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Peer Reviewed
See detailDrug-induced destructive cholangitis and total ductopenia in a young dog.
gabriel, Alexandra; Heimann, M.; van den ingh, T. et al

in Proceedings of the 13th Annual Congress of the ECVIM-CA (2003)

Detailed reference viewed: 119 (2 ULg)
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See detailDrug-induced thyroid dysfunction
Geenen, Vincent ULg

Conference (2016, April 16)

Detailed reference viewed: 53 (5 ULg)
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See detailDrug-induced toxic epidermal necrolysis and pancytopenia: a puzzling association.
Paquet, Philippe ULg; Jacob, Eric; Pirson, J. et al

in International Journal of Molecular Medicine (2005), 16(1), 29-33

The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. We report a unique case of antibiotic-induced TEN developed in a patient who also ... [more ▼]

The molecular mechanisms involved in the pathogenesis of toxic epidermal necrolysis (TEN) remain not fully understood. We report a unique case of antibiotic-induced TEN developed in a patient who also suffered from prolonged severe methotrexate-induced pancytopenia. The objective of the study was to explore the nature of the cutaneous inflammatory infiltrate and the density in dermal dendrocytes (DD). Immunohistochemistry was used to identify activated T lymphocytes (CD45R0), monocyte-macrophages (Mac 387, CD68), DD (Factor XIIIa), and Langerhans cells (CD1a). The proliferation marker (Ki67) and the antibody to Fas receptor (CD95R) were also used to assess the distribution of the germinative pool of keratinocytes and the FAS-related apoptotic process, respectively. Numerous Factor XIIIa+ DD were present in the papillary dermis with only sparce perivascular CD45RO+ T lymphocytes and scattered CD68+ or Mac 387+ macrophages. Double immunostainings revealed that a minority of Factor XIIIa+ DD co-expressed the CD68 glycoprotein (a marker of phagocytic activity). No cells co-expressed factor XIIIa and Mac 387 immunoreactivities. CD45RO+ T lymphocytes, CD68+ and Mac 387+ macrophages were absent in the epidermis. The expression of CD95R was present although restricted to the basal keratinocytes, while the L1-protein (Mac 387+) was diffusely present in the epidermis. Langerhans cells (CD1a+) were sparce, but normal in distribution. The presence of a great number of Factor XIIIa+ DD without any possible recent recruitment from bone marrow suggests that these cells differentiated from resident cells of the skin. Indeed, there was no co-expression of Factor XIIIa and L1-protein, thus showing the absence of recruitment from monocytes. The simultaneous over-expression of Factor XIIIa and CD68 in some DD indicates some phagocytic activity. In view of the absence of inflammatory cells in the epidermis, keratinocytes appeared responsible for their own destruction through CD95-mediated and/or calcium-dependent apoptotic pathways. This finding entails that TEN treatments should target the keratinocyte metabolism rather than the circulating inflammatory cells which presumably play a limited role, if any, in the epidermal destructive process. [less ▲]

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See detailDrug-induced valvular heart disease.
Cosyns, Bernard; Droogmans, Steven; Rosenhek, Raphael et al

in Heart (British Cardiac Society) (2013), 99(1), 7-12

Drug-induced valvular heart disease (DIVHD) was first described in the 1960s. Initially, associations with ergot derivatives used for migraine prevention, or with anorectic drugs, were described. Drugs ... [more ▼]

Drug-induced valvular heart disease (DIVHD) was first described in the 1960s. Initially, associations with ergot derivatives used for migraine prevention, or with anorectic drugs, were described. Drugs used for the treatment of Parkinson's disease and endocrine diseases, like hyperprolactinemia, may also induce VHD. More recently, the use of 3,4-methylendioxymetamphetamine (MDMA, 'Ecstasy') and benfluorexhave been found to be associated with DIVHD. Although some of these drugs were withdrawn from the market, several cases of patients requiring valve surgery even years after the cessation of therapy have been reported. DIVHD is not infrequent, may be severe, and has been described in association with several drugs. Even after drug cessation, long-term implications of this type of VHD may persist. The present review underlines the need for a careful evaluation of the associated clinical and echocardiographic risk factors to allow early recognition so as not to delay appropriate management. [less ▲]

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See detailDrug-polymer electrostatic complexes as new structuring agents for the formation of drug-loaded ordered mesoporous silica
Molina, Emilie; Warnant, Jérôme; Mathonnat, Mélody et al

in Langmuir (2015), 31(47), 12839-12844

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases ... [more ▼]

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behaviour was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors and, this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multi-step processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials. [less ▲]

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See detailDrugs and "Integrated"Policy. Between Intention and Execution
Lemaître, André ULg; Fincoeur, Bertrand ULg

in Cahiers de la Sécurité (2009)

