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See detailEvaluation of the effect of load eccentricity on pull-off strength
Moczulski, Grzegorj; Garbacz, Andrzej; Courard, Luc ULg

in Alexander, M. G.; Beushausen, H.-D.; Dehn, F. (Eds.) et al Concrete Repair, Rehabilitation and Retrofitting II (2009)

The efficiency of the composite repair system is usually evaluated through semi-destructive test: pull-off test. But some difficulties can also be induced by the eccentricity of the load application, due ... [more ▼]

The efficiency of the composite repair system is usually evaluated through semi-destructive test: pull-off test. But some difficulties can also be induced by the eccentricity of the load application, due to incorrect placement of the test device. The paper presents the results of a research project and the impact of incorrect design on tensile strength values. According to results of laboratory experiments and modelling, it can be observed that, if there is an influence of 2o and 4o angle of inclination on pull-off bond strength, it is however not statistically significant: the decrease of pull-off strength is usually no larger than 8% for 2o [less ▲]

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See detailEvaluation of the effect of two training regimes on the resumption of the ovarian activity by analysis of faecal 20 alpha-hydroxyprogesterone in trotter mares
Messina, Mariella; Prandi, Alberto; Bolelli, G. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2

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See detailAn evaluation of the effects of rural development policies in the North-East Region of Romania
Paveliuc Olariu, Codrin ULg; Ciurea, Ion Valeriu; Brezuleanu, Stejarel et al

in Advances in Agriculture & Botanics (2011), 3(1), 20-25

The European Union Common Agricultural Policy (CAP) holds as principal objectives, as they were outlined in the Treaty of Rome, the following: increase productivity, by promoting technical innovation and ... [more ▼]

The European Union Common Agricultural Policy (CAP) holds as principal objectives, as they were outlined in the Treaty of Rome, the following: increase productivity, by promoting technical innovation and ensuring optimum use of factors of production, ensure a fair standard of living for the agricultural community, stabilize agricultural markets, secure availability of agricultural supplies and provide consumers with food at reasonable prices. Over time, and depending on certain factors, new secondary objectives have been added such as: environmental protection, biodiversity, animal welfare, enhancement of rural areas. In the North-East Region of Romania, the impact of rural development policies implemented through the National Rural Development Programme (NRDP) has been assessed at regional and local level utilizing a combined analysis of statistical databases. [less ▲]

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See detailEvaluation of the efficacy and safety of etoricoxib compared with naproxen in two, 138-week randomised studies of patients with osteoarthritis
Reginster, Jean-Yves ULg; Malmstrom, K.; Mehta, A. et al

in Annals of the Rheumatic Diseases (2007), 66(7), 945-951

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year ... [more ▼]

Objectives: To assess the efficacy and safety of etoricoxib 60 mg once daily and naproxen 500 mg twice daily over a 138- week treatment period in patients with osteoarthritis ( OA). Methods: Two 1- year randomised, double blind, parallel group two- part base studies ( part I 12 weeks; part II 40 weeks), followed by an 86- week extension, in patients with OA ( hip or knee) were conducted at 80 clinical centres ( 19 countries). The studies had identical designs. Patients taking placebo in part I received etoricoxib or naproxen ( 1: 1 ratio) in part II and the extension; patients taking etoricoxib or naproxen in part I continued to receive the same treatment throughout the entire length of the studies. Co- primary efficacy end points were patient global assessment of disease status, and WOMAC questionnaire pain subscale and physical function subscale ( 100 mm VAS). Efficacy over 138 weeks was assessed by graphical analysis. Safety was assessed by observation of adverse experiences and laboratory and physical evaluations. Results: 997 patients entered ( 615 completed) the base studies. Of these patients, 463 patients entered the extensions. A total of 161 and 152 patients in the etoricoxib and naproxen groups, respectively, completed 138 treatment weeks. Etoricoxib and naproxen showed similar efficacy throughout the 138 weeks of treatment. For etoricoxib and naproxen, respectively, WOMAC pain assessments were 67 and 67 mm ( baseline); 28 and 29 mm ( 1 year), and 34 and 33 mm ( 138 weeks). Results for the other efficacy end points were similar to those seen with the WOMAC pain assessments. Both etoricoxib and naproxen were generally well tolerated. Conclusion: Both etoricoxib and naproxen demonstrated long- term clinical efficacy for the treatment of OA. Etoricoxib and naproxen were generally well tolerated. [less ▲]

