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See detailExtended-spectrum-beta-lactamase-producing Enterobacteriaceae in Yaounde, Cameroon
Gangoue Pieboji, Joseph ULg; Bedenic, B.; Koulla-Shiro, S. et al

in Journal of Clinical Microbiology (2005), 43(7), 3273-7

Organisms producing extended-spectrum beta-lactamases (ESBLs) have been reported in many countries, but there is no information on the prevalence of ESBL-producing members of the family Enterobacteriaceae ... [more ▼]

Organisms producing extended-spectrum beta-lactamases (ESBLs) have been reported in many countries, but there is no information on the prevalence of ESBL-producing members of the family Enterobacteriaceae in Cameroon. A total of 259 Enterobacteriaceae strains were isolated between 1995 and 1998 from patients at the Yaounde Central Hospital in Cameroon. Enterobacterial isolates resistant to extended-spectrum cephalosporin and monobactam were screened for ESBL production by the double-disk (DD) synergy test. Thirty-one (12%) of these Enterobacteriaceae strains were shown to be positive by the DD synergy test, suggesting the presence of ESBLs. Resistance to oxyimino-cephalosporins and monobactams of 12 (38.7%) of the 31 strains-i.e., 6 Klebsiella pneumoniae, 4 Escherichia coli, 1 Citrobacter freundii, and 1 Enterobacter cloacae strain-was transferred to E. coli HK-225 by conjugation. Resistance to gentamicin, gentamicin plus trimethoprim-sulfamethoxazole, or trimethoprim-sulfamethoxazole was cotransferred into 6, 2, and 1 of these transconjugants, respectively. All 12 transconjugants were resistant to amoxicillin, piperacillin, all of the cephalosporins, and aztreonam but remained susceptible to cefoxitin and imipenem. Crude extracts of beta-lactamase-producing transconjugants were able to reduce the diameters of inhibition zones around disks containing penicillins, narrow- to expanded-spectrum cephalosporins or monobactams when tested against a fully susceptible E. coli strain but had no effect on such zones around cefoxitin, imipenem, and amoxicillin-clavulanate disks. The beta-lactamases produced by the 12 tranconjugants turned out to be SHV-12 by DNA sequencing. Therefore, the ESBL SHV-12 is described for the first time in Cameroon. [less ▲]

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See detailExtending Donor Pool with Donation after Cardiac Death in Kidney and Liver Transplantation:What is the Price to Pay?
Le Dinh, Hieu ULg

Doctoral thesis (2012)

Through a series of clinical studies, this thesis aims to clarify the contribution of donation after cardiac death (DCD) to the deceased donor (DD) pool and results of kidney and liver transplantation ... [more ▼]

Through a series of clinical studies, this thesis aims to clarify the contribution of donation after cardiac death (DCD) to the deceased donor (DD) pool and results of kidney and liver transplantation coming from this donor source in Liège and Belgium. Additionally, an adapted DCD Maastricht classification is also discussed. Chapters 2.1 and 2.2 summarize the DCD procurement and transplant activity in Liège and Belgium from 2000 to 2009 with an update on data up to 2011. In Liège, DCD really contributes to the DD pool and boosts the transplant activity of the center in both kidneys and livers by on average 30%. By contrast, the steady rise in DCD activity in Belgium does not lead to major increase in the DD donation and transplantation. In other words, some kind of donor-type redistribution within the DD pool might occur. Chapters 2.2, 3.1, and 3.2 discuss the results of kidney transplantation (KT) from DCD. We demonstrate that Liège‟s experience is comparable to the national level in Belgium and does not differ from the general results in the world with regard to early graft dysfunction, medium-term graft function, graft and patient survival. The excellent results of DCD-KT are attributed to the relatively short warm and cold ischemia, favorable donor factors, and the role of hypothermic machine perfusion (in Belgian series). Chapters 4.1, and 4.2 discuss the results of liver transplantation (LT) from DCD. Liège‟s results are encouraging and apparently as good as those from donation-after-brain-death LT because of short warm and cold ischemia times. Belgian results show an increased incidence of primary non-function and ischemic cholangiopathy which is in agreement with previously published data. Chapter 5 proposes an adapted DCD Maastricht classification which maintains the original categories 1 to 4 that are now well-known and widely accepted, and adds a fifth category, so-called „DCD after euthanasia‟. Each category is divided into two or three sub-categories: sub-category A is linked to longer warm ischemia (and worse results) than sub-category B; and B versus C, respectively. In addition, sub-categories A (2A, 3A, 4A, and 5A) are mostly linked to DCD processes occurring in the ICU, which helps to understand and memorize this classification. By keeping the original skeleton of the 1995 Maastricht classification, room is left to add new sub-categories in the future, if deemed clinically relevant. [less ▲]

