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See detailEffects of adenosine on lymphangiogenesis.
Lenoir, Bénédicte ULiege; Wagner, Daniel R.; Blacher, Silvia ULiege et al

in PloS one (2014), 9(3), 92715

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood ... [more ▼]

BACKGROUND: The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and contributes to tumor progression through stimulation of angiogenesis. In this study, we determined whether adenosine affects lymphangiogenesis. METHODS: Lymphatic endothelial cells (HMVEC-dLy) were cultured in presence of adenosine and their proliferation, migration and tube formation was assessed. Gelatin sponges embedded with the stable analogue of adenosine 2-chloro adenosine were implanted in mice ear and lymphangiogenesis was quantified. Mice were intravenously injected with adenoviruses containing expression vector for 5'-endonucleotidase, which plays a major role in the formation of adenosine. RESULTS: In vitro, we observed that adenosine decreased the proliferation of lymphatic endothelial cells, their migration and tube formation. However, in vivo, gelatin sponges containing 2-chloro adenosine and implanted in mice ear displayed an elevated level of lymphangiogenesis (2.5-fold, p<0.001). Adenovirus-mediated over-expression of cytosolic 5'-nucleotidase IA stimulated lymphangiogenesis and the recruitment of macrophages in mouse liver. Proliferation of lymphatic endothelial cells was enhanced (2-fold, p<0.001) when incubated in the presence of conditioned medium from murine macrophages. CONCLUSION: We have shown that adenosine stimulates lymphangiogenesis in vivo, presumably through a macrophage-mediated mechanism. This observation suggests that blockade of adenosine receptors may help in anti-cancer therapies. [less ▲]

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See detailEffects of age and allergen-induced airway inflammation in cats: Radiographic and cytologic correlation
Kirschvink, Nathalie; Kersnak, Emilie; Leemans, Jérôme ULiege et al

in Veterinary Journal (2007), 174(3), 644-651

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2 ... [more ▼]

Thoracic radiography is an important diagnostic tool for feline respiratory medicine. The aim of this study was (1) to assess agerelated changes of thoracic radiographic views in healthy young cats and (2) to test if experimentally-induced bronchial inflammation by inhaling Ascaris suum (AS) allergens leads to radiographic changes after single or repeated exposures. Healthy cats (n = 15-30) aged between 6 and 30 months were evaluated. Eight healthy cats and eight AS-sensitised cats, respectively, inhaled sterile saline or allergen. Radiographs were taken 24 h before, and 6, 24 and 48 h after the challenge. Bronchoalveolar lavage (BAL) was performed after the last radiographic examination. AS-sensitised cats underwent three further allergen challenges at 3-month intervals. The radiographic evaluation was based on a scoring system considering bronchial, interstitial and alveolar patterns. A significant age-related increase in interstitial and total radiographic score was detected in healthy cats older than 18 months and in healthy cats older than 24 months. Whilst saline inhalation did not affect radiographic scores, a single AS challenge induced significant changes of all scores within 6-24 h. A significant positive correlation between radiographic scores and BAL neutrophils and eosinophils was found. Repeated AS challenges did not induce irreversible changes in radiographic scores. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEffects of age and Ascaris suum aerosol exposure on the pro- and antigelatinolytic activity in serum and airways of cats
Leemans, Jérôme ULiege; Kirschvink, N.; Billen, Frédéric et al

in Proceedings : 17th Congress of the European College of Veterinary Internal Medicine – Companion Animals, Budapest (2007)

Detailed reference viewed: 30 (1 ULiège)
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See detailEffects of age and breed on the phospholipid composition of canine surfactant
Clercx, Cécile ULiege; Venker Van-Haagen, A. J.; Den Breejen, J. N. et al

in 7th Comparative Respiratory Society Meeting - Liège - Belgique (1989)

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See detailEffects of age and education on the Stroop interference
Bruyer, R.; Van der Linden, Martial ULiege; Rectem, D. et al

in Archives de Psychologie (1995), 63

Detailed reference viewed: 8 (0 ULiège)
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See detailEffects of Age and Indomethacin on Response and Sensitivity of Pulmonary Artery to Phenylephrine and to Histamine in Pigs
Gustin, Pascal ULiege; Ansay, Michel; Advenier, C.

in Journal of Veterinary Pharmacology & Therapeutics (1993), 16(2), 207-213

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and ... [more ▼]

