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See detailFactors influencing multiple imputation in longitudinal ordinal data
Donneau, Anne-Françoise ULg

Conference (2012, October 25)

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See detailFactors influencing pharmacological treatment in acromegaly
Beckers, Albert ULg

Scientific conference (2009, March)

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See detailFactors influencing physicians' detection of cancer patients' and relatives distress : can a communication skills training program improve physicians' detection?
Merckaert, I.; Libert, Y.; Delvaux, N. et al

in Psycho-oncology (2008), 17

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See detailFactors Influencing Responsiveness and Interpretability of the Roland-Morris Disability Questionnaire
Demoulin, Christophe ULg; Smeets, Rob; Ostelo, Raymond et al

in Abstract book of the Boston International Forum X - Primary Care Research on low back pain (2009, June)

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See detailFactors influencing temporal regulations
Lejeune, Helga ULg; Richelle, Marc ULg

in Richelle, Marc; Lejeune, Helga (Eds.) Time in animal behaviour (1980)

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See detailFactors influencing the behavior of steel columns exposed to fire
Talamona, Didier; Kruppa, Joël; Franssen, Jean-Marc ULg et al

in Journal of Fire Protection Engineering (1996), 8(1), 31-43

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See detailFactors influencing the bioaccumulation of persistent organic pollutants in food webs of the Scheldt estuary
Van Ael, Evy; Covaci, Adrian; Das, Krishna ULg et al

in Environmental Science & Technology (2013)

Concentrations of several persistent organic pollutants (POPs: PCBs, PBDEs, OCPs) in aquatic species from the Scheldt estuary were related with factors (body size, lipids, trophic position), possibly ... [more ▼]

Concentrations of several persistent organic pollutants (POPs: PCBs, PBDEs, OCPs) in aquatic species from the Scheldt estuary were related with factors (body size, lipids, trophic position), possibly influencing their bioaccumulation. Stable nitrogen isotope ratios (δ15N) were used as a measure for trophic position. A decreasing trend in POP levels towards the sea was observed. For POP concentrations in sediments, this trend could be attributed to a dilution effect from mixing with seawater. However, concentrations in biota more downstream were higher than expected after taking into account the dilution effect, possibly due to differences in bioavailability. Tissue concentrations were correlated with the lipid content in biota, but not with body size. Biomagnification was only significant for some PCB congeners and p,p'-DDE at the most marine sampling location (Terneuzen, L1) and for p,p'-DDD and BDE 100 at the second sampling location (Bath, L2). A significant decreasing relationship was found for ɣ-HCH concentrations with increasing δ15N at Terneuzen. For Antwerpen (L3), no significant relationships were detected. TMFs ranged from 0.64 for ɣ-HCH up to 1.60 for PCB 194. These results suggest that biomagnification was more important in the marine part of the estuary, although the presence of multiple carbon sources at the freshwater side might have led to an underestimation of the influence of trophic position. [less ▲]

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See detailFactors influencing the immediate and late outcome of cushing-disease treated by transsphenoidal surgery : A retrospective study by the european cushings-disease survey group
Bochicchio, D.; Losa, M.; Buchfelder, M. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(11), 3114-3120

Hypercortisolism attributable to hypersecretion of ACTH by a pituitary adenoma is an uncommon and progressively lethal disease. Because of its rarity, it has been difficult to collect a large series of ... [more ▼]

Hypercortisolism attributable to hypersecretion of ACTH by a pituitary adenoma is an uncommon and progressively lethal disease. Because of its rarity, it has been difficult to collect a large series of patients in order to identify the prognostic factors influencing the outcome after transsphenoidal surgery. We conducted a multicenter, retrospective analysis of the early and late results of surgical treatment of Cushing's disease. Files of patients with Cushing's disease who underwent transsphenoidal surgery between 1975 and 1990 were collected from 25 institutions throughout Europe. Data from 668 of 716 patients were suitable for statistical analyses. Surgical mortality was 1.9%, and major morbidity occurred in 97 patients (14.5%). Clinical and biochemical remission of Cushing's disease after surgery occurred in 510 cases (76.3%). Identification of the tumor by neuroradiological imaging or at operation with histopathological corroboration was associated with remission of hypercortisolism. Recurrence of the disease occurred in 65 (12.7%) of 510 patients in remission after surgery at a mean time of 39.3 months (range 6-104 months). The distribution of the recurrences did not show any apparent plateau or cluster throughout the follow-up period. Low postoperative steroid levels, absence of cortisol response to CRH, and the need for long-term glucocorticoid substitution therapy were all associated with a high probability of long-term remission. Our study demonstrates that transsphenoidal surgery is a safe and effective treatment for patients with Cushing's disease. However, after successful surgery there is a steady increase in the percentage of recurrences, which continues with time. Patients who after operation had hypoadrenocorticism and needed long-term glucocorticoid substitution therapy had the lowest risk of relapse. [less ▲]

