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Peer Reviewed
See detailExtended Irreversible Thermodynamics and Non-linear Rheological Models
Dauby, Pierre ULg

in Dick, E.; Hogge, Michel (Eds.) Actes du Deuxième congrès national de mécanique théorique et appliquée, pp. 306-309, (Bruxelles, Palais des Académies, 17-18 mai 1990). (1990)

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See detailExtended Irreversible Thermodynamics Revisited ( 1988-1998)
Jou, David; Casas-Vazquez, Jose; Lebon, Georgy ULg

in Report in progress in physics (1998), 62

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Peer Reviewed
See detailExtended Irreversible Thermodynamics: a Review
jou, david; casas-vazquez, jose; Lebon, Georgy ULg

in Report in Progress in Physics (1988), 9

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See detailAn Extended LOTOS for the design of Real-Time Systems
Léonard, Luc; Leduc, Guy ULg

in Design and Analysis of Real Time Systems (1995, November)

We give a brief presentation of ET-LOTOS. ET-LOTOS extends with quantative time the formal description technique LOTOS. ET-LOTOS serves as basis for the time extension part of E-LOTOS, the new standard ... [more ▼]

We give a brief presentation of ET-LOTOS. ET-LOTOS extends with quantative time the formal description technique LOTOS. ET-LOTOS serves as basis for the time extension part of E-LOTOS, the new standard for LOTOS currently developed within ISO (ISO/IEC JTC1/SC21). [less ▲]

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See detailExtended mycophenolate mofetil and shortened cyclosporine failed to reduce graft-versus-host disease after unrelated hematopoietic cell transplantation with nonmyeloablative conditioning
Baron, Frédéric ULg; Sandmaier, Brenda M.; Storer, Barry E. et al

in Biology of Blood & Marrow Transplantation (2007), 13(9), 1041-1048

We previously reported data from 103 patients with hematologic malignancies (median age 54 years) who received peripheral blood stem cell (PBSC) grafts from HLA-matched unrelated donors after ... [more ▼]

We previously reported data from 103 patients with hematologic malignancies (median age 54 years) who received peripheral blood stem cell (PBSC) grafts from HLA-matched unrelated donors after nonmycloablative conditioning and were given postgrafting immunosuppression consisting of mycophenolate mofetil (MMF; administered from day 0 until day + 40 with taper through day + 96) and cyclosporine (CSP; given from day -3 to day + 100, with taper through day 180) (historical patients). The incidences of grade II-IV acute and extensive chronic graft-versus-host disease (aGVHD, cGVHD) were 52% and 49%, respectively, and the 1-year probabilities of relapse, nonrelapse mortality (NRM), and progression-free survival (PFS) were 26%, 18%, and 56%, respectively. Here, we treated 71 patients with hematologic malignancies (median age 56 years) with unrelated PBSC grafts and investigated whether postgrafting immunosuppression with an extended course of NMF, given at full dosing until day + 150 and then tapered through day + 180, and a shortened course of CSP, through day + 80, would promote tolerance induction and reduce the incidence of GVHD (current patients). We observed 77% grade ll-1V aGVHD and 45% extensive cGVHD (P =.03, and P =.43, respectively, in current compared to historical patients). The 1-year probabilities of relapse, NRM, and PFS were 23%, 29%, and 47%, respectively (P =.89, P =.02, and P =.08 compared to the historical patients). We conclude that postgrafting immunosuppression with extended MMF and shortened CSP failed to decrease the incidence of GVHD among unrelated PBSC recipients given nonmyeloablative conditioning. (c) 2007 American Society for Blood and Marrow Transplantation [less ▲]

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See detailExtended safety observations from denosumab administration in postmenopausal women from FREEDOM and FREEDOM extension trials
Brown, J. P.; Bone, H. G.; Chapurlat, R. et al

in Arthritis and Rheumatism (2011), 63(S10), 431-432

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See detailAn Extended Shallow-water-like Model Applied to Flows in Environmental and Civil Engineering
Kerger, François ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Hirsch, Gerhard; Kappel, Bernd (Eds.) Hydraulic Engineering: Structural Applications, Numerical Modeling and Environmental Impacts (2010)

