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See detailExercise-induced oxidative stress in overweight adolescent girls: roles of basal insulin resistance and inflammation and oxygen overconsumption.
Youssef, H.; Groussard, C.; Pincemail, Joël ULg et al

in International Journal of Obesity & Related Metabolic Disorders (2009), 33(4), 447-55

HYPOTHESIS: Basal insulin resistance (IR) and inflammation exacerbate post-exercise oxidative stress (OS) in overweight adolescent girls. DESIGN: Cross-sectional study, effect of incremental ergocycle ... [more ▼]

HYPOTHESIS: Basal insulin resistance (IR) and inflammation exacerbate post-exercise oxidative stress (OS) in overweight adolescent girls. DESIGN: Cross-sectional study, effect of incremental ergocycle exercise until exhaustion on OS markers. PARTICIPANTS: Normal-weight (control) (n=17, body mass index (BMI): 20-24.2 kg/m(2)) and overweight adolescent girls (n=29, BMI: 24.1-36.6 kg/m(2)). MEASUREMENTS: Dietary measurement, physical activity assessment (validated questionnaires), fat distribution parameters (by dual-energy X-ray absorptiometry and anthropometry) and maximal oxygen consumption (VO2peak). Blood assays include the following: (1) at fasting state: blood cell count, lipid profile, and IR parameters (leptin/adiponectin ratio (L/A), homeostasis model assessment of IR, insulin/glucose ratio; (2) before exercise: inflammation and OS markers (interleukin-6 (IL-6), C-reactive protein (CRP), myeloperoxidase (MPO), reduced glutathione/oxidized glutathione ratio (GSH/GSSG), 15 F(2)alpha-isoprostanes (F(2)-Isop), lipid hydroperoxides (ROOH), oxidized low-density lipoprotein (ox-LDL)) and antioxidant status (superoxide dismutase (SOD), glutathione peroxidase (GPX), vitamin C, alpha-tocopherol and beta-carotene); and (3) after exercise: inflammation and OS markers. RESULTS: At rest, overweight girls had a deteriorated lipid profile and significantly higher values of IR parameters and inflammation markers, compared with the control girls. These alterations were associated with a moderate rest OS state (lower GSH/GSSG ratio, alpha-tocopherol/total cholesterol (TC) ratio and GPX activity). In absolute values, overweight girls exhibited higher peak power output and oxygen consumption (VO2peak), compared with the control girls. Exercise exacerbated OS only in the overweight group (significant increase in F(2)-Isop, ROOH and MPO). As hypothesized, basal IR and inflammation state were correlated with the post-exercise OS. However, the adjustment of F(2)-Isop, ROOH and MPO variation per exercise VO(2) variation canceled the intergroup differences. CONCLUSION: In overweight adolescent girls, the main factors of OS, after incremental exhaustive exercise, are not the basal IR and inflammation states, but oxygen overconsumption. [less ▲]

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See detailExercise-induced physiological adjustments to stressful conditions in sports horses
Art, Tatiana ULg; Lekeux, Pierre ULg

in Livestock Production Science (2005), 92(2), 101-111

Among athletic/sports animals, the horse has a unique ability to increase its oxygen uptake by a factor of 60 during heavy exercise. This is achieved by physiological adaptations of all the links in the ... [more ▼]

Among athletic/sports animals, the horse has a unique ability to increase its oxygen uptake by a factor of 60 during heavy exercise. This is achieved by physiological adaptations of all the links in the oxygen chain. Ventilation is increased by a factor of 30. Since the horse is a compulsory nasal breather, this hyperpnea necessitates high transmural pressure changes, which may be responsible for the dynamic collapse of the airways. Blood flow is increased by a factor of 10. Since the left ventricle is not very compliant, this increase necessitates a high filling pressure in the pulmonary circulation, which may induce capillary stress failure and exercise-induced pulmonary haemorrhage. Lastly, oxygen transport is improved by splenic contraction which increases haemoglobinemia by 50%. Sports horses frequently suffer from several problems, which are related either to endogenous or exogenous stresses experienced during their career. These stresses, caused by the use of the horse as a competition animal, may lead to several medical problems. At a systemic level, endogenous stresses include hyperkaliemia, lactacidemia, and hyperthermia; oxidative stress may induce problems at a general, and/or a pulmonary level. External factors, e.g. poor quality of inspired air, transport, hot and humid ambient conditions, and microbiological agents, may also induce abnormal body attacks, and lead to health problems. [less ▲]

