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See detailEvaluation of the present and future general circulation over Greenland simulated by the IPCC AR5/CMIP5 GCMs with the help of a circulation type classification
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

Poster (2011, April 05)

Future projections of the Greenland ice sheet melt are based on General Circulation Model (GCM) simulations. In particular, the reliability of downscaling methods forced by these simulations depends on ... [more ▼]

Future projections of the Greenland ice sheet melt are based on General Circulation Model (GCM) simulations. In particular, the reliability of downscaling methods forced by these simulations depends on the quality of the atmospheric circulation simulated by GCMs. Therefore, it is essential to analyse and evaluate the GCMs modelled general circulation for current climate (1961-1990). Atmospheric circulation type classifications offer a very interesting approach for evaluating the GCM-based circulation at a daily time scale compared to the most used methods based only on monthly means. Indeed, the circulation type classification allows a precise and detailed analysis of each circulation type and so, it gives much more information on the ability of GCMs to simulate the different circulation types and consequently the climatic variability of a region. In fact, exceptional circulation events over Greenland, which cannot be taken into account by the monthly mean approach, have much more impact on the melt than the mean atmospheric state. Thus, an automated correlation-based atmospheric circulation type classification (CTC) is used for evaluating the new GCM outputs (available on http://cmip-pcmdi.llnl.gov/cmip5/) computed for the upcoming IPCC report (AR5). The daily geopotential height at 500 hPa simulations of the GCMs for current climate are compared to the NCEP-NCAR 1 and the ECMWF reanalysis data for the summer months (JJA), when melt is the most important. To achieve this, the classification is first done for the reanalysis data over 1961-1990 and afterwards, the types of the reanalysis based CTC are imposed for classifying the GCM datasets over 1961-1990 (from the historical experiment) to allow a direct type per type comparison based on the frequency distribution of each dataset. This approach also gives the opportunity to study the intraclass repartition differences between the reanalysis and the GCMs. After the evaluation of the GCM simulations for current climate, the future projections driven by RCP concentrations or emissions (2011-2040, 2041-2070 and 2071-2100) from the best matching GCMs are analysed in the same way. For current climate, it clearly appears that only a few GCMs are able to reproduce reliably the variability of the atmospheric circulation over Greenland during summer. The differences of frequency between the GCMs and the reanalysis are mainly due to biases of the geopotential height which is systematically over or underestimated by most GCMs and to the underestimation of the variability of the circulation by most GCMs. For future projections, no new circulation types are detected, but rather a general increase of the mean geopotential height regardless of the circulation type. It is also important to note that for many GCMs, the uncertainty of the current climate simulations (given by the differences of the classification results between the GCM simulations for current climate and the reanalysis data for the same time) are of the same order than the projected changes for future climate. Therefore, these projections may be questionable. [less ▲]

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See detailEvaluation of the present and future general circulation over western Europe simulated by the IPCC AR5/CMIP5 GCMs with the help of a circulation type classification
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

Conference (2011, April 08)

Downscaling methods forced by General Circulation Model (GCM) simulations are not able to correct the biases in the general circulation simulated by the GCMs. Moreover, since the GCMs have a coarse ... [more ▼]

