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See detailFive years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension.
Papapoulos, S.; Chapurlat, R.; Libanati, C. et al

in Journal of Bone and Mineral Research (2012), 27(3), 694-701

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to ... [more ▼]

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to enter an extension to continue the evaluation of denosumab efficacy and safety for up to 10 years. For the extension results presented here, women from the FREEDOM denosumab group had 2 more years of denosumab treatment (long-term group) and those from the FREEDOM placebo group had 2 years of denosumab exposure (cross-over group). We report results for bone turnover markers (BTMs), bone mineral density (BMD), fractures rates, and safety. A total of 4550 women enrolled in the extension (2343 long-term; 2207 cross-over). Reductions in BTMs were maintained (long-term group) or occurred rapidly (cross-over group) following denosumab administration. In the long-term group, lumbar spine and total hip BMD increased further, resulting in 5-year gains of 13.7% and 7.0%, respectively. In the cross-over group, BMD increased at the lumbar spine (7.7%) and total hip (4.0%) during the 2-year denosumab treatment. Yearly fracture incidences for both groups were below rates observed in the FREEDOM placebo group and below rates projected for a "virtual untreated twin" cohort. Adverse events did not increase with long-term denosumab administration. Two adverse events in the cross-over group were adjudicated as consistent with osteonecrosis of the jaw (ONJ). Five-year denosumab treatment of women with postmenopausal osteoporosis maintained BTM reduction and increased BMD, and was associated with low fracture rates and a favorable risk/benefit profile. (c) 2011 American Society for Bone and Mineral Research. [less ▲]

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See detailFive years of experience for the promotion of a better nutritional environment in schools : The programme "Je mange bien à l'école" (I eat well at school) an innovatie project developed in the French-speaking Community of Belgium
Vandoorne, Chantal ULg

in Bouwman, L. I.; Boonekamp, G. M. M.; Koelen, M. A. (Eds.) Proceedings of the International conference on Health Promotion and Nutrition (1996)

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See detailFive years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age.
Seeman, Ego; Boonen, Steven; Borgstrom, Frederik et al

in BONE (2010), 46(4), 1038-42

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures ... [more ▼]

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years. MATERIALS AND METHODS: To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5+/-3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D. RESULTS: By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR=0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR=0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR=0.67; 95% CI 0.50-0.89) and hip fracture risk by 24% (RR=0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years. DISCUSSION: Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving. [less ▲]

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See detailFive-year Denosumab treatment of postmenopausal women with osteoporosis: results from the first two years of the freedom trial extension
Papapoulos, S.; Man, Z.; Mellstrom, D. et al

in Osteoporosis International (2011, March), 22(Suppl.1), 107-108

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See detailFive-year follow-up of patients from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Compere, Stephanie; Rovati, Lucio C et al

in Arthritis and Rheumatism (2003, September), 48(number 9 (suppl.)), 80

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See detailFive-year follow-up of patients from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Compere, S.; Rovati, Lucio C et al

in Osteoarthritis and Cartilage (2003, October), 11(Suppl.1), 10-11

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See detailFive-year follow-up patients issued from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULg; Compère, S.; Gathy, C. et al

in Osteoporosis International (2003, November), 14(Suppl 7), 9

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See detailFixation de ferritine cationisee a la surface des cretes palatines du rat.
Renard, Ariane ULg; Heinen, Ernst ULg; Baeckeland, E.

in Bulletin de l'Association des Anatomistes (1982), 66(192), 117-25

Recently, we suggested that the cell coat of the surface epithelial cells of the palatal shelves and especially its sialyl groups are implied in the adhesion process which initiates the constitution of ... [more ▼]

Recently, we suggested that the cell coat of the surface epithelial cells of the palatal shelves and especially its sialyl groups are implied in the adhesion process which initiates the constitution of the secondary palate. In this work, use of cationized ferritin which interacts with anionic receptors of the plasma membrane give us the possibility to render these sialic acids visible. After five minutes incubation in presence of cationized ferritin, the labeling particles are distributed in monolayer over the plasmalemma of epithelial cells. Subsequent incubation in cationized ferritin free medium results in clustering of the marker followed by the detachment of the labeled patches. Otherwise, incubation in the presence of neuraminidase from Clostridium perfringens before the polycationic ligand contact prevents labeling. We think that lateral migration modifications of the anionic receptor could be associated with changes of the shelves capacity to adhere. [less ▲]

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See detailLa fixation de la frontière linguistique au parlement
Verjans, Pierre ULg

in Ubac, Pierre (Ed.) Génération Fourons (1993)

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See detailFixation du CO2 dans les blocs de béton à base de granulats recyclés
Parmentier, Véronique; Michel, Frédéric ULg; Courard, Luc ULg

in Gagné, Richard (Ed.) Actes de la 14ème édition des Journées Scientifiques (2013)

A l’heure où l’industrie cimentière est majoritairement responsable de la production de CO2 dans le secteur de la construction, il s’avère utile de compenser cette production par un phénomène inverse: la ... [more ▼]