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See detailDrugs and crime deviant pathways
Born, Michel ULg; Gavray, Claire ULg

in Brochu, S.; Da Agra, C.; Cousineau, M. (Eds.) Deviant trajectories at the turning point between adolescence and adulthood (2002)

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See detailDRUPSSuC : Design and Renovation of Urban Public Spaces for Sustainable Cities, Final report Phase 1
De Herde, André; Vermeir, Gerrit; Godart, Marie-Françoise et al

Report (2009)

Detailed reference viewed: 84 (12 ULg)
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See detailDry galloping on bridge cables: roughness and shape effects on an inclined circular cylinder
Benidir, Adel; Flamand, Olivier; Gaillet, Laurent et al

in Proceedings of the European-African Conference on Wind Engineering 2013 (2013, July 09)

Dry galloping of stays in cable-stayed bridges is a phenomenon that is still of interest to the scientific community. Over the course of the current three-year research project numerous experiments will ... [more ▼]

Dry galloping of stays in cable-stayed bridges is a phenomenon that is still of interest to the scientific community. Over the course of the current three-year research project numerous experiments will be carried out to investigate the effect of turbulence and inclination angle on dry galloping. The novel aspect of this study consists of an in-depth investigation into the effect of non uniformity of the pipe surrounding the stay cables on the dry galloping excitation mechanism. Previous studies reported that dry galloping is caused by the appearance of a negative pressure bubble on one side of the circular cylinder at the critical Reynolds number range, leading to a rapid drop in the drag coefficient and the appearance of a non negligible lift force. This paper presents results from initial experiments in the wind tunnel at CSTB – Nantes, France. [less ▲]

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See detailDry heathlands and sandy open grasslands in a suburban environment in the south of Brussels (Belgium) : Assessment of the conservation status
Taymans, Julien ULg; Mahy, Grégory ULg

Poster (2008, August)

The Brabant sablo-limoneux region is located in the south and near Brussels, in the phytogeographic district of Brabant (Atlantic domain). This region is characterized by a high diversity of local ... [more ▼]

The Brabant sablo-limoneux region is located in the south and near Brussels, in the phytogeographic district of Brabant (Atlantic domain). This region is characterized by a high diversity of local ecological conditions due to the alternance of important tertiary sand outcrops and quaternary silty layers. The agro-sylvo-pastoral activities, which were practiced on these sandy and sand-silty soils for centuries, caused the evolution of the climactic forest into semi-natural habitats such as dry heathland, sandy grassland and grassheath. The evolution of the heathland distribution from 1770 to the present has been studied on the scale of the Dyle hydrographic subbasin (43.000 ha). It is characterized by an important regression of this habitat in the study area (from 1460 ha in 1770 to 72 ha in 2006), mainly due to Pinus sylvestris orchards, and more recently, to urbanisation caused by the proximity of Brussels. A generalized ageing and an environmental closing characterize the evolution of heathland physiognomy since the middle of the 20th century. The phytosociology of heathlands, sandy grasslands and grassheaths has been characterized and 19 groups of vegetation have been differentiated. Among the 393 listed higher plant species, more than 30 are of great conservation interest in the regional context. A hierarchisation of restoration priorities has been established on the scale of the studied hydrographic subbasin and management measures have been proposed. [less ▲]

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Peer Reviewed
See detailDry peas as a source of protein for maize silage or dry sugar beet pulp in growing bulls.
Thewis, André ULg; Pouleau, F.; Leterme, Pascal

in 41st Annual Meeting of the EAAP, Toulouse (Fr), July 9-12, Vol.I (1990, July)

Detailed reference viewed: 10 (2 ULg)
Peer Reviewed
See detailDry powder of budesonide/hydroxypropyl-beta-cyclodextrin complex for inhalation as a new potential antiasthmatic treatment
Bigazzi, William ULg; Dufour, Gilles; Mingeot-Leclercq, Marie-Paule et al

Conference (2016, October 17)

Asthma is a respiratory disease characterized by chronic airway inflammation which can lead, if not correctly managed, to tissue remodeling associated with an irreversible decline in lung function ... [more ▼]

