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See detailEvaluation musculaire isocinétique
Croisier, Jean-Louis ULg

Learning material (2011)

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See detailEvaluation neuroendocrienne de la fonction catécholaminergique dans le comportement suicidaire
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez, Moreno et al

in Psychologie Médicale (1992), 24

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See detailEvaluation of 13 selected medicinal plants from Burkina Faso for their antiplasmodial properties.
Jansen, Olivia ULg; Angenot, Luc ULg; Tits, Monique ULg et al

in Journal of Ethnopharmacology (2010), 130

AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso. MATERIALS AND METHODS: In vitro ... [more ▼]

AIM OF THE STUDY: The aim of this study was to evaluate the antiplasmodial properties of 13 plants used against malaria in traditional medicine in Burkina Faso. MATERIALS AND METHODS: In vitro antiplasmodial activity of dichloromethane, methanol and aqueous crude extracts obtained from vegetal samples collected in Burkina Faso was first evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. RESULTS: Thirteen extracts obtained from 8 different species were found to exhibit antiplasmodial activity (IC(50)<50mug/ml). Five species demonstrated a moderate activity (15mug/ml<IC(50)<50mug/ml): Boswellia dalzielii (leaves), Waltheria indica (roots and aerial parts), Bergia suffruticosa (whole plant), Vitellaria paradoxa (bark) and Jatropha gossypiifolia (leaves). The best results were obtained with extracts from the Dicoma tomentosa whole plant, from Psorospermum senegalense leaves and from Gardenia sokotensis leaves. These extracts found to display promising antiplasmodial activity, with IC(50) values ranging from 7.0 to 14.0mug/ml. The most active plant extracts were then tested for in vitro activity on the Plasmodium falciparum W2 chloroquine-resistant strain and also for in vitro cytotoxicity on normal human fibroblasts (WI-38) in order to determine the selectivity index. CONCLUSIONS: Dicoma tomentosa (Asteraceae) and Psorospermum senegalense (Clusiaceae) appeared to be the best candidates for further investigation of their antiplasmodial properties, reported for the first time by this study. [less ▲]

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See detailEvaluation of [18F]UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.
Warnock, Geoffrey; Aerts, Joël ULg; Bahri, Mohamed Ali ULg et al

in Journal of Nuclear Medicine (The) (2014), 55(8), 1336-1341

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic ... [more ▼]

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic levetiracetam (LEV), making it an interesting therapeutic target for epilepsy. [18F]UCB-H is a novel PET imaging agent with a nanomolar affinity for human SV2A. Methods: preclinical PET studies were carried out in isoflurane anesthetized rats. Arterial input function was measured using an arteriovenous shunt and beta microprobe system. [18F]UCB-H was injected IV (140 ± 20 MBq bolus). Results: brain uptake of [18F]UCB-H was high, matching the expected homogeneous distribution of SV2A. The distribution volume (Vt) for [18F]UCB-H was calculated using Logan’s graphical analysis and the effect of LEV pretreatment on Vt measured. In control animals the mean whole-brain Vt was 9.76 ± 0.52 ml/cm3 (mean ± SD, n=4, test-retest), and the mean reproducibility in test-retest studies was 10.4 ± 6.5 %. Uptake of [18F]UCB-H was dose-dependently blocked by pretreatment with LEV (0.1 - 100 mg/kg IV). Conclusion: our results indicate that [18F]UCB-H is a suitable radiotracer for the imaging of SV2A in vivo. This is the first PET tracer for in vivo quantification of SV2A. The necessary steps for implementation of [18F]UCB-H production under GMP conditions and first in human studies are planned. [less ▲]

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See detailEvaluation of [73Se]PROMOSE as a tracer of the human cerebral pH.
Demonceau, G.; Cantineau, R.; Plenevaux, Alain ULg et al

Poster (1988, October 10)