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See detailFactors influencing the PCDD/F levels in plasma of Belgian blood donors
Debacker, Neomi; Van Wouwe, Nathalie; Sasse, André et al

in Organohalogen Compounds (2005)

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See detailFactors influencing total cell count in bronchoalveolar lavage fluid obtained in healthy dogs and dogs with respiratory conditions
Lavoué, Rachel ULg; Delvaux, François ULg; Massart, L. et al

in 19h ECVIM Meeting - Porto, Portugal - 8-10 septembre 2009 (2009, September 08)

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See detailFactors influencing wild boar presence in agricultural landscape: a habitat suitability modelling approach
Morelle, Kevin ULg; Lejeune, Philippe ULg

Conference (2012, September 04)

The wild boar (Sus scrofa L.) population has increased in most parts of Europe during the last three decades. As a consequence, population distribution ranges have shifted to more agricultural areas ... [more ▼]

The wild boar (Sus scrofa L.) population has increased in most parts of Europe during the last three decades. As a consequence, population distribution ranges have shifted to more agricultural areas. These newly colonized areas are characterized by highly fragmented forest cover and a preponderance of crop fields and grasslands, thus increasing the risk of problematic interactions with farming activities and small game species. Although plasticity of wild boar to various environmental conditions is well known, understanding the ecological patterns that promote the density distribution of the species within agricultural areas remains of importance for adapted management strategies within these landscapes. Inside a recently occupied area (between 10-30 years of wild boar regular presence) of southern Belgium, we studied the relation between occurences of wild boar population, estimated by hunting bag and crop damages, with a set of environmental, anthropic and landscape variables. We used Maximum Entropy (MaxEnt) approach to analyze the data. Considering the main factors known to favour wild boar distribution, we hypothesized that crop fields providing cover and food, deciduous forest (providing mast) and water stream density are the main factors influencing the wild boar density distribution. The results are used to derive a habitat suitability map of wild boar distribution in northern Wallonia where wild boar recently starts to spread. [less ▲]

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See detailFactors inftuencing ribavirin-induced hemolysis
Van Vlierberghe, H.; Delanghe, J. R.; De Vos, M. et al

in Journal of Hepatology (2001), 34

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study ... [more ▼]

BackgroundlAims: One of the major side eft'ects of the combination therapy for chronic hepatitis C is ribavirininduced hemolytic anemia. Little is known about variables inftuencing tbis anemia. Our study tried to search for these variables in a large group of patients with hepatitis C treated with the combination therapy. Methods: Two hundred and forty-four patients chronically infected with the hepatitis C virus were treated either with induction treatment (daily dose ofinterferon) or with a standard treatment (interferon thrice weekly). Both groups received 1000-1200 mg of ribavirin from week 4 until the end of the treatment. The drop in hemoglobin level was defined as the dift'erence between the pretreatment hemoglobin level and the hemoglobin level at week 8. Seventeen variables which could possibly influencê'this drop in hemoglobin level were examined. Results: After multivariate analysis, the drop in hemoglobin level was only significant influenced by pretreatment platelet level, treatment and haptoglobin phenotype. The ribavirin dose did not influence the drop in hemoglobin level or the early virological response. Conclusions: Ribavirin-induced hemolysis is inftuenced by the pretreatment platelet level, the administered amount of a-interferon and the haptoglobin phenotype. A careful search for the minimal dose of ribavirin needed in combination treatment is necessary. [less ▲]

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See detailFactors involved in the aggregation of Harmonia axyridis Pallas
Durieux, Delphine ULg; Fischer, Christophe ULg; Deneubourg, Jean-Louis et al

Conference (2012, May 22)

In order to survive cold winters, the invasive multicoloured Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae) forms large aggregations in dwellings to overwinter. The factors ... [more ▼]

In order to survive cold winters, the invasive multicoloured Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae) forms large aggregations in dwellings to overwinter. The factors involved in the selection of aggregation sites remain misunderstood. The work presented herein focussed on the study of the chemical compounds involved in this phenomenon. Chemical and behavioural analyses highlighted that long-chain hydrocarbons lead congeners towards aggregation sites and ensure the cohesion of the cluster. Subsequently, physical factors were investigated. We studied the influence of (1) the density of individuals and (2) the quality of available shelters on H. axyridis decision to settle and aggregate under shelters. A binary choice experiment conducted in laboratory showed that the multicoloured Asian ladybeetles present a permanent aggregative behaviour, even during non-wintering conditions. These experiments also highlighted the existence of social interactions between individuals. All these results contribute to improve knowledge of this behaviour in H. axyridis and could be used in the design of species-specific traps in order to control infestations in dwellings. [less ▲]

