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See detailElevated carbon dioxide concentration reduces alarm signaling in aphids
Boullis, Antoine ULg; Fassotte, Bérénice ULg; Sarles, Landry ULg et al

in Journal of Chemical Ecology (in press)

Insects often rely on olfaction to communicate with surrounding conspecifics. While the chemical language of insects has been deciphered in recent decades, few studies have assessed how changes in ... [more ▼]

Insects often rely on olfaction to communicate with surrounding conspecifics. While the chemical language of insects has been deciphered in recent decades, few studies have assessed how changes in atmospheric greenhouse gas concentrations will impact pheromonal communication by insects. Here, we hypothesize that changes in the concentration of atmospheric carbon dioxide (CO2) affect the whole dynamics of alarm signaling in aphids, including: (1) the production of the active compound (E)-β-farnesene (Eβf), (2) emission behavior when under attack, (3) perception by the olfactory apparatus, and (4) the escape response. We reared two strains of the pea aphid Acyrthosiphon pisum under ambient and elevated CO2 concentrations for several generations. We found that an increase in CO2 concentration reduced the production (i.e., individual content) and emission of Eβf (released under predation events). While no difference in Eβf neuronal perception was observed, we found that an increase in CO2 strongly reduces the escape behavior expressed by an aphid colony following exposure to natural doses of the alarm pheromone. In conclusion, our results confirm that changes to greenhouse gases do impact chemical communication in insects, and could potentially have a cascade effect on interactions with higher trophic levels. [less ▲]

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See detailElevated GH and normal IGF-1
Beckers, Albert ULg

in Acromegaly Consensus (2009)

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See detailElevated GH and normal IGF-1 : Discrepant biochemical results
Beckers, Albert ULg

Scientific conference (2009)

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See detailElevated heart rate at 24-36 h after admission and in-hospital mortality in acute in non-arrhythmic heart failure
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailElevated MMP-12 protein levels in induced sputum from patients with COPD
Demedts, Inge K.; Morel-Montero, A.; Lebecque, S. et al

in Thorax (2006), 61(3), 196-201

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of ... [more ▼]

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of cigarette smoke induced emphysema. A study was undertaken to investigate the role of MMP-12 in the development of COPD in human smokers. Methods: Induced sputum samples were collected from patients with stable COPD (n = 28), healthy smokers ( n = 14), never smokers ( n = 20), and former smokers ( n = 14). MMP-12 protein levels in induced sputum were determined by ELISA and compared between the four study groups. MMP-12 enzymatic activity in induced sputum was evaluated by casein zymography and by cleaving of a fluorescence quenched substrate. Results: Median (IQR) MMP-12 levels were significantly higher in COPD patients than in healthy smokers, never smokers, and former smokers (17.5 (7.1 - 42.1) v 6.7 (3.9 - 10.4) v 4.2 (2.4 - 11.3) v 6.1 (4.5 - 7.6) ng/ml, p = 0.0002). MMP-12 enzymatic activity was significantly higher in patients with COPD than in controls (4.11 (1.4 - 8.0) v 0.14 (0.1 - 0.2) mu g/ml, p = 0.0002). Conclusion: MMP-12 is markedly increased in induced sputum from patients with stable COPD compared with controls, suggesting a role for MMP-12 in the development of COPD in smokers. [less ▲]

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See detailElevated Plasma Alpha 1-Acid Glycoprotein Levels: Lack of Connection to Resistance to Vecuronium Blockade Induced by Anticonvulsant Therapy
Hans, Pol ULg; Brichant, Jean-François ULg; Pieron, F. et al

in Journal of Neurosurgical Anesthesiology (1997), 9(1), 3-7

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled ... [more ▼]

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled for routine neurosurgery were included in the study. The patients were treated (TG; n = 20) with phenytoin (n = 15) and/or carbamazepine (n = 4) and/or phenobarbital (n = 3) for > or = 6 days or were left untreated (UG; n = 11, control group). TG patients were further assigned to one of two subgroups according to the plasma anticonvulsant level measured the day before surgery and found to be within (TGW, n = 10) or below (TGB, n = 10) the therapeutic range. Finally, the 31 patients were divided into two more groups according to their plasma AAG levels: higher than (HAAG, n = 17) or within (NAAG, n = 14) the normal range (25-94 mg dl-1). Anesthesia was induced and maintained with propofol and sufentanil. Muscle relaxation was obtained with vecuronium 0.1 mg kg-1. A train-of-four (TOF) stimulation mode at 2 Hz was applied to the ulnar nerve every 15 s, and neuromuscular transmission was assessed using a TOF-Guard accelograph monitor. Plasma AAG concentrations (means +/- SEM) were 103.7 +/- 7.6 mg dl-1 in TG, 80.7 +/- 6.7 mg dl-1 in UG, 95.9 +/- 13.2 mg dl-1 in TGW, 111.6 +/- 7.6 mg dl-1 in TGB. 114.9 +/- 7.4 mg dl-1 in HAAG, and 71.4 +/- 3.8 mg dl-1 in NAAG groups. The differences in plasma AAG concentrations between UG and TG and between HAAG and NAAG groups were statistically significant. No significant relationship was found between plasma AAG levels and phenytoin concentrations (r = -0.26). The time (mean +/- SEM) to recovery of T1 to 25% of control was significantly shorter in TG (28.2 +/- 1.4 min) than in UG (42.2 +/- 3.1 min) but did not differ significantly according to the plasma anticonvulsant level (27.3 +/- 2.0 min in TGW; 29.1 +/- 1.9 min in TGB) and the plasma AAG level 31.7 +/- 1.9 min in HAAG; 35.3 +/- 3.3 min in NAAG). The time for the TOF ratio to recover to 25% yielded similar profiles and statistical significance levels: TG, 32.9 +/- 2.2 min; UG, 51.2 +/- 4.0 min; TGW, 35.0 +/- 3.9 min; TGB, 30.7 +/- 1.8 min; HAAG, 38.1 +/- 3.1 min; NAAG, 42.0 +/- 4.1 min. We conclude that anticonvulsant therapy induces an increase in plasma AAG independently of the plasma anticonvulsant level. However, duration and recovery of vecuronium blockade do not differ according to plasma AAG levels. Consequently, elevated AAG does not contribute to the resistance to vecuronium blockade induced by anticonvulsants. [less ▲]

