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See detailThe Fc-receptor function of human mononuclear phagocyte system: physiological role, alteration in immune diseases and modulation
Malaise, Michel ULg; Mahieu, P. R.

in Acta Clinica Belgica (1985), 40(1), 27-37

Circulating immune complexes (CIC) are detectable in high titer in patients with various immune diseases and the deposition of these complexes is believed to be important in the pathogenesis of these ... [more ▼]

Circulating immune complexes (CIC) are detectable in high titer in patients with various immune diseases and the deposition of these complexes is believed to be important in the pathogenesis of these disorders. The reticuloendothelial system (RES), which includes the KuptTer cells of the liver and the splenic macrophages, is involved in the removal of CIC from the vascular system. A defect in CIC clearance may enhance their tissue deposition. Accordingly, during the past few years, increased interest has been devoted to the measurement of immune clearance mediated by receptors for Fc, IgG coated autologous red blood cells (IgG-RBC) labelled with 51Cr have been used as immune tracer particles to follow the Fc-receptor function of whole RES in normal and pathological conditions. Prolonged clearance times of IgG-RBC are generally found in most immune complex-mediated diseases. Using IgG-RBC labelled with 99m Tc, it has been thereafter possible to determine not only the clearance half-time of the tracer, but also separated spleen and liver Fc-receptor binding capacities. It has been clearly demonstrated that the spleen to liver ratios per surface area (S/L s) are deeply pathological in immune disorders, even when clearance half-times (T 1/2) remain within the normal range. Abnormal ratios result from both a decreased splenic uptake and an increased liver uptake of IgG-RBC, this "hepatic compensation" preventing the T 1/2 to be out of the normal values. Abnormal T 1/2 are therefore observed only when the spleen and liver phagocytic capacities are saturated. The splenic Fc-receptor blockade is generally correlated with the disease activity and, less frequently, with the immune complex plasma levels. Serial measurements of S/Ls may be therefore of clinical interest by delineating those patients in whom the evolutivity of the disease is potentially high. Finally, serial S/Ls measurements have allowed the in vivo study of the modulation of the macrophagic Fc-receptor function by plasma exchange, corticosteroid administration and highdose gammaglobulin infusion. [less ▲]

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See detailFcpac: Fast Calculation Of Partial Atomic Charges Using Strictly Localized Molecular Orbitals
Swinnen, M.; Thomas, Annick ULg; Brasseur, Robert ULg

in Computational Materials Science (2002), 25(4), 590-595

Most force fields of molecular mechanics use constant partial atomic charges whereas it is now admitted that those charges strongly vary with the environment. Charge variations are particularly important ... [more ▼]

Most force fields of molecular mechanics use constant partial atomic charges whereas it is now admitted that those charges strongly vary with the environment. Charge variations are particularly important in hydrogen bonds where polar entities come close together. Moreover, organizing H-bonds in networks, like in secondary structures of proteins, go with cooperative effects which lead to an overall electrostatic stabilization of the system. This is why variable atomic charges are required to correctly mimic these effects. Different methods of charge calculation were developed, most use polarizable dipole or electronegativity equalization. In this work, we propose a semi-empirical method (fast calculation of partial atomic charges (FCPAC)) which derives partial atomic charges from strictly localized molecular orbitals. The approximations enable to treat molecular systems with hundreds of atoms within reasonable delays. Results reported here show that charges calculated with FCPAC are similar to charges derived from Mulliken’s population analysis of a restricted Hartree–Fock wave function using the split valence basis set 6-31G and including polarization orbitals p and d respectively for hydrogen and heavy atoms, RHF/6-31G(d,p). Comparison with ab initio calculation was also performed on a system composed of five formamide molecules disposed in the same geometry as peptide bonds in an a helix. Charges variations are similar and suggest that FCPAC is suitable for quantitative estimation of cooperative effects. [less ▲]

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See detailFDC : origin and function
Heinen, Ernst ULg; Bosseloir, A.; Bouzahzah, F. et al

in Current topics in Microbiology and Immunology (1995)

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See detailFDC-B1, a new monoclonal antibody directed against bovine follicular dendrititic cells.
Defaweux, Valérie ULg; Mélot, France ULg; Jolois, Olivier ULg et al

Poster (2003, March)