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See detailFactors involved in the bystander effect induced by Varicella zoster and Herpes simplex viral thymidine kinase suicide gene therapy
Grignet, Christine ULg; Cool, V.; Baudson, N. et al

in Journal of Gene Medicine (The) (1999), 1

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See detailFactors of knickpoint migration on the moderately uplifted Ardennes Plateau, Western Europe
Beckers, Arnaud ULg; Bovy, Benoît ULg; Demoulin, Alain ULg

Poster (2012, April 27)

In the last two decades, much research has been devoted to the development and refinement of numerical models of river incision. In settings of prevailing bedrock channel erosion, numerous studies used ... [more ▼]

In the last two decades, much research has been devoted to the development and refinement of numerical models of river incision. In settings of prevailing bedrock channel erosion, numerous studies used field data, notably knickpoint data, to calibrate the widely acknowledged stream power model of incision and to discuss the specific impact of various variables (e.g., sediment load, channel width) not appearing explicitly in the model’s simplest form. However, most of these studies were conducted in areas of very active tectonics and high relief, thus displaying an exacerbated geomorphic response to the tectonic signal. Here, we analyze the traces left in the drainage network 0.7 My after the NE Ardennes region (western Europe) underwent a moderate 100-150 m uplift. We identify a set of knickpoints that have travelled far upstream in the Ourthe catchment. Because time becomes a more sensitive variable than distance near the headwaters, we fit the stream power model to the data by minimizing time residuals (i.e., the differences between 0.7 My and the modelled times for the knickpoints to reach their actual location) rather than distance residuals. Our best fit of the stream power model parameters yields m/n = 0.75 and K = 4.63 10-8 m-0.5y-1. We suggest that the discrepancy with the m/n value of 0.5 obtained from field and long profile data of the currently graded downstream part of the catchment’s streams points to a narrowing of the bedrock channel at the passage of a knickpoint. Then, the time residuals of the model fit are regressed against quantitative expressions of bedrock resistance to erosion and junction crossing, showing that both variables significantly affect knickpoint migration. In particular, most of the small tributaries with highly delayed knickpoints display all features characteristic of hanging valleys. However, not all such small streams have developed hanging valleys, and further research is needed to unravel how other controls, e.g., amount and size of the tributary bed load, are determining for the creation of such valleys. [less ▲]

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See detailFactors of Learning in Mouse Models of Memory and Evaluation of Effects of Dimebon
Vignisse, Julie ULg

Master's dissertation (2010)

1. Factors of learning in mouse models of memory The impact of several most relevant biological factors in contextual learning in mice was investigated in the first part of our study. It is of general ... [more ▼]

1. Factors of learning in mouse models of memory The impact of several most relevant biological factors in contextual learning in mice was investigated in the first part of our study. It is of general importance to estimate an impact of each of them in animals’ acquisition of various learning tasks during practical experimental work. First, factors of strain differences, aging and stress, investigated in our work can confound behavioural testing in memory paradigms. Second, they can be used as a basis of behavioural models of memory deficits and, thus, model pathological conditions in humans. Step-down avoidance task performed on three strains (namely C57BL/6N, CD1 and BALB/c) has clearly highlighted differences of abilities in learn contextual memory in these strains. The step-down avoidance task was also applied on C57BL/6N old of 3-months or 7-months; older mice displayed lower scores of memory then the young onces, thus, even mild aging impaired contextual learning in this strain. Third, we investigated learning of C57BL/6 mice subjected to chronic stress in a fear conditioning paradigm. Our study showed that the acquisition of this task was disrupted in stressed group, as reflected by decreased scores of freezing behavior. The assessment of investigated here factors of learning provides a possibility to validate animal models of memory and evaluate their sensitivity. 2. Evaluation of effects of dimebon Dimebon, a heterocyclic compounds previously adopted in clinic as antihistaminic, has recently revealed enhancing cognitive properties in pre-clinical and clinical studies The aim of the present study was to identify the most optimal dosing and adequate memory test(s), which would be sensitive to the memory enhancing effects of dimebon. Amongst the different studies realized, Dimebon revealed enhancement in memory in the step-down avoidance test, a one trial hippocampus-dependant task, at dose 0.5 mg/kg administered acutely and in the Y-Maze test, a multiple training paradigm at dose 0.1 mg/kg delivered chronically. In conclusion, our study supports therefore that the step-down avoidance and Y-maze paradigms are the most convenient assays allowing a rapid and reliable assessment of effects of of drugs with memory enhancing properties such as dimebon and dimebon-like. [less ▲]