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and arachidonic acid derivatives were also studied by incubating the blood-vessels with indomethacin. Potency (pD2 values) and maximal effects (Emaxx) recorded in 5-week-old piglets (group I, n= 5) with phenylephrine [5.71 ± 0.17 and 0.76 ± 0.22 g/mg of dry tissue respectively (mean ± SEM)] were similar to values found in 12-week-old animals (group 2, n = 5) (5.49 ± 0.30 and 1.06 ± 0.27 g/mg of dry tissue respectively). The sensitivity and responsiveness of tissues to this agonist were significantly reduced in 26-week-old mature pigs (group 3, n = 6) as indicated by the decrease in pD2 (3.91 ± 0.23; P < 0.01) and Emax (0.27 ± 0.13 g/mg of dry tissue; P < 0.05) values observed in this group. Histamine (10_3M)-induced maximal responses (Emax) were significantly higher in group 2 (2.23 ± 0.49 g/mg) than in group 1 (0.85 ± 0.11 g/mg; P < 0.05) and in group 3 (0.48 ± 0.10 g/mg; P < 0.01). In 5-week-old animals, indomethacin (3.10˜5M) significantly (P < 0.05) shifted the concentration-response curve to phenylephrine to the right (0.28 log. units) and depressed contractions to this drug as shown by the significant decrease of 39.5% (P < 0.05) in Emax. This cyclo-oxygenase inhibitor had no effect in other groups. These data indicate that phenylephrine is a potent and effective vasoconstrictor agent for the main pulmonary arteries in 5-week-old piglets and that alpha-1-adrenergic-induced contractions are enhanced by cyclo-oxygenase products. These findings can be related with the high reactivity of pulmonary vascular smooth muscles in these animals [less ▲]

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See detailThe effects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage.
Hamaide, Annick ULiege; Arnoczky, Steven; Ciarelli, Mike et al

in American Journal of Veterinary Research (1998), 59

Detailed reference viewed: 16 (5 ULiège)
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See detailThe effects of age and location on the biomechanical and biochemical properties of canine tracheal ring cartilage.
Hamaide, Annick ULiege; Arnoczky, Steven; Ciarelli, Mike et al

Poster (1996)

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See detailEffects of age on echocardiographic measurements in healthy horses of the half-blood breed
Al Haidar, Ali; Sandersen, Charlotte ULiege; Farnir, Frédéric ULiege et al

Poster (2011, March 18)

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See detailEffects of age on plasma metabolites and hormones in finishing Belgian Blue double-muscled cull females
Cabaraux, Jean-François ULiege; Dufrasne, Isabelle ULiege; Istasse, Louis ULiege et al

in Animal Science (2004), 78(Part 2), 229-235

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year ... [more ▼]

Two groups of 12 Belgian Blue double-muscled cull females were used successively in a 2-year repeated experiment and divided into three groups according to age, allowing four animals per group each year. The aim of the trial was to relate, during the finishing period, the metabolic and endocrine parameters with age. Females were fattened with a diet based on maize silage and were blood sampled on several occasions. The average daily gain (ADG) decreased with the age of the cows. Plasma glucose and triglycerides decreased also with age while the youngest females showed lower concentrations of urea than those older. The composition of plasma non-esterified fatty acids also differed considerably between groups. The hormones that best related with ADG were IGF-1 and insulin. Plasma concentrations of thyroid hormones were lower in the oldest animals. No difference between groups was found for GH. Heifers presented lower concentrations of GH and IGF-1 than those reported elsewhere in fattening bulls of the same breed. It may be concluded that in Belgian Blue double-muscled females, glucose, IGF-1 and insulin are good indicators of the growth potential. Young adult cows presented intermediate characteristics of metabolic and endocrine status that were close either to younger or to older cows. [less ▲]

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See detailEffects of age, adipose percent, and reproduction on PCB concentrations and profiles in an extreme fasting north pacific marine mammal
Peterson, S. H.; Hassrick, J. L.; Lafontaine, Anne ULiege et al

in PLoS ONE (2014), 9(4), 96191

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See detailEffects of agents' mobility on opinion spreading in Sznajd model
Sousa, A. O.; Yu-Song, T.; Ausloos, Marcel ULiege

in European Physical Journal B -- Condensed Matter (2008), 66(1), 115-124

Under synchronous updating and allowing the agents to move in the lattice or underlying network, we find that the Sznajd model always reaches a consensus as a steady state, - because agent frustrations ... [more ▼]

