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See detailEffacement énonciatif et doxa dans le discours théorique : l'exemple de Julia Kristeva
Provenzano, François ULg

in Argumentation et Analyse du Discours (2010)

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See detailThe effcts of two levels of energy allowances on growth in captive neonates Testud hermanni boettgeri (Mojsisovic 1889)
Vanstrazeele, Boris; Pasten Vargas, Solange; Lhoest, Estelle et al

in Coenen, M.; Vervuert, I. (Eds.) Proceedings of the 11th ESVCN Congress (2007)

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See detailThe Effect of Daytime Naps on the Recall of Verbal Material
Muto, Vincenzo ULg; Arpaia, L; De Padova, V et al

in Sleep Medicine (2005)

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See detailEffect and profitability of storage facilities within zonal pricing systems
Oprescu, Bogdan; Quoilin, Sylvain ULg; Zucker, Andreas

in Proceedings of the 10th Conference on Sustainable Development of Energy, Water and Environment Systems (2015, September)

The new European Objectives along with environmental concerns are leading the energy sector in a new phase where conventional generation plants are progressively replaced by renewable energy sources. This ... [more ▼]

The new European Objectives along with environmental concerns are leading the energy sector in a new phase where conventional generation plants are progressively replaced by renewable energy sources. This new paradigm raises concerns regarding the optimal generation mix and the management of the power transmission constraints. This study focuses on the case of Italy tosimulate the dispatch in its power system with DispaSET, a unit commitment and optimal dispatch model developed within the Joint Research Centre. It aims at evaluating the value of storage and of interconnections in different renewables penetration scenarios. [less ▲]

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See detailEffect de l'entraînement sur la fonction mitochondriale musculaire du cheval d'endurance
Votion, Dominique ULg; Fraipont, Audrey ULg; Franck, Thierry ULg et al

in 35eme Journee de la Recherche Equine, jeudi 26 fevrier 2009, Paris, France (2009)

Athletic ability of endurance horses is intimately linked to muscle oxidative capacity. Microbiopsies of triceps brachii (TB) and gluteus medius (GM) were collected before and after 10 weeks of training ... [more ▼]

Athletic ability of endurance horses is intimately linked to muscle oxidative capacity. Microbiopsies of triceps brachii (TB) and gluteus medius (GM) were collected before and after 10 weeks of training in 7 endurance horses to assess the feasibility of studying training effect with the use of microbiopsies. Oxygen consumption of permeabilized fibers was evaluated by high resolution respirometry (HRR) with a titration protocol that defines the activity of the mitochondrial complexes. Differences among muscles before and after training as well as training effect were assessed by Wilcoxon matched pairs test (P<0.05). No complications occurred following microbiopsies in any horse. The in situ oxidative capacity of the TB and GM increased with training. No difference was found between the TB and GM when one horse was excluded from the statistical analysis. Indeed, this horse showed signs of exercise intolerance before sampling (after the training period) which were associated to a low rate of respiration in GM but not in TB. Results of this study showed that HRR may be used to follow training effect and suggest that metabolic impairment might be detected with HRR. [less ▲]

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See detailEffect of γ-radiation on free radicals formation, structural changesand functional properties of wheat starch
Atrous, Hager; Benbettaieb, Nasreddine; Hosni, Faouzi et al

in International Journal of Biological Macromolecules (2015), 80

Wheat starch was treated by different γ-radiation doses (3, 5, 10, 20, 35 and 50 kGy). The effects of γ-radiation on structural, thermal, physicochemical, morphological and rheological properties of wheat ... [more ▼]

Wheat starch was treated by different γ-radiation doses (3, 5, 10, 20, 35 and 50 kGy). The effects of γ-radiation on structural, thermal, physicochemical, morphological and rheological properties of wheat starch were studied. The presence of free radicals after γ-radiation treatment, which number decreased with time was confirmed. Structural analysis revealed decreases in the intensities of the O–H and C–H stretches and glycosidic linkages indicating the depolymerization of amylose and probably amy-lopectin into shorter chain molecules, but showed that γ-radiation treatment did not affect the crystalline structure. Differential scanning calorimetric (DSC) thermograms showed the absence of significant differences in the gelatinization temperatures, as well as the corresponding transition enthalpies since the DSC parameters are related to the crystalline ordering within the granules. Apparent amylose content decreased linearly with increasing irradiation dose leading to an increase in water solubility index. Anincrease in the swelling power was observed after irradiation treatment until 20 kGy, followed by a rapiddecrease at higher doses. Microscopic observations showed that the effect of γ-radiation was more visible on starch pastes than on starch granules. Rheological properties of the starch pastes decreased within creasing irradiation dose as a result of glycosidic bond cleavage. [less ▲]