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See detailFactors predicting the probability of relapse after discontinuation of migraine preventive treatment with topiramate.
Schoenen, Jean ULg; Reuter, Uwe; Diener, Hans*-Christoph et al

in Cephalalgia : An International Journal of Headache (2010), 30(11), 1290-5

INTRODUCTION: Demographic and clinical variables were examined in a post hoc analysis of the PROlonged Migraine Prevention with Topiramate (PROMPT) study to determine potential contribution to relapse ... [more ▼]

INTRODUCTION: Demographic and clinical variables were examined in a post hoc analysis of the PROlonged Migraine Prevention with Topiramate (PROMPT) study to determine potential contribution to relapse. METHODS: After a six-month open-label (OL) topiramate phase, patients were randomised to continue topiramate or switch to placebo in a six-month double-blind (DB) phase. 'Relapse' was investigated in terms of change in monthly migraine days after randomisation compared with the month before randomisation, and was analysed during the first ('initial relapse') and last month ('sustained relapse') of the DB phase. More than 40 potential predicting factors were entered into analyses of variance and covariance. RESULTS: For initial relapse, variable-by-treatment interactions were significant for the Headache Impact Test (HIT-6) at DB baseline, and decline in acute medication intake or reporting of 'anxiety' in the OL phase. For sustained relapse, no statistically significant interactions were observed. CONCLUSION: Relapse after topiramate discontinuation in migraine prophylaxis appears to be unaffected by patient characteristics or baseline migraine frequency. [less ▲]

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See detailFactors predictive of nephropathy in DCCT Type 1 diabetic patients with good or poor metabolic control
Zhang, Liying; Krzentowski, Georges; Albert, Adelin ULg et al

in Diabetic Medicine : A Journal of the British Diabetic Association (2003), 20(7), 580-585

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic ... [more ▼]

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic patients with either good or poor metabolic control (MC). Methods Based on material from the Diabetes Control and Complications Trial study (n = 1441), patients were considered as under good or poor MC if their HbA(1c) mean level up to last visit fell in the lowest (less than or equal to 6.9%) or highest (greater than or equal to 9.5%) quintile of the overall HbA(1c) distribution, respectively. Prevalence cases of nephropathy were excluded from the study. Survival analysis and Cox regression were applied to the data. Results Among patients with good MC (n = 277), 15% had developed nephropathy at the end of the study. Conversely, among patients with poor MC (n = 268), the proportion without the complication was 52%. When adjusting for MC, time to diabetic nephropathy was related to age (P < 0.0001), AER (P < 0.001), duration of diabetes (P < 0.005), body mass index (BMI) (P < 0.005), all at baseline, and to gender (P < 0.01). Patients with upper normal range AER levels, longer duration of diabetes and lower BMI were at higher risk, regardless of MC. The adverse effect of younger age on diabetic nephropathy was more marked in good than in poor MC. Although women tended to develop the complication more often under good MC, they appeared to be better protected under poor MC. Conclusions This study confirms occurrence of diabetic nephropathy under good MC and non-occurrence of the complication despite poor MC. It also demonstrates that some baseline covariates can affect, in a differential manner, time to diabetic nephropathy depending on MC. [less ▲]

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See detailFactors promoting rupture of abdominal aortic aneurysms
Van Damme, Hendrik ULg; Sakalihasan, N.; Limet, Raymond ULg

in Acta Chirurgica Belgica (2005), 105(1), 1-12

The risk for rupture of an abdominal aortic aneurysm is widely believed to be related to its maximum diameter. Rupture occurs at the site of maximum wall stress, when it exceeds the tensile strength of ... [more ▼]

The risk for rupture of an abdominal aortic aneurysm is widely believed to be related to its maximum diameter. Rupture occurs at the site of maximum wall stress, when it exceeds the tensile strength of the aortic wall. Basic research confirmed that peak wall stress and aortic wall biodegradation contribute to the mechanism of aneurysm rupture. In order to highlight the role of loss in wall strength and increase in focal peak stress, the authors reviewed recent literature. The clinical relevance of these recent insights in the etiopathogenesis of aneurysm rupture is analysed. [less ▲]

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