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Peer Reviewed
See detailEvaluation of the cytotoxicity of cyclodextrins on endothelial cells using MTT assay
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

Poster (2007, April)

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See detailEvaluation of the cytotoxicity of organic dust components on thp1 monocytes-derived-macrophages using high content analysis
Ramery, Eve ULg; O'Brien, Peter James

in Environmental Toxicology (2012)

Organic dust contains pathogen-associated molecular patterns (PAMPs) which can induce significant airway diseases following chronic exposure. Mononuclear phagocytes are key protecting cells of the ... [more ▼]

Organic dust contains pathogen-associated molecular patterns (PAMPs) which can induce significant airway diseases following chronic exposure. Mononuclear phagocytes are key protecting cells of the respiratory tract. Several studies have investigated the effects of PAMPs and mainly endotoxins, on cytokine production. However the sub-lethal cytotoxicity of organic dust components on macrophages has not been tested yet. The novel technology of high content analysis (HCA) is already used to assess subclinical drug-induced toxicity. It combines the capabilities of flow cytometry, intracellular fluorescence probes, and image analysis and enables rapid multiple analyses in large numbers of samples. In the present study, HCA was used to investigate the cytotoxicity of the 3 major PAMPs contained in organic dust, ie. endotoxin (LPS), peptidoglycan (PGN) and β-glucans (zymosan) on THP-1 monocyte-derived macrophages. LPS was used at concentrations of 0.005, 0.01, 0.02, 0.05, 0.1 and 1 μg/ml; PGN and zymosan were used at concentrations of 1, 5, 10, 50, 100 and 500 μg/ml. Cells were exposed to PAMPs for 24 h. In addition, the oxidative burst and the phagocytic capabilities of the cells were tested. An overlap between PGN intrinsic fluorescence and red/far-red fluorescent dyes occurred, rendering the evaluation of some parameters impossible for PGN. LPS induced sub-lethal cytotoxicity at the lowest dose (from 50 ng/ml). However, the greatest cytotoxic changes occurred with zymosan. In addition, zymosan, but not LPS, induced phagosome maturation and oxidative burst. Given the fact that β-glucans can be up to 100-fold more concentrated in organic dust than LPS, these results suggest that β-glucans could play a major role in macrophage impairment following heavy dust exposure and will merit further investigation in the near future. [less ▲]

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See detailEvaluation of the DR-CALUX screening of food and feed, according to regulation levels including DL-PCB
Scippo, Marie-Louise ULg; Rybertt, Soledad; Focant, Jean-François ULg et al

in Organohalogen Compounds (2005), 67

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See detailEvaluation of the durability of hydrophobic treatments on concrete architectural heritage
Lucquiaud, Vincent ULg; Courard, Luc ULg; Gérard, Olivier et al

in Restoration of Buildings and Monuments = Bauinstandsetzen und Baudenkmalpflege (2014), 20(6), 395404

The protection of historical concrete structures is a challenge for the coming years. Hydrophobic treatment may reduce the deterioration process while providing protection against water penetration ... [more ▼]

The protection of historical concrete structures is a challenge for the coming years. Hydrophobic treatment may reduce the deterioration process while providing protection against water penetration. Existing commercial products —mainly silane or siloxane in either water or solvent based formulations– were submitted to different ageing processes including UV radiation, dry-wet cycles, thermal shocks, freeze-thaw cycles, carbonation and their effectiveness has been evaluated on the basis of contact angle, vapour and chloride permeability and, capillarity water absorption. The results obtained clearly show that hydrophobic treatments display a good behaviour under the main ageing conditions. [less ▲]

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See detailEvaluation of the dynamic adsorption of gas on active carbon beds using in situ X-ray µ-tomography coupled with 3D image analysis
Almazan, Maria del Carmen; Léonard, Angélique ULg; Lodewyckx, Peter et al

Poster (2009, June)

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See detailEvaluation of the Economic Statistical Design of the Multivariate T2 Control Chart with Multiple Variable Sampling Intervals Scheme: NSGA-II Approach
Faraz, Alireza ULg; Seif, Asghar; Sadeghifar

in Journal of Statistical Computation & Simulation (2014)

