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Showing results 441 to 460 of 95203
  4ème Cours de Mécanique Analytique II (2011-12), Bac3 math & phys , fichier pdf+vidéos (mov, m4v)Surdej, Jean  Learning material (2011) Detailed reference viewed: 114 (21 ULg) 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology and structure-activity relationshipsPirotte, Bernard ; ; et alin Journal of Medicinal Chemistry (1998), 41 Detailed reference viewed: 5 (2 ULg)4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que nouveaux activateurs du canal potassique ATP-dépendantDe Tullio, Pascal ; Pirotte, Bernard ; et alPoster (1994, January 19) Detailed reference viewed: 3 (0 ULg)The 4m International Liquid Mirror Telescope (ILMT) (Invited talk)Surdej, Jean ; Bartczak, Przemyslaw ; Borkowski, Virginie et alConference (2007) Detailed reference viewed: 38 (16 ULg)The 4m international liquid mirror telescope (ILMT)Surdej, Jean ; Absil, Olivier ; Bartczak, Przemyslaw et alin Stepp, Larry (Ed.) Ground-based and Airborne Telescopes (2006, July 01) The entire funding has recently been obtained in Belgium for the construction of a 4m Liquid Mirror Telescope. Its prime focus will be equipped with a semi-conventional glass corrector allowing to correct ... [more ▼] The entire funding has recently been obtained in Belgium for the construction of a 4m Liquid Mirror Telescope. Its prime focus will be equipped with a semi-conventional glass corrector allowing to correct for the TDI effect and a thinned, high quantum efficiency, 4K × 4K pixel equivalent CCD camera. It will be capable of subarcsecond imaging in the i'(760 nm) and possibly r', g' band(s) over a field of ~ 30' in diameter. This facility will be entirely dedicated to a deep photometric and astrometric variability survey over a period of ~ 5 years. In this paper, the working principle of liquid mirror telescopes is first recalled, along with the advantages and disadvantages of the latter over classical telescopes. Several science cases are described. For a good access to one of the galactic poles, the best image quality sites for the ILMT are located either in Northern Chile (latitude near -29°30') or in North-East India (Nainital Hills, latitude near +29°30'). At those geographic latitudes, a deep (i' = 22.5 mag.) survey will approximately cover 90 square degrees at high galactic latitude, which is very useful for gravitational lensing studies as well as for the identification of various classes of interesting galactic and extragalactic objects (cf. microlensed stars, supernovae, clusters, etc.). A description of the telescope, its instrumentation and the handling of the data is also presented. [less ▲] Detailed reference viewed: 161 (48 ULg)The 4m International Liquid Mirror Telescope projectFinet, François Conference (2012) Detailed reference viewed: 4 (0 ULg)4o Foro de diálogo entre la sociedad civil y las instituciones de Gobierno de la Unión Europea y México. Un diálogo sin verdadero deseoMariage, Thibaud in Cuaderno de Trabajo a propósito de la XI Reunión de la Comisión parlamentaria mixta México-Unión Europea (2011) El punto de visto de un europeo en el 4o Foro de diálogo entre la sociedad civil y las instituciones de Gobierno de la Unión Europea y México. Detailed reference viewed: 15 (2 ULg)The 4s-4p Transitions in Neutral PhosphorusBiémont, Emile ; ; Quinet, Pascal et alin Astronomy and Astrophysics (1994), 283 Detailed reference viewed: 1 (0 ULg)4th International Symposium on Chemosynthesis-based Ecosystems; ; et al Poster (2009) Detailed reference viewed: 10 (1 ULg)4U 1700-37Surdej, Jean ; in IAU Astronomical Telegram N° 3290 (1978) IAUC 3290 available at Central Bureau for Astronomical Telegrams. Detailed reference viewed: 10 (1 ULg)5 ans d’expérience monocentrique de transplantation hépatique avec des donneurs à cœur arrêté de catégorie 3 de MaastrichtDetry, Olivier ; Seydel, Benoît ; et alin Journal de Chirurgie (2008, December), 145 Detailed reference viewed: 108 (17 ULg)5 notices: « Chose », « Il y a », « Néo-kantisme », « Ontologie fondamentale », « Vérité »Dewalque, Arnaud in Beaulieu, Alain (Ed.) Abécédaire de Martin Heiddegger (2008) Brève analyse du sens de quelques concepts heideggériens et du contexte dans lequel ils apparaissent. Detailed reference viewed: 7 (0 ULg)5 sens et un bon sens pour un diagnostic - De l'hypophyse à la surrénale : Ce que les hormones nous laissent voirBeckers, Albert Scientific conference (2006, December 09) Detailed reference viewed: 4 (0 