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See detailEloge du compromis. Pour une nouvelle pratique démocratique
Nachi, Mohamed ULg

Book published by Academia-Bruylant (2006)

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See detailÉloge du détournement
Saint-Amand, Denis ULg

Article for general public (2014)

Detailed reference viewed: 51 (2 ULg)
See detailEloge du politiquement correct
Delruelle, Edouard ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 9 (1 ULg)
See detailElogio de Collodi
Curreri, Luciano ULg

in Las aventuras de Pinocho : Historia de un títire (2011)

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See detailElogio di Collodi
Curreri, Luciano ULg

in Le avventure di Pinocchio : Storia di un burattino (2010)

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See detailElongated Structure of the Outer-Membrane Activator of Peptidoglycan Synthesis LpoA: Implications for PBP1A Stimulation
Jean, Nicolas; Bougault, Catherine; Lodge, Adam et al

in Structure (2014)

The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In ... [more ▼]

The bacterial cell envelope contains the stress-bearing peptidoglycan layer, which is enlarged during cell growth and division by membrane-anchored synthases guided by cytoskeletal elements. In Escherichia coli, the major peptidoglycan synthase PBP1A requires stimulation by the outer-membrane-anchored lipoprotein LpoA. Whereas the C-terminal domain of LpoA interacts with PBP1A to stimulate its peptide crosslinking activity, little is known about the role of the N-terminal domain. Herein we report its NMR structure, which adopts an all-α-helical fold comprising a series of helix-turn-helix tetratricopeptide-repeat (TPR)-like motifs. NMR spectroscopy of full-length LpoA revealed two extended flexible regions in the C-terminal domain and limited, if any, flexibility between the N- and C-terminal domains. Analytical ultracentrifugation and small-angle X-ray scattering results are consistent with LpoA adopting an elongated shape, with dimensions sufficient to span from the outer membrane through the periplasm to interact with the peptidoglycan synthase PBP1A. [less ▲]

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See detailElongation of telechelic ionomers under shear: a rheological and rheo-optical study
Chassenieux, Christophe; Tassin, Jean-François; Gohy, Jean-François et al

in Macromolecules (2000), 33(5), 1796-1800

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong ... [more ▼]

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong increase of birefringence and a pronounced and rapid alignment of the polymer chains toward the flow direction leading to an important elasticity of the fluids. The draw ratio of the polymer chains under shear has been estimated from the rheo-optical data. When the fraction of loops is taken into account, draw ratios on the order of 4 are calculated in the shear thickening regime. [less ▲]

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See detailElongator - an emerging role in neurological disorders
Nguyen, Laurent ULg; Humbert, Sandrine; Saudou, Frédéric et al

in Trends in Molecular Medicine (2010), 16

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based ... [more ▼]

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies. [less ▲]

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See detailElongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin
Creppe, Catherine ULg; Malinouskaya, Lina ULg; Volvert, Marie-Laure ULg et al

in Cell (2009), 136

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which ... [more ▼]

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha tubulin. A direct reduction of alpha tubulin acetylation leads to comparable defects in cortical neurons and suggests that alpha tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons. [less ▲]

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See detailElongator depletion causes defective transcript elongation of genes that regulate cell motility
Close, Pierre ULg; Hawkes, N; Cornez, I et al

Poster (2005, November 15)

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See detailElongator orchestrates cerebral cortical neurogenesis
creppe, catherine; malinouskaya, lina; Volvert, Marie-Laure ULg et al

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

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See detailElongator: an ancestral complex driving transcription and migration through protein acetylation.
Creppe, Catherine ULg; Buschbeck, Marcus

in Journal of biomedicine & biotechnology (2011), 2011

Elongator is an evolutionary highly conserved complex. At least two of its cellular functions rely on the intrinsic lysine acetyl-transferase activity of the elongator complex. Its two known substrates ... [more ▼]

Elongator is an evolutionary highly conserved complex. At least two of its cellular functions rely on the intrinsic lysine acetyl-transferase activity of the elongator complex. Its two known substrates--histone H3 and alpha-tubulin--reflect the different roles of elongator in the cytosol and the nucleus. A picture seems to emerge in which nuclear elongator could regulate the transcriptional elongation of a subset of stress-inducible genes through acetylation of histone H3 in the promoter-distal gene body. In the cytosol, elongator-mediated acetylation of alpha-tubulin contributes to intracellular trafficking and cell migration. Defects in both functions of elongator have been implicated in neurodegenerative disorders. [less ▲]