Downscaling methods forced by General Circulation Model (GCM) simulations are not able to correct the biases in the general circulation simulated by the GCMs. Moreover, since the GCMs have a coarse spatial resolution, they have difficulties to simulate reliably ground variables like temperature and precipitation which are affected by topography, land use and local features. So, we can attempt that they simulate better the large-scale atmospheric circulation. That is why it is of special interest to evaluate the GCM simulations of atmospheric circulation for current climate by comparing them with the NCEP-NCAR 1 and the ECMWF reanalysis data over 1961-1990. This analysis is done over western Europe for summer (JJA) and winter (DJF) for the GCMs (available on http://cmippcmdi.llnl.gov/cmip5/) proposed by the IPCC for its upcoming report (AR5). The method used is an automated circulation type classification based on the daily geopotential height at 500 hPa. It is a leader-algorithm correlation based method taking part of the COST733CAT classification catalogue. Unlike the usually used methods based on the monthly mean circulation, this approach allows a precise analysis of each circulation type. So, it gives much more information on the ability of the GCMs to simulate the different circulation types and consequently the climatic variability of a region. In order to allow a direct comparison between the GCM simulations and the reanalysis data, the classification is done first only for the reanalysis dataset over 1961-1990. Then, the main types individualised here are imposed for the classification of the GCM outputs. Since the circulation types are the same, the comparison between the datasets can be made on the basis of the differences of the frequency distribution throughout the classes. Moreover, the mean intraclass repartition of the circulation situations may differ from one dataset to another. So, the study of this mean and its standard deviation gives an idea of the differences between the reanalysis and the GCMs within each class. Firstly, this approach is applied to current climate (1961-1990) for evaluating the ability of the GCMs driven by the historical experiment to simulate the climate of the last decades over western Europe. In fact, if one GCM is not able to reproduce reliably the main characteristics of the current climate, its future projections may be questionable. Then, the best matching GCMs are retained and the same approach is applied to the future simulations driven by RCP concentrations or emissions (2011-2040, 2041-2070 and 2071-2100). So, the evolution of the frequency of the circulation types and maybe the appearance of new types can be analysed under climate change conditions. Moreover, it is interesting to compare the uncertainty of the current climate simulations to the projected changes for future climate. If the uncertainty is of the same order or higher than the projected changes, the reliability of the simulations for future climate may be very questionable. [less ▲]

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See detailEvaluation of the Production Performances of an Endangered Local Poultry Breed, the Famennoise
Moula, Nassim ULg; Antoine-Moussiaux, Nicolas ULg; Farnir, Frédéric ULg et al

in International Journal of Poultry Sciences (2009), 8(4), 389-396

The Famennoise is a Belgian poultry breed which is greatly endangered. Like most of the local breeds in this situation, the Famennoise remains largely unknown and is representative of the continuous loss ... [more ▼]

The Famennoise is a Belgian poultry breed which is greatly endangered. Like most of the local breeds in this situation, the Famennoise remains largely unknown and is representative of the continuous loss of genetic diversity that is threatening the future of animal production. From preliminary results, egg production traits in this breed showed valuable economic assets. The present study is, thus, aimed at assessing its production performances with the prospect that it might be conserved for future valorization. Egg production as well as growth traits were estimated. Both aspects showed exploitable performances. In absence of past selection for these traits, eggs presented a mean weight of 55.433.03 g, so being in the middle class of marketable eggs, a yolk to albumen ratio of 50.75.02%, an eggshell resistance (maximal force of breakage of 36.033.3 N) equal to commercial strains and superior to already valorized local breeds. In broilers, a mean weight 980.6716.62 g was reached at 8 weeks, 1815.9036.55 g at week 12 and 2191.9048.31 g at week 15. The Famennoise is, therefore, suggested for use as a dual-purpose breed with a good potential of selection for both productions. It could further serve in crosses for improvement of commercial strains. In conclusion, it appears to be highly urgent to screen endangered local poultry breeds for economically exploitable traits which would motivate conservation programs of biodiversity, before this extraordinary scientific and economic potential get irremediably lost. [less ▲]

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See detailEvaluation of the pulmonary inflammation and bronchial hyperresponsiveness in healthy mice induced by inhaled cyclodextrins
Guéders, Maud ULg; Bertholet, P.; Barillaro, Valery et al

in Journal of inclusion Phenomena and Macrocyclic Chesmistry (2005)

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See detailEvaluation of the pulmonary inflammation and the bronchial hyperresponsiveness in healthy mice induced by inhaled cyclodextrins
Guéders, Maud ULg; Bertholet, Pascal; Barillaro, Valery et al

Conference (2004, May)

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See detailEvaluation of the quantitative performances of Supercritical Fluid Chromatography : from method development to validation
Dispas, Amandine ULg; Lebrun, Pierre ULg; Ziemons, Eric ULg et al

in Journal of Chromatography. A (2014), 1353(Method Validation), 78-88

Recently, the number of papers about SFC increased drastically but scientists did not truly focus their work on quantitative performances of this technique. In order to prove the potential of UHPSFC, the ... [more ▼]

