Foci report on indigenous Dermacentor reticulatus populations in Belgium and a preliminary study of associated babesiosis pathogens.
; Lempereur, Laetitia ; et al
in Medical and Veterinary Entomology (2012), 26(3), 355-358
The occurrence of autochthonous clinical cases of canine and equine babesiosis in Belgium during the last two decades suggests that the vector of the pathogens responsible for these diseases, Dermacentor ... [more ▼]
The occurrence of autochthonous clinical cases of canine and equine babesiosis in Belgium during the last two decades suggests that the vector of the pathogens responsible for these diseases, Dermacentor reticulatus (Ixodida: Ixodidae), may be present in this country. Consequently, evidence for the presence of this tick species in different locations within Belgium was investigated. Four different locations were monitored by flagging in 2010; these included the locations at which D. reticulatus was previously found on a dog in 2009 and on two red deer in 2007. Two different species of tick were identified, Ixodes ricinus (Ixodida: Ixodidae) and D. reticulatus. A total of 282 D. reticulatus adult ticks (98 males, 184 females) were collected from the four sites. Ticks were found mainly from early March until the end of May and a peak in activity was apparent in March. A Babesia spp. (Piroplasmida: Babesiidae) genus-specific polymerase chain reaction test based on the amplification of a fragment of the 18S rRNA gene was used to investigate the potential presence of Babesia spp. All DNA extracts isolated from the total tick samples yielded negative results. Additional studies to accurately determine the distribution and vectorial capacity of this important tick species in Belgium are warranted. [less ▲]Detailed reference viewed: 50 (26 ULg)
Focii determination of an off axis ellipsoid : Theory to practice
Houbrechts, Yvette ; Roose, Stéphane ; Stockman, Yvan
in Osten, W.; Novak, E. (Eds.) Proceedings of the Eighth International Conference on Laser and Laser Information Technologies (2004, August 02)
In the frame of cryogenic test on an off axis ellipsoid, it has been required to set-up an unambiguous method to determine and track the foci position during temperature transitions. This procedure was ... [more ▼]
In the frame of cryogenic test on an off axis ellipsoid, it has been required to set-up an unambiguous method to determine and track the foci position during temperature transitions. This procedure was mandatory to avoid: (1) impact of the operator skills working on triple shift scheme to assure continuously monitoring of the ellipsoid shape during cool down. (2) correctly dissociate the impact of the thermal deformation on the mirror shape with respect to alignment errors. This paper will demonstrate the process, starting from ideal ellipsoid shape, then introducing 3D metrology data in a model, and finally presents the results in a practical situation. [less ▲]Detailed reference viewed: 18 (1 ULg)
Focus cardiac ultrasound: the European Association of Cardiovascular Imaging viewpoint.
; ; et al
in European heart journal cardiovascular Imaging (2014)
The concept of point-of-care, problem-oriented focus cardiac ultrasound examination (FoCUS) is increasingly applied in the settings of medical emergencies, including cardiac diseases. The European ... [more ▼]
The concept of point-of-care, problem-oriented focus cardiac ultrasound examination (FoCUS) is increasingly applied in the settings of medical emergencies, including cardiac diseases. The European Association of Cardiovascular Imaging (EACVI) recognizes that cardiologists are not the only medical professionals dealing with cardiovascular emergencies. In reality, emergency cardiac diagnostics and treatment are also carried out by a wide range of specialists. For the benefit of the patients, the EACVI encourages any medical professional, sufficiently trained to obtain valuable information from FoCUS, to use it in emergency settings. These medical professionals need to have the necessary knowledge to understand the obtained information entirely, and to use it correctly, thoughtfully and with care. In this document, the EACVI underlines major differences between echocardiography and FoCUS, and underscores the need for specific education and training in order to fully utilize advantages and minimize drawbacks of this type of cardiac ultrasound examination in the critically ill patients. [less ▲]Detailed reference viewed: 4 (0 ULg)
Focus on skin cancer association and progression under TNF antagonist therapy.