Under synchronous updating and allowing the agents to move in the lattice or underlying network, we find that the Sznajd model always reaches a consensus as a steady state, - because agent frustrations are removed due to their diffusion. Moreover, we succeed in obtaining the well-known phase transition of the traditional Sznajd model, which depends on the initial concentration of individuals following an opinion. How the time for reaching consensus depends on the system size, and on the topology have been exhaustively investigated. The analyzed topologies were: annealed and quenched dilution on a square lattice, as well as on a variant of the well-known Barabasi-Albert model, called triad network. [less ▲]

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See detailEffects of aggressive encounters on plasma corticosteroid-binding globulin and its ligands in white-crowned sparrows.
Charlier, Thierry ULiege; Underhill, Caroline; Hammond, Geoffrey L. et al

in Hormones & Behavior (2009), 56(3), 339-47

In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. The concentration of each ligand can alter the binding of the other ligands through competitive ... [more ▼]

In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone. The concentration of each ligand can alter the binding of the other ligands through competitive interactions. Thus, an increase in corticosterone or progesterone may displace testosterone bound to CBG, leading to an increase in bioactive free testosterone levels without affecting total testosterone levels in the circulation. Aggressive interactions increase plasma total testosterone levels in some birds but not in others. Here, we tested the hypothesis that aggressive encounters in the late breeding season would not increase total testosterone levels in plasma, but would alter CBG, total corticosterone or total progesterone levels in such a way as to modify the number of available binding sites and therefore occupancy by testosterone. A marked decrease in CBG occupancy by testosterone would indirectly suggest an increase in free testosterone levels in plasma. Wild male white-crowned sparrows were exposed to a simulated territorial intrusion (STI) or control for 30 min. Subjects were then caught and bled. We measured CBG using a ligand-binding assay and corticosterone, progesterone and testosterone using highly sensitive radioimmunoassays. STI significantly increased aggressive behaviors but did not affect plasma total testosterone levels. STI significantly increased plasma CBG and total corticosterone levels and decreased plasma total progesterone levels. We predict that CBG occupancy by corticosterone will increase slightly following an aggressive encounter. However, this small change is unlikely to increase free testosterone levels, because of the large number of seemingly unoccupied CBG binding sites in these subjects. [less ▲]

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See detailEffects of aging and daytime recovery sleep on N-REM slow oscillations
Lafortune, M; Viens, I; Poirier, J et al

Poster (2009, April)

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See detailEffects of aging and daytime recovery sleep on N-REM slow oscillations
Lafortune, M; Viens, I; Poirier, G et al

in Sleep (2009), 32(Suppl. 1),

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See detailThe effects of aging on location-based and distance-based processes in memory for time
Bastin, Christine ULiege; Van der Linden, Martial ULiege; Michel, Anne-Pascale et al

in Acta Psychologica (2004), 116

Retrieving when an event occurred may depend on an estimation of the age of the event (distance-based processes) or on strategic reconstruction processes based on contextual information associated with ... [more ▼]

Retrieving when an event occurred may depend on an estimation of the age of the event (distance-based processes) or on strategic reconstruction processes based on contextual information associated with the event (location-based processes). Young and older participants performed a list discrimination task that has been designed to dissociate the contribution of both types of processes. An adapted Remember/Know/Guess procedure [Can. J. Exp. Psychol. 50 (1996) 114] was developed to evaluate the processes used by the participants to recognize the stimuli and retrieve their list of occurrence. The results showed that aging disrupts location- based processes more than distance-based processes. In addition, a limitation of speed of processing and working-memory capacities was the main predictor of age-related differences on location-based processes, whereas working-memory capacities mediated partly age differences on distance-based processes. [less ▲]

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See detailEffects of aging on task- and stimulus-related attention during a working memory task
Kurth, Sophie ULiege; Hagelstein, Catherine ULiege; Collette, Fabienne ULiege et al

in Proceedings of the Annual Meeting of the Belgian Association for Psychological Sciences (2013)

Detailed reference viewed: 43 (12 ULiège)
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See detailEffects of aging on task- and stimulus-related cerebral attention networks
Kurth, Sophie ULiege; Majerus, Steve ULiege; Bastin, Christine ULiege et al

in Neurobiology of Aging (2016), 44

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an ... [more ▼]

Interactions between a dorsal attention (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short term memory (STM) tasks. Since it remains an under-investigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of a STM task. Older and young groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants. [less ▲]

Detailed reference viewed: 68 (32 ULiège)