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See detailFli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway.
Czuwara-Ladykowska, Joanna; Shirasaki, Fumiaki; Jackers, Pascale ULg et al

in Journal of Biological Chemistry (2001), 276(24), 20839-20848

Fibrosis is characterized by the excessive deposition of extracellular matrix (ECM), especially collagen. Because Ets factors are implicated in physiological and pathological ECM remodeling, the aim of ... [more ▼]

Fibrosis is characterized by the excessive deposition of extracellular matrix (ECM), especially collagen. Because Ets factors are implicated in physiological and pathological ECM remodeling, the aim of this study was to investigate the role of Ets factors in collagen production. We demonstrate that the expression of collagenous proteins and collagen alpha2(I) (COL1A2) mRNA was inhibited following stable transfection of Fli-1 in dermal fibroblasts. Subsequent analysis of the COL1A2 promoter identified a critical Ets binding site that mediates Fli-1 inhibition. In contrast, Ets-1 stimulates COL1A2 promoter activity. In vitro binding assays demonstrate that both Fli-1 and Ets-1 form DNA-protein complexes with sequences present in COL1A2 promoter. Furthermore, Fli-1 binding to the COL1A2 is enhanced via Sp1-dependent interaction. Studies using Fli-1 dominant interference and DNA binding mutants indicate that Fli-1 inhibition is mediated by both direct (DNA binding) and indirect (via protein-protein interaction) mechanisms and that Sp1 is an important mediator of the Fli-1 function. Furthermore, experiments using the Gal4 system in the context of different cell types as well as experiments with the COL1A2 promoter in different cell lines demonstrate that the direction and magnitude of the effect of Fli-1 is promoter- and cell context-specific. We propose that Fli-1 inhibits COL1A2 promoter activity by competition with Ets-1. In addition, we postulate that another factor (co-repressor) may be required for maximal inhibition after recruitment to the Fli-1-Sp1 complex. We conclude that the ratio of Fli-1 to Ets-1 and the presence of co-regulatory proteins ultimately control ECM production in fibroblasts. [less ▲]

Detailed reference viewed: 54 (29 ULg)
Peer Reviewed
See detailFlight Simulator with IR and MMW Radar Image Generation Capabilities
Bonjean, Maxime E.; Lapierre, Fabian D.; Schiefele, Jeff et al

Conference (2006)

Detailed reference viewed: 6 (0 ULg)
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See detailFlight-Regime Dependent Reduced Order Models of CFD/FE aeroelastic systems in transonic flow
Dimitriadis, Grigorios ULg; Vio, Gareth Arthur; Cooper, Jonathan Edward

in Proceedings of the 48th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference (2007, April)

This paper is part of a study investigating the prediction of the aeroelastic behavior of aircraft subjected to transonic aerodynamic forces. The main objective of the work is the creation of Reduced ... [more ▼]

This paper is part of a study investigating the prediction of the aeroelastic behavior of aircraft subjected to transonic aerodynamic forces. The main objective of the work is the creation of Reduced Order Models from coupled Computational Fluid Dynamic and Finite Element calculations. The novelty of the approach lies in the identification of different types of Reduced Order Model in different flight regimes. Linear modal models are used in the Mach range range where the full CFD/FE system is linear and nonlinear modal models in the transonic flight regime where the CFD/FE system undergoes Limit Cycle Oscillations. Static solutions of the CFD/FE system are used in order to determine the extent of the nonlinear Mach number range. The model treated in this work is a three-dimensional wing in a transonic flowfield. [less ▲]

Detailed reference viewed: 34 (0 ULg)
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See detailFloating Population and Migration in China. The Impact of Economic Reforms
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (1998), Vol. XVI

Detailed reference viewed: 20 (1 ULg)
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See detailFloch e le forme dell'impronta
Dondero, Maria Giulia ULg

in Espressione/Contenuto : Rivista dell’Associazione Italiana di Studi Semiotici (2005)