The economic and statistical merits of a multiple variable sampling intervals (MVSI) scheme are studied. The problem is formulated as a double-objective optimization problem with the adjusted average time ... [more ▼]

The economic and statistical merits of a multiple variable sampling intervals (MVSI) scheme are studied. The problem is formulated as a double-objective optimization problem with the adjusted average time to signal as the statistical objective and the expected cost per hour as the economic objective. Bai and Lee’s ‎[2] economic model is considered. Then we find the Pareto-optimal designs in which the two objectives are minimized simultaneously by using the non-dominated sorting genetic algorithm. Through an illustrative example, the advantages of the proposed approach is shown by providing a list of viable optimal solutions and graphical representations, which indicate the advantage of flexibility and adaptability of our approach. [less ▲]

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See detailEvaluation of the ecotoxicological effects of POPs and heavy metals, reflecting pathological, microbiological and genetic analyses, on the Mekong River population of Irrawaddy dolphins (Orcaella brevirostris)
Siebert, Ursula; Das, Krishna ULg

Report (2011)

For this report, samples of Irrawaddy River dolphins found dead along the Mekong River between 2006 and 2010 were analysed in different laboratories in Europe, Canada and Cambodia. The aim of the ... [more ▼]

For this report, samples of Irrawaddy River dolphins found dead along the Mekong River between 2006 and 2010 were analysed in different laboratories in Europe, Canada and Cambodia. The aim of the investigation was to gain additional knowledge on histological and toxicological findings as well as on the genetic variation of the Mekong population. The report summarizes those results in relation to previous investigations conducted in Cambodia and the United States of America. [less ▲]

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See detailEvaluation of the effect of general anaesthesia on ultrasonographic images of the small intestine in horses.
Salciccia, Alexandra ULg; Gougnard, Alexandra ULg; de la Rebière de Pouyade, Geoffroy ULg et al

Poster (2011, July)

ultrasonography is currently more and more used in equine acute abdominal disease as well as in the follow-up of surgical colic patients because of its sensibility for the detection of small intestinal ... [more ▼]

ultrasonography is currently more and more used in equine acute abdominal disease as well as in the follow-up of surgical colic patients because of its sensibility for the detection of small intestinal distension. General anaesthesia is known to diminish gastrointestinal motility even if there are no clinical signs associated with it. The aim of this study was to evaluate the effect of general anaesthesia on transabdominal ultrasonographic images of the small intestine in horses undergoing routine non abdominal surgeries. The ultrasonographic exams were performed in 19 horses before and after the general anaesthesia (immediately after the recovery and then 2h, 12h and 24h after it). Each ultrasonographic exam focused on the duodenum, the jejunum and the presence of peritoneal fluid. For the jejunum, 5 locations were used: on the ventral midline just caudally to the sternum, on the left and right cranial ventral parts of the abdomen, on the left and right inguinal regions. Other parameters such as the gut sounds and the postoperative fecal output were also recorded. Anova and Chi-square tests were used for the statistical analysis. No horse showed colic signs. No significant difference was found between the pre and post anaesthetic period considering the maximal diameter of the duodenum, the maximal diameter of the jejunum on the 5 locations and the peritoneal fluid. The contractions of the duodenum were increased at the recovery compared to before the anaesthesia (p= 0,0299). The small intestine was most visible at the recovery (57,5%) and then at 2 hours after it (38,3%). It seemed that the ventral midline just caudally to the sternum and the right and left inguinal regions were the best locations to observe the jejunum (with a mean of respectively 44,6%, 39,8% and 38,5% of visualization of the jejunum).The gut sounds were very significantly decreased at the recovery (p < 0,0001) and at 2h after it (p = 0,0006). The postoperative fecal output was not decreased. In conclusion, even if general anaesthesia seems to reduce temporarily the intestinal activity (decreased gut sounds in the early post anaesthetic period), it does not cause significant distension of the small intestine (almost the small intestinal diameters were in the normal range). If an increased diameter of small intestine is observed by ultrasonography after surgery it should therefore be attributed to a pathological process and not to the anaesthesia. [less ▲]

