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See detailGenetics of the mineral contents in bovine milk predicted by mid-infrared spectrometry
Soyeurt, Hélène ULg; Dehareng, Frédéric; Romnée, Jean-Michel et al

Conference (2012, August 27)

Knowing the contents of minerals in milk like Ca or Na could be interesting to improve the nutritional quality of milk and to assess the animal health status. This study had two aims: 1) development of ... [more ▼]

Knowing the contents of minerals in milk like Ca or Na could be interesting to improve the nutritional quality of milk and to assess the animal health status. This study had two aims: 1) development of mid-infrared equations for mineral contents in milk by using an approach combining multiple countries, breeds, and production systems and 2) study of the genetic variability of these traits in the Walloon Holstein dairy cattle. Samples included in the calibration set were collected in Belgium, Luxembourg and France over 5 years. The calibration set included at least 400 samples analyzed by coupled plasma atomic emission spectrometry to quantify the contents of Na, Ca, Mg, P and K. The calibration coefficient of determination ranged between 0.69 for K and 0.93 for Na. The standard error of cross-validation was 63.35, 49.24, 64.33, 7.04, and 93.22 mg/kg of milk for Na, Ca, P, Mg and K. From these results, the quantification of milk minerals by mid-infrared is feasible. These equations were applied to more than 140,000 spectral records collected from 43,797 first parity Holstein cows in 1,233 herds. The variance components were estimated using Gibbs Sampling using single trait random regression models derived from the one used for the Walloon genetic evaluation of milk production traits. First results gave a daily heritability of 0.26 for Na, 0.45 for Ca, 0.48 for P, 0.46 for Mg, and 0.41 for K. Moderate negative genetic correlations were found between Na and the other studied traits. The highest correlation (0.69) was observed between P and Mg. These results confirmed the genetic variability of these traits. Further studies will be conducted to study the relationship between these traits and other traits (e.g., production, health). [less ▲]

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See detailGenetics of ulcerative colitis: the come-back of interleukin 10.
Louis, Edouard ULg; Libioulle, Cécile ULg; Reenaers, Catherine ULg et al

in Gut (2009), 58(9), 1173-6

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See detailGénétique de la Néphropathie diabétique
Hadjadj, Samy; Weekers, Laurent ULg; Marre, Michel

in Sang Thrombose Vaisseaux [=STV] (2000), 12(3), 151-156

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See detailGénétique de la neuropathie laryngée récurrente chez le cheval
Dupuis, Marie-Capucine ULg

Doctoral thesis (2011)

Recurrent laryngeal neuropathy (RLN), known as « roaring » or « whistling », has been considered as the most important equine airway disease of the horse. It can cause abnormal respiratory noise during ... [more ▼]

Recurrent laryngeal neuropathy (RLN), known as « roaring » or « whistling », has been considered as the most important equine airway disease of the horse. It can cause abnormal respiratory noise during fast exercise, secondary to a reduced abduction of the left arytenoid cartilage, which may impair performance. Despite significant research into the disease, some aspects, such as etiology and pathogenesis, remain unknown. Several papers suggest a genetic basis but molecular studies have never been reported. Using the EquineSNP50 Beadchip, we genotyped 234 cases (196 Warmbloods, 20 Trotters, 14 Thoroughbreds and 4 Draft Horses), 228 breed-matched controls and 69 parents. Linkage disequilibrium and population structure were quantified before performing single marker and haplotype-based association studies, as well as family-based linkage analyses. Two genome-wide suggestive loci were identified on chromosomes 21 and 31, driven by the enrichment of a “protective” haplotype in controls compared to cases. Our study indicates that predisposition to RLN has a complex determinism, probably involving a high number of genes, of which the candidates on chromosome 21 and 31 may have the largest effects. We performed a copy-number variants analysis on the same data. After characterization of the regions harbouring these variants, an association study with RLN was conducted. A duplication on chromosome 10 was identified in ten affected horses and two unphenotyped parents that were sharing a long haplotype. This work provides novel insights in the genetic determinism of NLR and opens new field of research. If the genuine nature of these loci is confirmed in independent cohorts, identifying the causative genes may increase our understanding of RLN pathogenesis. Assuming that RLN is very polygenic, predictive diagnosis and selection may be more effective using a genomic selection type of approach. [less ▲]

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See detailLa génétique des migraines : des canaux ioniques aux polymorphismes de nucléotide ?
FUMAL, Arnaud ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (2004), 59(6), 367-377

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See detailGénétique des Néoplasies Endocriniennes Multiples de type 1
Beckers, Albert ULg

Scientific conference (1999, January 16)