Follicular dendritic cells (FDCs) are unique immunological accessory cells located in the light and dark zones of the germinal centres in lymph follicles. Characterized by long branching processes forming ... [more ▼]

Follicular dendritic cells (FDCs) are unique immunological accessory cells located in the light and dark zones of the germinal centres in lymph follicles. Characterized by long branching processes forming a three-dimensional network, FDCs create particular microenvironments for germinal centre B and T cells and contribute to the maturation of B cells into memory cells. An involvement of the FDCs is suspected in various disorders affecting lymphoid tissues, malignant lymphoma or in some viral diseases. Moreover, in prion diseases, FDCs seem to be the major sites of extraneuronal cellular prion protein expression and the principal sites of the infectious agent accumulation in lymph organs. Because no antibody commercially available was specific to bovine FDCs, a new monoclonal antibody directed against bovine FDCs (FDC-B1) has been produced and characterized in our laboratory. The antigen detected by FDC-B1 is expressed on FDC surfaces in ruminant (bovine, ovine and caprine) lymphoid organs. This protein seems to be a membrane glycoprotein of more or less 28 kDa whose sequence will be soon determined. Moreover, FDC-B1 can be used in various applications: immunofluorescence, immunoperoxidase, immunogold labellings and western blotting. FDCs are potential targets for therapy or prophylaxis in natural TSEs, such as bovine spongiform encephalopathies and scrapie. Thus, it appears of great interest to identify bovine and ovine FDCs in routine lymphoid tissues sections. An other application of this antibody to immunofluorescence histochemistry techniques will enable the study of possible direct contacts between bovine FDCs and nerve endings and thus clarify prions neuroinvasion scheme in the case of BSE and scrapie. [less ▲]

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See detailFDC-B1: a new monoclonal antibody directed against bovine follicular dendritic cells
Defaweux, Valérie ULg; Mélot, France ULg; Jolois, Olivier ULg et al

in Veterinary Immunology and Immunopathology (2004), 97(1-2), 1-9

Follicular dendritic cells (FDCs) are a unique population of accessory cells located in the light zone of the germinal centres of lymphoid follicles. Their involvement in the generation of Immoral immune ... [more ▼]

Follicular dendritic cells (FDCs) are a unique population of accessory cells located in the light zone of the germinal centres of lymphoid follicles. Their involvement in the generation of Immoral immune responses implies a potential role for these cells in many disorders. Indeed, in prion diseases, FDCs seem to be the major sites of extraneuronal cellular prion protein expression and the principal sites of the infectious agent accumulation in lymphoid organs. The identification of FDC is useful for the analysis of their distribution in reactive lymphoid tissue as well as in pathological conditions. The production and characterisation of a new mouse monoclonal antibody directed against bovine follicular dendritic cells (FDC-B1) is reported. The antigen detected by FDC-B1 is expressed exclusively on the surface of FDCs in ruminant lymphoid organs. The antigen has an approximate molecular weight of 28 kDa. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailFDG PET/CT for diagnostic arterial prosthetic graft infection : preliminary report.
NAMUR, Gauthier ULg; VAN DAMME, Hendrik ULg; BECKERS, Catherine ULg et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailFDG PET/CT in Crohn's disease: correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity.
Saboury, Babak; Salavati, Ali; Brothers, Alex et al

in European journal of nuclear medicine and molecular imaging (2013)

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography ... [more ▼]

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT employing a new quantitative approach. METHODS: A total of 22 subjects (mean age 37) with CD who had undergone FDG PET/CT followed by ileocolonoscopy within 1 week were included in this analysis. The CD endoscopy index of severity (CDEIS) for various bowel segments was calculated. The CD activity index (CDAI) was evaluated, and fecal calprotectin was measured. On PET, regions with increased FDG uptake in large bowel were segmented with an adaptive contrast-oriented thresholding algorithm, and metabolically active volume (MAV), uncorrected mean standardized uptake value (SUVmean), partial volume-corrected SUVmean (PVC-SUVmean), SUVmax, uncorrected total lesion glycolysis (TLG = MAV x SUVmean), and PVC total lesion glycolysis (PVC-TLG = MAV x PVC-SUVmean) were measured. Global CD activity score (GCDAS) was calculated as the sum of PVC-TLG over all clinically significant FDG-avid regions in each subject. Correlations between regional PET quantification measures (SUVs, TLGs) and CDEIS were calculated. Correlations between the global PET quantification measure (GCDAS, global SUVs) with CDAI, fecal calprotectin, CDEIS, and CRP level were also calculated. RESULTS: SUVmax, PVC-SUVmean, and PVC-TLG significantly correlated with segment CDEIS subscores (r = 0.50, r = 0.69, and r = 0.31, respectively; p < 0.05). GCDAS significantly correlated with CDAI and fecal calprotectin (r = 0.64 and r = 0.51, respectively; p < 0.05). CONCLUSION: By employing this new quantitative approach, we were able to calculate indices of regional and global CD activity, which correlated well with both clinical and pathological disease activity surrogate markers. This approach may be of clinical importance in measuring both global disease activity and treatment response in patients with CD. [less ▲]