ULg)5',6'-Dehydroguiachrysine and 5',6'-Dehydroguiaflavine, Two Curarizing Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis; ; et al in Phytochemistry (2001), 58(4), 619-26 Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of ... [more ▼] Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of spectral data. Their inhibitory effects on neuromuscular transmission are also reported and compared to that of other quaternary alkaloids. [less ▲] Detailed reference viewed: 8 (2 ULg)A 5,6-Dihydro-Isopyoverdin From Azomonas Macrocytogenes; ; et al in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(11-12), Detailed reference viewed: 8 (2 ULg)5,8 analogies per hour, A designer's view on analogical reasoning.Leclercq, Pierre ; in Proceedings of the 7th International Conference on Artificial Intelligence in Design (2002) Detailed reference viewed: 19 (0 ULg)5-(Diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide : Synthesis and Evaluation of Spin Trapping Properties; ; Olive, Gilles et alin Journal of the Chemical Society. Perkin Transactions 2 (1997), 9 A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been ... [more ▼] A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been investigated and the hydroxyl and superoxide spin adducts characterised. The persistence of the superoxide spin adduct obtained with 3 is compared with those of the analogues obtained with DEPMPO [5-(diethoxyphosphoryl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide] and DMPO in both phosphate buffer and pyridine. In 0.1 M phosphate buffer at pH 7.0, the HOO-3? adduct is found to be 2.8 times more persistent than HOO-DMPO?, but 5.7 times less than HOO-DEPMPO?. In phosphate buffer, HOO-3? decomposes to give HO-3?. The stereoselectivity of the addition of free radicals on 3 is generally poor, and mixtures of diastereomers have been observed by EPR. The overall spin trapping behaviour of nitrone 3 is more similar to that of DMPO than that of DEPMPO. [less ▲] Detailed reference viewed: 7 (2 ULg)5-ALA based PDT and NF-kB inhibitors on human glioblastoma cell survivalCoupienne, Isabelle ; Bontems, Sébastien ; Piette, Jacques Poster (2009, April) Detailed reference viewed: 15 (3 ULg) 5-ALA-PDT induces RIP3-dependent necrosis in glioblastomaCoupienne, Isabelle ; Fettweis, Grégory ; Piette, Jacques Poster (2012, January 27) Detailed reference viewed: 12 (2 ULg)5-ALA-PDT induces RIP3-dependent necrosis in glioblastomaCoupienne, Isabelle ; Fettweis, Grégory ; Rubio-Romero, Noemi et alin Photochemical & Photobiological Sciences (2011) Glioblastoma constitute the most frequent and deadliest brain tumors of astrocytic origin. They are resistant to all current therapies and are associated with a high rate of recurrence. Glioblastoma were ... [more ▼] Glioblastoma constitute the most frequent and deadliest brain tumors of astrocytic origin. They are resistant to all current therapies and are associated with a high rate of recurrence. Glioblastoma were previously shown to respond to treatments by 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) mainly by activating a necrotic type of cell death. The receptor-interacting protein 3 (RIP3) has recently been outlined as a key mediator of this caspase-independent form of programmed cell death. In the present study, we analyzed the necrotic mechanism induced by 5-ALA-PDT in human glioblastoma cells and explored the role of RIP3 in this context. Our results show that PDT-induced necrosis is dependent on RIP3, which forms aggregates and colocalizes with RIP1 following photosensitization. We demonstrate that PDT-mediated singlet oxygen production is the cause of RIP3-dependent necrotic pathway activation. We also prove that PDT induces the formation of a pro-necrotic complex containing RIP3 and RIP1 but lacking caspase-8 and FADD, two proteins usually part of the necrosome when TNF-α is used as a stimulus. Thus, we hypothesize that PDT might lead to the formation of a different necrosome whose components, besides RIP1 and RIP3, are still unknown. In most cases, glioblastoma are characterized by a constitutive activation of NF-κB. This factor is a key regulator of various processes, such as inflammation, immune response, cell growth or apoptosis. Its inhibition was shown to further sensitize glioblastoma cells to PDT-induced necrosis, however, no difference in RIP3 upshift or aggregation could be observed when NF-κB was inhibited. [less ▲] Detailed reference viewed: 17 (4 ULg) |
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