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See detailEvaluation of the biocompatibility of DPSCs into functionalized 3D polymeric textile
Ortiz Magdaleno, Marine ULg

in Dental Materials Journal (2013)

Detailed reference viewed: 16 (3 ULg)
Peer Reviewed
See detailEvaluation of the bronchoprotective effects of inhaled salmeterol, fenoterol and oxitropium in healthy cats
Kirschvink, Nathalie; Leemans, Jérôme ULg; Delvaux, F. et al

in Fundamental & Clinical Pharmacology (2005), 19

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See detailEvaluation of the contamination of North Sea Porpoises (Phocoena phocoena) by endocrine disrupting chemicals using CG-MS and in vitro assays
Didimo Imazaki, Pedro Henrique ULg; Brose, François ULg; Remacle, Anne-Sophie ULg et al

Poster (2009)

During the last decades, the production of endocrine disrupting chemicals reached such elevated levels that they are now spread all over the environment. Endocrine disrupting chemicals are known to be ... [more ▼]

During the last decades, the production of endocrine disrupting chemicals reached such elevated levels that they are now spread all over the environment. Endocrine disrupting chemicals are known to be very slowly degraded, decreasing the environmental quality and causing ecological risks. Marine mammals inhabiting polluted environments accumulate high quantities of these chemicals, and are good indicators of marine pollution Thirteen major organochloride pollutants (known from literature to contaminate north sea porpoise) were chosen in this study – o,p’-DDD; p,p’-DDD; p,p’-DDE; o,p’-DDT; p,p’-DDT; HCB; α-HCH; β-HCH; γ-HCH; δ-HCH; PCB 138; PCB 153 and PCB 180. The thirteen chemicals were tested individually and in mixtures by the use of report gene expression assays. The MCF7-ERE cells used in the assays were originated from MCF7 human mammary tumor cells transfected with the ERE-luciferase reporter system. Preliminary results suggest that o,p’-DDD; p,p’-DDD; o,p’-DDT; HCB; β-HCH; δ-HCH; PCB 138 and PCB 180 are able to stimulate the luciferase expression of MCF7-ERE cells when they are present individually or in mixtures. No synergism was observed within mixtures. When MCF7-ERE cells were exposed to the chemicals and 17β-oestradiol simultaneously, p,p’-DDE; α-HCH; PCB 138 and PCB 180 could raise the luciferase expression in comparison to the exposition of 17β-oestradiol alone; on the other hand, o,p’-DDD; p,p’-DDT; HCB; β-HCH; γ-HCH and δ-HCH seem to inhibit the luciferase expression at low doses. In the next step, the pollutants will be searched and quantified in the blubber tissue of porpoises by use of gas chromatography-mass spectrometry. The blubber tissue samples will also have their endocrine disrupting effects characterized. This work is ongoing and It is expected a relevant level of these compounds to be found in the samples. Conversely, their endocrine disrupting effects and how they act in agonist, antagonist ways are subject that still needs to be studied. [less ▲]

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See detailAn evaluation of the contributions of the distant and near-Earth neutral lines to magnetotail reconnection rates and magnetic flux closure
Milan, Steve; Boakes, Peter; Imber, Suzanne et al

Conference (2010, May 01)

The expanding-contracting polar cap paradigm relates the dayside and nightside rates of magnetic reconnection to changes in the size of the ionospheric polar cap, the amount of magnetic flux in the ... [more ▼]

The expanding-contracting polar cap paradigm relates the dayside and nightside rates of magnetic reconnection to changes in the size of the ionospheric polar cap, the amount of magnetic flux in the magnetotail lobes, and the excitation of ionospheric and magnetospheric plasma convection. Expansions of the polar cap are the consequence of dayside reconnection, the merging of interplanetary magnetic flux with the terrestrial dipole to increase the proportion of the dipole that is open. Contractions of the polar cap are caused by magnetic reconnection in the magnetotail at a distant neutral (or X-) line (DXL) and near-Earth neutral line (NEXL), the latter especially during substorms, to reduce the open flux in the magnetosphere. There is debate surrounding the proportion of flux closure provided by the DXL and NEXL, and hence whether substorms dominate the nightside contribution to ionospheric and magnetospheric convection. This study utilizes a 7-day interval of auroral observations from the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) satellite and convection measurements by the Super Dual Auroral Radar Network (SuperDARN) to quantify the nightside rates of reconnection during substorm and non-substorm periods and hence investigate DXL and NEXL flux closure. [less ▲]