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See detailThe effect of 2 and 3 years of Raloxifene on vertebral and non-vertebral fractures in postmenopausal women with osteoporosis
Ensrud, K; Black, D; Recker, R et al

in BONE (1998), 23(S5), 174

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See detailEffect of 2 years of high-dose growth hormone therapy on cognitive and psychosocial development in short children born small for gestational age.
Lagrou, K.; Vanderfaeillie, J.; Froidecoeur, Christelle ULg et al

in European journal of endocrinology / European Federation of Endocrine Societies (2007), 156(2), 195-201

OBJECTIVE AND DESIGN: Children born small for gestational age (SGA) are not only at risk for short stature, but also for neurodevelopmental and behavioral problems. In this study, we analyzed the effects ... [more ▼]

OBJECTIVE AND DESIGN: Children born small for gestational age (SGA) are not only at risk for short stature, but also for neurodevelopmental and behavioral problems. In this study, we analyzed the effects of high-dose GH therapy on cognitive development and psychosocial functioning in 34 prepubertal (3-8 years) short SGA children, equally randomized into a GH-treated group (TRG) and an untreated group (UTRG). METHODS: At start and after 2 years, children underwent standardized tests measuring the intellectual abilities (Wechsler Preschool and Primary Scale of Intelligence-Revised, or Wechsler Intelligence Scale for Children-Revised); their parents completed a standardized questionnaire evaluating psychosocial functioning (Child Behavior Checklist; CBCL). RESULTS: At start, total IQ scores were significantly (P < 0.05) lower in the SGA group than in the general population: 32% of the SGA patients had scores below 85. After 2 years, IQ scores remained unchanged in the TRG, but increased significantly (P < 0.05) in the UTRG. After exclusion of children with developmental problems, however, no significant changes in IQ scores occurred in the UTRG as well as the TRG. At baseline, 24% (8/34) children had problematic CBCL total problems scores, equally distributed among the two groups; no significant changes in the different subscale scores occurred after 2 years. CONCLUSION: No beneficial effect of 2 years of GH therapy on cognitive and behavioral profile could be observed in a cohort of rather young short SGA children presenting a variable degree of developmental delay and behavioral problems. Subsequent follow-up could reveal potential long-term effects of GH therapy on development and behavior. [less ▲]

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See detailEffect of 211At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes
Turtoi, Andrei ULg; Schneeweiss, Frank H.A.

in International Journal of Radiation Biology (2009), 85(5), 403-12

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See detailEffect of 2D and 3D vision on the learning of fine motor skills according to the instrumental dimension: The case of minimal invasive surgery
Blavier, Adelaïde ULg; Nyssen, Anne-Sophie ULg

Conference (2007, June 01)

New technology in surgery is more and more present and allows to study cognitive processes in complex and natural environment. Comparing to classical minimal access surgery, a new robotic system allows to ... [more ▼]

New technology in surgery is more and more present and allows to study cognitive processes in complex and natural environment. Comparing to classical minimal access surgery, a new robotic system allows to recover a 3D view and all degrees of freedom for instruments movement. The purpose of this study was to evaluate the perceptual (2D vs 3D view) and instrumental (classical versus robotic) impacts of this new robotic system on learning curves. 40 medical students without any surgical experience were randomized into 4 groups (classical laparoscopy with 3D-direct view or with 2D-indirect view, robotic system in 3D or in 2D) and repeated a surgical task 6 times. After these 6 repetitions, they performed 2 trials with the same technique but in the other viewing condition (perceptive switch). Finally, subjects performed last three trials with the technique they never used (technical switch). We measured the speed, the accuracy and their subjective impressions about their performance (satisfaction, self-confidence and difficulty). Our results showed better performance and improvement in 3D view than in 2D view, whatever the instrumental aspect. Participants reported less mastery, familiarity, self-confidence and more difficulty in classical laparoscopy with 2D view than in the other conditions. In conclusion, robotic surgery improves surgical performance and learning, particularly by 3D view advantage. However, the bad performances after the perceptive and technical switches emphasize the need to adapt and pursue training also with traditional technology in order to prevent risks when a robotic procedure has to be converted in a classical laparoscopic procedure. [less ▲]

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See detailThe Effect of 3 or 6 Years of Denosumab Exposure in Women With Postmenopausal Osteoporosis: Results From the FREEDOM Extension.
Bone, Henry G.; Chapurlat, Roland; Brandi, Maria-Luisa et al

in The Journal of clinical endocrinology and metabolism (2013)