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See detailEvaluation of the Efficacy and Safety of Oral Tiludronate in Paget's Disease of Bone. A Double-Blind, Multiple-Dosage, Placebo-Controlled Study
Reginster, Jean-Yves ULg; Colson, F.; Morlock, G. et al

in Arthritis & Rheumatism : Arthritis Care & Research (1992), 35(8), 967-74

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial ... [more ▼]

OBJECTIVE. To assess the optimal dosage of oral tiludronate in Paget's disease of bone. METHODS. We studied 149 patients with Paget's disease, in a double-blind, randomized, placebo-controlled trial. Patients were randomly assigned to 1 of 5 therapeutic groups: a daily dose of 100 mg, 200 mg, 400 mg, or 800 mg of oral tiludronate, or a placebo. Treatment was for 3 months, followed by 3 months of placebo-controlled followup. Serum alkaline phosphatase activity (SAP) and fasting urinary excretion of hydroxyproline/creatinine (OH/Cr) were measured monthly, as were biochemical parameters reflecting renal, hepatic, and hematologic functions. Analgesic efficacy was self-evaluated from a visual analog scale and a global pain index. RESULTS. Statistical analysis revealed that beginning at a dosage of 200 mg/day, there was a direct dose-dependent effect on the reduction of SAP and OH/Cr levels. Reduction of SAP levels was clinically significant at a dosage of 400 mg (44.9 +/- 4.2% reduction at 90 days and 49.2 +/- 4.5% at 180 days, mean +/- SEM) and at 800 mg (53.4 +/- 5% at 90 days and 59.3 +/- 4.6% at 180 days). There was a significant reduction in pain in all groups, including the group taking placebo. In only those taking 800 mg/day of tiludronate was there a significant frequency of complete resolution of pain (versus placebo). Aside from mild gastrointestinal disturbances, as experienced with other oral bisphosphonates, clinical tolerance of all 5 regimens was good. Exhaustive biochemical investigations failed to reveal significant toxicity of tiludronate up to the 800-mg daily dose investigated. CONCLUSION. Because of its significantly better antiresorptive effects and greater analgesic properties (compared with lower dosages), combined with the excellent clinical and biochemical tolerance, the 800-mg daily dose of tiludronate appears to be optimal for the treatment of Paget's disease of bone. [less ▲]

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See detailEvaluation of the endorcine disrupting chemicals contamination in the North Sea porpoise population using in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Van Der Heiden, Edwige ULg et al

Poster (2009)

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental ... [more ▼]

During the last decades, the production endocrine disrupting chemicals reached such levels that they are now spread all over nature. They are known to be very slowly degraded, decreasing the environmental quality and posing ecological risks. Marine mammals inhabiting polluted environments accumulate high levels of these chemicals, so they can be considered good indicators of marine pollution. Thirteen major organochloride pollutants were chosen to make subject of this study: o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. All these chemicals will have their endocrine disrupting effects characterized individually and collectively by report gene expression assays. The MCF7-ERE cells used in these assays were produced in the Molecular Biology and Genetic Engineering Laboratory of the University of Liège and are originated from a human mammary carcinoma. They carry a gene expressing the synthesis of luciferase and controlled by oestrogen receptors. Then, the thirteen chemicals will be searched in the blubber tissues of porpoises by the use of gas chromatography-mass spectrometry. The blubber samples will also have their endocrine disrupting effect characterized. For the moment, the estrogenic effects of the HCH isomers were put in evidence. The next steps of this work must be soon accomplished. It is expected a great level of these compounds to be found in the samples. On the other hand, their endocrine disrupting effects and how they act in agonist, antagonist and synergist ways are subject that still needs to be cleared. [less ▲]

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See detailEvaluation of the Enhanced Assumed Strain and Assumed Natural Strain in the SSH3D and RESS3 Solid Shell Elements for Single Point Incremental Forming Simulation
Guzmán Inostroza, Carlos Felipe ULg; Ben Bettaieb, Amine ULg; Velosa de Sena, José Ilidio et al

in Key Engineering Materials [=KEM] (2012), 504-506

Single Point Incremental Forming (SPIF) is a recent sheet forming process which can give a symmetrical or asymmetrical shape by using a small tool. Without the need of dies, the SPIF is capable to deal ... [more ▼]