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See detailExtending electronic portals with new services: Exploring the usefulness of brand extension models
Van Riel, Allard ULg; Ouwersloot, Hans

in Journal of Retailing and Consumer Services (2005), 12(4), 245-254

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See detailExtending of the Merchant-Rankine formula for the assessment of the ultimate load of frames with semi-rigid joints
Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1988), 11

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See detailExtending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
Burroughs, Lauri; Mielcarek, Marco; Leisenring, Wendy et al

in Transplantation (2006), 81(6), 818-25

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity ... [more ▼]

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity, timing, and/or corticosteroid-responsiveness of graft-versus-host disease (GVHD). METHODS: We retrospectively analyzed outcomes among 185 patients with hematologic malignancies who were given grafts from HLA-matched related donors following conditioning with 2 Gy total body irradiation alone or in combination with fludarabine between December 1998 and March 2003. Postgrafting immunosuppression consisted of mycophenolate mofetil (days 0-27) in combination with 3 different cyclosporine (CSP) regimens: taper from (A) days 35 to 56 (n=107), (B) days 56 to 77 (n=35), and (C) days 56 to 180 (n=43). RESULTS: The overall incidences of grades II-IV and III-IV acute GVHD, and extensive chronic GVHD were 52%, 13%, and 56%, respectively. The duration of CSP prophylaxis did not significantly influence the overall rate of acute GVHD (grade II-IV), extensive chronic GVHD, or non-relapse mortality. However, prolonged administration of CSP (group C) was associated with a significantly decreased hazard of grades III-IV acute GVHD (HR 0.2, 95% CI [0.04, 0.9]) and with an increased likelihood of discontinuing all systemic immunosuppression (HR 2.4, 95% CI [1.1, 5.2]) when compared to the shortest course of CSP (group A). CONCLUSION: Longer CSP duration decreased the risk of severe GVHD and increased the likelihood of discontinuing all systemic immunosuppression after nonmyeloablative HCT with HLA-matched related grafts. [less ▲]

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See detailExtending Routers Utilisability and Life Cycle through Automated Configuration Management
Rodriguez, Francisco; Hoerdt, Mickael; Mathy, Laurent ULg

in IPOM '09 Proceedings (2009, October)

We present the design of a distributed router platform aimed at consolidating multiple hardware routers. The goal of the approach is twofold: firstly decouple the logical routing and forwarding ... [more ▼]

We present the design of a distributed router platform aimed at consolidating multiple hardware routers. The goal of the approach is twofold: firstly decouple the logical routing and forwarding functionality from the limitations of the hardware that runs it, through automated configuration management only; and secondly, give component routers a longer lease of life, as constituting parts of a larger router system. We focus on the logical intra-domain routing function provided by routers, and show the need for a centralized intra-domain route server. [less ▲]

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See detailExtending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships
Rigali, Sébastien ULg; Schlicht, M.; Hoskisson, P. et al

in Nucleic Acids Research (2004), 32(11), 3418-3426

Transcription factors (TFs) of bacterial helix-turn-helix superfamilies exhibit different effector-binding domains (EBDs) fused to a DNA-binding domain with a common feature. In a previous study of the ... [more ▼]

Transcription factors (TFs) of bacterial helix-turn-helix superfamilies exhibit different effector-binding domains (EBDs) fused to a DNA-binding domain with a common feature. In a previous study of the GntR superfamily, we demonstrated that classifying members into subfamilies according to the EBD heterogeneity highlighted unsuspected and accurate TF-binding site signatures. In this work, we present how such in silico analysis can provide prediction tools to discover new cis/trans relationships. The TF-binding site consensus of the HutC/GntR subfamily was used to (i) predict target sites within the Streptomyces coelicolor genome, (ii) discover a new HutC/GntR regulon and (iii) discover its specific TF. By scanning the S.coelicolor genome we identified a presumed new HutC regulon that comprises genes of the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag). A weight matrix was derived from the compilation of the predicted cis-acting elements upstream of each gene of the presumed regulon. Under the assumption that TFs are often subject to autoregulation, we used this matrix to scan the upstream region of the 24 HutC-like members of S.coelicolor. orf SCO5231 (dasR) was selected as the best candidate according to the high score of a 16 bp sequence identified in its upstream region. Our prediction that DasR regulates the PTSNag regulon was confirmed by in vivo and in vitro experiments. In conclusion, our in silico approach permitted to highlight the specific TF of a regulon out of the 673 orfs annotated as 'regulatory proteins' within the genome of S.coelicolor. [less ▲]

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See detailExtending the GHER 3D Model to the modelling of ecosystems in Western Mediterranean coastal zones: results from an exploratory study
Lacroix, Geneviève; Djenidi, Salim ULg

in Martin, Jean-Marie; Barth, Hartmut (Eds.) EROS 2000 (European River Ocean System) (1992)

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See detailExtending the job Demands-Resources Model : safety behaviour and perceived safety climate.
Hansez, Isabelle ULg; Chmiel, N.

