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See detailEngineering of poly(2-oxazoline)s for a potential use in biomedical applications
Legros, Camille ULg

Doctoral thesis (2014)

This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in ... [more ▼]

This PhD work is based on the design of poly(2-oxazoline) (POx) hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene imine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymer bearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2- oxazoline units, proved to self-assemble into micelles when heated above its LCST, for a short period of time (< 1h30). When annealed for a longer time (> 1h30), crystallization-driven self-assembly led to the formation of different morphologies (fiber rods and cross-linked micelles). [less ▲]

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See detailEngineering resistance to geminiviruses--review and perspectives.
Vanderschuren, Hervé ULg; Stupak, Martin; Futterer, Johannes et al

in Plant biotechnology journal (2007), 5(2), 207-20

Following the conceptual development of virus resistance strategies ranging from coat protein-mediated interference of virus propagation to RNA-mediated virus gene silencing, much progress has been ... [more ▼]

Following the conceptual development of virus resistance strategies ranging from coat protein-mediated interference of virus propagation to RNA-mediated virus gene silencing, much progress has been achieved to protect plants against RNA and DNA virus infections. Geminiviruses are a major threat to world agriculture, and breeding resistant crops against these DNA viruses is one of the major challenges faced by plant virologists and biotechnologists. In this article, we review the most recent transgene-based approaches that have been developed to achieve durable geminivirus resistance. Although most of the strategies have been tested in model plant systems, they are ready to be adopted for the protection of crop plants. Furthermore, a better understanding of geminivirus gene and protein functions, as well as the native immune system which protects plants against viruses, will allow us to develop novel tools to expand our current capacity to stabilize crop production in geminivirus epidemic zones. [less ▲]

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See detailEngineering RNA-mediated resistance to geminiviruses in cassava
Vanderschuren, Hervé ULg

Doctoral thesis (2007)

Cassava mosaic disease (CMD) is the most important disease affecting cassava in Africa. The disease is caused by several whitefly-transmitted geminivirus species. The increasing impact of geminivirus ... [more ▼]

Cassava mosaic disease (CMD) is the most important disease affecting cassava in Africa. The disease is caused by several whitefly-transmitted geminivirus species. The increasing impact of geminivirus-caused diseases on cassava production due to the recent pandemics has urged the scientific community to provide stable virus resistance in cassava. Advances in engineering virus resistance via RNA-based strategies have opened promising perspectives for the production of transgenic geminivirus resistant plants. In this thesis, three RNA-based strategies are developed to improve the resistance to African cassava mosaic virus (ACMV) in transgenic cassava. The first strategy was based on expression of antisense viral sequences. Three different viral coding sequences were targeted and several transgenic cassava lines expressing antisense viral sequences were ACMV resistant. The second strategy was to express intron hairpin double-stranded RNAs (dsRNAs) homologous to ACMV bidirectional Promoter. Transgenic cassava lines expressing small dsRNAs homologous to the ACMV promoter were not completely immune to ACMV infection but showed an enhanced recovery phenotype as cornpared to the infected wild-type cassava plants. The third strategy relied on the expression of intron hairpin dsRNAs homologousto viral coding sequences. Transgenic cassava lines expressing high levels of small RNAs homologous to the viral coding sequences were immune under ACMV infection tests in which virus load had been sufficient to break resistance elaborated with the first two strategies. This work demonstrated that ACMV resistance could be achieved in cassava via an RNA-based approach and that the strategy used (i.e. antisense RNA, hairpin dsRNA against non-coding viral sequence, hairpin dsRNA against viral coding sequences) had an impact on the resistance level. [less ▲]

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See detailEngineering Specificity Changes on a RanBP2 Zinc Finger that Binds Single-Stranded RNA.
Vandevenne, Marylène ULg; O'Connell, M.R.; Helder, S. et al

in Angewandte Chemie International Edition (2014)

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See detailEngineering the stability of a cold-active alpha-amylase
D'Amico, Salvino; Gerday, Charles ULg; Feller, Georges ULg

Poster (1999)