Single Point Incremental Forming (SPIF) is a recent sheet forming process which can give a symmetrical or asymmetrical shape by using a small tool. Without the need of dies, the SPIF is capable to deal with rapid prototyping and small batch productions at low cost. Extensive research from both experimental and numerical sides has been carried out in the last years. Recent developments in the finite element simulations for sheet metal forming have allowed new modeling techniques, such as the Solid Shell elements, which combine the main features of shell hypothesis with a solid-brick element. In this article, two recently developed elements -SSH3D element [1, 2] and RESS3 element [3]- implemented in Lagamine (finite element code developed by the ArGEnCo department of the University of Liège) are explained and evaluated using the SPIF line test. To avoid locking problems, the well-known Enhanced Assumed Strain (EAS) and Assumed Natural Strain (ANS) techniques are used. The influence of the different EAS and ANS parameters are analysed comparing the predicted tool forces and the shape of a transversal cut, at the end of the process. The results show a strong influence of the EAS in the forces prediction, proving that a correct choice is fundamental for an accurate simulation of the SPIF using Solid Shell elements. [less ▲]

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See detailEvaluation of the exercise performed by horses during the country phase of a three-day events competition : a field study
Amory, Hélène ULg; Linden, Annick ULg; Art, Tatiana ULg et al

in Archives Internationales de Physiologie et de Biochimie (1991)

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See detailEvaluation of the function of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo
Kesteloot, Frédéric ULg; Lapière, Charles M; Colige, Alain ULg et al

in Acta Clinica Belgica (2004), 59(2), 120

Angiogenesis is required for development, growth, tissue remodeling, and wound healing. Pathologies such as diabetic retinopathy, rheumatoid arthritis and cancer would benefit from therapies controlling ... [more ▼]

Angiogenesis is required for development, growth, tissue remodeling, and wound healing. Pathologies such as diabetic retinopathy, rheumatoid arthritis and cancer would benefit from therapies controlling and reducing angiogenesis. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They contain however some specific features, such as a variable number of domains known as “ThromboSpondin type I repeat” (TSPI). ADAMTS-1 and -8 are 20-fold more anti-angiogenic than angiostatin and endostatin, two potent inhibitors of angiogenesis. The primary function of ADAMTS-2 is the maturation of collagen type I and II molecules by excising the amino-propeptide. In addition, ADAMTS-2 could also modulate angiogenesis, as it contains the same sequences than those responsible for the anti-angiogenic activity of ADAMTS-1 and -8. This hypothesis was investigated in vitro in different experimental models such as cell proliferation and formation of capillary structures by human endothelial cells. An ex vivo angiogenesis model was also used. It consists in mice or rat aorta pieces embedded in a collagen gel in order to allow the growth of capillaries from the vascular endothelium. As compared to control mice (TS2+/+), angiogenesis was slightly increased, in absence of ADAMTS-2, from aortas of ADAMTS-2 KO mice (TS2-/-). Using rat aortas, addition of recombinant ADAMTS-2 reduced the formation of capillary structure, also confirming the anti-angiogenic activity of ADAMTS-2. Finally, an in vivo model of angiogenesis was also used. Biocompatible sponges (Ivalon) were implanted under the skin of TS2+/+ or TS2-/- mice in order to evaluate the formation of capillaries in the granulation tissue invading the sponge. In absence of ADAMTS-2, angiogenesis and granulation tissue formation were both reduced. Additional investigations are being performed in order to identify the underlying mechanism(s) inducing these modifications. [less ▲]

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See detailEvaluation of the genetic diversity of honey bees, Apis mellifera L. in the Walloon Region and selection of strains tolerant to the mite Varroa destructor Anderson and Trueman
Leclercq, Gil ULg; Nguyen, Bach Kim ULg; Gengler, Nicolas ULg et al

Poster (2012, February 10)

For more than a decade, high losses of honey bee colonies have been noticed in several countries, including Belgium. Currently often the mite Varroa destructor is considered a main threat for beekeeping ... [more ▼]

For more than a decade, high losses of honey bee colonies have been noticed in several countries, including Belgium. Currently often the mite Varroa destructor is considered a main threat for beekeeping. In view of the inefficiency of the current chemical treatments, one of the solutions is to select honey bees tolerant to this parasite using genomic selection. To reach this objective the genetic diversity of honey bees needs first to be studied using mainly ‘Single Nucleotide Polymorphisms’ (SNP). Records and samples will be collected all over the Walloon Region in order to create an informative phenotypic and genomic data base that will be used for ‘Genome Wide Association Studies’ (GWAS) to detect associations between SNPs and tolerance, and to select bees tolerant to Varroa destructor. [less ▲]