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See detailEvaluation of the correlation between "in vitro" and "in vivo" release of sulfamethazine from a long-acting ovine bolus
Evrard, Brigitte ULg; Delattre, Luc ULg

in Proceedingsof 1st World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (1995)

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See detailEvaluation of the Crack Propagation in an overlay subjected to both traffic and thermal effects
Rigo, Jean-Marie ULg; Courard, Luc ULg; Cescotto, Serge ULg et al

in Rigo, Jean-Marie; Degeimbre, Robert; Franken, Louis (Eds.) Reflective cracking in Pavements - State of ARt and Design Recommendations (1993)

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See detailEvaluation of the cranial rectus abdominus muscle pedicle flap as a blood supply for the caudal superficial epigastric skin flaps in dogs.
Degner, Daniel; Walshaw, Richard; Arnoczky, Steven et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1996), 25

Detailed reference viewed: 18 (4 ULg)
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See detailEvaluation of the cross-reactivity of 25-hydroxyvitamin D2 on seven commercial immunoassays on native samples
LE GOFF, Caroline ULg; PEETERS, Stéphanie ULg; CRINE, Yannick ULg et al

in Clinical Chemistry & Laboratory Medicine (2012), 50(11), 2031-2

Detailed reference viewed: 38 (14 ULg)
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See detailEvaluation of the cytotoxicity of cyclodextrins on endothelial cells using MTT assay
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

Poster (2007, April)

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See detailEvaluation of the cytotoxicity of organic dust components on thp1 monocytes-derived-macrophages using high content analysis
Ramery, Eve ULg; O'Brien, Peter James

in Environmental Toxicology (2012)

Organic dust contains pathogen-associated molecular patterns (PAMPs) which can induce significant airway diseases following chronic exposure. Mononuclear phagocytes are key protecting cells of the ... [more ▼]

Organic dust contains pathogen-associated molecular patterns (PAMPs) which can induce significant airway diseases following chronic exposure. Mononuclear phagocytes are key protecting cells of the respiratory tract. Several studies have investigated the effects of PAMPs and mainly endotoxins, on cytokine production. However the sub-lethal cytotoxicity of organic dust components on macrophages has not been tested yet. The novel technology of high content analysis (HCA) is already used to assess subclinical drug-induced toxicity. It combines the capabilities of flow cytometry, intracellular fluorescence probes, and image analysis and enables rapid multiple analyses in large numbers of samples. In the present study, HCA was used to investigate the cytotoxicity of the 3 major PAMPs contained in organic dust, ie. endotoxin (LPS), peptidoglycan (PGN) and β-glucans (zymosan) on THP-1 monocyte-derived macrophages. LPS was used at concentrations of 0.005, 0.01, 0.02, 0.05, 0.1 and 1 μg/ml; PGN and zymosan were used at concentrations of 1, 5, 10, 50, 100 and 500 μg/ml. Cells were exposed to PAMPs for 24 h. In addition, the oxidative burst and the phagocytic capabilities of the cells were tested. An overlap between PGN intrinsic fluorescence and red/far-red fluorescent dyes occurred, rendering the evaluation of some parameters impossible for PGN. LPS induced sub-lethal cytotoxicity at the lowest dose (from 50 ng/ml). However, the greatest cytotoxic changes occurred with zymosan. In addition, zymosan, but not LPS, induced phagosome maturation and oxidative burst. Given the fact that β-glucans can be up to 100-fold more concentrated in organic dust than LPS, these results suggest that β-glucans could play a major role in macrophage impairment following heavy dust exposure and will merit further investigation in the near future. [less ▲]

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See detailEvaluation of the DR-CALUX screening of food and feed, according to regulation levels including DL-PCB
Scippo, Marie-Louise ULg; Rybertt, Soledad; Focant, Jean-François ULg et al

in Organohalogen compounds (2005), 67

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See detailEvaluation of the DR-CALUX screening of food and feed, according to regulation levels including DL-PCB
Scippo, Marie-Louise ULg; Rybertt, Maria Soledad; Focant, Jean-François ULg et al

in Organohalogen Compounds (2005), 67

Detailed reference viewed: 18 (0 ULg)
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See detailEvaluation of the dynamic adsorption of gas on active carbon beds using in situ X-ray µ-tomography coupled with 3D image analysis
Almazan, Maria del Carmen; Léonard, Angélique ULg; Lodewyckx, Peter et al

Poster (2009, June)

Detailed reference viewed: 44 (9 ULg)