essor des métiers du conseil : dynamiques et tensions
Divay, Sophie; Orianne, Jean-François ULg

in SociologieS (2010)

Detailed reference viewed: 62 (12 ULg)
See detailEst-ce ainsi que les jeunes Belges lisent? Résultat d'une enquête internationale
Lafontaine, Dominique ULg; Lafontaine, Annette ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1994), 31(7), 31

Detailed reference viewed: 37 (1 ULg)
See detailEst-ce du racisme ?
Martiniello, Marco ULg

Conference given outside the academic context (2013)

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See detailEst-ce qu'il est possible d'obtenir le résultat véritable d'un élève même si celui-ci tente de tricher ?
Raîche, Gilles; Blais, Jean-Guy; Magis, David ULg

Conference (2007, October)

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See detailEst-ce que vous chantez juste?
Larrouy, Pauline ULg

Diverse speeche and writing (2013)

Detailed reference viewed: 45 (2 ULg)
See detailEst-ce si difficile d'apprendre une langue étrangère est ?!?
Defays, Jean-Marc ULg

Conference given outside the academic context (2001)

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See detailEst-il déraisonnable de ne pas accorder une pension de survie au compagnon du travailleur décédé ?
Michiels, Olivier ULg; Joskin, Véronique

in Revue Trimestrielle de Droit Familial (2002), (1), 161-166

L'article envisage la question de savoir si le compagnon qui formait un ménage avec un travailleur décédé est en droit de pouvoir revendiquer une pension de survie.

Detailed reference viewed: 69 (10 ULg)