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See detailElp3 drives Wnt-dependent tumor initiation and regeneration in the intestine
LADANG, Aurélie ULg; Rapino, Francesca ULg; Heukamp, Lukas et al

in Journal of Experimental Medicine (2015), 212(12), 2057-75

Tumor initiation in the intestine can rapidly occur from Lgr5(+) crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer ... [more ▼]

Tumor initiation in the intestine can rapidly occur from Lgr5(+) crypt columnar stem cells. Dclk1 is a marker of differentiated Tuft cells and, when coexpressed with Lgr5, also marks intestinal cancer stem cells. Here, we show that Elp3, the catalytic subunit of the Elongator complex, is required for Wnt-driven intestinal tumor initiation and radiation-induced regeneration by maintaining a subpool of Lgr5(+)/Dclk1(+)/Sox9(+) cells. Elp3 deficiency dramatically delayed tumor appearance in Apc-mutated intestinal epithelia and greatly prolonged mice survival without affecting the normal epithelium. Specific ablation of Elp3 in Lgr5(+) cells resulted in marked reduction of polyp formation upon Apc inactivation, in part due to a decreased number of Lgr5(+)/Dclk1(+)/Sox9(+) cells. Mechanistically, Elp3 is induced by Wnt signaling and promotes Sox9 translation, which is needed to maintain the subpool of Lgr5(+)/Dclk1(+) cancer stem cells. Consequently, Elp3 or Sox9 depletion led to similar defects in Dclk1(+) cancer stem cells in ex vivo organoids. Finally, Elp3 deficiency strongly impaired radiation-induced intestinal regeneration, in part because of decreased Sox9 protein levels. Together, our data demonstrate the crucial role of Elp3 in maintaining a subpopulation of Lgr5-derived and Sox9-expressing cells needed to trigger Wnt-driven tumor initiation in the intestine. [less ▲]

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See detailElp3 is required for initiation of colon cancer
Ladang, Aurélie ULg; Heukamp, L; Buettner, R et al

Poster (2013, September 18)

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See detailEls problemes de la violència esportiva. 10 anys després de Heysel
Comeron, Manuel ULg; Van Limbergen, Kris

in Revista d’Historia L'Avenç (1997), (211), 25-32

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es ... [more ▼]

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es relaciona llavors amb comportaments d'agressio fisica i de vandalisme produïts pels espectadors d'una manifestacio esportiva, mes concretament dels partits de futbol. [less ▲]

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See detailEls Terratrèmols de l'any 1373 al Pirineu : Efectes a Espanya i França
Olivera, Carme; Riera, Antoni; Alexandre, Pierre ULg et al

Book published by Servei Geologic de Catalunya (1994)

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See detailElsvier, Computers in Industry, Special Issue on Natural Language Processing and Text Analytics in Industry
Ittoo, Ashwin ULg; Bosh, v.d., Antal; Nguyen, Le Minh

Book published by Elsevier (2015)

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See detailElucidating the altered transcriptional programs in breast cancer using independent component analysis
Teschendorff, A. E.; Journee, Michel ULg; Absil, P.-A. et al

in PLoS Computational Biology (2007), 3(8), 1539-1554

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of ... [more ▼]

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of unsupervised algorithms that have been applied to microarray gene expression data in an attempt to understand phenotype differences in terms of changes in the activation/ inhibition patterns of biological pathways. While the ICA model has been shown to outperform other linear representations of the data such as Principal Components Analysis ( PCA), a validation using explicit pathway and regulatory element information has not yet been performed. We apply a range of popular ICA algorithms to six of the largest microarray cancer datasets and use pathway- knowledge and regulatory- element databases for validation. We show that ICA outperforms PCA and clustering- based methods in that ICA components map closer to known cancer- related pathways, regulatory modules, and cancer phenotypes. Furthermore, we identify cancer signalling and oncogenic pathways and regulatory modules that play a prominent role in breast cancer and relate the differential activation patterns of these to breast cancer phenotypes. Importantly, we find novel associations linking immune response and epithelial - mesenchymal transition pathways with estrogen receptor status and histological grade, respectively. In addition, we find associations linking the activity levels of biological pathways and transcription factors ( NF1 and NFAT) with clinical outcome in breast cancer. ICA provides a framework for a more biologically relevant interpretation of genomewide transcriptomic data. Adopting ICA as the analysis tool of choice will help understand the phenotype - pathway relationship and thus help elucidate the molecular taxonomy of heterogeneous cancers and of other complex genetic diseases. [less ▲]

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