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See detailEffect of Intravenous Lidocaine on the Depth of Propofol Anesthesia Measured by the Bispectral Index
HANS, Grégory ULiege; Lauwick, Severine; Defechereux, Thierry et al

in Anesthesiology (2007), 107

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULiege; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailEffect of intravessel irradiation of venous blood on fever syndrome in rats
Chichkan, D. N.; Koulchitsky, Stanislav ULiege; Tikhonov, A. V. et al

in Bulletin of Experimental Biology and Medicine (1998), 126(4), 991992

Experiments on wakeful rats revealed that the second phase of hyperthermal response evoked by intraperitoneal administration of endotoxin is eliminated after intravascular irradiation of venous blood in ... [more ▼]

Experiments on wakeful rats revealed that the second phase of hyperthermal response evoked by intraperitoneal administration of endotoxin is eliminated after intravascular irradiation of venous blood in the ultraviolet range during the first phase of experimental fever. [less ▲]

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See detailEffect of inulin and wheat bran in the creep feed of neonatal piglets
Li, Bing ULiege; Leblois, Julie ULiege; Bindelle, Jérôme ULiege et al

Conference (2015, May 22)

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See detailEffect of inventory plot patterns in the floristic analysis of tropical woodland and dense forest
Houeto, Georges; Glele Kakai, Romain L.; Salako, Valère et al

in African Journal of Ecology (2013), 51(3),

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See detailEffect of iodised fertilisation on iodine content in grass and on thyroid hormones concentrations in dairy heifers.
Dufrasne, Isabelle ULiege; Dotreppe, Olivier ULiege; Meura, S. et al

in Permanent and temporary grassland plant, environment and economy, A De Vliegher an L. Carlier editors, Book of abstracts of 14th Symposium of European Grassland Federation (2007)

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See detailEffect of ionic aggregation on ionomer chain dimensions. 1. Telechelic polystyrenes
Register, Richard A; Cooper, Stuart L; Thiyagarajan, Pappannan et al

in Macromolecules (1990), 23(11), 2978-2983

Carboxy-telechelic polystyrenes with degrees of polymerization of ca. 70 were examined by small-angle neutron scattering in the Na+ ionomer and methyl ester forms to ascertain the effect of ionic ... [more ▼]

Carboxy-telechelic polystyrenes with degrees of polymerization of ca. 70 were examined by small-angle neutron scattering in the Na+ ionomer and methyl ester forms to ascertain the effect of ionic aggregation on the chain dimensions. The ionomers contain ionic aggregates, as demonstrated by smallangle X-ray scattering. The chain dimensions were found to be identical for the ionomer and ester, in agreement with the predictions of Squires et al. but in disagreement with the theories of Forsman and Dreyfus. Detailed analysis of the data showed that the contacts between the two isotopic types were random, as intended. The data were satisfactorily described by a polydisperse assembly of wormlike chains, with a Kuhn statistical length comparable to that for homopolystyrene. [less ▲]

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See detailThe effect of IR-helium-neon laser in human chondrocyte cultivated in three dimensions
Bassleer, C; Reginster, Jean-Yves ULiege; Dachy, M et al

in Calcified Tissue International (1985), 38(S1), 38

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See detailEffect of iron nanoparticles synthesized by a sol-gel process on Rhodococcus erythropolis T902.1 for biphenyl degradation
Wannoussa, Wissal ULiege; Masy, Thibaut ULiege; Lambert, Stéphanie ULiege et al

in Journal of Water Resource and Protection (2015), 7

Nanoparticles (NPS) are considered as a new generation of compounds to improve environmental remediation and biological processes. The aim of this study is to investigate the effect of iron NPS ... [more ▼]

Nanoparticles (NPS) are considered as a new generation of compounds to improve environmental remediation and biological processes. The aim of this study is to investigate the effect of iron NPS encapsulated in porous silica (SiO2) on the biphenyl biodegradation by Rhodococcus erythropolis T902.1 (RT902.1). The iron NPS (major iron oxide FexOy form) were dispersed in the porosity of a SiO2 support synthesized by sol-gel process. These Fe/SiO2 NPS offer a stimulating effect on the biodegradation rate of biphenyl, an organic pollutant that is very stable and water-insoluble. This positive impact of NPS on the microbial biodegradation was found to be dependent on the NPS concentration ranging from 10−6 M to 10−4 M. After 18 days of incubation the cultures containing NPS at a concentration of 10−4 M of iron improved RT902.1 growth and degraded 35% more biphenyl than those without NPS (positive control) or with the sole SiO2 particles. Though the microorganism could not interact directly with the insoluble iron NPS, the results show that about 10% and 35% of the initial 10−4 M iron NPS encapsulated in the SiO2 matrix would be incorporated inside or adsorbed on the cell surface respectively and 35% would be released in the supernatant. These results suggest that RT902.1 would produce siderophore-like molecules to attract iron from the porous silica matrix. [less ▲]