Recently, the number of papers about SFC increased drastically but scientists did not truly focus their work on quantitative performances of this technique. In order to prove the potential of UHPSFC, the present work discussed about the different steps of the analytical life cycle of a method: from development to validation and application. Moreover, the UHPSFC quantitative performances were evaluated in comparison with UHPLC, which is the main technique used for quality control in the pharmaceutical industry and then could be considered as a reference. The methods were developed using Design Space strategy, leading to the optimization of robust method. In this context, when the Design Space optimization shows guarantee of quality, no more robustness study is required prior to the validation. Then, the methods were geometrically transferred in order to reduce the analysis time. The UHPSFC and UHPLC methods were validated based on the total error approach using accuracy profile. Even if UHPLC showed better precision and sensitivity, UHPSFC method is able to give accurate results in a dosing range larger than the 80–120% range required by the European Medicines Agency. Consequently, UHPSFC results are valid and could be used for the control of active substance in a finished pharmaceutical product. Finally, UHPSFC validated method was used to analyse real samples and gave similar results than the reference method (UHPLC). [less ▲]

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See detailEVALUATION OF THE RAPID DETECTION OF ST-17 AND ST-1 GROUP B STREPTOCOCCI USING A MICROFLEX MALDI-TOF MS (BRUKER)
MEEX, Cécile ULg; SACHELI, Rosalie ULg; DESCY, Julie ULg et al

Poster (2014, May)

Objectives Clearly associated to neonatal meningitis, Group B streptococci (GBS) classified as sequence type-17 (ST-17) are defined as the “highly virulent” clone amongst GBS. The aim of this study was to ... [more ▼]

Objectives Clearly associated to neonatal meningitis, Group B streptococci (GBS) classified as sequence type-17 (ST-17) are defined as the “highly virulent” clone amongst GBS. The aim of this study was to evaluate an easy and rapid method, recently described to detect ST-17 and ST-1 GBS, based on distinguishing peak-shifts present on the protein spectrum of these 2 sequence types, using a Microflex (Bruker) matrix-assisted laser desorption/ionization time of flight mass spectrometer (MALDI-TOF MS). Methods This study was performed on 67 multi locus sequence typed (MLST) GBS originated from the Belgian and Czech National Reference Centers, including 18 ST-17 and 16 ST-1. After culture on blood agar, an ethanol/formic acid extraction was performed on each strain. Each extract was spotted once on a target plate, overlaid with 1 µl alpha-cyano-4-hydroxycinnamic acid matrix and further analysed by a Microflex MALDI-TOF MS. One spectrum per isolate was recorded, 240 laser shots being recorded for each spectrum. The spectra were further analysed using a Bruker prototype software, and 2 logarithmic values, one for ST-17 and one for ST-1, calculated from the intensities of the present and absent peaks, were obtained for each strain. If >0, this value indicated the presence of the specific sequence type. In a second step, the test was repeated on each strain with discordant result when compared with MLST. Results Compared with MLST method, the first analysis of the strains gave poor results, leading to very low sensitivities (77.8% for ST-17 and 50% for ST-1) but rather good specificities (85.7% for ST-17 and 98.0% for ST-1). After repeating the analysis on the strains with discordant result, sensitivity, 100% and 93.8%, and specificity, 87.8% and 98.0%, for ST-17 and ST-1 respectively were highly improved. Conclusion Since ST-17 and ST-1 GBS both show distinguishing peak-shifts on their protein spectrum, as described by Lartigue et al., the distinction of these 2 sequence types is now possible by MALDI-TOF MS. To our knowledge, this study is the first describing this application on a Microflex MS using a software to classify the strains. The observed results are promising but, given to the variability of the logarithmic value given by the software, the need to perform several measures on a same strain seems to be essential. After optimization of the analysis procedure, this rapid, easy and cheap method could be used to precociously detect ST-17 among GBS isolated from prenatal screenings, allowing a better follow up of the colonized mothers and a closer monitoring of their newborns. We would like to thank the Bruker Company which allowed us to evaluate the prototype software they have developed. [less ▲]

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See detailEvaluation of the regional climate model WRF over Svalbard
Lang, Charlotte ULg; Fettweis, Xavier ULg; Doutreloup, Sébastien ULg et al

Poster (2012, April 24)

It is well known that high latitude zones are very sensitive to climate change. As a result of global warming, ice sheet melting has increased which in turn has an influence on climate through ... [more ▼]