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See detailExercise-induced pulmonary perfusion redistribution in heaves
Harmegnies, N. F.; Duvivier, D. H.; Vandenput, Sandrina ULg et al

in Equine Veterinary Journal. Supplement (2002), 34(suppl), 478-484

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in ... [more ▼]

This study aimed to compare exercise-induced pulmonary perfusion redistribution in healthy vs. 'heavey' horses using scintigraphy, a minimally invasive technique. Six healthy (A) and 5 'heavey' horses in remission (B(I)) and during clinical signs of disease (B(II)) were investigated. Dimensions of the exercising pulmonary perfusion (QE) images were expressed in percent of the resting perfusion (QR) images. Computed QE to QR ratios (QE/QR) images enabled the definition of the region more perfused at exercise than at rest (R1). In all groups, exercise induced a major enlargement of the Q image but a larger increase of the lung height was found in 'heavey' horses. Compared to A, 'heavey' horses showed a larger R1 region with a significantly higher QE/QR. Location of R1 pointed out the dorsal lung region as a major site of pulmonary perfusion redistribution for all groups. This work demonstrated (1) the feasibility of using scintigraphy for studying exercise-induced pulmonary perfusion redistribution; (2) perfusion redistribution to the dorsal lung with exercise and (3) an intensified redistribution in 'heavey' horses, either clinically affected or not. [less ▲]

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See detailExercises in astronomy.
Kleczek, J.; Minnaert, M. G. J.; Allen, D. A. et al

in Exercises in astronomy.. J. Kleczek (Editor).Revised and extended edition of "Practical work in elementary astronomy" by M. G. J. Minnaert. D. ReidelPublishing Co., Dordrecht, The Netherlands. 24+339 pp. Price Dfl. 140.00, US 64.00, £ 49.50 cloth; Dfl. 59.00, US 19.50, £ 18.00 paper (1987). ISBN 90-277-2409-1 cloth, ISBN 90-277-2423-7 paper. (1987)

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated ... [more ▼]

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated by the editor in collaboration with the contributing authors D. A. Allen, Z. Ceplechka, S. Ferraz Mello, K. J. Gordon, L. Houziaux, C. Jaschek, Z. Kopal, J. Manfroid, J. PalouÅ¡, J. Podolský, G. R. Quast, J. Surdej, A. B. Underhill, J. M. Vreux, D. G. Wentzel.The exercises are organized in the following sections:A. The planetary system: 1. Space and time, instruments. 2. The motions of celestial bodies. 3. Planets and satellites.B. The stars: 1. The Sun. 2. Stars and nebulae. 3. Stellar systems. [less ▲]

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See detailExérèse microchirurgicale atraumatique intranodulaire d'un schwanome bénin du sciatique poplité externe
LEJEUNE, G; LECLERCQ, Daniel ULg; CARLIER, Alain ULg et al

in Actualités chirurgicales - 81ème Congrès Fr. Chirurgie, Orthopédie, Traumatologie (1980)

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See detailExergetic, environmental and economic analysis of a biomass cogeneration plant connected to a district heating network.
Sartor, Kevin ULg

in Book of abstracts of WREC2014 (2014, August 05)

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See detailExergetical Evaluation of Biobased Synthesis Pathways
Frenzel, Philipp; Hillerbrand, Rafaela; Pfennig, Andreas ULg

in Polymers (2014), 6(2), 327-345

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See detailExergetical Evaluation of Biobased Synthesis Pathways
Frenzel, P; Fayyaz, S; Hillerbrand, R et al

Conference (2011)

See detailExergetische Bewertung der Routen zur stofflichen Nutzung von Biomasse
Frenzel, Philipp; Fayyaz, Sara; Hillerbrand, Rafaela et al

Conference (2011)

See detailExergetische Bewertung der Routen zur stofflichen Nutzung von Biomasse
Fayyaz, S; Frenzel, P; Hillerbrand, R et al