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See detailGenetique et environnement dans les maladies inflammatoires chroniques de l'intestin.
Louis, Edouard ULg; VAN KEMSEKE, Catherine ULg; LATOUR, Pascale ULg et al

in Revue Médicale de Liège (2012), 67(5-6), 298-304

Inflammatory bowel diseases are both environmental and genetic illnesses. More than one hundred genes or loci involved in the regulation of innate or acquired immune response as well as intestinal mucosa ... [more ▼]

Inflammatory bowel diseases are both environmental and genetic illnesses. More than one hundred genes or loci involved in the regulation of innate or acquired immune response as well as intestinal mucosa homeostasis have been identified. Environmental studies have been less numerous up to now and only smoking and appendectomy have been validated, as protector for ulcerative colitis, while smoking is clearly associated with an increased risk and more severe forms of Crohn's disease. An important role is also currently suspected for the intestinal flora and the dysbiosis described in inflammatory bowel disease could contribute to the triggering or the persistence of the inflammation. New therapeutic strategies are currently studied, particularly aiming at targeting immune, inflammatory or homeostatic pathways corresponding to the predisposing gene variants. [less ▲]

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See detailGénétique moléculaire des récepteurs olfactifs
Parmentier, M.; Vanderhaeghen, P.; Schurmans, Stéphane ULg et al

in Medecine Sciences : M/S (1994), 10

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des ... [more ▼]

Les gènes codant pour les récepteurs olfactifs ont été isolés à partir d'une banque d'ADNc de la muqueuse olfactive. Ils constituent une famille très étendue (plusieurs centaines de gènes) codant pour des récepteurs à sept passages transmembranaires couplés, par l'intermédiaire de protéines G, à l'activation de l'adénylyl cyclase et de la phospholipase C. La grande diversité des récepteurs olfactifs réside surtout dans les domaines transmembranaires III, IV, V et VI, qui portent les sites de liaison des ligands, les molécules odorantes, et répond sans doute à la diversité des ligands [less ▲]

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See detailGeneva photometry of HD 129929 (Aerts+, 2004)
Aerts, C.; Waelkens, C.; Daszynska-Daszkiewicz, J. et al

in SIMBAD (2003), 341

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a ... [more ▼]

We have gathered and analysed a timeseries of 1493 high-quality multicolour Geneva photometric data of the B3V {beta} Cep star Hd 129929. The dataset has a time base of 21.2 years. The occurrence of a beating phenomenon is evident from the data. We find evidence for the presence of at least six frequencies, among which we see components of two frequency multiplets with an average spacing of ~0.0121c/d which points towards very slow rotation. This result is in agreement with new spectroscopic data of the star and also with previously taken UV spectra. We provide the amplitudes of the six frequencies in all seven photometric filters. The metal content of the star is Z=0.018+/-0.004. All these observational results will be used to perform detailed seismic modelling of this massive star in a subsequent paper. (1 data file). [less ▲]

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See detailGeneva photometry of HDE 318107 (Manfroid+, 2000)
Manfroid, Jean ULg; Mathys, G.

Report (2000)

File table1 contains the individual photometric measurements of HDE 318107 in the Geneva system. (1 data file).

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See detailGénie des procédés chimiques et développement durable
Léonard, Angélique ULg

Conference given outside the academic context (2011)

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See detailThe GENIE nulling experiment
Absil, Olivier ULg; Gondoin, Ph; den Hartog, R. et al

in Combes, F. (Ed.) SF2A-2002: Semaine de l'Astrophysique Francaise (2002, June)

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very ... [more ▼]

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very Large Telescope Interferometer (VLTI). The main objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer representative of the ESA IRSI-Darwin space mission. GENIE will prepare the Darwin science programme through a systematic search for exo-zodiacal dust clouds around Darwin candidate targets. GENIE also aims to perform Darwin related science including the detection of low-mass companions (if possible, hot Jupiters) around nearby stars. The prospective performances of some candidate configurations are presented in this paper. [less ▲]

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See detailLe « génie orienté produit » appliqué à l’élaboration de matrices poreuses pour l’ingénierie tissulaire.
de Bien, Charlotte ULg; Ounally, Thameur ULg; Collard, Valérie ULg et al

in Récents Progrès en Génie des Procédés (2013, October 08)

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les ... [more ▼]