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See detailEvaluation of the effect of load eccentricity in a tensile pull-off test on bond strength
Courard, Luc ULg; Garbacz, Andrezj

Report (2010)

The report presents the results of a research project and the impact of incorrect design on tensile strength values. According to results of laboratory experiments and modelling, it can be observed that ... [more ▼]

The report presents the results of a research project and the impact of incorrect design on tensile strength values. According to results of laboratory experiments and modelling, it can be observed that, if there is an influence of 2° and 4° angle of inclination on pull-off bond strength, it is however not statistically significant: the decrease of pull-off strength is usually no larger than 14% for 4°. [less ▲]

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See detailEvaluation of the effect of load eccentricity on pull-off strength
Moczulski, Grzegorj; Garbacz, Andrzej; Courard, Luc ULg

in Alexander, M. G.; Beushausen, H.-D.; Dehn, F. (Eds.) et al Concrete Repair, Rehabilitation and Retrofitting II (2009)

The efficiency of the composite repair system is usually evaluated through semi-destructive test: pull-off test. But some difficulties can also be induced by the eccentricity of the load application, due ... [more ▼]

The efficiency of the composite repair system is usually evaluated through semi-destructive test: pull-off test. But some difficulties can also be induced by the eccentricity of the load application, due to incorrect placement of the test device. The paper presents the results of a research project and the impact of incorrect design on tensile strength values. According to results of laboratory experiments and modelling, it can be observed that, if there is an influence of 2o and 4o angle of inclination on pull-off bond strength, it is however not statistically significant: the decrease of pull-off strength is usually no larger than 8% for 2o [less ▲]

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Peer Reviewed
See detailEvaluation of the effect of two training regimes on the resumption of the ovarian activity by analysis of faecal 20 alpha-hydroxyprogesterone in trotter mares
Messina, Mariella; Prandi, Alberto; Bolelli, G. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

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See detailAn evaluation of the effects of rural development policies in the North-East Region of Romania
Paveliuc Olariu, Codrin ULg; Ciurea, Ion Valeriu; Brezuleanu, Stejarel et al

in Advances in Agriculture & Botanics (2011), 3(1), 20-25

The European Union Common Agricultural Policy (CAP) holds as principal objectives, as they were outlined in the Treaty of Rome, the following: increase productivity, by promoting technical innovation and ... [more ▼]

The European Union Common Agricultural Policy (CAP) holds as principal objectives, as they were outlined in the Treaty of Rome, the following: increase productivity, by promoting technical innovation and ensuring optimum use of factors of production, ensure a fair standard of living for the agricultural community, stabilize agricultural markets, secure availability of agricultural supplies and provide consumers with food at reasonable prices. Over time, and depending on certain factors, new secondary objectives have been added such as: environmental protection, biodiversity, animal welfare, enhancement of rural areas. In the North-East Region of Romania, the impact of rural development policies implemented through the National Rural Development Programme (NRDP) has been assessed at regional and local level utilizing a combined analysis of statistical databases. [less ▲]

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See detailEvaluation of the efficacy and safety of etoricoxib compared with naproxen in two, 138-week randomised studies of patients with osteoarthritis
Reginster, Jean-Yves ULg; Malmstrom, K.; Mehta, A. et al

in Annals of the Rheumatic Diseases (2007), 66(7), 945-951

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year ... [more ▼]

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year randomised, double blind, parallel group two- part base studies ( part I 12 weeks; part II 40 weeks), followed by an 86- week extension, in patients with OA ( hip or knee) were conducted at 80 clinical centres ( 19 countries). The studies had identical designs. Patients taking placebo in part I received etoricoxib or naproxen ( 1: 1 ratio) in part II and the extension; patients taking etoricoxib or naproxen in part I continued to receive the same treatment throughout the entire length of the studies. Co- primary efficacy end points were patient global assessment of disease status, and WOMAC questionnaire pain subscale and physical function subscale ( 100 mm VAS). Efficacy over 138 weeks was assessed by graphical analysis. Safety was assessed by observation of adverse experiences and laboratory and physical evaluations. Results: 997 patients entered ( 615 completed) the base studies. Of these patients, 463 patients entered the extensions. A total of 161 and 152 patients in the etoricoxib and naproxen groups, respectively, completed 138 treatment weeks. Etoricoxib and naproxen showed similar efficacy throughout the 138 weeks of treatment. For etoricoxib and naproxen, respectively, WOMAC pain assessments were 67 and 67 mm ( baseline); 28 and 29 mm ( 1 year), and 34 and 33 mm ( 138 weeks). Results for the other efficacy end points were similar to those seen with the WOMAC pain assessments. Both etoricoxib and naproxen were generally well tolerated. Conclusion: Both etoricoxib and naproxen demonstrated long- term clinical efficacy for the treatment of OA. Etoricoxib and naproxen were generally well tolerated. [less ▲]