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See detailElevated Plasma Soluble ST2 Is Associated with Heart Failure Symptoms and Outcome in Aortic Stenosis.
LANCELLOTTI, Patrizio ULg; DULGHERU, Raluca Elena ULg; Magne, Julien et al

in PloS one (2015), 10(9), 0138940

B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, a new biomarker of cardiac stretch, is ... [more ▼]

B-type natriuretic peptide (BNP) is often used as a complementary finding in the diagnostic work-up of patients with aortic stenosis (AS). Whether soluble ST2, a new biomarker of cardiac stretch, is associated with symptomatic status and outcome in asymptomatic AS is unknown. sST2 and BNP levels were measured in 86 patients (74+/-13 years; 59 asymptomatic, 69%) with AS (<1.5 cm2) and preserved left ventricular ejection fraction who were followed-up for 26+/-16 months. Both BNP and sST2 were associated with NYHA class but sST2 (>23 ng/mL, AUC = 0.68, p<0.01) was more accurate to identify asymptomatic patients or those who developed symptoms during follow-up. sST2 was independently related to left atrial index (p<0.0001) and aortic valve area (p = 0.004; model R2 = 0.32). A modest correlation was found with BNP (r = 0.4, p<0.01). During follow-up, 29 asymptomatic patients (34%) developed heart failure symptoms. With multivariable analysis, peak aortic jet velocity (HR = 2.7, p = 0.007) and sST2 level (HR = 1.04, p = 0.03) were independent predictors of cardiovascular events. In AS, sST2 levels could provide complementary information regarding symptomatic status, new onset heart failure symptoms and outcome. It might become a promising biomarker in these patients. [less ▲]

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See detailElevation des biomarqueurs cardiaques apres un effort physique intense.
DUGAUQUIER, Christophe ULg; Hanssen, M.; GACH, Olivier ULg et al

in Revue medicale de Liege (2009), 64(7-8), 370-2

We present the case of a patient who felt faint after a strenuous exercise. A coronary angiography was performed because of an elevated level of troponin, but it failed to demonstrat any significant ... [more ▼]

We present the case of a patient who felt faint after a strenuous exercise. A coronary angiography was performed because of an elevated level of troponin, but it failed to demonstrat any significant coronary stenosis. We discuss the effect of strenuous exercise on cardiac biomarkers. Most previous published studies involved young trained populations. The frequency of these abnormalities in older, less trained people is unknown. Moreover, the possible impact of these abnormalities on mid- or long-term outcome is a matter of debate. Seniors practising intensive sport activities should systematically be submitted to a cardiological evaluation. [less ▲]

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See detailElévation faible d’hCG en dehors d’un contexte gravidique : à propos de deux cas et revue de la littérature
DE BACKER, Benjamin ULg; GOFFIN, Frédéric ULg; NISOLLE, Michelle ULg et al

in Annales de Biologie Clinique (2013), 71(4), 496-502

Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to ... [more ▼]

Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophile antibodies. We report the cases of two non-pregnant patients with low serum hCG. In the first case, hCG levels raised during several years following a spontaneous abortion. The likelihood of heterophilic antibodies interference was ruled out and extensive clinical investigation excluded the presence of a tumour. The diagnosis was QTD. In the second case, elevated hCG came to light as an incidental finding in a women with chronic renal failure and led the clinicians to question the laboratory. The cause was probably an increase in pituitary hCG consecutive to terminal renal failure. These cases illustrate the importance of understanding the biology of the hCG and the causes of its persistent low elevation, which are reviewed in this article. It is essential to demonstrate clinically the presence of a tumour in order to avoid unnecessary and ineffective chemotherapy and/or hysterectomy. [less ▲]

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See detailElevation of cardiac and oxidative stress biomarkers after a running activity in sedentary subjects
LE GOFF, Caroline ULg; Bury, Thierry ULg; Rodriguez de la Cruz, Carlos ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailELEVATIONAL PATTERNS OF GENETIC VARIATION IN THE COSMOPOLITAN MOSS BRYUM ARGENTEUM (BRYACEAE)
Pisa, S; Werner, OJ; Vanderpoorten, Alain ULg et al

in American Journal of Botany (2013), 100

Detailed reference viewed: 29 (5 ULg)
See detailElever les truies gestantes en groupes. Témoignages d'éleveurs
Boudry, Christelle ULg

Article for general public (2009)

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See detailLes élèves apprennent mieux les langues quand ils y croient!
Blondin, Christiane ULg; Goffin, Christelle ULg; Baye, Ariane ULg

Learning material (2014)

Written for the teachers, the short paper shows a few results of ESLC about students' attitudes toward the languages and their competences

Detailed reference viewed: 90 (6 ULg)
See detailElèves issus de l’immigration et diversité linguistique et culturelle
Lucchini, Silvia ULg

Scientific conference (2010, January 05)

Detailed reference viewed: 12 (5 ULg)