Impairment of the M-protein and unmasking of a superficial type-specific antigen by proteolytic treatment of influenza A virions with preservation of host-specific antigenicity

in Intervirology (1976), 6(4-5), 239-248

Influenza PR8 particles resulting from strong treatment with caseinase C are spikeless, devoid of neuraminidase and hemagglutinin 1 and 2 glycopeptides, and contain a Schiff-neg. polypeptide of about 13 ... [more ▼]

Influenza PR8 particles resulting from strong treatment with caseinase C are spikeless, devoid of neuraminidase and hemagglutinin 1 and 2 glycopeptides, and contain a Schiff-neg. polypeptide of about 13,000 mol. wt. which exists as traces in intact virions. Their M-protein polypeptide content is reduced to 50% of its original value, but there is no evidence of particle disruption nor of lipid release. They fix complement in the presence of both anti-M-protein and antiserum raised against a host polysaccharide. During exposure to caseinase C, an antigen is unmasked. It is type-specific and its identity with the M-protein is discussed [less ▲]

Impala: A Simple Restraint Field To Simulate The Biological Membrane In Molecular Structure Studies

in Proteins-Structure Function and Bioinformatics (1998), 30(4), 357-71

The lipid bilayer is crucial for the folding of integral membrane proteins. This article presents an empirical method to account for water-lipid interfaces in the insertion of molecules interacting with ... [more ▼]

The lipid bilayer is crucial for the folding of integral membrane proteins. This article presents an empirical method to account for water-lipid interfaces in the insertion of molecules interacting with bilayers. The interactions between the molecule and the bilayer are described by restraint functions designed to mimic the membrane effect. These functions are calculated for each atom and are proportional to the accessible surface of the latter. The membrane is described as a continuous medium whose properties are varying along the axis perpendicular to the bilayer plane. The insertion is analyzed by a Monte Carlo procedure applied to the restraint functions. The method was successfully applied to small alpha peptides of known configurations. It provides insights of the behaviors of the peptide dynamics that cannot be obtained with statistical approaches (e.g., hydropathy analysis). [less ▲]

Impasse du commerce: Fréret linguiste

in Grell, C.; Volpilhac-Auger, C. (Eds.) Nicolas Fréret, légende et vérité : Colloque des 18 et 19 octobre 1991, Clermont-Ferrand (1994)

L'impatto della scoperta del manoscritto veronese sull’insegnamento del diritto romano nel Belgio

in Milazzo, Francesco (Ed.) Gaius Noster: Nei segni del Veronese: atti del Convegno (Copanello 8-11 giugno 2012) (2013)

Impedance spectroscopy of GeSn/Ge heterostructures by a numerical method

in 222nd ECS Meeting, 2012 (2012)

In this work, we investigated the electrical characteristics of p-GeSn/p-Ge and p-GeSn/n-Ge structures obtained by simulation of the semiconductor equations. We developed a numerical formalism based on a ... [more ▼]

In this work, we investigated the electrical characteristics of p-GeSn/p-Ge and p-GeSn/n-Ge structures obtained by simulation of the semiconductor equations. We developed a numerical formalism based on a drift-diffusion model including a trap level and applied it to typical GeSn-based heterostructures by focusing on the electrical response under small-signal alternating current regime. The results demonstrate that our method provides an access to both microscopic and macroscopic properties, and thereon, to a physical interpretation of the electrical characteristics of GeSn-based structures by linking measurable quantities to micro-scale variations in the structures. [less ▲]

Imperial Reflections: The Post-Colonial Verse-Novel as Post-Epic

in Hardwick, Lorna (Ed.) Classics in Post-Colonial Worlds (2007)

Impiety in Epigraphic Evidence

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2011), 24

The aim of this paper is to highlight several features of the concept of impiety (asebeia) and of its use in inscriptions. Two main types of epigraphic texts mention impiety: 1. preventive laws, where ... [more ▼]

The aim of this paper is to highlight several features of the concept of impiety (asebeia) and of its use in inscriptions. Two main types of epigraphic texts mention impiety: 1. preventive laws, where formulations such as asebes esto, asebeito and enokhos esto asebeiai have a double effect inasmuch as they categorize an offence as an impiety and, in addition, they give a culprit the status of impious and 2. reports of trials or of past wrongs. Being regarded as impious entails other consequences on the relationship between the culprit and gods but also between the culprit and the human community – the main issue being that these consequences are seldom explicitly mentioned. Moreover, instead of a single law or text defining impiety or proceedings to take place in case of impiety, there is an array of texts in which impiety appears, the sum of which forms what a community would legally recognize as an impiety. [less ▲]

Implant comprising a core and a tube encasing the core

Patent (2012)

The present invention relates to an implant comprising: - a core material comprising polydimethylsiloxane or at least one hydrogel polymer; - a tube encasing said core material comprising an ethylene ... [more ▼]

The present invention relates to an implant comprising: - a core material comprising polydimethylsiloxane or at least one hydrogel polymer; - a tube encasing said core material comprising an ethylene vinyl acetate polymer or at least one hydrogel polymer; - a sealant for closure of the open ends of said tube comprising polydimethylsiloxane or a mono-, di-, or triacetoxy derivative thereof, or at least one hydrogel polymer; and - at least one active ingredient; with the proviso that when the sealant is said at least one hydrogel polymer, the core material comprises polydimethylsiloxane. Furthermore, the invention relates to an implant for use as a medicament. In particular, the invention relates to an implant for use in the treatment of endometriosis. [less ▲]

Implantable hydrogels

Poster (2007, August 31)

Implantation d'acide hyaluronique estérifié lors de la microchirurgie des lésions cordales bénignes

Doctoral thesis (2008)

La microchirurgie des pathologies cordales bénignes est pratiquée afin d’améliorer les caractéristiques mécaniques du vibrateur laryngé. C’est en augmentant la souplesse tissulaire et la fermeture ... [more ▼]

La microchirurgie des pathologies cordales bénignes est pratiquée afin d’améliorer les caractéristiques mécaniques du vibrateur laryngé. C’est en augmentant la souplesse tissulaire et la fermeture glottique en phonation que le micro-chirurgien espère améliorer les caractéristiques du son laryngé émis. Les techniques microchirurgicales ont évolué de manière spectaculaire au cours des 20 dernières années grâce à la connaissance de plus en plus approfondie de la structure cordale normale et surtout de son tissu conjonctif : la lamina propria. C’est la partie la plus superficielle de la lamina propria, l’espace de Reinke, qui joue le rôle le plus important dans la production du son. C’est aussi l’espace de Reinke qui est occupé, détruit ou remanié en cas de pathologie cordale bénigne. La microchirurgie vise à le libérer du processus pathologique. L’originalité des techniques microchirurgicales exposées dans ce travail est de tenter, non seulement de libérer l’espace vibrant de la lésion cordale, mais aussi de modifier les processus cicatriciels post-opératoires par l’utilisation d’un implant résorbable d’acide hyaluronique estérifié. Les objectifs de ce travail sont : - de contribuer à la connaissance des résultats fonctionnels laryngés et vocaux observés après une microchirurgie cordale - d’évaluer l’impact fonctionnel, sur ces résultats, de l’utilisation d’un implant résorbable d’acide hyaluronique estérifié, en fin d’intervention chirurgicale. [less ▲]