Objective of this text is to rigorously develop a unified mathematical model to simulate a wide range of environmental flows. Particular emphasis is placed on flows relevant in civil and environmental ... [more ▼]

Objective of this text is to rigorously develop a unified mathematical model to simulate a wide range of environmental flows. Particular emphasis is placed on flows relevant in civil and environmental engineering. [less ▲]

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See detailAn Extended thermodynamic approach of suspensions
Lebon, Georgy ULg; Lhuillier, D.; Dauby, Pierre ULg et al

in 3rd International Meeting of IEEES (2007)

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See detailExtended Thermodynamic Description of Thermodiffusive Mass Transport
Lebon, Georgy ULg; Desaive, Thomas ULg; Dauby, Pierre ULg et al

in Proc. 6 th Int. Meeting on Thermodiffusion (IMT6), Varenna, July 2004 (2004)

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See detailAn extended thermodynamic model of transient heat conduction at sub-continuum scales
Lebon, Georgy ULg; Machrafi, Hatim ULg; Grmela, M. et al

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2011), 467

A thermodynamic description of transient heat conduction at small length and timescales is proposed. It is based on extended irreversible thermodynamics and the main feature of this formalism is to ... [more ▼]

A thermodynamic description of transient heat conduction at small length and timescales is proposed. It is based on extended irreversible thermodynamics and the main feature of this formalism is to elevate the heat flux vector to the status of independent variable at the same level as the classical variable, the temperature. The present model assumes the coexistence of two kinds of heat carriers: diffusive and ballistic phonons. The behaviour of the diffusive phonons is governed by a Cattaneo-type equation to take into account the high-frequency phenomena generally present at nanoscales. To include non-local effects that are dominant in nanostructures, it is assumed that the ballistic carriers are obeying a Guyer–Krumhansl relation. The model is applied to the problem of transient heat conduction through a thin nanofilm. The numerical results are compared with those provided by Fourier, Cattaneo and other recent models. [less ▲]

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See detailExtended transsternal thymectomy for myasthenia gravis: a report of 19 consecutive cases.
Durieux, Rodolphe ULg; Radermecker, Marc ULg; Dekoster, Guy ULg et al

in Acta Chirurgica Belgica (2008), 108(1), 102-6

BACKGROUND: Thymectomy is considered as an effective therapeutic option for patients with myasthenia gravis (MG). This study reports the experience of our centre's investigation into the efficacy and the ... [more ▼]

BACKGROUND: Thymectomy is considered as an effective therapeutic option for patients with myasthenia gravis (MG). This study reports the experience of our centre's investigation into the efficacy and the safety of the procedure and the influence of different pre-operative factors on the surgical outcome. METHODS: A retrospective chart review/interview was made of 19 consecutive patients who underwent extended transsternal thymectomy for MG from 1992 to 2003. The severity of the disease was determined according to the Osserman Classification. Efficacy was measured by determining the change in clinical status, the rate of remission during follow-up, and the reduction in medication requirements after thymectomy. Complete remission (CR) was defined as asymptomatic off medication for 6 months. The CR rate was calculated using the Kaplan-Meyer method. RESULTS: The mean age of the patients at surgery was 34 years (range, 9-63) and 78.9% were female. Mean length of follow up was 86 months (range, 24-163). The overall complication rate was 10.6% (1 episode of atrial fibrillation and a left recurrent laryngeal nerve palsy that resolved after the first postoperative month). There was no operative mortality. The mean hospital stay was 9.4 days (range, 5-23). The crude CR rate was 32% (n = 6). The Kaplan-Meier estimate of CR was 42% at 6 years. Age, gender, duration of symptoms, thymic histology, Osserman stage and the presence of thymoma were not identified as prognostic variables. The average daily dose of Medrol and Mestinon decreased significantly between the pre-operative period and the last follow-up (Medrol, p = 0.0081; Mestinon, p = 0.0013). CONCLUSIONS: Transsternal thymectomy for MG is safe and effective. It benefits patients with MG at all stages. Patients with thymoma are not associated with poorer remission rates. Complete responses are durable, as the CR rate remains stable over time. [less ▲]