Ce travail vise à appliquer une approche « génie-orienté produit » à la fabrication de matrices poreuses synthétiques (scaffolds) susceptibles d’être utilisées en ingénierie tissulaire. Parmi les différents polymères biosourcés et biodégradables déjà utilisés pour la fabrication de scaffolds, l’acide polylactique (PLA) a été choisi. Des matrices poreuses ont été obtenues par un procédé de moussage par lyophilisation puis leur microstructure 2D/3D a été caractérisée par microtomographie à rayons X avant d’être mise en lien avec les conditions d’élaboration testées. La diminution de la porosité ainsi que l’augmentation de l’épaisseur des parois avec l’augmentation de rapport polymère/solvant ont été confirmées. [less ▲]

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See detailGENIE, the Ground-based European Nulling Interferometry Experiment
Absil, Olivier ULg

Scientific conference (2002, May 15)

L’instrument GENIE (Ground-based European Nulling Interferometer Experiment), projet co-financé par l’ESA et l’ESO, est un interféromètre en frange noire qui sera installé vers mi-2006 sur le site du VLTI ... [more ▼]

L’instrument GENIE (Ground-based European Nulling Interferometer Experiment), projet co-financé par l’ESA et l’ESO, est un interféromètre en frange noire qui sera installé vers mi-2006 sur le site du VLTI. Cet instrument, actuellement en phase de définition, sera avant tout un démonstrateur technologique pour la mission spatiale Darwin. Mais il permettra aussi de détecter des disques de poussière zodiacale autour d’étoiles proches, de faire la spectroscopie des plus brillants d’entre eux, et probablement de détecter pour la première fois le rayonnement thermique de certains Jupiters chauds. Dans cet exposé, je discuterai les performances attendues de GENIE en fonction de la configuration instrumentale choisie, aussi bien pour la détection de disques que d’exoplanètes. [less ▲]

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See detailGENIE, the Ground-based European Nulling Interferometry Experiment
Absil, Olivier ULg

Scientific conference (2002, June 27)

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very ... [more ▼]

Within the frame of the Darwin program, the European Space Agency and the European Southern Observatory (ESO) intend to build a ground-based technology demonstrator called Darwin-GENIE, using the Very Large Telescope Interferometer (VLTI). The main objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer representative of the ESA IRSI-Darwin space mission. GENIE will prepare the Darwin science programme through a systematic search for exo-zodiacal dust clouds around Darwin candidate targets. GENIE also aims to perform Darwin related science including the detection of low-mass companions (if possible, hot Jupiters) around nearby stars. The prospective performances of some candidate configurations are presented in this paper. [less ▲]

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See detailGENIE: a Ground-Based European Nulling Instrument at ESO Very Large Telescope Interferometer
Gondoin, P.; den Hartog, R.; Fridlund, M. et al

in Richichi, A.; Delplancke, F.; Paresce, F. (Eds.) et al The Power of Optical/IR Interferometry: Recent Scientific Results and 2nd Generation Instrumentation (2008)

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars, to analyze the ... [more ▼]

Darwin is one of the most challenging space projects ever considered by the European Space Agency (ESA). Its principal objectives are to detect Earth-like planets around nearby stars, to analyze the composition of their atmospheres and to assess their ability to sustain life as we know it. Darwin is conceived as a space ``nulling interferometer'' which makes use of on-axis destructive interferences to extinguish the stellar light while keeping the off-axis signal of the orbiting planet. Within the frame of the Darwin program, definition studies of a Ground based European Nulling Interferometry Experiment, called GENIE, were completed in 2005. This instrument built around the Very Large Telescope Interferometer (VLTI) in Paranal will test some of the key technologies required for the Darwin Infrared Space Interferometer. GENIE will operate in the L' band around 3.8 microns as a single Bracewell nulling interferometer using either two Auxiliary Telescopes (ATs) or two 8m Unit Telescopes (UTs). Its science objectives include the detection and characterization of dust disks and low-mass companions around nearby stars. [less ▲]

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See detailGENIE: a ground-based precursor for Darwin
Absil, Olivier ULg

Scientific conference (2003, November 21)

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See detailGENIE: a ground-based precursor for the IRSI-Darwin mission
Absil, Olivier ULg

in Aime, Claude; Soummer, Rémi (Eds.) Astronomy with High Contrast Imaging (2003)

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and ... [more ▼]

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and hot Jupiter detection. Their expected performances have been computed in light of the measured or expected performances of the VLTI sub-systems. A simple Bracewell nulling interferometer, formed of two Unit Telescopes and working in the L' or N bands, has been identified as a good candidate configuration for exozodiacal cloud detection. External or internal chopping, fringe tracking and intensity matching will be critical issues for this configuration. In the case of hot Jupiter detection, a double Bracewell with internal modulation in the L' band seems well appropriate, and should allow to carry out low resolution spectroscopy on a few bright exoplanets. The basic assumptions and computations which have lead to these candidate configurations are described in this paper. [less ▲]

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