It is well known that high latitude zones are very sensitive to climate change. As a result of global warming, ice sheet melting has increased which in turn has an influence on climate through modifications of the thermohaline circulation, feedback of ice albedo, sea level rise, … Svalbard is an archipelago between 74 and 81°lat N and 60 percent of its area (62 248 km2) is covered with glaciers and ice sheets. The impact of global warming on the Svalbard cryosphere can be estimated with climate models. However, we need to use regional climate models as they offer the possibility of a higher resolution than general circulation models. We have ran two regional climate models (MAR and WRF) at a 10-kilometre resolution between 2006 and 2010 over Svalbard and compared their simulated climate to near surface measurements at several weather stations through the archipelago in order to determine which one of them could best represent the Svalbard climate. [less ▲]

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See detailEvaluation of the relationship between IGF-1, IGF-BP3, BMD and age in men presenting at a multiple risk detection campaign
Hanssens, L.; Tancredi, Annalisa ULg; DeCeulaer, F. et al

in Osteoporosis International (2004, May), 15(Suppl.1), 48-49

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See detailEvaluation of the relationship between IGF-I, IGF-BP3, BMD and age in men presenting at a multiple risk detection campaign
Hanssens, L.; Tancredi, Annalisa ULg; De Ceulaer, F. et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 90-91

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See detailEvaluation of the relationships between characteristics of the vertebral column of different cetaceans and their ecology: A preliminary study.
Gillet, Amandine ULg; Ninane, Catherine ULg; Remy, François ULg et al

Poster (2014, April)

Ecomorphology is the study of the relationships between functional design and the environment. One of its aims is to understand how the environmental factors can constraint the performance of an organism ... [more ▼]

Ecomorphology is the study of the relationships between functional design and the environment. One of its aims is to understand how the environmental factors can constraint the performance of an organism or act on its phenotype. Different studies have already showed in different cetaceans that the number and shape of vertebrae can reflect the stiffness of the body and consequently can impact their swimming mode. The aim of this preliminary study is to establish relationships between characteristics of the vertebral column of different cetaceans and their ecology. To this purpose, we have studied meristic and morphometric data on the vertebrae (centrum length, height and width, neural and haemal spine height and the transverse process length) of different species of mysticetes and odontocetes coming from the Aquarium-Museum of Liège and Royal Institute of Natural Sciences of Bruxelles. Preliminary results showed the distinction of three morphotypes: firstly, the active, cruising, fast swimmers with rigid body, secondly, the maneuverers, slow swimmers with flexible body and thirdly, the steady swimmers. [less ▲]

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See detailEvaluation of the residual solvent content of counterfeit tablets and capsules
Deconinck, Eric; Canfyn, Michael; Sacre, Pierre-Yves ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2013), 81-82

A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had ... [more ▼]

A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research. [less ▲]

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See detailEvaluation of the Response of Shear Critical Walls Using a Three-Parameter Kinematic Theory
Mihaylov, Boyan ULg; Hannewald, Pia; Beyer, Katrin

in The 4th International fib Congress 2014 Mumbai - Proceedings (2014, February)

This paper discusses a newly developed three-parameter kinematic theory (3PKT) for shear critical walls with the help of four wall tests. The 3PKT is used to predict the pre- and post- peak response of ... [more ▼]

This paper discusses a newly developed three-parameter kinematic theory (3PKT) for shear critical walls with the help of four wall tests. The 3PKT is used to predict the pre- and post- peak response of the test units. Comparisons are performed with finite element (FE) models and plastic hinge models in combination with a shear degradation model. It is found that the latter underestimate the displacement capacity of the walls while the former do not predict well the post-peak response. The 3PKT with only three degrees of freedom captures the complete response of the walls provided that the size of the critical loading zone (CLZ) of the wall is well predicted. [less ▲]

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See detailEvaluation of the sensitivity of the terminal deoxynucleotidyl transferase-immunogold technique on Balbani ring genes.
Thiry, Marc ULg; Daneholt, B.