Conference (2009, May 16)

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See detailExtending the nuclear roles of I kappa B kinase subunits
Gloire, Geoffrey ULg; Dejardin, Emmanuel ULg; Piette, Jacques ULg

in Biochemical Pharmacology (2006), 72(9), 1081-1089

The transcription factor NF-kappa B plays a key role in a wide variety of cellular processes such as innate and adaptive immunity, cellular proliferation, apoptosis and development. In unstimulated cells ... [more ▼]

The transcription factor NF-kappa B plays a key role in a wide variety of cellular processes such as innate and adaptive immunity, cellular proliferation, apoptosis and development. In unstimulated cells, NF-kappa B is sequestered in the cytoplasm through its tight association with inhibitory proteins called I kappa BS, comprising notably I kappa B alpha. A key step in NF-kappa B activation is the phosphorylation Of I kappa B alpha by the so-called I kappa B kinase (IKK) complex, which targets the inhibitory protein for proteasomal degradation and allows the freed NF-kappa B to enter the nucleus where it can transactivate its target genes. The IKK complex is composed of two catalytic subunits called IKK alpha and IKK beta, and a regulatory subunit called NEMO/IKK gamma. Despite their key role in mediating I kappa B alpha phosphorylation in the cytoplasm, recent works have provided evidence that IKK subunits also translocate into the nucleus to regulate NF-kappa B-dependent and -independent gene expression, paving the way of a novel and exciting field of research. In this review, we will describe the current knowledge in that research area. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailExtending the theory of planned behavior as a model of cognitive and motivational influences on academic performance
Broonen, Jean-Paul ULg

in Dubois, Daniel (Ed.) Computing anticipatory systems : Casys 4th international conference, Liège, Belgium, 7-12 August (2001)

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See detailExtension de la notion du rapport anharmonique: définition de ce rapport pour le n° ordre en général: son utilité dans l'étude des courbes et surfaces supérieures
Folie, François ULg

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1877), 2e série, t. 44(11), 469-477

In projective geometry, the cross-ratio is the starting point of all theories of surveyors of modern history as Steiner and Chasles. This report leads in particular to the involution theory developed here.

See detailExtension de la notion linguistique de sens implicite à l'image visuelle
Géron, Stéphanie ULg

Master's dissertation (1997)

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See detailExtension des théorèmes analogues à celui de Pascal à des courbes tracées sur une surface quelconque
Folie, François ULg

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1874), 2e série, t. 37(6), 811-815

The author shows, by an example, how we can apply his theorems extensions to the curves traced on an arbitrary surface.

See detailExtension du domaine de la littérature
Demoulin, Laurent ULg

in Toussaint, Jean-Philippe (Ed.) La Mélancolie de Zidane (2006)

En se penchant sur la finale de la Coupe du monde de football, Jean-Philippe Toussaint élargit le domaine de la littérature légitime.

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See detailExtension du domaine de la littérature
Demoulin, Laurent ULg

in Toussaint, Jean-Philippe (Ed.) La Mélancolie de Zidane (2009)

En se penchant sur la finale de la Coupe du monde de foot, Jean-Philippe Toussaint élargit le domaine de la littérature légitime.

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See detailExtension du modèle de Cascade Intranucléaire de Liège aux énergies comprises entre 2 et 10 GeV
Pedoux, Sophie ULg

Master of advanced studies dissertation (2006)

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See detailExtension du patrimoine commun
Leleu, Yves-Henri ULg

in Leleu, Yves-Henri; Verbeke, Alain; Taymans, Jean-François (Eds.) et al Manuel de planification patrimoniale. Le couple, vie commune (2009)

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See detailExtension du patrimoine commun:apport d'un bien futur
Dehalleux, Virginie ULg

in Leleu, Yves-Henri; Verbeke, Alain; Taymans, Jean-François (Eds.) et al Manuel de planification patrimoniale, Le couple, Décès (2009)

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