Cet article reparcourt un texte fondamental de J.-M. Floch sur la photographie (Formes de l’empreinte, Périgueux, Fanlac, 1986) et vise à faire un point sur la tradition sémiotique greimassienne à partir ... [more ▼]

Cet article reparcourt un texte fondamental de J.-M. Floch sur la photographie (Formes de l’empreinte, Périgueux, Fanlac, 1986) et vise à faire un point sur la tradition sémiotique greimassienne à partir des exigences de la sémiotique d’aujourd’hui, notamment à partir des programmes d’une sémiotique de l’expérience et d’une sémiotique des pratiques culturelles. Ce travail enquête des questions que la sémiotique greimassienne du discours n’a jamais pris en compte, telles les techniques productives de l’image, ses pratiques d’utilisation, ses statuts sociaux. [less ▲]

Detailed reference viewed: 55 (0 ULg)
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See detailFloctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs
Lequesne, M; Fannius, J; Reginster, Jean-Yves ULg et al

in Revue du Rhumatisme (English ed.) (1997), 64(5), 327-333

Detailed reference viewed: 16 (3 ULg)
See detailFlood protection barriers in HCMC - part I Sept 2009
Rigo, Philippe ULg

Report (2009)

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese ... [more ▼]

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese Administrative for the design of 3 flood protection barriers in HCMC [less ▲]

Detailed reference viewed: 17 (1 ULg)
See detailFlood protection barriers in HCMC - part II Dec 2009
Rigo, Philippe ULg

Report (2009)

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese ... [more ▼]

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese Administrative for the design of 3 flood protection barriers in HCMC [less ▲]

Detailed reference viewed: 22 (2 ULg)
See detailFlood protection barriers in HCMC - part III Aprill 2010
Rigo, Philippe ULg

Report (2010)

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese ... [more ▼]

HCMC - Protection de la ville de Saigon (Ho-Chin-Min) contre les inondations – aménagement de «Storm Surge barriers», Team Leader of an international expert group in charge to advise the Vietnamese Administrative for the design of 3 flood protection barriers in HCMC [less ▲]

Detailed reference viewed: 54 (8 ULg)
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See detailFlood Protection Design Based on Micro-scale Risk Modelling
Ernst, Julien ULg; Dewals, Benjamin ULg; Detrembleur, Sylvain ULg et al

Poster (2010, April 22)

Detailed reference viewed: 40 (12 ULg)
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See detailFlood risk analysis and design of flood mitigation measures
Dewals, Benjamin ULg

in Contribution to the news of Belgian television RTBF (2011)

Detailed reference viewed: 36 (7 ULg)
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See detailFlood risk analysis in the Meuse river basin
Gouverneur, Ludovic ULg; Dewals, Benjamin ULg; Detrembleur, Sylvain ULg et al

in Urban Flood Risk Management (2011, September 21)

The goal of the study presented in the paper consists in understanding the vulnerability of economic systems to a modification of the hydrology due to climate change in the Meuse river basin. The latter ... [more ▼]

The goal of the study presented in the paper consists in understanding the vulnerability of economic systems to a modification of the hydrology due to climate change in the Meuse river basin. The latter extends over several regions in four different countries. A transnational approach is thus necessary to keep consistency throughout the international catchment. In this paper, we begin by illustrating how a strong collaboration between scientists and water authorities of the different parts of the basin has lead to a consistent approach for conducting flood risk analysis. Hazard modeling was conducted to get flood maps in the whole basin, considering various climate scenarios. In Wallonia, accurate hydraulic simulations were performed with the fully dynamic flow model WOLF2D entirely developed at the University of Liege (Erpicum et al., 2010). The outcomes of this inundation modeling constitute suitable inputs for the subsequent exposure analysis. The latter has been performed at a meso-scale using land use maps (CORINE) and geographic database (PLI), aggregated into a set of five damage categories. Recently developed damage functions, which are the key part of the vulnerability analysis, has been chosen in relation with the damage categories indentified in the exposure analysis. To determine the value of the assets, a monetary approach has been employed, with the purpose of assessing prices per square meter for each damage category. In this paper, the focus is set on comparing several approaches to calculate the specific price of the residential damage category in Wallonia, and to compare with an existing micro-scale approach (Ernst et al., 2010). [less ▲]

