Implication of plasmacytoid dendritic cells in the malignant transformation of cervical epithelial metaplasia

Poster (2011)

Implication of plasmacytoid dendritic cells in the malignant transformation of cervical epithelial metaplasia

Poster (2010, September)

The cervical transformation zone is a dynamic area of a few millimeters in which a glandular epithelium has been replaced by a squamous epithelium through a metaplastic process. Interestingly, a ... [more ▼]

The cervical transformation zone is a dynamic area of a few millimeters in which a glandular epithelium has been replaced by a squamous epithelium through a metaplastic process. Interestingly, a substantial majority (87%) of cervical (pre)cancerous lesions develops within this peculiar microenvironment. Our previous studies reported that intrinsic immune features altered in the metaplastic epithelium could contribute to cancer development by preventing efficient antitumor/antiviral immune response. Plasmacytoid dendritic cells (pDC) are key effectors in host innate immunity and orchestrate adaptive immune responses. Recently, infiltration by these subtypes of dendritic cells has been shown in different cancers. However their implication in antitumor response is largely debated. The present study was performed to determine the implication of pDC in the cervical “metaplasia-dysplasia-cancer” sequence. We demonstrated that the density of pDC increases in the epithelium of metaplastic and (pre)cancerous cervical tissues as well as in underlying stroma as compared with normal exocervical epithelium. This could be partially explained by the increased expression of chemerin, their chemotactic peptide, observed in those areas. We developed a method to efficiently generate pDC cells exhibiting morphological and immunohistochemical features of blood pDC from a limited number of CD34+ cord blood progenitors. Using these in vitro generated pDC, we demonstrated that medium conditioned by transformed keratinocytes modified the activation status of pDC, by inducing a decreased expression of costimulatory molecules such as CD86 and HLA-DR. Moreover, malignant keratinocytes diminished the ability of pDC to produce IFNα in response to an oligonucleotide containing CpG motifs, a defined microbial stimulus for pDC. These results suggest that pDC could be educated within the metaplastic and/or (pre)cancerous microenvironment to acquire a tolerogenic phenotype that could promote carcinogenesis. In agreement with those results, we observed that both metaplastic areas and (pre)cancerous lesions of the cervix are infiltrated by T regulatory cells. [less ▲]

Implication of surface charge effects in color removal from effluents by chemical coagulation - the case of CI Reactive Blue 4 dye

in Pratsinis, S. (Ed.) Proceeedings CD of Partec 2004 Inetrnational Congress of Particle Technology (2004, March)

Characterisation of dye flcos during colour removal from synthetic waste water is presented. Surface charge and floc size and shapes are measured and an implications towards the predominant removal ... [more ▼]

Characterisation of dye flcos during colour removal from synthetic waste water is presented. Surface charge and floc size and shapes are measured and an implications towards the predominant removal emchanisms is made. [less ▲]

Implication of the PAI-1/uPA/uPAR complex in the antiangiogenic action of 16K prolactin

Poster (2012, April)

Implication of the PAI-1/uPA/uPAR signalosome in the antiangiogenic action of 16K prolactin

Poster (2012, May 19)

Implication of tilted peptides in viral fusion

Poster (2008, August)

Implication of VEGF receptor soluble forms, sVEGFR-1 and sVEGFR-2, in angiogenesis

in Acta Clinica Belgica (2008), 63/1

Implications cliniques de l'association d'un tonus sympathique accru, du syndrome métabolique et de l'hypertension

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (2003), 2

Les implications de l'internationalisation sur les processus de gestion de la Petite ou Moyenne Entreprise

in CEFIP (Ed.) L'internationalisation de la PME (titre provisoire) (2012)

In the economic, political, social and financial context that has been a feature of the early 21st century, factors such as the deregulation of markets and commercial practices and the growing ... [more ▼]

In the economic, political, social and financial context that has been a feature of the early 21st century, factors such as the deregulation of markets and commercial practices and the growing interconnection of markets have resulted, virtually inevitably, with Small and Medium-Sized Enterprises having to get to grips with the phenomenon of internationalisation. This challenge is having inescapable consequences on the organisation and day-to-day operation of SMEs, forcing them in particular to make their management practices more professional, especially in terms of implementing systematic control procedures into their activities. SMEs have also had effectively to introduce a multicultural dimension linked closely to the internationalisation of their business to their management practices and processes, and to their way of making strategic choices. These changes are having an effect on the tools, rules, lines of conduct, internal directives, informal practices, etc. that together make up the system of processes deployed by SME managers to enable their companies to be managed with regular and recurrent performance in mind. This is characterised in particular by the fact that they need to be capable of achieving the financial, manufacturing and employment-related objectives that they set themselves. The aim of this contribution is to identify, through a structured framework of analysis, what the implications are that internationalisation may have on the system of processes within SMEs that are performing well. It is based on a summary of the elements highlighted in the specialist scientific and business literature devoted to the impact of internationalisation in the context of an SME. It is structured and uses the modelling of the (non-)performance of the SME proposed by Crutzen and Van Caillie (2009) as its organisational framework [less ▲]

Implications de la distribution des acides nucléiques sur l'organisation morpho-fonctionnelle du nucléole

Scientific conference (1993)