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See detailEl doble juego de una vida y de una obra. Jorge Semprun y la literatura comprometida
Denis, Benoît ULg

in Pla, Xavier (Ed.) Jorge Semprun o les espirales de la memoria (2010)

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See detailDobutamine cardiac stress testing in conscious healthy dogs
Mc Entee, Kathleen ULg; Amory, Hélène ULg; Pypendop, B. et al

in 6th ESVIM Meeting - Velhoven - Septembre 1996 (1996, September)

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See detailDobutamine Stress Echocardiography Versus Quantitative Technetium-99m Sestamibi Spect for Detecting Residual Stenosis and Multivessel Disease after Myocardial Infarction
LANCELLOTTI, Patrizio ULg; Benoit, T.; Rigo, Pierre ULg et al

in Heart (2001), 86(5), 510-5

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting ... [more ▼]

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN: Prospective study. SETTING: University hospital. METHODS: 75 patients underwent simultaneous DSE and mibi SPECT at (mean (SD)) 5 (2) days after a first acute myocardial infarct. Quantitative coronary angiography was performed in all patients after imaging studies. RESULTS: Significant stenosis (> 50%) of the infarct related artery was detected in 69 patients. Residual ischaemia was identified by DSE in 55 patients and by quantitative mibi SPECT in 49. The sensitivity of DSE and mibi SPECT for detecting significant infarct related artery stenosis was 78% and 70%, respectively, with a specificity of 83% for both tests. The combination of DSE and mibi SPECT did not change the specificity (83%) but increased the sensitivity to 94%. Mibi SPECT was more sensitive than DSE for detecting mild stenosis (73% v 9%; p = 0.008). The sensitivity of DSE for detecting moderate or severe stenosis was greater than mibi SPECT (97% v 74%; p = 0.007). Wall motion abnormalities with DSE and transient perfusion defects with mibi SPECT outside the infarction zone were sensitive (80% v 67%; NS) and highly specific (95% v 93%; NS) for multivessel disease. CONCLUSIONS: DSE and mibi SPECT have equivalent accuracy for detecting residual infarct related artery stenosis of >/= 50% and multivessel disease early after acute myocardial infarction. DSE is more predictive of moderate or severe infarct related artery stenosis. Combined imaging only improves the detection of mild stenosis. [less ▲]

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See detailDobutamine stress testing in a canine model of progressive heart failure by rapid ventricular pacing: preliminary results
Mc Entee, Kathleen ULg; Clercx, Cécile ULg; Balligand, Marc ULg et al

in 8th ESVIM Meeting - Vienne - Autriche - septembre 1998 (1998, September)

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See detailDoc'Data: mesure de la persévérance au doctorat à l'Université de Liège
Aerts, Stéphanie ULg; Haesbroeck, Gentiane ULg; Schyns, Michael ULg

Report (2015)

Le Conseil du Doctorat a parmi ses missions celle d’accompagner les doctorants dans leur parcours et de mettre en place des actions en vue de favoriser la réussite. Cependant, pour réellement mesurer ... [more ▼]

Le Conseil du Doctorat a parmi ses missions celle d’accompagner les doctorants dans leur parcours et de mettre en place des actions en vue de favoriser la réussite. Cependant, pour réellement mesurer l’impact des actions mises en oeuvre dans cette optique, il faut d’abord pouvoir quantifier le taux de réussite. Or, mesurer le taux de réussite dans les études de 3ème cycle n’est pas une démarche évidente. De nombreux raccourcis de raisonnement sont tentants mais mènent à des résultats très variables et incorrects. Le but de ce document est de présenter les difficultés inhérentes au calcul d’un taux de réussite et de proposer quelques procédures appropriées. Dans un premier temps, les chances (ou, d’un point de vue plus formel, les probabilités) de réussite et d'abandon des doctorants sont modélisées en fonction du nombre d’années d’inscription et en tenant compte de caractéristiques du doctorant comme son genre, sa nationalité, son âge au moment de l’inscription, son statut professionnel... L'analyse descriptive et exploratoire est ensuite confirmée par l’application d’une analyse de survie avec risques compétitifs. [less ▲]

