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See detailEnterohaemorrhagic Escherichia coli serogroup O111 inhibits NF-(kappa)B-dependent innate responses in a manner independent of a type III secreted OspG orthologue.
Nobe, Rika; Nougayrede, Jean*-Philippe; Taieb, Frederic et al

in Microbiology (2009), 155(Pt 10), 3214-25

Enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) inject a repertoire of effector proteins into host cells via a type III secretion system (T3SS) encoded by the locus of enterocyte ... [more ▼]

Enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) inject a repertoire of effector proteins into host cells via a type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE). OspG is an effector protein initially identified in Shigella that was shown to inhibit the host innate immune response. In this study, we found ospG homologues in EHEC (mainly of serogroup O111) and in Yersinia enterocolitica. The T3SS encoded by the LEE was able to inject these different OspG homologues into host cells. Infection of HeLa cells with EHEC O111 inhibited the NF-kappaB-dependent innate immune response via a T3SS-dependent mechanism. However, an EHEC O111 ospG mutant was still able to inhibit NF-kappaB p65 transfer to the nucleus in infected cells stimulated by tumour necrosis factor alpha (TNF-alpha). In addition, no difference in the inflammatory response was observed between wild-type EHEC O111 and the isogenic ospG mutant in the rabbit ligated intestinal loop model. These results suggest that OspG is not the sole effector protein involved in the inactivation of the host innate immune system during EHEC O111 infection. [less ▲]

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See detailL’Entéropathie Epizootique des lapins : passé, présent et futur
Marlier, Didier ULg

in ITAVI (Ed.) Proceedings des 16èmes journées de la recherche cunicole (2015, November 24)

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See detailL'Entéropathie Epizootique du Lapin (EEL) : étude du rôle des infections par clostridium perfringens dans l’étio-pathogénie de ce syndrome
Dewrée, Roxane; Licois, Dominique; Coudert, Pierre et al

in Proceedings of the 10èmes Journées de la Recherche Cunicole (2003, November 20)

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See detailL'Entéropathie Epizootique du Lapin (EEL) : un bilan provisoire des résultats après 20 mois de recherches
Marlier, Didier ULg; Dewrée, Roxane; Licois, Dominique et al

in Proceedings of the 10èmes Journées de la Recherche Cunicole (2003, November 20)

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See detailEnteropathogenic (EPEC), enterohaemorragic (EHEC) and verotoxigenic (VTEC) Escherichia coli in wild cervids
Bardiau, Marjorie ULg; Grégoire, Fabien ULg; Muylaert, Adeline ULg et al

in Journal of Applied Microbiology (2010), 109(6), 2214-2222

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See detailEnteropathogenic and enterohaemorrhagic Escherichia coli deliver a novel effector called Cif, which blocks cell cycle G(2)/M transition
Marches, O.; Ledger, T. N.; Boury, M. et al

in Molecular Microbiology (2003), 50(5), 1553-1567

Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are closely related pathogens. Both use a type III secretion system (TTSS) encoded by the 'locus of enterocyte effacement ... [more ▼]

Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are closely related pathogens. Both use a type III secretion system (TTSS) encoded by the 'locus of enterocyte effacement' (LEE) to subvert and attach to epithelial cells through the injection of a repertoire of effector molecules. Here, we report the identification of a new TTSS translocated effector molecule called Cif, which blocks cell cycle G(2)/M transition and induces the formation of stress fibres through the recruitment of focal adhesions. Cif is not encoded by the LEE but by a lambdoid prophage present in EPEC and EHEC. A cif mutant causes localized effacement of microvilli and intimately attaches to the host cell surface, but is defective in the ability to block mitosis. When expressed in TTSS competent LEE-positive pathogens, Cif is injected into the infected epithelial cells. These cells arrested at the G(2)/M phase displayed accumulation of inactive phosphorylated Cdk1. In conclusion, Cif is a new member of a growing family of bacterial cyclomodulins that subvert the host eukaryotic cell cycle. [less ▲]

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See detailEnterotoxaemia in foods animals
Linden, A.; Manteca, C.; Daube, G. et al

Conference (2004)

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See detailEnterotoxaemia-like syndrome and Clostridium perfringens in veal calves
Muylaert, Adeline ULg; Lebrun, M.; Duprez, Jean-Noël ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2010), 167

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See detailL'entérotoxémie bovine en Belgique. I. Introduction et contexte bibliographique.
Manteca, C.; Daube, Georges ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailL'entérotoxémie bovine en Belgique. II. Epizootiologie élémentaire et pathologie descriptive.
Manteca, Christophe; Daube, Georges ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (2000), 145

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See detailLes entérotoxémies
Moreau, F.; Saegerman, Claude ULg

in Probio-Revue (1989)