Asthma is a respiratory disease characterized by chronic airway inflammation which can lead, if not correctly managed, to tissue remodeling associated with an irreversible decline in lung function. Hypersensitivity of the respiratory tract to non-specific stimuli, which causes triggering of asthma attacks, is also observed. Despite medical advances, asthma remains an important socio-economic and public health concern since this condition affects 300 million people and causes more than 300 000 deaths worldwide every year. Furthermore its annual cost is estimated at over 30 billion euros in Europe. These issues can be partially linked to an inadequate control of asthma due to undesirable effects of existing medication such as corticosteroids. Hence, the development of new medications with improved effectiveness and reduced adverse effects could allow a better management of the disease. It has been recently discovered that inhaled solution of hydroxylpropyl-beta-cyclodextrin (HPBCD) is able to reduce allergen-induced bronchoconstriction in asthmatic patients, with no toxicity observed in healthy patients further to administration. Based on these results, our project seeks to develop new antiasthmatic medication containing an association of HPBCD and budesonide, a widely used corticosteroid in long-term treatment of asthma. Thus, we investigated complexation between the two molecules. Interestingly, it was observed that when budesonide is complexed with HPBCD, its permeability across a Calu-3 cell layer is reduced. Several experiments in mouse models confirmed that HPBCD acts as a sustained delivery system which progressively releases budesonide into the lung parenchyma, leading to a prolonged anti-inflammatory effect. Due to high Peclet number of HPBCD, the spray dried complex exhibited wrinkled particles whose interest in dry powder for inhalation is well known. Thanks to its anti-inflammatory effect and its sustained release potential, HPBCD could significantly reduce corticosteroids needed doses for management of asthma. However, a clinical study has to be performed to determine the optimal budesonide/HPBCD ratio and the minimal effective dose of complex. Further investigations are also needed to exploit the potential of spray dried HPBCD and develop a powder for inhalation by particle engineering. [less ▲]

Detailed reference viewed: 95 (16 ULg)
See detailDry Season Carbon Dynamics in Savannah Grassland and Rainforest Dominated River Basins of Madagascar
Marwick, T.; van Acker, K.; Darchambeau, François ULg et al

Poster (2011)

Detailed reference viewed: 33 (7 ULg)
Peer Reviewed
See detailDry synthesis of Pt/C and Pt-Ni/C catalysts for PEM fuel cells by low-pressure plasma
Busby, Yan; da Silva., Mathieu; Stergiopoulos, Vaios ULg et al

Conference (2016, September 19)

Detailed reference viewed: 19 (2 ULg)
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See detailDry-season status, trend and distribution of Konkombouri elephants and implications for their management, Burkina Faso
Bouché, Philippe ULg

in Pachyderm (2007), 42

Konkombouri Hunting Zone is part of the transfrontier W–Arly–Pendjari ecosystem. Monthly dry-season records from wildlife monitoring show that the free-ranging elephant population increased from month to ... [more ▼]

Konkombouri Hunting Zone is part of the transfrontier W–Arly–Pendjari ecosystem. Monthly dry-season records from wildlife monitoring show that the free-ranging elephant population increased from month to month with the progression of the dry season and the reduction of water points that still contained water. However, with the arrival of the first important rains, elephant density continued to increase because water and new shoots were available everywhere. In 2005 and 2006 elephant density in the Konkombouri Hunting Zone reached the highest mean dry-season elephant density recorded in West Africa in recent decades. This situation increases the impact on habitat close to water points and heightens human–elephant conflicts. [less ▲]

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See detailDrying induced shrinkage of Boom Clay: an experimental investigation
Prime, Noémie; Levasseur, Séverine ULg; Miny, Laurent et al

in Canadian Geotechnical Journal (2016), 53(3), 396-409

Drying induced shrinkage of geomaterials may have a strong effect on geostructure stability and deformation. Settlement of foundations, fracture opening on slopes, roads, tunnel walls may be due to drying ... [more ▼]

Drying induced shrinkage of geomaterials may have a strong effect on geostructure stability and deformation. Settlement of foundations, fracture opening on slopes, roads, tunnel walls may be due to drying shrinkage. However, there is still a lack of knowledge concerning shrinkage evolution in time and shrinkage propagation within the material. In this study, the shrinkage of a specific clayey rock, Boom Clay, under drying conditions is experimentally investigated. This rock is a deep geological formation which is under study for high-level and long-life radioactive waste storage in Belgium. Two experimental campaigns are here presented. The first one, based on vapour equilibrium drying technique and completed by sample size manual measurement, aims to characterize the material shrinkage in balanced states. The second one, based on convective drying technique completed by shape monitoring using X-ray tomography, aims to analyse how shrinkage develops before reaching a steady state. Both approaches put in evidence the shrinkage anisotropy of this structurally bedded rock, with a ratio around 2 between the direction of maximum strains and the direction of minimum strains. However, the two drying techniques also provide complementary results, as the relation between the amount of shrinkage and the retention curve (for the uniform drying imposed with saline solutions) and the kinetics of shrinkage propagation inside the material (for the non-uniform drying imposed with air convection). [less ▲]

Detailed reference viewed: 139 (40 ULg)