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See detailEvaluation of the Efficacy and Safety of Oral Tiludronate in Paget's Disease of Bone. A Double-Blind, Multiple-Dosage, Placebo-Controlled Study
Reginster, Jean-Yves ULg; Colson, F.; Morlock, G. et al

in Arthritis & Rheumatism : Arthritis Care & Research (1992), 35(8), 967-74

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial ... [more ▼]

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial. Patients were randomly assigned to 1 of 5 therapeutic groups: a daily dose of 100 mg, 200 mg, 400 mg, or 800 mg of oral tiludronate, or a placebo. Treatment was for 3 months, followed by 3 months of placebo-controlled followup. Serum alkaline phosphatase activity (SAP) and fasting urinary excretion of hydroxyproline/creatinine (OH/Cr) were measured monthly, as were biochemical parameters reflecting renal, hepatic, and hematologic functions. Analgesic efficacy was self-evaluated from a visual analog scale and a global pain index. RESULTS. Statistical analysis revealed that beginning at a dosage of 200 mg/day, there was a direct dose-dependent effect on the reduction of SAP and OH/Cr levels. Reduction of SAP levels was clinically significant at a dosage of 400 mg (44.9 +/- 4.2% reduction at 90 days and 49.2 +/- 4.5% at 180 days, mean +/- SEM) and at 800 mg (53.4 +/- 5% at 90 days and 59.3 +/- 4.6% at 180 days). There was a significant reduction in pain in all groups, including the group taking placebo. In only those taking 800 mg/day of tiludronate was there a significant frequency of complete resolution of pain (versus placebo). Aside from mild gastrointestinal disturbances, as experienced with other oral bisphosphonates, clinical tolerance of all 5 regimens was good. Exhaustive biochemical investigations failed to reveal significant toxicity of tiludronate up to the 800-mg daily dose investigated. CONCLUSION. Because of its significantly better antiresorptive effects and greater analgesic properties (compared with lower dosages), combined with the excellent clinical and biochemical tolerance, the 800-mg daily dose of tiludronate appears to be optimal for the treatment of Paget's disease of bone. [less ▲]

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See detailEvaluation of the endorcine disrupting chemicals contamination in the North Sea porpoise population using in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Van Der Heiden, Edwige ULg et al

Poster (2009)

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental ... [more ▼]

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental quality and posing ecological risks. Marine mammals inhabiting polluted environments accumulate high levels of these chemicals, so they can be considered good indicators of marine pollution. Thirteen major organochloride pollutants were chosen to make subject of this study: o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. All these chemicals will have their endocrine disrupting effects characterized individually and collectively by report gene expression assays. The MCF7-ERE cells used in these assays were produced in the Molecular Biology and Genetic Engineering Laboratory of the University of Liège and are originated from a human mammary carcinoma. They carry a gene expressing the synthesis of luciferase and controlled by oestrogen receptors. Then, the thirteen chemicals will be searched in the blubber tissues of porpoises by the use of gas chromatography-mass spectrometry. The blubber samples will also have their endocrine disrupting effect characterized. For the moment, the estrogenic effects of the HCH isomers were put in evidence. The next steps of this work must be soon accomplished. It is expected a great level of these compounds to be found in the samples. On the other hand, their endocrine disrupting effects and how they act in agonist, antagonist and synergist ways are subject that still needs to be cleared. [less ▲]

Detailed reference viewed: 18 (2 ULg)