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See detailEvaluation Of The Genetic Variability Of 23 Bovine Microsatellite Markers In Four Belgian Cattle Breeds
Peelman, Lj.; Mortiaux, F.; Van Zeveren, A. et al

in Animal Genetics (1998), 29(3),

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See detailEvaluation of the GERD Impact Scale, an international, validated patient questionnaire, in daily practice. Results of the ALEGRIA study.
Louis, Edouard ULg; Tack, Jacques ULg; Vandenhoven, G. et al

in Acta Gastro-Enterologica Belgica (2009), 72(1), 3-8

BACKGROUND AND STUDY AIMS: Gastroesophageal reflux disease (GERD) is a common chronic disease that is primarily diagnosed based on symptom severity and frequency. This study gathered epidemiological data ... [more ▼]

BACKGROUND AND STUDY AIMS: Gastroesophageal reflux disease (GERD) is a common chronic disease that is primarily diagnosed based on symptom severity and frequency. This study gathered epidemiological data in a population of GERD patients and evaluated the added-value of the GERD Impact Scale (GIS), a novel, validated patient questionnaire, as a tool for initial and long-term patient management. PATIENTS AND METHODS: This observational study recruited patients (296 study centers) with symptomatic GERD and a history of erosive, or reflux, esophagitis. Symptoms were assessed by GIS and physician-subject interview and recorded at baseline (visit 1), at 4-6 weeks (visit 2) and 8-14 weeks (visit 3); also recorded at each visit was the physician's assessment of GERD severity and treatment changes. Analyses were performed on an intent-to-treat basis. RESULTS: Subjects (n = 1919; mean age, 55 years) were 54% female. Lifestyle characteristics included stress (approximately 70% of subjects), mean daily consumption of five cups of caffeine-containing beverages (approximately 70%), alcohol consumption of approximately nine units per week (approximately 50%) and smoking/ex-smoker (41%). Proton pump inhibitors were prescribed in 99% of cases: mainly esomeprazole (82%), with a median dose of 40 mg. Prescribed therapy was changed (mainly dosage levels) between visits in approximately 60% of subjects. The severity of GERD symptoms and GIS scores decreased substantially throughout the study. Mean GIS scores correlated positively with increasing GERD severity and clinical judgment at all visits. Physicians reported that the GIS helped them define the appropriate treatment for the patient and to evaluate the patient's response to treatment in 81% of cases. CONCLUSIONS: This study demonstrates the added-value and usefulness of the patient self-assessment GIS as a management tool for GERD. [less ▲]

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See detailEvaluation of the Greenland ice sheet surface mass balance simulated by a regional climate model forced by some selected IPCC AR5/CMIP5 AOGCMs over the current climate.
Fettweis, Xavier ULg; van den Broeke, Michiel; van de Berg, Willem Jan et al

Conference (2011, April 05)

Abstract. As part of the ICE2SEA project, the regional climate model MAR was forced by the general circulation model ECHAM5 for making future projections of the Greenland Ice Sheet (GrIS) Surface Mass ... [more ▼]

Abstract. As part of the ICE2SEA project, the regional climate model MAR was forced by the general circulation model ECHAM5 for making future projections of the Greenland Ice Sheet (GrIS) Surface Mass Balance (SMB) over 1980-2099 at a resolution of 25km. For the A1B scenario, MAR projects a highly negative (-500 GT/yr) SMB rate at the end of this century and a induced mass loss corresponding to a sea level rise of ~7 cm over 2000-2100. However, the comparison with MAR forced by the ERA-40 reanalysis over 1980-1999 shows that MAR forced by the 20C3M scenario is not able to represent reliably the current SMB due to biases in the general circulation and in the free atmosphere summer temperature modeled by ECHAM5 around the GrIS. These biases induce in MAR an underestimation of the snow accumulation and an overestimation of the surface melt. Therefore, this questions the reliability of these ECHAM5-forced future projections, knowing that i) these biases could be amplified in future and that ii) the MAR outputs are used to force ice sheets models for the ICE2SEA project. That is why, by waiting the outputs from the next generation of GCMs (CMIP5), we investigate the impacts of current climate biases over the future projections and we suggest corrections of ECHAM5 forcing files for having a better agreement with the ERA-40 forced simulation. This is useful for the ice sheet model wanting to use the absolute values of MAR future projections instead of anomalies. [less ▲]