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See detailEngineering three-dimensional chains of porous nanoballs from a 1,2,4-triazole-carboxylate supramolecular synthon
Naik, A. D.; Dǐrtu, M. M.; Léonard, Alexandre ULg et al

in Crystal Growth & Design (2010), 10(4), 1798-1807

Glycine ethyl ester was recruited in an amine exchange process based on a transamination to afford ethyl 4H-1,2,4-triazol-4-yl-acetate (L1). The acid hydrolysis of this molecule leads to quantitative ... [more ▼]

Glycine ethyl ester was recruited in an amine exchange process based on a transamination to afford ethyl 4H-1,2,4-triazol-4-yl-acetate (L1). The acid hydrolysis of this molecule leads to quantitative isolation of 4H-1,2,4-triazol-4-yl acetic acid (L2). This versatile synthon crystallizes in a noncentrosymmetric orthorhombic space group (Fdd2) with Z = 16. This crystal structure is the first one for a 1,2,4-triazole ligand constructed from an amino acid derivative. The strong intermolecular hydrogen bonding O-HN (2.570(3)Å) connects molecules into infinite one-dimensional chains running parallel to the b axis, and the structure is further extended by numerous but moderate strength hydrogen bonds (C-HO). Prominent features of L2 are the presence of diverse potential coordinating groups such as carboxylic acid and triazole on the same framework as well as the inherent flexibility of the ligand backbone. Reaction of L1 or L2 with aq. Cu(BF 4) 2 in aq. DMF gives dark blue crystals which crystallize in a noncentrosymmetric, cubic space group (I4̌3m) and which were formulated as [Cu 3(μ 3-O)(L2) 3(H 2O) 3]BF 4H 2O (C1). The self-assembly of C 3-symmetric, μ 3-oxo bridged triangular tricopper secondary building blocks (SBB) formed an unique architecture which encompasses voluminous nanoball voids of 1 nm. The total solvent accessible volume is 4477.5 Å 3 which accounts for 48% of the cell volume. The crystal network stability was studied by thermogravimetric analysis (TGA)'differential thermal analysis (DTA) and scanning electron microscopy (SEM) analyses. Sorption properties and gas storage capacities were measured by BET. C1 shows no preference for N 2(g), but a reversible H 2(g) uptake of 21 cm 3/g was observed. Morphology analysis by SEM on single crystals of C1 shows "ultrawellś of square shape irregularly located on the surface, whose origin is due to desolvation or crystal defects. Mercury porosimetry measurements reveal pore size distribution with a diameter ranging from 350 nm to 2.3 μm © 2010 American Chemical Society. [less ▲]

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See detailEngineering Ultrafast Magnetism
Radu, I.; Stamm, C.; Eschenlohr, A. et al

in Ultrafast Magnetism I (2015)

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See detailEnglish and French Canadians, Flemish and Francophone Belgians. The Linguistic Composition of the Canadian and Belgian Federal Cabinet
Reuchamps, Min ULg

Conference (2007, April 27)

In divided societies, such as Belgium and Canada, the federal principle and consociational power-sharing have been implemented in order to accommodate ethno-linguistic communities. The combination of ... [more ▼]

In divided societies, such as Belgium and Canada, the federal principle and consociational power-sharing have been implemented in order to accommodate ethno-linguistic communities. The combination of Daniel Elazar’s seminal work on federalism in plural societies and of Arend Lijphart’s on consociationalism offers a theoretical framework which can be usefully applied to study the distribution of power between the two main ethno-linguistic communities at the highest level of the state. Using the existing “model of points” and the author’s own “model of the weight of ministerial portfolios”, this paper explores the linguistic composition of the federal governments in both countries over the last thirty years (1970-2006). Whereas the Belgian Constitution has required since 1970 that the federal cabinet be staffed by an equal number of Flemish and Francophone ministers, the Canadian Constitution does not require such a linguistic parity and therefore leaves a greater freedom for the composition of the government. On this background, two logics may explain the linguistic composition in the two cases: a logic of transaction between the two main communities and a logic of representation. The paper opens, on the one hand, with the elaboration of the theoretical framework combining the works of Elazar and Lijphart and, on the other hand, with the construction of the two models. The framework and the models are applied to each case, emphasizing the logic of transaction and the logic of representation. On the basis of this examination, this paper concludes by suggesting that Flemish and Francophone Belgians as well and English and French Canadians benefit from the composition of the federal cabinet. The conclusion opens—new—ways and means to hinder political tensions in plural societies through the institutional arrangement. [less ▲]