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See detailA docetaxel-induced rash on a radiotherapy port.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in American Journal of Clinical Dermatology (2010), 11(5), 367-9

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See detailDocimologie critique : des difficultés de noter des copies et d'attribuer des notes aux élèves
Leclercq, Dieudonné ULg; Nicaise, J.; Demeuse, Marc ULg

in Demeuse, Marc (Ed.) Introduction aux théories et aux méthodes de la mesure en sciences psychologiques et en sciences de l'éducation : 2e candidature en Sciences psychologiques et de l'Education, 1ère licence en Sciences de l'Education (Passerelle) (2004)

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULg; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailDocteur
Poskin, Antoine ULg

Doctoral thesis (2016)

During summer 2011, cattle presented severe hyperthermia combined with dropped milk yield and diarrhoea from unknown origin. In October 2011, blood was collected from cattle presenting these clinical ... [more ▼]

During summer 2011, cattle presented severe hyperthermia combined with dropped milk yield and diarrhoea from unknown origin. In October 2011, blood was collected from cattle presenting these clinical signs in Schmallenberg, a small city in West Germany. A new Orthobunyavirus, responsible for these unspecific clinical signs was identified and named Schmallenberg virus (SBV). Upon November 2011, an epizootic outbreak of abortion, stillbirths and malformed new-born was observed in bovine, ovine and caprine herds in Europe due to transplacental transmission of SBV to the foetus. The SBV vectors are small hematophagous midges of the gender Culicoides. This work contributed to estimate the impact of the SBV epidemic in Belgium (Study 1). On the basis of farmer’s observations, between 0.5% and 4% of calves were aborted, stillborn or malformed due to SBV in 2011-2012. Abortions and stillbirths were not clear consequences of the SBV outbreak in cattle. In sheep, between 11% and 19% of lambs were aborted, stillborn or malformed due to SBV in 2011-2012. Deformed animal was the most important finding of SBV outbreak at herd level and an essential condition for the farmer to send suspected samples to the National Reference Laboratory (NRL) for SBV analysis. The results gathered from the study indicate that SBV surveillance and monitoring should be implemented by SBV RNA detection with rRT-PCR in organs collected from stillborn and deformed calves and lambs born in big herds. The high impact of SBV highlighted in the Study 1 was putatively explained by unknown host supporting the SBV activity. In this respect, the role of pigs had never been evaluated. This was essential considering the suggested role of the domestic pigs in the life- cycle of the SBV-closely related Akabane virus (AKAV) (Huang et al., 2003). The absence of RNAemia after experimental infection of piglets with SBV realized in the Study 2 of the i thesis suggests the absence of obvious role of domestic pigs in SBV life-cycle. The absence of RNAemia is indeed a strong indication that further spread of SBV from the pigs to the Culicoides during a blood meal of the vector is not likely to occur, therefore making impossible an SBV transmission. The limited and temporary seroconversion observed after SBV inoculation in only half of the inoculated piglets and the absence of seroconversion reported in a limited number of field collected samples support this consideration. To prevent SBV progression, it was crucial to further study the pathogenesis of SBV. The Study 1 proved that the most important clinical impact of SBV was the consequence of the malformed new-born; hereto it was particularly crucial to improve the knowledge on the development of the SBV-related teratogenic effects. In this respect, experimental infection of pregnant sheep with SBV constituted an appropriate research approach. An experimental model was therefore essential to standardize. This thesis contributed to the standardization of in vivo experiments (in collaboration with another working group) by determining the minimum infectious dose of an SBV infectious inoculum. This reference infectious serum must contain approximately 20 TCID50 to induce a homogeneous effective infection in sheep. This dose is rather low and could be inoculated by a single Culicoides under natural conditions. Beyond this minimum infectious dose, no dose dependent effect was observed in productively inoculated ewes, either in the duration of the RNAemia, the quantity of SBV RNA detected by rRT–PCR in the blood, or in the number of SBV RNA copies present in the organs collected at necropsy. The experimental model developed (partly) in the Study 3 was used to inoculate pregnant ewes at day 45 and 60 of gestation, and increase the knowledge on SBV transplacental transmission. The inoculation induced the persistence of SBV RNA in placental organs until birth. Schmallenberg virus RNA was recovered from the organs collected at birth from the lambs of both groups. However, the chance to obtain SBV RNA positive placental ii organs was significantly higher when the infectious inoculum was inoculated at day 60 of gestation. Positive organs in lambs included CNS and muscle, but no malformation was observed in new-born lambs. This absence of malformations suggests that SBV inoculation must occur earlier than the day 45 of gestation to produce teratogenic effects in sheep. Also, the persistence of SBV RNA in the foetal envelope is indicative of a putative mean for SBV overwintering. The Study 4 highlighted a 6 month persistent seroconversion in the absence of SBV surinfection. In the meantime, SBV circulation drastically dropped on the field and the absence of SBV circulation could induce the sheep to become seronegative under natural conditions. In the Study 5, the experimental model developed in the Study 3 was used to demonstrate that one single SBV inoculation can induce a protective immunity in sheep that persists during a minimum period of 15 months. This experiment highlights that 2 successive periods of SBV circulation, spared of one year, is not likely to induce malformations on the field the second year. Based on the experience gathered with the closely related AKAV, recurrent outbreaks of congenital events can be expected for a long period. Vaccination of seronegative animals could be used to prevent the deleterious effects of SBV in case of SBV re-emergence. During this epidemic, different surveillance approaches including syndromic surveillance, sentinel herd surveillance, cross-sectional seroprevalence studies and pathogen surveillance in vectors have proven their utility and complementarity and should be considered to continue in the future in order to monitor the SBV dynamic. [less ▲]