A l’heure où l’industrie cimentière est majoritairement responsable de la production de CO2 dans le secteur de la construction, il s’avère utile de compenser cette production par un phénomène inverse: la captation du CO2. Ce processus d’absorption de CO2, appelé carbonatation, améliore certaines propriétés du béton lors de la conversion du dioxyde de carbone CO2 en carbonate de calcium CaCO3. Les préoccupations environnementales actuelles motivent l’étude de la carbonatation dans le but de maximiser l'absorption du dioxyde de carbone. Les granulats recyclés, produits à base de déchets de béton concassés mécaniquement, peuvent prendre place dans de nouvelles applications en béton. Ils peuvent remplacer les granulats naturels en tout ou en partie, épargnant ainsi l’extraction des matières premières naturelles. La combinaison des deux approches vise à élaborer un produit dont l’impact environnemental est réduit au minimum. [less ▲]

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See detailFixation of oxoglutarate on the external face of the internal minochondrial membrane of rat hearts (proceedings)
Sluse, Francis ULg; Sluse-Goffart, Claudine; Duyckaerts, Claire ULg et al

in Archives Internationales de Physiologie et de Biochimie (1978), 86

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See detailFixed discrimination factors in diet reconstruction?
Caut, Stéphane; Das, Krishna ULg

Conference (2008, August 25)

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See detailFixed implant rehabilitation of the edentulous maxilla: a systematic literature review.
LAMBERT, France ULg; Weber, HP; Gallucci, German et al

Poster (2006, September)

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See detailFixed interval performance in a large sample of rats (N=113) : interindividual differences
Lejeune, Helga ULg; Richelle, Marc ULg

in Psychologica Belgica (1985), 25(1), 73-79

Hundred and thirteen male adult albino rats (Wistar) have successively been submitted to 3 CFR, 3 FI 30, 3 FI 60, 3 FI 90 and 40 FI 120 seconds sessions. The daily sessions lasted in every case 30 minutes ... [more ▼]

Hundred and thirteen male adult albino rats (Wistar) have successively been submitted to 3 CFR, 3 FI 30, 3 FI 60, 3 FI 90 and 40 FI 120 seconds sessions. The daily sessions lasted in every case 30 minutes. Daily distributions of the Curvature Indice (Fry, Kelleher & Cook, 1960) values showed that the mean value increased up to a stabilization point at the 20th FI 120 seconds session and that the inter-individual differences as estimated by the standard deviation increased progressively throughout the session series. Rank correlations (Kendall Tau t) computed between individual Curvature Index values from adjacent or remote sessions were highly osgnificant and showed that the level of adjustment to the FI schedule early in training has a predictive value. [less ▲]

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See detailFixed interval performance in turtle doves: A comparison with pigeons and rats
Lejeune, Helga ULg; Richelle, Marc ULg

in Behaviour Analysis Letters (1982), 2

Turtle doves, pigeons and rats were trained on fixed-interval (FI) 2, 4, 6, 8- and 110-mi, schedules. Response rates were at each FI value, higher in both bird psecies. They decreased as FI value ... [more ▼]

Turtle doves, pigeons and rats were trained on fixed-interval (FI) 2, 4, 6, 8- and 110-mi, schedules. Response rates were at each FI value, higher in both bird psecies. They decreased as FI value increased in rats and pigeons. Rat's curvature indices were in all cases superior to those of birds, and the turtle dove differed significantly from pigeons at 2, 4 and 6 min. Curvature indices decreased in rats and increased in birds (except for 2 turtle doves) as the FI value increased. These results question the traditionally assumed cross-species generality of performance in FI schedules. [less ▲]

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See detailFixed-rank matrix factorizations and Riemannian low-rank optimization
Mishra, Bamdev ULg; Meyer, Gilles ULg; Bonnabel, Silvere et al

E-print/Working paper (2012)

Motivated by the problem of learning a linear regression model whose parameter is a large fixed-rank non-symmetric matrix, we consider the optimization of a smooth cost function defined on the set of ... [more ▼]

Motivated by the problem of learning a linear regression model whose parameter is a large fixed-rank non-symmetric matrix, we consider the optimization of a smooth cost function defined on the set of fixed-rank matrices. We adopt the geometric optimization framework of optimization on Riemannian matrix manifolds. We study the underlying geometries of several well-known fixed-rank matrix factorizations and then exploit the Riemannian geometry of the search space in the design of a class of gradient descent and trust-region algorithms. The proposed algorithms generalize our previous results on fixed-rank symmetric positive semidefinite matrices, apply to a broad range of applications, scale to high-dimensional problems and confer a geometric basis to recent contributions on the learning of fixed-rank non-symmetric matrices. We make connections with existing algorithms in the context of low-rank matrix completion and discuss relative usefulness of the proposed framework. Numerical experiments suggest that the proposed algorithms compete with the state-of-the-art and that manifold optimization offers an effective and versatile framework for the design of machine learning algorithms that learn a fixed-rank matrix. [less ▲]

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