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See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2016), 18(11), 1609-1678

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See detail2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, Alberico L.; Graham, Ian; De Backer, Guy et al

in European Heart Journal (2016)

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See detail2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, Massimo F.; Hoes, Arno W.; Agewall, Stefan et al

in European Heart Journal (2016)

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See detail2016-2017 Notice pédagogique atelier Bac 1
Bianchi, Michaël ULg; Wang, Antoine ULg; Serrão, Margarida ULg et al

Learning material (2016)

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See detail214 Fractal Structure in Volumetric Contrast Enhancement of Malignant Gliomas Correlates With Oxidative Metabolic Pathway Gene Expression.
Miller, Kai; Berendsen, Sharon; Seute, Tatjana et al

in Neurosurgery (2016), 63 Suppl 1

INTRODUCTION: Fractal structure is found throughout many processes in nature, and often arises from sets of simple rules. We examined the contrast enhancement pattern in glioblastoma brain tumor MRIs for ... [more ▼]

INTRODUCTION: Fractal structure is found throughout many processes in nature, and often arises from sets of simple rules. We examined the contrast enhancement pattern in glioblastoma brain tumor MRIs for evidence of fractal structure, which might then be compared with expression of specific gene sets obtained from surgical specimens of each tumor. METHODS: Volumetric T1 postcontrast imaging was obtained in 39 patients prior to surgical resection of pathology-confirmed glioblastoma lesions. For each tumor, we calculated the fractal dimension (Minkowski Bouligand dimension) using a box-counting (cubic scaling) approach. RNA expression microarray data from resected tissue were explored by gene set enrichment analysis (GSEA). RESULTS: We found robust evidence for fractal structure in the contrast enhancement pattern, with an average fractal dimension of 2.17 +/- 0.10, with a visually apparent split at 2.10. GSEA analysis showed a definitive association between this split in fractal dimension and 6 gene sets (of 4080), all 6 of which are linked to mitochondrial respiration/ATP production pathways. CONCLUSION: There is fractal structure in the volumetric enhancement pattern of glioblastoma tumors, with dimension approximately 2.15. Variation in this fractal dimension, and therefore the complexity of contrast enhancement it reflects, is specifically associated with genetic correlates of a shift to glycolytic metabolism in tumor cells. Drugs that shift glioblastoma to oxidative metabolism have recently been identified as independent therapeutic agents as well as sensitizing agents for irradiation. Therefore, a radiogenomic marker of glucose metabolism, such as this fractal structure in enhancement, might help to guide individualized therapy. [less ▲]

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See detail21st century Antarctic surface mass balance downscaling from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Poster (2011, October)

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See detail21st century high-resolution downscaling of the Antarctic surface mass balance from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Conference (2011, April)

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present ... [more ▼]

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present accumulation and predicted change are largest at the ice sheet margins because they are driven by snowfall, which mostly comes from warm, moist air arising over the land slopes. The coastal belt is also where complex processes of sublimation, melt and redistribution by the wind occur. Thus, high-resolution modelling (5 to 10 km) is necessary to adequately capture the effects of small-scale variations in topography on the atmospheric variables in this area, but limitations in computing resources prevent such resolution at the scale of Antarctica in full climate models. We present here a downscaling method leading to 10-km SMB resolution for century time-scales over Antarctica. We compute the effect of the fine topography on orographic precipitation and on boundary layer processes that lead to melt and sublimation. We show that the accumulation downscaled from ERA-Interim is in good agreement with field measurements for the last 40 years. We then display the SMB downscaled from LMDZ4 AGCM outputs (~60-km resolution), and show that the downscaling improves the agreement between present modelled and observed SMB. Finally, we present hi-resolution features of the Antarctic SMB evolution during the 21st century downscaled from LMDZ4 and discuss the effect of the resolution on the Antarctic SMB contribution to sea level change. The downscaling model is a powerful tool that will be applied to others climate models for a better assessment of future sea level rise. [less ▲]