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See detailEvaluation of the group B differential agar for the detection of group B streptococci from vaginal specimens
MELIN, Pierrette ULg; Rodriguez Cuns, Grisel; Lorquet, Sophie et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 104th General Meeting of the American Society for Microbiology (2004, May)

Background Group B streptococci (GBS) are the leading cause of severe perinatal infections. Most current guidelines for the prevention of GBS perinatal disease are based on prenatal screening culture for ... [more ▼]

Background Group B streptococci (GBS) are the leading cause of severe perinatal infections. Most current guidelines for the prevention of GBS perinatal disease are based on prenatal screening culture for vaginal GBS colonisation. Use of selective and differential media could improve the sensitivity of these cultures. Objective To evaluate the GBS-Differential Agar (GBSDA) recently formulated by Becton Dickinson for the selective growth and production of orange colonies of b- hemolytic (b-H) GBS. Methods 283 vaginal swabs (VAG) collected from pregnant women were inoculated in selective Lim broth. After overnight incubation, Lim broth were subcultured on GBSDA, on Granada agar (Biomedics, Spain) and on Columbia blood agar (BA). To evaluate the stability, 99 isolates of GBS (REF) from adult or neonatal infections (Belgian GBS reference laboratory collection) were cultured on GBSDA and Granada at their limit of expiration, and on BA. GBSDA and Granada were incubated anaerobically and BA aerobically + 7% CO2, at 35°C, 24 to 48 h. Positive and negative control strains (GBS ; E. faecalis) were cultured with each run. Specific identification of colonies suggestive of GBS (pale to dark orange on GBSDA and Granada, b-H on BA) was performed. Results b-H GBS were recovered from 63 VAG (22.3 %): 62 were easily identified after overnight incubation on GBSDA and 63 on Granada without requiring any subculture. All GBS were also recovered from BA however it was after many subcultures. All orange colonies were confirmed as GBS. Among REF, 3 strains were non hemolytic ; they grew but were not differentiated as orange colonies on GBSDA or Granada. 96 REF were b-H, 94 (97.9%) produced orange to very dark orange colonies on GBSDA, 2 produced white colonies, and on Granada, 74 (77.1 %) produced pale to dark orange colonies and 22 white to white-orange colonies. Conclusion 1) GBSDA and Granada: a) very high sensitivity and specificity for the detection of b-H GBS, in a single step b) Results available within 48 h after inoculation in Lim broth, low workload 2) Excellent stability up to expiration date for GBSDA 3) Non hemolytic GBS: grown but not differentiated on GBSDA or Granada. [less ▲]

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See detailEvaluation of the homocysteine assay on the Abbott IMx
Chapelle, Jean-Paul ULg; Lutteri, Laurence ULg; Gielen, J.

in Clinical Chemistry (1999), 45(6), 134

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See detailEvaluation of the Hycel Diagnostics Diana-5 Hematology Analyzer
Boemer, François ULg; Cielniaszek, Nadine; Paulus, Jean-Michel et al

in Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology (2002), 8

The Hycel Diagnostics Diana-5, a compact 5-part differential hematology analyzer, was evaluated in the hematology laboratory of Liège University Hospital, Belgium. Within-and between-batch precision ... [more ▼]

The Hycel Diagnostics Diana-5, a compact 5-part differential hematology analyzer, was evaluated in the hematology laboratory of Liège University Hospital, Belgium. Within-and between-batch precision, linearity, and absence of carryover were all excellent. All parameters were stable for 48 hours at 4 ° C and for 8 hours at room temperature. Comparability of complete blood counts to Bayer Technicon Advia 120 measurements was highly satisfactory, with the exception of the mean cell volume, which was slightly underestimated by the Diana-5 compared to the Advia 120. Comparisons of differential leukocyte counts to 400-cell microscopic differentials were excellent for neutrophils, lymphocytes, and eosinophils and were acceptable for monocytes. The efficiency of the flagging system was high for the detection of blasts and less satisfactory for the detection of immature granulocytes and atypical lymphocytes. The instrument was reliable and easy to use. [less ▲]

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