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See detailEvaluation of a Bovine Concentrated Lactoserum for Preventing Neonatal Diarrhoea in Belgian Blue Calves
Vandeputte, Sébastien ULg; Rollin, Frédéric ULg; Guyot, Hugues ULg et al

in Open Veterinary Science Journal (The) (2010), 4

The purpose of this study was to evaluate, under field conditions, the efficacy of an european registered bovine concentrated lactoserum (Locatim) in 3 farms with neonatal diarrhoea in calves. A total of ... [more ▼]

The purpose of this study was to evaluate, under field conditions, the efficacy of an european registered bovine concentrated lactoserum (Locatim) in 3 farms with neonatal diarrhoea in calves. A total of 117 healthy Belgian Blue (BB) calves were allocated in 2 groups. Two thirds of the calves received Locatim orally immediately after birth and maternal colostrum one hour later (treated group), while control calves only received maternal colostrum. Every day during 14 days, mental status, faeces consistency, suckling reflex and hydration status of each calf were monitored. Individual blood samples were assessed for passive transfer and specific Escherichia coli antibodies against strains F5, CS31A, F17 and F41. Faecal samples from diarrheic and non diarrheic calves were analysed for rotavirus, bovine coronavirus, Cryptosporidium parvum and Escherichia coli F5. Locatim had no significant effect on the onset, duration and incidence of diarrhoea. The mean serum IgG concentration of 23.1 ± 7.8 mg/ml indicates a good IgG transfer. Only the CS31A strain titer was significantly higher in the treated group. The major identified causative agent of diarrhoea was C. parvum. In conclusion, Locatim only has a slight effect when IgG transfer is optimal, but could be justified when specific antibodies lacking in colostrum are needed [less ▲]

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See detailEvaluation of a campaign for osteoporosis screening in the general population: what is the follow-up given by general practitioners to a positive screening result?
Richy, Florent; Pire, G.; Maassen, P. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 67

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See detailEvaluation of a Diphenylphosphorylazide-Crosslinked Collagen Membrane for Guided Bone Regeneration in Mandibular Defects in Rats
Zahedi, Sharam ULg; Legrand, Roman ULg; Brunel, G. et al

in Journal of Periodontology (1998), 69(11), 1238-46

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of ... [more ▼]

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of guided bone regeneration. The experiment was carried out on 25 Wistar rats. After exposing the mandibular ramus bilaterally, 5 mm diameter full-thickness circular bone defects were surgically created. While the defect on one side was covered by the membrane (experimental), the defect on the other side was left uncovered (control) before closure of the overlying soft tissues. The rats were sacrificed in groups of 5 after 7, 15, 30, 90, and 180 days of healing. Although at early stages of healing similar amounts of bone formation were observed in the experimental and control defects, after 1 month of healing, most of the experimental defects were completely closed with new bone, while in the control defects, only limited amounts of new bone were observed at the rims and in the lingual aspect of the lesions. In the 90- and 180-day animals, all experimental defects were completely closed, while in the control defects, no statistically significant increase in bone regeneration was observed. The increase in percentage of bone regeneration in the experimental defects was statistically significant between the 15-day specimens as compared with the 7-day specimens (P < 0.01) and likewise between 30-day and 15-day specimens (P < 0.001). It can be concluded that a DPPA-crosslinked collagen membrane yields biocompatibility, ad hoc mechanical hindrance, and handling characteristics suitable for guided bone regeneration applications in this experimental model. [less ▲]

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See detailEvaluation of a Fine-mapping Method Exploiting Linkage Disequilibrium in Livestock Populations: Simulation Study
Kim, J. J.; Farnir, Frédéric ULg

in Asian-Australian Journal of Animal Science (2006), 19(12), 1702

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See detailEvaluation of a geometry-based knee joint compared to a planar knee joint
Sandholm, Anders; Schwartz, Cédric ULg; Pronost, Nicolas et al

in Visual Computer (2011)