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See detailThe Effect of Isoenergetic Substitution Of Energy Sources On Glucose Tolerance and Insulin Sensitivity in Healthy Non-obese Cats
Verbrugghe, Adronie; Papadopoulos, I.; Gommeren, Kris ULiege et al

in 17th Annual International ECVIM-CA Congress (2007, September)

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See detailEffect of isoflurane on the auditory steady-state response and on consciousness in human volunteers.
Plourde, Gilles; Villemure, Chantal; Fiset, Pierre et al

in Anesthesiology (1998), 89(4), 844-51

BACKGROUND: The auditory steady state response (ASSR) is a sustained electrical response of the brain to auditory stimuli delivered at fast rates (30-50 responses/s). The aim of this study was to evaluate ... [more ▼]

BACKGROUND: The auditory steady state response (ASSR) is a sustained electrical response of the brain to auditory stimuli delivered at fast rates (30-50 responses/s). The aim of this study was to evaluate the effect of 0.26-0.50% isoflurane on the ASSR and on consciousness, defined as responsiveness to verbal commands. METHODS: Ten volunteers (21-31 yr) participated. Isoflurane was administered at three stable, end-tidal concentrations: 0.26%, 0.38%, and 0.50%. The ASSR in response to 18,000 stimuli (500-Hz tonebursts, 10 ms, 82-dB, the right ear, 35-45 bursts/s) was recorded from the vertex with reference to the right mastoid. Recordings were made during baseline, at each isoflurane concentration, and during recovery. RESULTS: The mean (SD) ASSR amplitudes were 0.32 (0.23) microV during baseline, 0.24 (0.17) microV during 0.26% isoflurane, 0.09 (0.05) microV during 0.38% isoflurane, 0.04 (0.03) microV during 0.50% isoflurane, and 0.29 (0.33) microV during recovery. The amplitude during baseline and recovery was larger than during 0.38% and 0.50% isoflurane (P < 0.001). The amplitude at 0.26% was larger than at the other concentrations (P < 0.025). The logarithm of the ASSR amplitude was related linearly to the concentration of isoflurane (r = 0.85; P < 0.0001). The prediction probability (Pk) for loss of consciousness was 0.95 for both ASSR and measured isoflurane concentration. An ASSR amplitude < 0.07 microV was always associated with unconsciousness. CONCLUSIONS: The ASSR is attenuated in a concentration-dependent manner by isoflurane. Suppression of consciousness and maximal attenuation of ASSR occur in the same isoflurane concentration range. Profound attenuation of ASSR appears to reflect unconsciousness, defined as unresponsiveness to verbal commands. [less ▲]

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See detailEffect of isoprostanes on bronchial smooth muscle in healthy and asthma-like horses
Kirschvink, Nathalie; Lekeux, Pierre ULiege; Art, Tatiana ULiege et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(3), 274

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See detailEffect of isothermal ageing on the Zn-Al alloys creep characteristics
Lecomte-Beckers, Jacqueline ULiege; Terziev; Wegria et al

in Proceedings of The 3rd International Conference on Zn-Al Alloys - Advances in Science, Technology and Applications of Zn-Al Alloys (1994)

The aim of this study is to correlate the creep parameters of aged Zn-Al samples with the microstructure developed during heat treatment, and to point out the practical interest of such microstructure ... [more ▼]

The aim of this study is to correlate the creep parameters of aged Zn-Al samples with the microstructure developed during heat treatment, and to point out the practical interest of such microstructure modifications. Two different isothermal ageings were carried out at 100°C and at 250°C for different periods of times (from 30 min. to 8 weeks). During those ageings, complex precipitations occur. The decomposition of the initial supersaturated solid solution begins with a cellular reaction leading to cfc and hcp lamellar. The cfc phase decomposes into transition phases. The ageing temperature (100 or 250°C) influences the decomposition stages. Creep testson aged samples reveal the influence of the microstructure developed during the heat treatment at 100 or 250°C. An improvement of the creep properties by one order of magnitude can be observed when the sample exhibits the appropriate structure. [less ▲]