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See detailExtended-spectrum β-lactamase-producing Enterobacteriaceae in Cameroonian hospitals
Lonchel, Carine Magoué; MELIN, Pierrette ULg; Gangoué-Piéboji, Joseph et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2013), 32(1), 79-87

Abstract Extended-spectrum β-lactamase (ESBL)-produc- ing Enterobacteriaceae have been described worldwide, but there are few reports on the carriage of these bacteria in Cameroon. In order to investigate ... [more ▼]

Abstract Extended-spectrum β-lactamase (ESBL)-produc- ing Enterobacteriaceae have been described worldwide, but there are few reports on the carriage of these bacteria in Cameroon. In order to investigate the types of ESBLs and to analyse some risk factors associated with ESBL carriage, faecal samples were collected between 3 January and 3 April 2009 from hospitalised patients at Yaounde Central Hospital and at two hospitals in Ngaoundere, Cameroon. Enterobacterial isolates resistant to third-generation cepha- losporins were screened for ESBL production using the double-disk synergy test. Polymerase chain reaction (PCR) and DNA sequencing were performed in order to find out the different types of ESBL genes in presumptive ESBL- positive isolates. During the study period, a total of 121 different patients were screened for ESBL carriage. The prevalence among these patients whose faecal samples were found to contain ESBL-producers was 55.3 % (67/121). According to a univariate analysis, hospitalisation during the previous year was found to be associated with ESBL carriage. Of the 71 bacteria isolated, Escherichia coli was predominant and represented 48 % of all isolates. ESBL characterisation revealed two types of ESBLs, CTX-M-15 (96 %) and SHV-12 (4 %). The present study emphasises the importance of screening for ESBLs in laboratories in Afri- can countries. The monitoring and detection of ESBL- producing bacteria are important in the setting up of appro- priate treatment of patients and to ensure effective infection control efforts. [less ▲]

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See detailExtended-spectrum-beta-lactamase-producing Enterobacteriaceae in Yaounde, Cameroon
Gangoue Pieboji, Joseph ULg; Bedenic, B.; Koulla-Shiro, S. et al

in Journal of Clinical Microbiology (2005), 43(7), 3273-7

Organisms producing extended-spectrum beta-lactamases (ESBLs) have been reported in many countries, but there is no information on the prevalence of ESBL-producing members of the family Enterobacteriaceae ... [more ▼]

Organisms producing extended-spectrum beta-lactamases (ESBLs) have been reported in many countries, but there is no information on the prevalence of ESBL-producing members of the family Enterobacteriaceae in Cameroon. A total of 259 Enterobacteriaceae strains were isolated between 1995 and 1998 from patients at the Yaounde Central Hospital in Cameroon. Enterobacterial isolates resistant to extended-spectrum cephalosporin and monobactam were screened for ESBL production by the double-disk (DD) synergy test. Thirty-one (12%) of these Enterobacteriaceae strains were shown to be positive by the DD synergy test, suggesting the presence of ESBLs. Resistance to oxyimino-cephalosporins and monobactams of 12 (38.7%) of the 31 strains-i.e., 6 Klebsiella pneumoniae, 4 Escherichia coli, 1 Citrobacter freundii, and 1 Enterobacter cloacae strain-was transferred to E. coli HK-225 by conjugation. Resistance to gentamicin, gentamicin plus trimethoprim-sulfamethoxazole, or trimethoprim-sulfamethoxazole was cotransferred into 6, 2, and 1 of these transconjugants, respectively. All 12 transconjugants were resistant to amoxicillin, piperacillin, all of the cephalosporins, and aztreonam but remained susceptible to cefoxitin and imipenem. Crude extracts of beta-lactamase-producing transconjugants were able to reduce the diameters of inhibition zones around disks containing penicillins, narrow- to expanded-spectrum cephalosporins or monobactams when tested against a fully susceptible E. coli strain but had no effect on such zones around cefoxitin, imipenem, and amoxicillin-clavulanate disks. The beta-lactamases produced by the 12 tranconjugants turned out to be SHV-12 by DNA sequencing. Therefore, the ESBL SHV-12 is described for the first time in Cameroon. [less ▲]