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See detailEnteroviral meningoencephalitis as complication of Rituximab therapy in a patient treated for diffuse large B-cell lymphoma
Servais, Sophie ULg; Caers, Jo ULg; Warling, Odette et al

in British Journal of Haematology (2010), 150(3), 379-381

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See detailEnterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes
Alidjinou, Enagnon Kazali; Sané, Famara; Engelmann, Ilka et al

in Discovery Medicine (2014), 18

Beyond acute clinical conditions, the role of enteroviruses (EVs) in chronic human diseases has been described. Although they are considered as highly cytolytic viruses, EVs can persist in various tissues ... [more ▼]

Beyond acute clinical conditions, the role of enteroviruses (EVs) in chronic human diseases has been described. Although they are considered as highly cytolytic viruses, EVs can persist in various tissues. The persistence is believed to play a major role in the pathogenesis of EV related chronic dis- eases such as type 1 diabetes (T1D). T1D is charac- terized by an autoimmune destruction of pancreatic beta cells, and results from interplay between a genetic predisposition, the immune system, and environmental factors. EVs and especially group B coxsackieviruses (CVB) have been the most incrimi- nated as exogenous agents involved in the develop- ment of T1D. Enteroviral persistence is the result of a virus-host coevolution combining a cell resistance to lysis through mutations or down-regulation of viral receptor, and a decrease of the viral replication by genomic modifications or the production of a sta- ble double-stranded RNA form. CVB can persist in pancreatic cells and therefore could trigger, in genet- ically predisposed individuals, the autoimmune destruction of beta cells mainly through an activa- tion of inflammation. The persistence of the virus in other tissues such as intestine, blood cells, and thy- mus has been described, and could also contribute to some extent to the enteroviral pathogenesis of T1D. The molecular and cellular mechanisms of CVB per- sistence and the link with the development of T1D should be investigated further. [less ▲]

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See detailEntgegnung auf die Mitteilung des Herrn J. Kefsler, über die angebliche Nichtexistenz der Pentathiosaure
Spring, Walthère ULg

in Justus Liebigs Annalen der Chemie (1880), 201

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See detailEnthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2
Krintel, Christian; Francotte, Pierre ULg; Pickering, Darryl S. et al

in Biophysical Journal (2016), 110

The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g ... [more ▼]

The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer’s disease. The modulators bind in a cleft formed by the interface of two neighboring ligand binding domains and act by stabilizing the agonist-bound open- channel conformation. The driving forces behind the binding of these modulators can be significantly altered with only minor substitutions to the parent molecules. In this study, we show that changing the 7-fluorine substituent of modulators BPAM97 (2) and BPAM344 (3) into a hydroxyl group (BPAM557 (4) and BPAM521 (5), respectively), leads to a more favorable binding enthalpy (DH, kcal/mol) from 4.9 (2) and 7.5 (3) to 6.2 (4) and 14.5 (5), but also a less favorable binding entropy ( TDS, kcal/mol) from 2.3 (2) and 1.3 (3) to 0.5 (4) and 4.8 (5). Thus, the dissociation constants (Kd, mM) of 4 (11.2) and 5 (0.16) are similar to those of 2 (5.6) and 3 (0.35). Functionally, 4 and 5 potentiated responses of 10 mM L-glutamate at homomeric rat GluA2(Q)i receptors with EC50 values of 67.3 and 2.45 mM, respectively. The binding mode of 5 was examined with x-ray crystallography, showing that the only change compared to that of earlier compounds was the orientation of Ser-497 pointing toward the hydroxyl group of 5. The favorable enthalpy can be explained by the formation of a hydrogen bond from the side-chain hydroxyl group of Ser-497 to the hydroxyl group of 5, whereas the unfavorable entropy might be due to desolva- tion effects combined with a conformational restriction of Ser-497 and 5. In summary, this study shows a remarkable example of enthalpy-entropy compensation in drug development accompanied with a likely explanation of the underlying structural mechanism. [less ▲]

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See detailUne entite electrocardiographique peu connue, mais pourtant importante aux urgences ... le syndrome de Wellens.
Javillier, B.; Jacquet, C.; Legrand, Victor ULg

in Revue medicale de Liege (2012), 67(10), 527-30

We report the case of a 54-year-old patient admitted to an emergency department, because of a thoracic pain suspicious for angina pectoris. Although the patient had become asymptomatic on admission, his ... [more ▼]

We report the case of a 54-year-old patient admitted to an emergency department, because of a thoracic pain suspicious for angina pectoris. Although the patient had become asymptomatic on admission, his electrocardiogram presented abnormalities (biphasic T waves in V1 to V4 ) which prompted a diagnosis of unstable angina.This electrocardiophic pattern is known as Wellens' syndrome. [less ▲]

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