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See detailFlood risk analysis in Wallonia: micro (and meso-)scale approaches
Dewals, Benjamin ULg; Detrembleur, Sylvain ULg; Archambeau, Pierre ULg et al

Conference (2010, October 25)

Flood risk analysis has been undertaken in Wallonia in the framework of several national and international research projects. The analysis relies on a micro-scale procedure, which involves • hazard ... [more ▼]

Flood risk analysis has been undertaken in Wallonia in the framework of several national and international research projects. The analysis relies on a micro-scale procedure, which involves • hazard modelling by means of detailed 2D inundation modelling • as well as processing of high resolution topographic and land use database for vulnerability modelling. The inundation modelling is conducted using the fully dynamic flow model WOLF 2D, entirely developed at the University of Liege. The model is run on a highly accurate DEM resulting from the combination of laser altimetry and, when available, sonar bathymetry. The typical grid spacing for the simulations is kept as low as 2m, which is definitely fine enough to represent the complex flows occurring at the scale of individual buildings and streets in urbanized floodplains. In this way, both the static and dynamic impacts of the flow may be characterized for all affected assets. This approach has been extensively applied since 2003 to issue inundation maps throughout the Walloon region based on detailed 2D flow modelling. Consequently, the outcomes of such detailed inundation modelling constitute suitable inputs for the subsequent exposure analysis, performed at a micro-scale using detailed land use maps and geographic database. Eventually, based on a multidisciplinary work, the procedure may incorporate social flood impact analysis and evaluation of direct economic damage to different categories of buildings and land types. Besides detailing the characteristics and performance of the hazard modelling, the presentation will describe the flow of data within the overall risk analysis procedure and will demonstrate its applicability by means of a case study, for which three different flood protection measures have been evaluated. These include rehabilitation of an old canal, recalibration of a floodplain as well as heightening of a protection wall by means of mobile dikes. The risk-oriented analysis of these flood protection measures has lead to findings which would not have arisen from a more standard hydraulic study such as based on a design flood. The flood risk analysis procedure is now readily available for large scale applications throughout the hydrographic basins in Wallonia and, in the near future, it will be combined with catchment modelling (accounting for climate change projections) to evaluate upstream flood mitigation measures as well as for the fine tuning of reservoir management rules in the framework of adaptation strategies to climate change. [less ▲]

Detailed reference viewed: 69 (16 ULg)
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See detailFlood risk management and reservoir operation
Dewals, Benjamin ULg

in Contribution to the news of Belgian television RTL (2011)

Detailed reference viewed: 31 (6 ULg)
See detailFlora and plant communities of the city of Bujumbura (Burundi): diversity, origin and conservation value.
Bigirimana, J; Bogaert, Jan ULg; De Cannière, C et al

Poster (2010, September)

Detailed reference viewed: 16 (2 ULg)
See detailFlora and plant communities of the city of Bujumbura (Burundi): diversity, origin and conservation value.
Bigirimana, J; Bogaert, Jan ULg; De Cannière, C et al

in Bogaerts, A; Robbrecht, E; Rammeloo, J (Eds.) ). Botanical diversity: exploration, understanding and use (2010)

Detailed reference viewed: 8 (1 ULg)
See detailFlora and vegetation of Turtell V, Turtell Islands group (Queensland, Australia).
De Sloover, Jacques; Dufrêne, Marc ULg

in Bulletin du Jardin Botanique National de Belgique (1999), 67

Detailed reference viewed: 8 (0 ULg)