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See detailExtending Donor Pool with Donation after Cardiac Death in Kidney and Liver Transplantation:What is the Price to Pay?
Le Dinh, Hieu ULg

Doctoral thesis (2012)

Through a series of clinical studies, this thesis aims to clarify the contribution of donation after cardiac death (DCD) to the deceased donor (DD) pool and results of kidney and liver transplantation ... [more ▼]

Through a series of clinical studies, this thesis aims to clarify the contribution of donation after cardiac death (DCD) to the deceased donor (DD) pool and results of kidney and liver transplantation coming from this donor source in Liège and Belgium. Additionally, an adapted DCD Maastricht classification is also discussed. Chapters 2.1 and 2.2 summarize the DCD procurement and transplant activity in Liège and Belgium from 2000 to 2009 with an update on data up to 2011. In Liège, DCD really contributes to the DD pool and boosts the transplant activity of the center in both kidneys and livers by on average 30%. By contrast, the steady rise in DCD activity in Belgium does not lead to major increase in the DD donation and transplantation. In other words, some kind of donor-type redistribution within the DD pool might occur. Chapters 2.2, 3.1, and 3.2 discuss the results of kidney transplantation (KT) from DCD. We demonstrate that Liège‟s experience is comparable to the national level in Belgium and does not differ from the general results in the world with regard to early graft dysfunction, medium-term graft function, graft and patient survival. The excellent results of DCD-KT are attributed to the relatively short warm and cold ischemia, favorable donor factors, and the role of hypothermic machine perfusion (in Belgian series). Chapters 4.1, and 4.2 discuss the results of liver transplantation (LT) from DCD. Liège‟s results are encouraging and apparently as good as those from donation-after-brain-death LT because of short warm and cold ischemia times. Belgian results show an increased incidence of primary non-function and ischemic cholangiopathy which is in agreement with previously published data. Chapter 5 proposes an adapted DCD Maastricht classification which maintains the original categories 1 to 4 that are now well-known and widely accepted, and adds a fifth category, so-called „DCD after euthanasia‟. Each category is divided into two or three sub-categories: sub-category A is linked to longer warm ischemia (and worse results) than sub-category B; and B versus C, respectively. In addition, sub-categories A (2A, 3A, 4A, and 5A) are mostly linked to DCD processes occurring in the ICU, which helps to understand and memorize this classification. By keeping the original skeleton of the 1995 Maastricht classification, room is left to add new sub-categories in the future, if deemed clinically relevant. [less ▲]

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See detailExtending electronic portals with new services: Exploring the usefulness of brand extension models
Van Riel, Allard ULg; Ouwersloot, Hans

in Journal of Retailing and Consumer Services (2005), 12(4), 245-254

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Peer Reviewed
See detailExtending of the Merchant-Rankine formula for the assessment of the ultimate load of frames with semi-rigid joints
Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1988), 11

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See detailExtending postgrafting cyclosporine decreases the risk of severe graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation
Burroughs, Lauri; Mielcarek, Marco; Leisenring, Wendy et al

in Transplantation (2006), 81(6), 818-25

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity ... [more ▼]