Context:The FREEDOM extension is evaluating the long-term efficacy and safety of denosumab for up to 10 years.Objective:Report results from the first 3 years of the extension, representing up to 6 years ... [more ▼]

Context:The FREEDOM extension is evaluating the long-term efficacy and safety of denosumab for up to 10 years.Objective:Report results from the first 3 years of the extension, representing up to 6 years of denosumab exposure.Design, Setting, and Participants: Multicenter, international, open-label study of 4550 women.Intervention:Women from the FREEDOM denosumab group received 3 more years of denosumab for a total of 6 years (long-term) and women from the FREEDOM placebo group received 3 years of denosumab (cross-over).Main Outcome Measures:Bone turnover markers (BTMs), bone mineral density (BMD), fracture, and safety.Results:Reductions in BTMs were maintained (long-term) or achieved rapidly (cross-over) following denosumab administration. In the long-term group, BMD further increased for cumulative 6-year gains of 15.2% (lumbar spine) and 7.5% (total hip). During the first 3 years of denosumab treatment, the cross-over group had significant gains in lumbar spine (9.4%) and total hip (4.8%) BMD, similar to the long-term group during the 3-year FREEDOM trial. In the long-term group, fracture incidences remained low and below rates projected for a "virtual placebo" cohort. In the cross-over group, 3-year incidences of new vertebral and nonvertebral fractures were similar to those of the FREEDOM denosumab group. Incidence rates of adverse events did not increase over time. Six participants had events of ONJ confirmed by adjudication. One participant had a fracture adjudicated as consistent with atypical femoral fracture.Conclusion:Denosumab treatment for 6 years remained well tolerated, maintained reduced bone turnover, and continued to increase BMD. Fracture incidence remained low. [less ▲]

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See detailEffect of 5 different types of exercise, transportation and ACTH administration on plasma cortisol concentration in sports horses.
Linden, Annick ULg; Art, Tatiana ULg; Amory, Hélène ULg et al

in Persson, S. G. B.; Jeffcott, L. B.; Lindholm, A. (Eds.) Equine Exercise Physiology III (1991)

This study was carried out to compare the changes in plasma cortisol concentration produced by 5 different types of exercise, transportation and ACTH administration. Venous blood was analysed for cortisol ... [more ▼]

This study was carried out to compare the changes in plasma cortisol concentration produced by 5 different types of exercise, transportation and ACTH administration. Venous blood was analysed for cortisol concentration before and after each stimulus. The types of exercise were show jumping (n=28), cross country phase of a three-day event (n=32), trot race (n=9), gallop race (n = 10) and endurance ride (n=8). The response following the intravenous injection of synthetic ACTH (200 µg) in 6 of the event horses was determined. The ACTH test was carried out one week after competition. In 5 horses, the response to road transport of one hour was studied. All stimuli, except transportation produced a significant increase in plasma cortisol concentration. The endurance ride produced the largest increase and the show jumping the smallest. ACTH administration resulted in a 164% rire in plasma cortisol. Il was concluded that I) the degree of increase in plasma cortisol concentration appeared to reflect both intensity and dotation of workload; endurance ride appeared to be the most exhaustive and show jumping the least; 2) there was a correlation (r2=0.82) between the individual cortisol response to cross country exercise and to exogenous ACTH in the saure horses and 3) there was an important individual effect on transport-induced cortisol changes. [less ▲]

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See detailEffect of 5-year risedronate therapy on fracture reduction and bone histology and histomorphometry
Watts, NB; Sorensen, O; Eriksen, E et al

in Arthritis and Rheumatism (2001), 44(1220), 256

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See detailThe effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study.
PAPAPOULOS, S.; LIPPUNER, K.; ROUX, C. et al

in Osteoporosis International (2015), 26(12), 2773-2783

Summary: The FREEDOM study and its Extension provide long-term information about the effects of denosumab for the treatment of postmenopausal osteoporosis. Treatment for up to 8 years was associated with ... [more ▼]

