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See detailEtude de la résistance au feu de deux ponts-cadres sur le Canal du Centre
Hanus, François ULg; janssen, David; Franssen, Jean-Marc ULg

Report (2007)

The fire resistance of two short concrete tunnel is evaluated in the scenario of a trafic accident. Theses two tunnels are under a canal in Belgium.

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See detailEtude de la sécrétion et de la clairance métabolique de l'insuline avant et après cure de jeûne protidique chez le sujet obèse
Paquot, Nicolas ULg; Scheen, André ULg; Juchmes, Jacques et al

in Diabètes & Métabolism (1990), 16(suppl), 81

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See detailEtude de la sélectivité tissulaire d’un nouvel antagoniste des récepteurs au thromboxane A2, le BM-613
Hanson, Julien ULg; Rolin, S.; De Leval, X. et al

Poster (2003, January 31)

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See detailEtude de la sémaphorine virale codée par le gène A3 de l’herpèsvirus alcélaphin 1
Myster, Françoise

Doctoral thesis (2015)

Among gammaherpesvirus, the Macavirus genus is composed of viruses associated to malignant catarrhal fever (MCF) and other phylogenetically related viruses. MCF is a frequently fatal lymphoproliferative ... [more ▼]

Among gammaherpesvirus, the Macavirus genus is composed of viruses associated to malignant catarrhal fever (MCF) and other phylogenetically related viruses. MCF is a frequently fatal lymphoproliferative disease. Three macaviruses inducing MCF have been entirely sequenced: alcelaphine herpesvirus 2 (AlHV-2), ovine herpesvirus 2 (OvHV-2) and alcelaphine herpesvirus 1 (AlHV-1). Sheep carries OvHV-2 asymptomatically while wildebeest is infected with AlHV-1 without developing any clinical signs or lesions. Both viruses represent the most studied macaviruses. In susceptible ruminants, OvHV-2 and AlHV-1 induce the sheep-associated form and the wildebeest-derived form of MCF (WD-MCF), respectively. Economic consequences of WD-MCF are significant in sub-Saharan Africa. WD-MCF is characterized by the proliferation and infiltration of lymphoblastoid T cells surrounding blood vessels and can be considered as a model for peripheral T cell lymphoma caused by a virus. Rabbits are used as experimental model to study MCF. This species develops clinical signs and lesions that they are indistinguishable from those observed in other susceptible species. Until recently, available data on WD-MCF pathogenesis were limited to the simple description clinical signs and lesions. Recently, it was demonstrated that CD8+ T cells proliferate and that this cellular expansion is associated with a severe increase of the viral load in PBMC and lymphoid organs (Dewals et al., 2008). The cloning of the AlHV-1 genome as an infectious and pathogenic bacterial artificial chromosome (BAC) has greatly facilitated the study of individual gene of AlHV-1 (Dewals et al., 2006). Among herpesviruses, viral semaphorins can only be found in members of the Macavirus genus. OvHV 2 encodes Ov3, and AlHV-2 and AlHV-1 encode A3, both genes encoding a semaphorin homolog. Semaphorins are proteins characterized by a conserved amino-terminal domain, the SEMA domain. The roles of the semaphorins on cytoskeleton dynamics have been widely studied. Viral semaphorins could mediate immune evasion mechanisms or viral dissemination and could be involved in specific properties of macaviruses. The first study of the present thesis was dedicated to the investigation of the pathogenesis of WD-MCF and the role of latency. We investigated the distribution of the AlHV-1 infection in the lesions and demonstrated that the infiltration of CD8+ T cells in different lymphoid and non-lymphoid organs and tissues is directly associated with a non-productive viral infection. The second study focused on the A3 gene of AlHV-1 and its potential functions during WD-MCF. We showed that the A3 gene is expressed during the early phase of the viral infection and encodes a functional semaphorin that was termed AlHV-sema. AlHV-sema was able to induce cell retraction. Despite the observed independent acquisition of pox- and herpesvirus semaphorins, AlHV-sema inhibited phagocytosis by dendritic cells and migration to the draining lymph node through mechanisms similar to poxvirus semaphorin. AlHV-sema could also facilitate viral dissemination or confer immune evasion functions. Next, we investigated whether AlHV-sema could affect WD-MCF induction. We did not observe any effect of the absence of AlHV-sema expression during the development of WD-MCF after rabbit nasal infection. Macaviruses are swine and ruminant gammaherpesviruses responsible for a latent asymptomatic infection in their natural species. The development of MCF in other ruminant susceptible species is due to cross-species transmission. During evolution, the gene selection in susceptible species is certainly reduced due to the fact that these species are dead-end hosts. Thus, it is difficult to address the role of AlHV-1 specific genes in MCF as these genes have evolved in other species. Nevertheless, we brought in this work important insight for our understanding of the pathogenesis of WD-MCF and we identified AlHV-sema as a potential immunoevasion factor. DEWALS B., MYSTER F., PALMEIRA L., GILLET L., ACKERMANN M., VANDERPLASSCHEN A. Ex vivo bioluminescence detection of alcelaphine herpesvirus 1 infection during malignant catarrhal fever. J. Virol., 2011, 85, 6941-6954. MYSTER F., PALMEIRA L., SOREL O., BOUILLENNE F., DEPAUW E., SCHWARTZ-CORNIL I., VANDERPLASSCHEN A., DEWALS B.G. Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gamma-herpesvirus-induced lymphoproliferation in malignant catarrhal fever. J. Virol., 2015. [less ▲]