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1998), 46(3), 345-51

Recently, we developed the terminal deoxynucleotidyl transferase (TdT)-immunogold technique for in situ detection of DNA molecules. In this study the potential value and the limitations of the method were ... [more ▼]

Recently, we developed the terminal deoxynucleotidyl transferase (TdT)-immunogold technique for in situ detection of DNA molecules. In this study the potential value and the limitations of the method were evaluated using the giant polytene chromosomes from Chironomus tentans salivary glands. Emphasis was put on the Balbiani rings (BRs), specialized chromosomal sites with exceptionally intense synthesis of large mRNA molecules. Immunolabeling was recorded not only over the bands and interbands of the polytene chromosomes but also over the BR structures. In the BRs, gold particles were present over segments of active transcription units, each with a central chromatin axis and a number of growing RNP products attached to the axis. One third of the transversely sectioned transcription units showed labeling in the central parts, i.e., where the unfolded chromatin axis is located, whereas the growing RNP fibers remained unlabeled. The absence of labeling of the RNP fibers is not likely to be due to lack of accessibility, because anti-RNA antibodies readily decorated the RNP fibers. The nuclear sap and cytoplasm displayed no significant label. These results clearly indicate that the TdT-immunogold technique is specific for DNA and detects not only DNA in compacted chromatin but also fully extended DNA. Its ability to efficiently label a single DNA molecule demonstrates the method's very high sensitivity. [less ▲]

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See detailEvaluation of the shedding potential of textile materials
De Wael, K.; Lepot, Laurent ULg; Lunstroot, K. et al

in Science & Justice : Journal of the Forensic Science Society (2010), 50(4), 192-194

A practical method is proposed to assess the shedding potential of textile materials. The evaluation of the sheddability is based on the use of adhesive tapes and on comparison, using three different ... [more ▼]

A practical method is proposed to assess the shedding potential of textile materials. The evaluation of the sheddability is based on the use of adhesive tapes and on comparison, using three different sheddability scales for cotton, wool and fine man-made fibres. (c) 2010 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailEvaluation of the Simple Calculated Osteoporosis Risk Estimation (Score) in a Sample of White Women from Belgium
Ben Sedrine, Wafa ULg; Devogelaer, J. P.; Kaufman, J. M. et al

in BONE (2001), 29(4), 374-80

Identifying patients at risk of developing an osteoporosis-related fracture will continue to be a challenge. The "gold standard" for osteoporosis diagnosis is bone densitometry. However, economic issues ... [more ▼]

Identifying patients at risk of developing an osteoporosis-related fracture will continue to be a challenge. The "gold standard" for osteoporosis diagnosis is bone densitometry. However, economic issues or availability of the technology may prevent its use under a mass screening scenario. A risk assessment instrument, the "simple calculated osteoporosis risk estimation" (SCORE), has been reported to appropriately identify women likely to have low (t score < or = -2 SD) bone mineral density (BMD) and who should be referred for bone densitometry. The aim of our study is to evaluate the discriminatory performance of SCORE in a random sample of postmenopausal white women from Belgium. For this purpose, we gathered medical data on 4035 consecutive patients aged > or = 45 years, either consulting spontaneously or referred for a BMD measurement to an outpatient osteoporosis center located at the University of Liege, Belgium. BMD measurements, using dual-energy X-ray absorptiometry (DXA) technology, were taken at the hip (total and neck) and lumbar spine (L2-4). At the recommended cutoff point of 6, SCORE had a sensitivity of 91.5% to detect low BMD at any of the measured sites, a specificity of 26.5%, a positive predictive value of 52.8%, and a negative predictive value of 77.7%. According to SCORE, 18% of the patients would not be recommended for densitometry. Among these, 10.9% were misclassified as they had osteoporosis (t score < or = -2.5 SD) at one or more of the sites investigated. The negative predictive errors of SCORE, when failing to detect osteoporosis, were only 1% for the total hip, 3.2% for the femoral neck, and 8.8% for the lumbar spine. We conclude that, notwithstanding the high values of sensitivity, SCORE specificity is too low to be useful as a diagnostic tool for screening patients at high risk to later develop osteoporosis. Nevertheless, from a resource allocation perspective, this instrument can be used with relative confidence to exclude patients who do not need a BMD measurement, and would therefore provide an opportunity to realize substantial cost savings in comparison to a mass screening strategy. [less ▲]

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