Today neuromuscular simulations are used in sev- eral fields, such as diagnostics and planing of surgery, to get a deeper understanding of the musculoskeletal system. Dur- ing the last year, new models ... [more ▼]

Today neuromuscular simulations are used in sev- eral fields, such as diagnostics and planing of surgery, to get a deeper understanding of the musculoskeletal system. Dur- ing the last year, new models and datasets have been pre- sented which can provide us with more in-depth simulations and results. The same kind of development has occurred in the field of studying the human knee joint using complex three dimensional finite element models and simulations. In the field ofmusculoskeletal simulations, no such knee joints can be used. Instead themost common knee joint description is an idealized knee joint with limited accuracy or a planar knee joint which only describes the knee motion in a plane. In this paper, a new knee joint based on both equations and geometry is introduced and compared to a common clinical planar knee joint. The two kinematical models are analyzed using a gait motion, and are evaluated using the muscle ac- tivation and joint reaction forces which are compared to in- vivo measured forces. We show that we are able to predict the lateral, anterior and longitudinal moments, and that we are able to predict better knee and hip joint reaction forces. [less ▲]

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See detailEvaluation of a high-resolution regional climate simulation over Greenland
Lefebre, Filip; Fettweis, Xavier ULg; Gallée, Hubert et al

in Climate Dynamics (2005), 25(1), 99-116

A simulation of the 1991 summer has been performed over south Greenland with a coupled atmosphere–snow regional climate model (RCM) forced by the ECMWF re-analysis. The simulation is evaluated with in ... [more ▼]

A simulation of the 1991 summer has been performed over south Greenland with a coupled atmosphere–snow regional climate model (RCM) forced by the ECMWF re-analysis. The simulation is evaluated with in-situ coastal and ice-sheet atmospheric and glaciological observations. Modelled air temperature, specific humidity, wind speed and radiative fluxes are in good agreement with the available observations, although uncertainties in the radiative transfer scheme need further investigation to improve the model’s performance. In the sub-surface snow-ice model, surface albedo is calculated from the simulated snow grain shape and size, snow depth, meltwater accumulation, cloudiness and ice albedo. The use of snow metamorphism processes allows a realistic modelling of the temporal variations in the surface albedo during both melting periods and accumulation events. Concerning the surface albedo, the main finding is that an accurate albedo simulation during the melting season strongly depends on a proper initialization of the surface conditions which mainly result from winter accumulation processes. Furthermore, in a sensitivity experiment with a constant 0.8 albedo over the whole ice sheet, the average amount of melt decreased by more than 60%, which highlights the importance of a correctly simulated surface albedo. The use of this coupled atmosphere–snow RCM offers new perspectives in the study of the Greenland surface mass balance due to the represented feedback between the surface climate and the surface albedo, which is the most sensitive parameter in energy-balance-based ablation calculations. [less ▲]

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See detailEvaluation of a hydro-alcoholic solution as pre-surgical hand antisepsis in a veterinary setting.
Verwilghen, Denis ULg; Mastrocicco, Emilie; Mainil, Jacques ULg et al

Conference (2010, July 02)

Introduction: Despite the fact that presurgical antiseptic hand treatment of surgical staff has since become a worldwide accepted procedure, surgical site infection is still one of the most frequent types ... [more ▼]