Summary: The FREEDOM study and its Extension provide long-term information about the effects of denosumab for the treatment of postmenopausal osteoporosis. Treatment for up to 8 years was associated with persistent reduction of bone turnover, continued increases in bone mineral density, low fracture incidence, and a favorable benefit/risk profile. Introduction: This study aims to report the results through year 5 of the FREEDOM Extension study, representing up to 8 years of continued denosumab treatment in postmenopausal women with osteoporosis. Methods : Women who completed the 3-year FREEDOM study were eligible to enter the 7-year open-label FREEDOM Extension in which all participants are scheduled to receive denosumab, since placebo assignment was discontinued for ethical reasons. A total of 4550 women enrolled in the Extension (2343 long-term; 2207 cross-over). In this analysis, women in the long-term and cross-over groups received denosumab for up to 8 and 5 years, respectively. Results Throughout the Extension, sustained reduction of bone turnover markers (BTMs) was observed in both groups. In the long-term group, mean bone mineral density (BMD) continued to increase significantly at each time point measured, for cumulative 8-year gains of 18.4 and 8.3 % at the lumbar spine and total hip, respectively. In the cross-over group, mean BMD increased significantly from the Extension baseline for 5-year cumulative gains of 13.1 and 6.2 % at the lumbar spine and total hip, respectively. The yearly incidence of new vertebral and nonvertebral fractures remained low in both groups. The incidence of adverse and serious adverse events did not increase over time. Through Extension year 5, eight events of osteonecrosis of the jaw and two events of atypical femoral fracture were confirmed. [less ▲]

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See detailEffect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses
Raisis, Anthea L; Young, Lesley E; Blissitt, Karen J et al

in American Journal of Veterinary Research (2000), 61(10), 1282-1288

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia ... [more ▼]

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia was induced by use of romifidine (100 microg/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO), velocity time integral, maximal aortic blood flow velocity and acceleration, and left ventricular preejection period and ejection time were measured from aortic velocity waveforms obtained by transesophageal Doppler echocardiography. Velocity waveforms were recorded from the femoral vessels, using Doppler ultrasonography. The time-averaged mean velocity and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular perfusion was measured in the semimembranosus muscles by laser Doppler flowmetry. Data were recorded 60 minutes after induction of anesthesia (control) and at 15 and 30 minutes after start of an infusion of dobutamine (0.5 microg/kg/min). RESULTS: Aortic pressures were significantly increased during the infusion of dobutamine. No change was observed in the indices of left ventricular systolic function including CO. Femoral arterial flow significantly increased, and the PI and EDDS decreased. No change was observed in the femoral venous flow or in microvascular perfusion. CONCLUSIONS AND CLINICAL RELEVANCE: At this dosage, dobutamine did not alter left ventricular systolic function. Femoral blood flow was preferentially increased as the result of local vasodilatation. The lack of effect of dobutamine on microvascular perfusion suggests that increased femoral flow is not necessarily associated with improved perfusion of skeletal muscles [less ▲]

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See detailEffect of a 4-Week Treatment with Theophylline on Sputum Eosinophilia and Sputum Eosinophil Chemotactic Activity in Steroid-Naive Asthmatics
Louis, Renaud ULg; Bettiol, J.; Cataldo, Didier ULg et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2000), 30(8), 1151-60

BACKGROUND: The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect. OBJECTIVE: The purpose of this ... [more ▼]

BACKGROUND: The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect. OBJECTIVE: The purpose of this study was to assess the effect of theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics. METHOD: We performed a 4-week randomized double-blind, placebo-controlled, parallel group study in 21 mild to moderate steroid-naive asthmatics whose sputum eosinophilia was found twice > 5% during the run in period. Eleven subjects received 600 mg/24 h theophylline for the first 2 weeks and 900 mg/24 h for the last 2 weeks while 10 subjects took a placebo for 4 weeks. Sputum was induced after 2 and 4 weeks of treatment and 1 week after stopping the treatment. The sputum samples were compared for their cell counts, eosinophil cationic protein (ECP) levels and eosinophil chemotactic activity using micro-Boyden chambers. RESULTS: Serum theophylline concentrations reached 7 and 11 microg/mL at V3 and V4, respectively. Intragroup comparisons showed that theophylline, but not placebo, caused a significant reduction in sputum eosinophil counts at V3 (62 +/- 10% from baseline, P < 0.01) and a strong trend at V4 (67 +/- 16% from baseline, P = 0.07) when compared to baseline. The intergroup difference obtained after comparing the area under the curve over the 4 week treatment period only approached the statistical significance (P = 0.08). At baseline the fluid phase of the sputum contained a significant eosinophil chemotactic activity which was inhibited after a 4-week treatment by theophylline (P < 0. 01) but not by placebo. The mean sputum theophylline levels after 4 weeks of treament (1.7 microg/mL) was lower than that required to cause significant inhibition of eosinophil chemotaxis in vitro. CONCLUSION: Theophylline decreases the natural sputum eosinophil chemotactic activity present in asthmatics. However, when using a small sample size, the 35% reduction in sputum eosinophilia achieved by theophylline failed to reach statistical significance when compared to that seen after placebo. [less ▲]

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