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See detailEffect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-Label Studies.
Dirix, Luc; Swaisland, Helen; Verheul, Henk M. W. et al

in Clinical Therapeutics (2016), 38(10), 2286-2299

PURPOSE: The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA-mutated ovarian cancer, is mediated by cytochrome P450 (CYP ... [more ▼]

PURPOSE: The metabolism of olaparib, a potent inhibitor of poly(ADP-ribose) polymerase (PARP) with demonstrated efficacy in patients with BRCA-mutated ovarian cancer, is mediated by cytochrome P450 (CYP) enzymes (predominantly CYP3A4/5). We assessed the potential of a CYP3A4 inhibitor (itraconazole) and inducer (rifampin) to alter the pharmacokinetic (PK) profile of olaparib following single oral tablet doses. METHODS: Two Phase I, open-label, non-randomized trials were conducted in patients with advanced solid tumors. In Study 7, patients received olaparib alone and co-administered with itraconazole; in Study 8, a separate group of patients received olaparib alone and co-administered with rifampin. No interaction between itraconazole and olaparib was concluded if two-sided 90% CIs for the treatment ratios of AUC and/or AUC0-t and Cmax fell within the bioequivalence range of 0.80-1.25. An interaction between rifampin and olaparib was concluded if the lower limit of the 90% CI for the treatment ratios was <0.5 (ie, >50% decrease in olaparib AUC or Cmax in the presence of rifampin compared with olaparib alone). FINDINGS: In Study 7 (N = 59; 17 male, 42 female), 56 and 53 patients were evaluable for PK analysis following treatment with olaparib alone and olaparib plus itraconazole, respectively; in Study 8 (N = 22; 4 male, 18 female), all patients were evaluable. Co-administration of olaparib with itraconazole resulted in a statistically significant increase in the relative bioavailability of olaparib: Cmax treatment ratio, 1.42 (90% CI, 1.33-1.52); mean AUC treatment ratio, 2.70 (90% CI, 2.44-2.97). Mean CL/F and Vz/F were reduced (8.16 vs 3.05 L/h and 192 vs 75.1 L), although mean t(1/2) was unchanged (15.0 vs 15.6 hours). Co-administration of olaparib with rifampin resulted in a statistically significant decrease in the relative bioavailability of olaparib: Cmax treatment ratio, 0.29 (90% CI, 0.24-0.33); mean AUC treatment ratio, 0.13 (90% CI, 0.11-0.16). CL/F and Vz/F were increased when olaparib and rifampin were co-administered (6.36 vs 48.3 L/h and 112 vs 1076 L); however, mean t(1/2) was unchanged (13.0 vs 15.8 hours). Safety data for olaparib following tablet dosing were consistent with the known safety profile. IMPLICATIONS: Exposure to olaparib was significantly increased when co-administered with the potent CYP3A4 inhibitor itraconazole, and significantly decreased when co-administered with the potent CYP3A4 inducer rifampin, compared with olaparib alone. Potent CYP3A4 enzyme inhibitors and inducers should be avoided during olaparib treatment. ClinicalTrials.gov identifiers: NCT01900028 (Study 7) and NCT01929603 (Study 8). [less ▲]

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See detailEffect of itraconazole and rifampin on the pharmacokinetics of olaparib table formulation in patients with advanced solid tumors : phase I open-label studies
Plummer, Elizabeth R.; Verheul, Henk M.W.; Rottey, Sylvie et al

in Journal of Clinical Oncology (2015), 33(suppl : abstr 2565),

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See detailEffect of Ketoconazole 1% and 2% Shampoos on Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments
Pierard-Franchimont, Claudine ULiege; Pierard, Gérald ULiege; Arrese, J. E. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(2), 171-6

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was ... [more ▼]

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies. [less ▲]

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See detailEffect of Ketoprofen on Paf-Induced Bovine Platelet Aggregation
Bastos da Silva, Miriam; Gustin, Pascal ULiege; Herion, Francine ULiege et al

in Veterinary Journal (1998), 155(2), 201-203

Detailed reference viewed: 98 (6 ULiège)