Introduction: Despite the fact that presurgical antiseptic hand treatment of surgical staff has since become a worldwide accepted procedure, surgical site infection is still one of the most frequent types of nosocomial infections. Many products have been used for hand antisepsis, but the popularity of alcoholic rubs amongst human surgeons is increasing as they have shown to provide a rapid and immediate action, are considerably faster than disinfecting soap scrubs and cause less skin damage after repeated use. The purpose of this study was 1) to identify surgical hand antisepsis habits amongst veterinary surgery specialists in Europe (ECVS) and the United States (ACVS), 2) to compare povidone iodine and chlorhexidine gluconate scrubs with a hydro-alcoholic rub hand antisepsis protocol and 3) to evaluate the usefulness of a hydro-alcoholic rub solution in a veterinary surgical setting. Materials and Methods: Emails were sent to 1300 Diplomates to invite them to participate to an online survey in order to obtain an idea about pre-surgical hand disinfection techniques. In a preliminary trial the efficiency of 4% chlorhexidine gluconate, 7.5 % PVP-iodine and an alcoholic solution containing 45% 2-propanol, 30% 1-propanol, 0.2% mecetronium ethylsulphate (Sterillium®) in bacterial reduction on hands was compared. In a clinical trial, the suitability of Sterillium® was assessed in an equine and small animal set up during surgery procedures. Fingertips were pressed on blood agar plates and Gassner plates prior to hand antisepsis (PHA), after handantisepsis (AHA) and three hours after wearing sterile gloves (AG) in the preliminary trial or at the end of surgery (AS) in the clinical trial. Bacterial counts (colony forming units : CFU’s) were obtained after 24 h of incubation of the plates. The obtained values of CFU from PHA, AHA, AG and AS were expressed as log10 values. For each sample, a reduction factor (RF) was obtained from the difference of log10 pre-value and log10 post-value. An ANOVA comparison between the effects of the different antisepsis protocols on the mean log10 CFU values and RF’s in function of the different steps was established. Results: A 42.6% response rate was obtained for the survey. Most surgeons’ still use a disinfecting soap only (79.9%) for hand antisepsis prior to surgery, the majority based on chlorhexidine gluconate (81.4%). Significant differences were found between immediate and sustained activities of the different products tested. Sterillium® was shown to have significantly lower LSM log10 CFU at AG compared to both other products. At AHA, povidone iodine revealed to have significantly higher LSM log10 CFU than Sterillium® and chlorhexidine gluconate, with the last two products having comparable activities. Reduction factors for the Sterillium® were significantly greater than for the other products. Only RF1 was comparable between Sterillium® and chlorhexidine gluconate. In the clinical trial, no significant differences were found between surgeons regarding LSM log10 CFU after hand antisepsis, neither between RF from samples taken at the small animal versus the equine surgery theatre. Discussion: This study confirms that Sterillium® is more effective in reducing bacterial counts on hands prior to surgery in a veterinary setting as are chlorhexidine gluconate (CHX) and povidone iodine soap. Moreover, they provide better tolerance and compliance to surgical hygiene protocols. Despite this, veterinary surgeons from all over the world still prefer the use of CHX soap, which has far more disadvantages than commonly accepted. Apart from the better skin tolerance and the absence of known resitance to the product, the use of Sterillium® offers the advantage of a fast (1.5 minute) surgical handantisepsis. This study shows that, as previously reported for human medicine, Sterillium® can safely be used in a veterinary surgical setting. [less ▲]

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See detailEvaluation of a Large-Scale Topology Discovery Algorithm
Donnet, Benoît ULg; Huffaker, Bradley; Friedman, Timur et al

in IEEE International IP Operation and Management (IPOM) Workshop (2006, October)

In the past few years, the network measurement community has been interested in the problem of internet topology discovery using a large number (hundreds or thousands) of measurement monitors. The ... [more ▼]

In the past few years, the network measurement community has been interested in the problem of internet topology discovery using a large number (hundreds or thousands) of measurement monitors. The standard way to obtain information about the internet topology is to use the traceroute tool from a small number of monitors. Recent papers have made the case that increasing the number of monitors will give a more accurate view of the topology. However, scaling up the number of monitors is not a trivial process. Duplication of effort close to the monitors wastes time by reexploring well-known parts of the network, and close to destinations might appear to be a distributed denial-of-service (DDoS) attack as the probes converge from a set of sources towards a given destination. In prior work, authors of this paper proposed Doubletree, an algorithm for cooperative topology discovery, that reduces the load on the network, i.e., router IP interfaces and end-hosts, while discovering almost as many nodes and links as standard approaches based on traceroute. This paper presents our open-source and freely downloadable implementation of Doubletree in a tool we call traceroute@home. We evaluate the performance of our implementation on the PlanetLab testbed and discuss a large-scale monitoring infrastructure that could benefit of Doubletree. [less ▲]