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See detailEtude de la sensibilité à la douleur : comparaison entre populations contrôle et fibromyalgique
Maquet, Didier ULg; Demoulin, Christophe ULg; Croisier, Jean-Louis ULg et al

in Revue du Rhumatisme (2006), 73

Introduction : Le seuil de sensibilité à la douleur (SSD) peut être apprécié à partir de la pression minimale induisant une perception nociceptive. Ce seuil s’objective aisément en pratique clinique par ... [more ▼]

Introduction : Le seuil de sensibilité à la douleur (SSD) peut être apprécié à partir de la pression minimale induisant une perception nociceptive. Ce seuil s’objective aisément en pratique clinique par une mesure dolorimétrique. Le but de ce travail consiste à comparer, à partir d’une mesure dolorimétrique, le SSD de sujets contrôles et fibromyalgiques et, d’autre part, d’établir des valeurs normatives. Patients et méthodes : Cent sujets contrôles (50 féminins et 50 masculins) et 20 patientes fibromyalgiques sont inclus dans l’étude. Le SSD des 18 points sensibles définis par le Collège Américain de Rhumatologie dans le cadre des critères de classification de la fibromyalgie est mesuré à partir d’un dolorimètre électronique. La pression transmise est augmentée graduellement au rythme de 1 kg/cm² chaque seconde et ce, jusqu’à l’apparition d’une véritable douleur, et non plus d’une simple sensibilité. Le SSD (en kg/cm²) des 9 points spécifiques bilatéraux est déterminé et un score myalgique s’établit par l’addition de ceux-ci. Un test-retest réalisé à 3 jours d’intervalle apprécie la reproductibilité intra-examinateur des SSD. Résultats : Les coefficients de variation correspondent respectivement à 17 % et 13 % chez les sujets contrôles féminins et masculins, et 24 % chez les fibromyalgiques. La reproductibilité apparaît la plus favorable pour les points « fessier » et « genou ». Les SSD s’avèrent significativement inférieurs chez les sujets contrôles féminins en comparaison des volontaires masculins (p < 0,01) et aucun effet de latéralité n’est constaté. Les SSD mesurés chez les fibromyalgiques demeurent systématiquement inférieurs (réduction de 60 %) à ceux de la population contrôle (p < 0,0001). Les SSD les plus faibles sont mesurés aux points « trapèze », « occiput », « cervical antérieur » et « 2ème côte » tant chez les sujets contrôles que fibromyalgiques. Le score myalgique atteint 20 + 7,4 kg/cm² et 49,9 kg/cm² respectivement chez les patients fibromyalgiques et chez les sujets contrôles féminins. Discussion : Une mesure dolorimétrique permet d’objectiver le SSD avec une reproductibilité satisfaisante. Ce travail démontre des valeurs de SSD particulièrement faibles chez les fibromyalgiques. De façon originale, nous objectivons, chez les sujets contrôles, particulièrement de sexe féminin, des SSD souvent inférieurs au seuil décrit par l’ACR (4 kg/cm²). Conclusion : L’établissement d’un score myalgique permet d’apprécier, à partir d’une mesure dolorimétrique, la sensibilité nociceptive et offre la possibilité d’un suivi longitudinal du patient en terme de douleur. [less ▲]

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See detailEtude de la sensibilité de 100 souches hospitalières d'entérobactéries productrices de beta-lactamases à spectre élargi
Evrard, Béatrice; CHRISTIAENS, Geneviève ULg; Dandrifosse, A.-C. et al

Poster (1995, October)

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See detailEtude de la séquence hyperplasie-adénome dans la tumorigenèse de l'hypophyse : rôle des mutations du gène
Villa, C.; Lagonigro, M.; Magri, F. et al

in Annales d'Endocrinologie (2010, September), 71(5), 411

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See detailEtude de la séquence hyperplasie-adénome dans la tumorigenèse de l'hypophyse : rôle des mutations du gène AIP
Villa, C.; Lagonigro, M.; Magri, F. et al

in 27ème Congrès de la Société Française d'Endocrinologie - Deauville, 29 septembre - 2 octobre 2010 (2010, September)

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See detailEtude de la sphéroïdisation de la perlite et de la recristallisation de la ferrite sous champ magnétique
Nutal, Nicolas ULg

Doctoral thesis (2013)