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See detailFDG-PET and lung cancer: evaluation of solitary pulmonary nodule and mediastinal staging.
PAULUS, P.; HUSTINX, Roland ULg; BURY, Thierry ULg et al

in Proceedings of the VIIth International PET Conference, Institute for Clinical PET (1996)

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See detailFDG-PET for the routine follow-up in NHL: First prospective evaluation
Jerusalem, Guy ULg; Silvestre, R.; Beguin, Yves ULg et al

in Journal of Clinical Oncology (2006, June 20), 24(18, Part 1 Suppl. S), 439

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See detailFDG-PET imaging for assessing pleural malignancy : a semi-quantitative analysis.
LAROCK, Marie-Paule ULg; DUYSINX, Bernard ULg; NGUYEN, D. et al

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 426

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See detailFDG-PET imaging for diagnosing bone infection.
LETESSON, G.; FOIDART-WILLEMS, Jacqueline ULg; HUSTINX, Roland ULg

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 323

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See detailFDG-PET imaging for monitoring rheumatoid arthritis treated by infliximab injections.
BECKERS, Catherine ULg; RIBBENS, Clio ULg; ANDRE, Béatrice ULg et al

in Journal of Nuclear Medicine (The) (2002), 43

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See detailFe and Mg Isotope Fractionation in Olivine from the NWA 1068 Shergottite
Collinet, Max ULg; Charlier, Bernard ULg; Namur, Olivier et al

Conference (2014, June 09)

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See detailFE modelling of anorthosite diapirism: the Egersund-Ogna massif, South Norway
Hoffer, B.; Barnichon, J.-D.; Charlier, Robert ULg et al

in Proc. of the Int. Meeting on Deformation Mechanisms in nature and experiments (1997, March)

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See detailFe(II)2.67Fe(III)4(PO4)5.35(HPO4)0.65 and Fe(II)2.23Fe(III)4(PO4)4.45(HPO4)1.55, two new mixed-valence iron phosphates.
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg

in Acta Crystallographica Section C-Crystal Structure Communications (2012), C68

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See detailFe-2(II)(PO4)(OH), a synthetic analogue of wolfeite
Hatert, Frédéric ULg

in Acta Crystallographica Section C-Crystal Structure Communications (2007), 63(Part 12), 119-121

This paper reports the hydrothermal synthesis and crystal structure refinement of diiron(II) phosphate hydroxide, Fe-2(II)(PO4)(OH), obtained at 1063 K and 2.5 GPa. This phosphate is the synthetic ... [more ▼]

This paper reports the hydrothermal synthesis and crystal structure refinement of diiron(II) phosphate hydroxide, Fe-2(II)(PO4)(OH), obtained at 1063 K and 2.5 GPa. This phosphate is the synthetic analogue of the mineral wolfeite, and has a crystal structure topologically identical to those of minerals of the triplite-triploidite group. The complex framework contains edge-and corner-sharing FeO4(OH) and FeO4(OH)(2) polyhedra, linked via corner-sharing to the PO4 tetrahedra (average P-O distances are between 1.537 and 1.544 angstrom). Four five-coordinated Fe sites are at the centers of distorted trigonal bipyramids (average Fe-O distances are between 2.070 and 2.105 angstrom), whereas the coordination environments of the remaining Fe sites are distorted octahedra (average Fe-O distances are between 2.146 and 2.180 angstrom). The Fe-O distances are similar to those observed in natural Mg-rich wolfeite, except for two Fe-O bond distances, which are significantly longer in synthetic Fe-2(2+) (PO4)(OH). [less ▲]

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