PIERARD-FRANCHIMONT, Claudine ; PIERARD, Gérald ; QUATRESOOZ, Pascale
in Expert Opinion on Biological Therapy (2011), 11(9), 1215-22
INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal ... [more ▼]
INTRODUCTION: Basal and squamous cell carcinomas are the most common non-melanoma skin cancers (NMSC) in humans. Their prevalence is higher in immunocompromized patients. Results of some animal experiments have indicated that TNF acts both as a tumour promotor and an inductor of apoptosis. AREAS COVERED: Peer-reviewed articles about human skin cancers possibly related to TNF antagonists. The occurrence and growth kinetics of NMSC are possibly increased in some patients under TNF antagonist therapy. Other issues of such biological treatment suggested include the activation of other distinct skin malignancies, including malignant melanoma. Benign melanocytic tumours appear to be boosted as well. At present, most of the reported findings only represent anecdotal case reports. The influence of cumulative co-factors must not be neglected, particularly the effect of other therapies administered to the patients. The occurrence of antibodies to some TNF antagonists may decrease both the treatment efficacy and the risk of skin cancer progression. EXPERT OPINION: More research needs to be performed in order to firmly establish and understand the risk of anti-TNF biologicals in the area of human skin cancers. At present, NMSC progression appears to be boosted on areas of skin field cancerization. Benign melanocytic naevi may develop as well. [less ▲]Detailed reference viewed: 27 (0 ULg)
Focus on the epidemiology of metabolic syndrome in Luxembourg. Data from ORISCAV-LUX study
; ; Guillaume, Michèle
Conference (2010)Detailed reference viewed: 7 (0 ULg)
Focus sur la flexicurité au niveau institutionnel belge : entre jeux de pouvoir et appropriation stratégique
Gérard, Julie ; Beuker, Laura
Report (2013)Detailed reference viewed: 23 (8 ULg)
Foedera aequa entre Rome et les cités grecques : nouveaux documents, nouvelles perspectives
Conference (2011, September 21)Detailed reference viewed: 11 (9 ULg)
A fog forecasting method in a deeply embanked valley.
Boreux, Jean-Jacques ;
in Atmospheric Environment, Part A : General Topics (1992), 26(5), 759-764
This paper presents a statistical model used to forecast fog in the Meuse Valley in Belgium. The method is a bootstrap discriminant analysis using eight predictors: river surface temperature, air pressure ... [more ▼]
This paper presents a statistical model used to forecast fog in the Meuse Valley in Belgium. The method is a bootstrap discriminant analysis using eight predictors: river surface temperature, air pressure, air temperature at two elevations, wind speed and relative humidity at the same two locations. These data are measured from November 1989 to April 1990. Tests are done to determine the number of resampling needed for this data set and the optimum projection delay for prediction from the meteorological data. The best results are obtained for the prediction at 0700h UT using meteorological data at 0400 h UT. [less ▲]Detailed reference viewed: 22 (4 ULg)
La foi de Charlemagne
Scientific conference (2013, January 24)
En 2000, Henri Mayr-Harting contesta l’idée qu’Arnold Angenendt se faisait de la religion de Charlemagne . Au modèle d’une religion magique, essentiellement propitiatoire, il opposa un certain génie ... [more ▼]
En 2000, Henri Mayr-Harting contesta l’idée qu’Arnold Angenendt se faisait de la religion de Charlemagne . Au modèle d’une religion magique, essentiellement propitiatoire, il opposa un certain génie éthique carolingien teinté de quelques supports quasi-magiques et posa les jalons d’une enquête sur le sens profond de la religion de Charlemagne, son contenu éthique et son objet. Tout en admettant qu’on ne connaîtrait jamais les convictions personnelles de Charlemagne, il a avancé l’hypothèse qu’on était en mesure d’entendre sa voix dans certains documents faisant échos à un débat qui aurait opposé différents membres de la cour. Confortée par les recherches d’Henry Mayr-Harting, cette conférence visait à évaluer la sincérité des convictions religieuses de celui qui déploya tous les moyens matériels, militaires et humains qu’il avait à sa disposition, pour enseigner à son peuple ce qu’il était nécessaire de croire pour être sauvé. [less ▲]Detailed reference viewed: 21 (5 ULg)
Foi et démocratie. Débat contradictoire avec le R.P. Ignace Berten, O.P.
Conference given outside the academic context (2008)Detailed reference viewed: 6 (0 ULg)
Foi et Modernité aux XIXe-XXe s. : quelle(s) transaction(s) ?