The steel industry is constantly looking for innovations and solutions to improve production processes as well as product properties. However, current technologies result from decades of development and ... [more ▼]

The steel industry is constantly looking for innovations and solutions to improve production processes as well as product properties. However, current technologies result from decades of development and thus have already reached maturity. Therefore, bright innovations have to arise from technological breakthroughs. The objective of those novelties is to induce drastic changes in terms of process or product. Magnetic heat treatment might be a solution to reach both objectives. Indeed, recent researches have shown that magnetic fields can significantly modify the transformation kinetics in steels. This can turn into very positive impacts on the metallurgical processes. However, researches on this topic are in the early stage and a lot of fields have not been studied yet. This work has been carried out in this challenging context. The main objective is to study the effect of magnetic fields on cementite spheroidization and ferrite recrystallization. So far, these two transformations involve long thermal treatments at high temperatures. Thus, a reduction of the processing time or an improvement of the mechanical properties of the steels by using magnetic field processing would be a significant improvement for this kind of thermal treatment. The transformations that are studied imply large microstructure modifications: lamellae breaks into spheroids while ferrite recrystallizes. As a consequence, the developments of dedicated microstructure characterization techniques are concomitant objectives. As it will be shown latter, we decided to develop and optimize image analysis tools. Practically, the completion of this work has required the pursuit of four objectives: Objective 1: develop an image analysis tool dedicated to pearlite spheroidization study, Objective 2: study the effect of magnetic field on cementite spheroidization, Objective 3: develop an image analysis tool dedicated to ferrite recrystallization study, Objective 4: study the effect of magnetic field on ferrite recrystallization. This work is divided in four parts described below. A general introduction constitutes the first part. It contains two chapters. Chapter I focuses on a literature review of the effect of magnetic fields on steels. The first section of this chapter deals with the basics of metallurgy and magnetism required to understand this work. Then, the reader will find a literature review about the effects of homogeneous magnetic fields on steel transformations. As it has been said before, the specificity of this work lies in the fact that the transformations studied were analysed and characterized using image analysis. The Chapter II is dedicated to this technique. The basics of image analysis are summarized in the first section of this chapter. Then, specific sections are dedicated to each step of image analysis: pre-treatment, image segmentation and characterizations. The limits of this technique, as well as its applications are described in the two last sections of this chapter. The second part of this work is divided in three chapters and deals with cementite spheroidization under magnetic field. Chapter III provides a detailed introduction to cementite spheroidization. The first section of this chapter introduces the pearlite as well as its microstructure. Using these concepts, the mechanisms and the kinetic of cementite spheroidization and cementite ripening will be introduced. Finally, the last section of this chapter will focus literature results which indicate that a potential effect of magnetic field on cementite spheroidization might be expected. After this detailed introduction, the tools used to study the cementite spheroidization under magnetic field will be described in Chapter IV. The first section deals with the characterization techniques used to study pearlite spheroidization. Then, the furnace and the heat treatments that have been performed will be described. With these tools, we will describe, in Chapter V, the results that have been achieved about cementite spheroidization under magnetic field. First, we will deeply analyse the effect of temperature and heat treatment duration on cementite spheroidization. This will be the opportunity to study in details the mechanism of cementite spheroidization and spheroids ripening. Microstructure evolutions induced by these two transformations will also be analysed. The effects of magnetic field on cementite spheroidization are described in the last section of this chapter. The analysis of the effect of magnetic field on ferrite recrystallization constitutes the third part of this work. It is divided in three chapters. Chapter VI provides a detailed introduction to ferrite recrystallization. The first section of this chapter deals with the crystalline structure defects induced by the steel forming. The detailed description of the mechanisms and the kinetics of defects elimination by the recovery, primary recrystallization and secondary recrystallization constitute the three next sections of this chapter. The last section of this chapter summarizes the results of different relevant studies on the effects of magnetic fields on these three processes. The chapter VI is followed by a detailed description of the characterization techniques as well as the heat treatment performed to study ferrite recrystallization (Chapter VII). Chapter VIII describes the results that have been obtained about ferrite recrystallization under magnetic field. We will study the effect of temperature and heat treatment duration on ferrite recrystallization. The involved transformations will be studied in detail. Finally, the effect of magnetic field on ferrite recrystallization will be discussed in the last section of this chapter. The general conclusions as well as the prospects of this work will be addressed in the fourth part of this work, respectively in Chapters IX and X. [less ▲]

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See detailEtude de la stabilité antigénique d'une souche non cytopathogène de virus BVD chez des animaux infectés expérimentalement de manière persistante
Mignon, Bernard ULg; Schwers, A.; Waxweiler, S. et al

in Annales de Médecine Vétérinaire (1990), 134

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See detailEtude de la statégie alimentaire du balbuzard pêcheur
Rosoux, René; Libois, Roland ULg; Schweyer, Jean Baptiste

Learning material (2010)

Detailed reference viewed: 34 (5 ULg)