Conference (2011, May 05)

See detailExergetische Bewertung neuer Syntheserouten ausgehend von biobasierten Rohstoffen
Fayyaz, Sara; Frenzel, Philipp; Hillerbrand, Rafaela et al

Conference (2011)

See detailExergySim – Fließschemasimulationen in einem frühen Entwicklungsstadium mit dem Fokus auf Exergiebilanzen
Frenzel, P; Hillerbrand, R; Pfennig, Andreas ULg

Conference (2012, November 13)

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See detailExertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.
Stolz, Daiana; Boersma, Wim; Blasi, Francesco et al

in Chest (2014)

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess ... [more ▼]

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD. METHODS: 1233 6-minute walking tests and circulating proadrenomedullin levels from 574 patients with clinically stable, moderate to very severe COPD enrolled in a multinational cohort study and followed-up for 2 years were concomitantly analyzed. RESULTS: The prevalence of exertional hypoxemia was 29.1%. In a matrix derived from a fitted-multi-state model, the annual probability to develop exertional hypoxemia was 21.6%. Exertional hypoxemia was associated with greater deterioration of specific domains of health-related QoL, higher severe exacerbation and death annual rates. In the logistic linear and conditional Cox-regression multivariable analyses, both FEV1% predicted and proADM proved independent predictors of exertional hypoxemia (p<0.001 for both). Adjustment for comorbidities, including cardiovascular disorders, and exacerbation-rate did not influence results. Relative to using FEV1% pred alone, adding proADM resulted in a significant improvement of the predictive properties (p=0.018). Based on the suggested non-linear nomogram, patients with moderate COPD (FEV1 predicted=50%) but high proADM levels (>2nmol/l) presented increased risk (>30%) for exertional desaturation. CONCLUSIONS: Exertional desaturation is common and associated with poorer clinical outcomes in COPD. Adrenomedullin improves prediction of exertional desaturation as compared to the use of FEV1%pred alone. [less ▲]

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See detailExfoliated polylactide/clay nanocomposites by in-situ coordination-insertion polymerization
Paul, Marie-Amélie; Alexandre, Michaël ULg; Degée, Philippe et al

in Macromolecular Rapid Communications (2003), 24(9), 561-566

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted ... [more ▼]

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted of an ammonium cation bearing primary hydroxyl groups, polymerization was initiated by the alcohol functions after adequate activation. The growing polymer chains were directly "grafted" onto the clay surface through the hydroxyl-functionalized ammonium cations yielding exfoliated nano-composites with enhanced thermal stability. [less ▲]

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See detailExfoliation of clays in poly(dimethylsiloxane) rubber using an unexpected couple: a silicone surfactant and water
Labruyère, Céline ULg; Monteverde, Fabien; Alexandre, Michaël ULg et al

in Journal of Nanoscience and Nanotechnology (2009), 9(4), 2731-2738

Poly(dimethylsiloxane) (PDMS)/montmorillonite (MMT) composites have been prepared using a newly synthesized ω-ammonium functionalized poly(dimethylsiloxane) compatibilizer coupled with a dispersion ... [more ▼]

Poly(dimethylsiloxane) (PDMS)/montmorillonite (MMT) composites have been prepared using a newly synthesized ω-ammonium functionalized poly(dimethylsiloxane) compatibilizer coupled with a dispersion technique in water. The organoclay containing the new siloxane surfactant was characterized by TGA and XRD. For the first time, a nanoscopic dispersion of MMT nanoplatelets in the PDMS composite cured by hydrosilylation and a good compatibility between clay layers and matrix were obtained. The beneficial effect of both the surfactant and the water onto clay nanoplatelet dispersion was evaluated by different microscopy techniques and by measuring different properties such as the viscosity of the uncured PDMS/MMT nanodispersions, and the swelling rate and Young's modulus of the cured PDMS/MMT nanocomposites. [less ▲]

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See detailExforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact
Krzesinski, Jean-Marie ULg; Cohen, Eric P.

in Core Evidence (2008), 3(2), 117-126

Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of ... [more ▼]

Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan. Evidence review: The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension. Clinical value: Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage. [less ▲]

Detailed reference viewed: 187 (6 ULg)