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See detailEnglish and Spanish Size Noun-constructions, a locus of ongoing grammaticalization
Brems, Lieselotte ULg; Verveckken, Katrien

Conference (2008)

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See detailEnglish and Spanish Size Noun-constructions, a locus of ongoing grammaticalization
Brems, Lieselotte ULg; Verveckken, Katrien

Conference (2008)

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See detailThe English Experience of Soft Densification (Les expériences anglaises en matière de densification douce). Phase I Draft Report
Bibby, Petter; Phillips, Andrew; Halleux, Jean-Marie ULg et al

Report (2015)

The first work package of our programme of work is a quantitative overview of the varying incidence of soft densification across England emphasizing outcomes in the period between 2001 and 2011. Its aim ... [more ▼]

The first work package of our programme of work is a quantitative overview of the varying incidence of soft densification across England emphasizing outcomes in the period between 2001 and 2011. Its aim is to introduce the policy framework which allowed or encouraged soft densification, to explore its relationship to underlying associated variation in physical and economic conditions, and to suggest the broad contours of its socio-economic effects. In addition to its principal role of providing a framework helping to guide subsequent more detailed examinations, this body of work seeks to address a series of questions close to PUCA's key concerns: · within a policy framework conducive to soft densification, what is the extent of its contribution to the flow of additional dwelling units? · under such a regime, what influences variation in the scale of that contribution from place to place? · and finally, what needs are met by the units generated by soft densification, and what are the associated changes in the social and demographic composition of neighbourhoods? [less ▲]

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See detailThe English Experience of Soft Densification (Les expériences anglaises en matière de densification douce). Phase II Draft Report
Bibby, Peter; Dunning, Richard; Ferrari, Ed et al

Report (2016)

This report is the second phase of research into the English Experience of Soft Densification and builds upon the quantitative data analysis undertaken in phase I. Adopting an intensive qualitative case ... [more ▼]

This report is the second phase of research into the English Experience of Soft Densification and builds upon the quantitative data analysis undertaken in phase I. Adopting an intensive qualitative case study approach two local authorities, the London Borough of Ealing and Bristol City Council, are considered in detail. Ealing represents a suburban area that experienced concurrently significant soft densification and de-conversion of existing stock in the period 2001 to 2011, whilst Bristol over the same period experienced a high level of housing growth. [less ▲]

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See detailEnglish language immersion in french-speaking children : does learning to read have an impact on the subsequent acquisition of french orthographic code ?
Nicolay, Anne-Catherine ULg; Fantauzzi, A.; Sadzot, Agnès ULg et al

Poster (2006, May 19)

Apprendre à lire dans une langue n’interfère pas avec l’apprentissage de la lecture dans une autre langue mais prépare plutôt le terrain pour apprendre à lire dans une autre langue. Comme dans le langage ... [more ▼]

Apprendre à lire dans une langue n’interfère pas avec l’apprentissage de la lecture dans une autre langue mais prépare plutôt le terrain pour apprendre à lire dans une autre langue. Comme dans le langage oral, il peut y avoir quelques « mixing » de prononciation au niveau des mots qui disparaissent progressivement au fur et à mesure que les langues se compartimentalisent. Avec le temps, l’enfant apprendra également que des mots qui s’écrivent de la même manière dans les deux langues peuvent se prononcer de manière différente. Une recherche menée sur des enfants francophones Belges suivant un programme d’immersion scolaire en anglais et ayant appris à lire en anglais confirment ces observations. 150 enfants âgés de 7 à 12 ans fréquentant ce programme ont été testés sur leurs compétences en lecture du français (décodage et compréhension). Leurs performances (type et nombre d’erreurs, vitesse de lecture) ont été comparées à celles d’enfants francophones fréquentant un enseignement unilingue. Leurs habiletés métaphonologiques (manipulation de la rime et du phonème) ont également été testées. [less ▲]

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See detailEnglish Renaissance Lyrics
Delrez, Marc ULg

Learning material (2004)

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See detailEnglish translation and cross-cultural adaptation of the SARQOL Questionnaire
Beaudart, Charlotte ULg; Edwards, M.; Dennisson, E. et al

in Journal of Frailty & Aging (2016), 5(Supplement 1), 58

Detailed reference viewed: 93 (2 ULg)