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See detailDocteur en Médecine, Chirurgie et Accouchements
LANCELLOTTI, Patrizio ULg

Master of advanced studies dissertation (1995)

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See detailLe doctorat : une formation à la recherche par la recherche
Halleux, Isabelle ULg

Learning material (2014)

Texte de référence pour l'explication de l'organisation de la formation doctorale en Communauté française de Belgique

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See detailDoctors, Nurses and Patients 2.0: Myth or Reality?
Slomian, Cynthia ULg

Conference (2015, April 21)

This communication aims at drawing the general context underlying the Belgian health care sector and to address the key issues of the computerization of the patient health records. Two case studies are ... [more ▼]

This communication aims at drawing the general context underlying the Belgian health care sector and to address the key issues of the computerization of the patient health records. Two case studies are presented: the introduction of a nursing health record within a hospital and the computerization of the general practitioner's record. Finally, the discussion focuses on the medical knowledge in general, using the embodied, inscribed, enacted phenomenology developed by Richard Freeman and Steven Sturdy. [less ▲]

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See detailLa doctrine kantienne du temps et la musique
Seba, Jean-Renaud ULg

Scientific conference (2007, April 13)

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See detailDoctrines militaires et sécuritaires: une organisation défaillante
Vinatier, Laurent; Bachkatov, Nina ULg; Casini, Silvio et al

in Vinatier, Laurent (Ed.) La Russie, de Poutine à Medvedev (2008)

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See detailLe document d'histoire de l'art en classe d'histoire : trahison ou contribution à la formation esthétique des élèves ?
Jadoulle, Jean-Louis ULg

in E. CRAMER, M.-E. RICKER et P. SOUVERYNS (Ed.) Didactiques de l'histoire de l'art et de l'histoire : divergences, convergences et complémentarités (2006)

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See detailLe document et le sens. Pour une poétique de l'histoire
Havelange, Carl ULg

in Havelange, Carl; Henneau, Marie-Elisabeth (Eds.) Temps, cultures, religions. Autour de Jean-Pierre Massaut (2004)

Detailed reference viewed: 31 (8 ULg)