Scientific conference (1993, September 15)Detailed reference viewed: 4 (0 ULg)
Folate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome
Ramaekers, Vincent ; ; et al
in Neuropediatrics (2007), 38(4), 179-183
Rett syndrome was associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF) in 42-50% of European patients whereas approximately 93% of the patients from North-America had a normal ... [more ▼]
Rett syndrome was associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF) in 42-50% of European patients whereas approximately 93% of the patients from North-America had a normal CSF 5MTHF status. We determined the CSF folate status in Rett patients living in North- and South-Western Europe and measured serum folate receptor (FR) autoantibodies of the blocking type to explain the reduced folate transport across the choroid plexus. Irrespective of their MECP2 genotype and despite normal plasma folate values, 14 of 33 Rett patients (42%) had low CSF folate levels. Blocking FR autoantibodies were found in 8 of the Rett patients (24%), 6 of whom had low CSF folate levels. FR autoimmunity was primarily found within the group of Rett patients with low CSF folate status with a higher incidence in North-Western Europe. In Rett patients from North-America 74 of 76 girls had higher folate values in both serum and CSF than European patients. The food folate fortification in North-America may account for the higher folate levels and may prevent CFD in these Rett patients. FR autoimmunity occurred predominantly in Rett patients from North-Western Europe and may contribute to cerebral folate deficiency (CFD). © Georg Thieme Verlag KG Stuttgart. [less ▲]Detailed reference viewed: 4 (1 ULg)
Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits
RAMAEKERS, Vincent ; ; et al
in Neuropediatrics (2007), 38(6), 276-281
Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with ... [more ▼]
Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with early-onset low-functioning autism with or without neurological deficits, were evaluated for serum folate, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies of the blocking type to determine the significance of folate receptor (FR) autoantibodies with respect to folate transport across the blood-CSF barrier. In spite of normal serum folate, CSF 5MTHF was low in 23 of 25 patients. The reduced CSF folate in 19 of these 23 patients could be explained by serum FR autoantibodies blocking the folate binding site of the membrane-attached FR on the choroid epithelial cells. Oral folinic acid supplements led to normal CSF 5MTHF and partial or complete clinical recovery after 12 months. Serum FR autoimmunity appears to represent an important factor in the pathogenesis of reduced folate transport to the nervous system among children with early-onset low-functioning autism associated with or without neurological deficits. Early detection of FR autoantibodies may be a key factor in the prevention and therapeutic intervention among this subgroup of patients with autism. © Georg Thieme Verlag KG Stuttgart. [less ▲]Detailed reference viewed: 26 (1 ULg)
Folding and Stability of Class A beta-Lactamases
Matagne, André ;
in Frère, Jean-Marie (Ed.) Beta-Lactamases (2012)
Class A β-lactamases have proved useful as model proteins in studying a wide variety of aspects of protein folding. We review those features that have shed light on kinetic intermediates that take part in ... [more ▼]
Class A β-lactamases have proved useful as model proteins in studying a wide variety of aspects of protein folding. We review those features that have shed light on kinetic intermediates that take part in folding, including some insight into the molecular basis of the kinetic and stable molten-globule states that have been identified. The contrast between the folding behaviour of PC1 and the two lactamase mutants, P54 and P2, can be attributed in some detail to changes in molecular conformation. The early, very rapid stages of folding of β-lactamases have been shown to be multiphasic, and an interesting intermediate is described that has non-native contacts involving burial of the C-terminal tryptophan. A further feature is that the region around the disulphide bond in the TEM enzymes is formed very early in the foldingreaction. The unusual feature of class A β-lactamases, i.e. a cispeptide bond critical in the stereochemistry of the active site that usually, but not always, involves a proline residue, has been shown to be important in accounting for the slow folding reactions. The effect of substrates on the stabilization of the enzymes and on their reversible deactivation is also reviewed. [less ▲]Detailed reference viewed: 9 (0 ULg)
Folding mechanism of single domain antibody fragments (VHHs) and influence of the internal disulphide bridge on their stability and folding pathway.
Poster (2009, February)Detailed reference viewed: 15 (3 ULg)
Folding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways.
Vandenameele, Julie ; Lejeune, Annabelle ; Di Paolo, Alexandre et al
in Biochemistry (2010), 49(19), 4264-75
Class A beta-lactamases (M(r) approximately 29000) provide good models for studying the folding mechanism of large monomeric proteins. In particular, the highly conserved cis peptide bond between residues ... [more ▼]
Class A beta-lactamases (M(r) approximately 29000) provide good models for studying the folding mechanism of large monomeric proteins. In particular, the highly conserved cis peptide bond between residues 166 and 167 at the active site of these enzymes controls important steps in their refolding reaction. In this work, we analyzed how conformational folding, reactivation, and cis/trans peptide bond isomerizations are interrelated in the folding kinetics of beta-lactamases that differ in the nature of the cis peptide bond, which involves a Pro167 in the BS3 and TEM-1 enzyme, a Leu167 in the NMCA enzyme, and which is missing in the PER-1 enzyme. The analysis of folding by spectroscopic probes and by the regain of enzymatic activity in combination with double-mixing procedures indicates that conformational folding can proceed when the 166-167 bond is still in the incorrect trans form. The very slow trans --> cis isomerization of the Glu166-Xaa167 peptide bond, however, controls the final step of folding and is required for the regain of the enzymatic activity. This very slow phase is absent in the refolding of PER-1, in which the Glu166-Ala167 peptide bond is trans. The double-mixing experiments revealed that a second slow kinetic phase is caused by the cis/trans isomerization of prolines that are trans in the folded proteins. The folding of beta-lactamases is best described by a model that involves parallel pathways. It highlights the role of peptide bond cis/trans isomerization as a kinetic determinant of folding. [less ▲]Detailed reference viewed: 52 (14 ULg)