BACKGROUND: It is unknown whether the duration of systemic immunosuppressive treatment after allogeneic nonmyeloablative hematopoietic cell transplantation (HCT) might influence the incidence, severity, timing, and/or corticosteroid-responsiveness of graft-versus-host disease (GVHD). METHODS: We retrospectively analyzed outcomes among 185 patients with hematologic malignancies who were given grafts from HLA-matched related donors following conditioning with 2 Gy total body irradiation alone or in combination with fludarabine between December 1998 and March 2003. Postgrafting immunosuppression consisted of mycophenolate mofetil (days 0-27) in combination with 3 different cyclosporine (CSP) regimens: taper from (A) days 35 to 56 (n=107), (B) days 56 to 77 (n=35), and (C) days 56 to 180 (n=43). RESULTS: The overall incidences of grades II-IV and III-IV acute GVHD, and extensive chronic GVHD were 52%, 13%, and 56%, respectively. The duration of CSP prophylaxis did not significantly influence the overall rate of acute GVHD (grade II-IV), extensive chronic GVHD, or non-relapse mortality. However, prolonged administration of CSP (group C) was associated with a significantly decreased hazard of grades III-IV acute GVHD (HR 0.2, 95% CI [0.04, 0.9]) and with an increased likelihood of discontinuing all systemic immunosuppression (HR 2.4, 95% CI [1.1, 5.2]) when compared to the shortest course of CSP (group A). CONCLUSION: Longer CSP duration decreased the risk of severe GVHD and increased the likelihood of discontinuing all systemic immunosuppression after nonmyeloablative HCT with HLA-matched related grafts. [less ▲]

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See detailExtending Routers Utilisability and Life Cycle through Automated Configuration Management
Rodriguez, Francisco; Hoerdt, Mickael; Mathy, Laurent ULg

in IPOM '09 Proceedings (2009, October)

We present the design of a distributed router platform aimed at consolidating multiple hardware routers. The goal of the approach is twofold: firstly decouple the logical routing and forwarding ... [more ▼]

We present the design of a distributed router platform aimed at consolidating multiple hardware routers. The goal of the approach is twofold: firstly decouple the logical routing and forwarding functionality from the limitations of the hardware that runs it, through automated configuration management only; and secondly, give component routers a longer lease of life, as constituting parts of a larger router system. We focus on the logical intra-domain routing function provided by routers, and show the need for a centralized intra-domain route server. [less ▲]

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See detailExtending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships
Rigali, Sébastien ULg; Schlicht, M.; Hoskisson, P. et al

in Nucleic Acids Research (2004), 32(11), 3418-3426

Transcription factors (TFs) of bacterial helix-turn-helix superfamilies exhibit different effector-binding domains (EBDs) fused to a DNA-binding domain with a common feature. In a previous study of the ... [more ▼]

Transcription factors (TFs) of bacterial helix-turn-helix superfamilies exhibit different effector-binding domains (EBDs) fused to a DNA-binding domain with a common feature. In a previous study of the GntR superfamily, we demonstrated that classifying members into subfamilies according to the EBD heterogeneity highlighted unsuspected and accurate TF-binding site signatures. In this work, we present how such in silico analysis can provide prediction tools to discover new cis/trans relationships. The TF-binding site consensus of the HutC/GntR subfamily was used to (i) predict target sites within the Streptomyces coelicolor genome, (ii) discover a new HutC/GntR regulon and (iii) discover its specific TF. By scanning the S.coelicolor genome we identified a presumed new HutC regulon that comprises genes of the phosphotransferase system (PTS) specific for the uptake of N-acetylglucosamine (PTSNag). A weight matrix was derived from the compilation of the predicted cis-acting elements upstream of each gene of the presumed regulon. Under the assumption that TFs are often subject to autoregulation, we used this matrix to scan the upstream region of the 24 HutC-like members of S.coelicolor. orf SCO5231 (dasR) was selected as the best candidate according to the high score of a 16 bp sequence identified in its upstream region. Our prediction that DasR regulates the PTSNag regulon was confirmed by in vivo and in vitro experiments. In conclusion, our in silico approach permitted to highlight the specific TF of a regulon out of the 673 orfs annotated as 'regulatory proteins' within the genome of S.coelicolor. [less ▲]

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