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See detailEvaluation of a loop mediated isothermal amplification (LAMP) assay for the detection of group B streptococci
MELIN, Pierrette ULg

Conference (2012, October 09)

BACKGROUND GBS are still the leading cause of severe neonatal disease. Screening for vaginal-rectal GBS colonization in pregnant women at 35-37 weeks of gestation, followed by intrapartum ... [more ▼]

BACKGROUND GBS are still the leading cause of severe neonatal disease. Screening for vaginal-rectal GBS colonization in pregnant women at 35-37 weeks of gestation, followed by intrapartum antibioprophylaxis to colonized women has proven to be the most effective strategy for prevention of perinatal GBS disease. Despite GBS improved culture method, predictive values (PV) of prenatal screening for GBS colonization at delivery remain limited and contribute to ongoing disease. Switching from time-consuming cultures to a rapid molecular based assay for prenatal screening could be considered: a new assay, the illumigene® Group B Streptococcus (illuB) from Meridian Bioscience, based on LAMP technology is awaited to improve antenatal screening sensitivity. OBJECTIVE To evaluate the illuB performed on culture obtained by 18-24 hours incubation of vaginal-rectal swab in Lim broth versus the reference culture for GBS screening. To determine if and how the illuB may be integrated in the current recommended screening strategy. METHODS Vaginal-rectal specimens collected from 242 pregnant women, were sent to and processed by the labs of the University Hospital of Liege and Hospital Sint Lucas of Gent to determine the status of GBS colonization by the reference culture method for prenatal GBS screening and by illuB. Cultures were performed by direct plating onto Granada agar and inoculation in a selective enrichment Lim broth subsequently subcultured after overnight incubation onto Granada and StrepB Select agar. All illuB were performed from the same incubated Lim broth. Discrepant results were controlled by a PCR assay detecting a gene different from the target of the illuB. RESULTS GBS were recovered in culture from 20.7% of the specimens. By comparison with culture, sensitivity and specificity (S, Sp) of the illuB for identifying GBS colonization were 90% and 98.9%. The positive and negative PV (PPV,NPV) were 95.7% and 97.4% respectively. Among the discrepancies, the 2 illuB positive/culture negative results were also tested positive by the control PCR assay, confirming the presence of GBS DNA even if GBS were not cultured from these specimens. Overall for GBS detection, Sp and PPV were 100%. Out of the 5 false negative illuB, 3 matched cultures with very rare GBS meaning that GBS could have been absent in the aliquots used for illuB. Therefore, S and NPV of the illuB for the detection of GBS are probably higher than 90.4% and 97.4%. CONCLUSION The illuB demonstrated S and Sp close to those of the reference culture method and did not significantly improve the GBS detection. The higher cost of such molecular test may be an obstacle to its wide use as there is not a net benefice when compared with culture method; but a shorter turnaround time and limited hands on time could balance positively the decision. Additional clinical trials are needed. [less ▲]

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See detailEvaluation of a method for estimating configuration parameters in bistatic radars using directive antennas
Neyt, Xavier; Lapierre, Fabian D.; Verly, Jacques ULg

Conference (2004)

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See detailEvaluation of a Model-Based Hemodynamic Monitoring Method in a Porcine Study of Septic Shock
Revie, James; Stevenson, David; Chase, J. Geoffrey et al

in Computational and Mathematical Methods in Medicine (2013)

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See detailEvaluation of a monostatic STAP-radar range-compensation method applied to selected bistatic configurations
Lapierre, Fabian D.; Verly, Jacques ULg

Conference (2002, March)

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