Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailEloge académique du professeur Charles-Léon Lapière
Angenot, Luc ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2012), 167(1), 21-27

Detailed reference viewed: 25 (0 ULg)
Full Text
Peer Reviewed
See detailEloge academique du professeur Maurice Welsch, membre titulaire et ancien président
Ghuysen, Jean-Marie ULg; Reginster, M.

Article for general public (1987)

Detailed reference viewed: 77 (6 ULg)
Full Text
Peer Reviewed
See detailÉloge de l'hétérogénéité des structures d'analyse de textes
Bénel, Aurélien; Lejeune, Christophe ULg; Zhou, Chao

in Document Numérique (2010), 13(2), 41-56

This paper deals with how we used a "knowledge organization system" management infrastructure to build software for researchers involved in text interpretation. Founded on a viewpoints-based model, this ... [more ▼]

This paper deals with how we used a "knowledge organization system" management infrastructure to build software for researchers involved in text interpretation. Founded on a viewpoints-based model, this implementation highlighted the heterogeneity of analyses structures, whether it comes from authors diversity or from automation level. [less ▲]

Detailed reference viewed: 244 (58 ULg)
Full Text
See detailL'Eloge de la folie d'Erasme
Adam, Renaud ULg

in Toussaint, Jacques (Ed.) Pulsion(s) : images de la folie du Moyen Age au siècle des Lumières (2012)

Detailed reference viewed: 58 (8 ULg)
Full Text
Peer Reviewed
See detailL'éloge de la folie en hôpital de jour: présent du passé et perspectives
Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2003)

Detailed reference viewed: 39 (7 ULg)
See detailEloge de Marcel Migeotte (1912-1992)
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1994), V(6), 271-278

Detailed reference viewed: 9 (2 ULg)
See detailEloge du compromis. Pour une nouvelle pratique démocratique
Nachi, Mohamed ULg

Book published by Academia-Bruylant (2006)

Detailed reference viewed: 55 (1 ULg)
See detailEloge du compromis. Pour une nouvelle pratique démocratique
Nachi, Mohamed ULg

Scientific conference (2008, March)

La place du compromis dans les espaces publics démocratiques

Detailed reference viewed: 29 (3 ULg)
Full Text
See detailÉloge du détournement
Saint-Amand, Denis ULg

Article for general public (2014)

Detailed reference viewed: 65 (2 ULg)
See detailEloge du politiquement correct
Delruelle, Edouard ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 11 (1 ULg)
See detailElogio de Collodi
Curreri, Luciano ULg

in Las aventuras de Pinocho : Historia de un títire (2011)

Detailed reference viewed: 21 (1 ULg)
See detailElogio di Collodi
Curreri, Luciano ULg

in Le avventure di Pinocchio : Storia di un burattino (2010)

Detailed reference viewed: 26 (2 ULg)
Full Text
Peer Reviewed
See detailElongated Structure of the Outer-Membrane Activator of Peptidoglycan Synthesis LpoA: Implications for PBP1A Stimulation
Jean, Nicolas; Bougault, Catherine; Lodge, Adam et al

in Structure (2014)

The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In ... [more ▼]

The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In Escherichia coli, the major peptidoglycan synthase PBP1A requires stimulation by the outer-membrane-anchored lipoprotein LpoA. Whereas the C-terminal domain of LpoA interacts with PBP1A to stimulate its peptide crosslinking activity, little is known about the role of the N-terminal domain. Herein we report its NMR structure, which adopts an all-α-helical fold comprising a series of helix-turn-helix tetratricopeptide-repeat (TPR)-like motifs. NMR spectroscopy of full-length LpoA revealed two extended flexible regions in the C-terminal domain and limited, if any, flexibility between the N- and C-terminal domains. Analytical ultracentrifugation and small-angle X-ray scattering results are consistent with LpoA adopting an elongated shape, with dimensions sufficient to span from the outer membrane through the periplasm to interact with the peptidoglycan synthase PBP1A. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailElongation of telechelic ionomers under shear: a rheological and rheo-optical study
Chassenieux, Christophe; Tassin, Jean-François; Gohy, Jean-François et al

in Macromolecules (2000), 33(5), 1796-1800

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong ... [more ▼]

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong increase of birefringence and a pronounced and rapid alignment of the polymer chains toward the flow direction leading to an important elasticity of the fluids. The draw ratio of the polymer chains under shear has been estimated from the rheo-optical data. When the fraction of loops is taken into account, draw ratios on the order of 4 are calculated in the shear thickening regime. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailElongator - an emerging role in neurological disorders
Nguyen, Laurent ULg; Humbert, Sandrine; Saudou, Frédéric et al

in Trends in Molecular Medicine (2010), 16

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based ... [more ▼]

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies. [less ▲]

Detailed reference viewed: 65 (13 ULg)
Full Text
Peer Reviewed
See detailElongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin
Creppe, Catherine ULg; Malinouskaya, Lina ULg; Volvert, Marie-Laure ULg et al

in Cell (2009), 136

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which ... [more ▼]

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha tubulin. A direct reduction of alpha tubulin acetylation leads to comparable defects in cortical neurons and suggests that alpha tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons. [less ▲]

Detailed reference viewed: 304 (105 ULg)
Peer Reviewed
See detailElongator depletion causes defective transcript elongation of genes that regulate cell motility
Close, Pierre ULg; Hawkes, N; Cornez, I et al

Poster (2005, November 15)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailElongator drives breast cancer initiation and metastasis formation
Delaunay, Sylvain ULg

Poster (2014, May 08)

Elongator complex functions in diverse cellular processes, such as protein acetylation and tRNA modification, and is essential for cell migration and neuronal differentiation. Although it is well ... [more ▼]

Elongator complex functions in diverse cellular processes, such as protein acetylation and tRNA modification, and is essential for cell migration and neuronal differentiation. Although it is well established that tumor development involves modifications of acetylation-deacetylation dynamics as well as changes in protein translation, the role of Elongator in tumor initiation and invasion remains to be studied. Breast cancer is amongst the most common cause of cancer-related deaths in women, and the majority of them involved metastasis dissemination. In vitro, the inactivation of elongator affects the migration and the clonogenic potential of breast cancer cells. In vivo, expression of the ELP1 and Elp3 subunits is elevated over tumor development and in lung metastasis of PyMT-MMTV breast cancer mice. To address the role of elongator in tumor development in vivo, we generated a mouse model in which the catalytic subunit Elp3 is specifically invalidated in the mammary epithelium (Elp3ΔMEC), that we crossed with the PyMT-MMTV model of breast cancer. Elp3 ablation in the mammary epithelium of the PyMT mice caused a delay in primary tumor initiation and reduced metastasis to distal sites. Moreover, PyMT tumor cells formed less mammospheres in the absence of Elp3. Together, our data demonstrate that elongator complex is a key actor in breast cancer initiation and dissemination. [less ▲]

Full Text
See detailElongator orchestrates cerebral cortical neurogenesis
creppe, catherine; malinouskaya, lina; Volvert, Marie-Laure ULg et al

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

Detailed reference viewed: 72 (20 ULg)