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See detail21st century projections of surface mass balance changes for major drainage systems of the Greenland ice sheet
Tedesco, M.; Fettweis, Xavier ULg

in Environmental Research Letters (2012), 7

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins ... [more ▼]

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins of the Greenland ice sheet (GrIS). The regional model is forced with the outputs of three different Earth System Models (CanESM2, NorESM1 and MIROC5) obtained when considering two greenhouse gas future scenarios with levels of CO2 equivalent of, respectively, 850 and >1370 ppm by 2100. Results indicate that the increase in runoff due to warming will exceed the increased precipitation deriving from the increase in evaporation for all basins, with the amount of net loss of mass at the surface varying spatially. Basins along the southwest and north coast are projected to have the highest sensitivity of SMB to increasing temperatures. For these basins, the global temperature anomaly corresponding to a decrease of the SMB below the 1980–99 average (when the ice sheet was near the equilibrium) ranges between +0.60 and +2.16 °C. For the basins along the northwest and northeast, these values range between +1.50 and +3.40 °C. Our results are conservative as they do not account for ice dynamics and changes in the ice sheet topography. [less ▲]

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See detail22nd Annual Conference of the Multinational Finance Society
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Conference (2015)

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See detailThe 24-h recall instrument for home nursing to measure the activity profile of home nurses:development and psychometric testing
De Vliegher, Kristel; Aaertgeerts, Bert; Declercq, Anja et al

in Primary Health Care Research & Development (2014)

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See detail24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J.; Scheen, André ULg; Leproult, R. et al

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

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See detailA 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density: Results From the ADAMO Trial.
Langdahl, Bente L.; Teglbjaerg, Christence S.; Ho, Pei-Ran et al

in The Journal of clinical endocrinology and metabolism (2015), 100(4), 1335-1342

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men ... [more ▼]

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men with low BMD. Design: Phase 3 study with two treatment periods: a previously reported 12-month double-blind, placebo-controlled phase and a 12-month open-label phase. Setting: Multicenter in North America and Europe. Participants: 228 men entered the open-label phase and 219 completed the study. Intervention: Men from the original denosumab (long-term) and placebo (crossover) groups received denosumab 60 mg SC every 6 months. Main Outcome Measures: BMD, serum C-telopeptide (sCTX), and safety. Results: During the open-label phase, continued BMD increases occurred with long-term denosumab treatment (2.2% lumbar spine; 0.9% total hip; 1.3% femoral neck; 1.3% trochanter; and 0.2% 1/3 radius), resulting in cumulative 24-month gains from baseline of 8.0%, 3.4%, 3.4%, 4.6%, and 0.7%, respectively (all P<0.01). The crossover group showed BMD gains after 12 months of denosumab treatment similar to the long-term denosumab group during the first treatment year. Significant reductions in sCTX were observed following denosumab administration. Adverse events rates were similar between groups and no new safety signals identified. Conclusions: In men with low BMD, denosumab treatment for a second year continued to increase BMD, maintained reductions in bone resorption, and was well tolerated. BMD increased in men initiating denosumab during the second year. These effects were similar to those previously seen in postmenopausal women with osteoporosis and men with prostate cancer on androgen deprivation therapy. [less ▲]

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See detailThe 24th Chapter of the Tattvasamgraha : Refutation of the Mîmâmsâ Doctrine of Vedapaurusheyatva
Verpoorten, Jean-Marie ULg

in Dwivedi, R.C. (Ed.) Studies in Mîmâmsâ.Dr.Mandan Mishra Felicitation Volume (1994)

Ce chapitre de 725 strophes a été écrit par Śāntarakṣita (725-783 de n.è.) et commenté par son élève Kamalaśīla (740-795 de n.è.). Il traite d’un topos de la pensée indienne : l’éternité et ... [more ▼]

Ce chapitre de 725 strophes a été écrit par Śāntarakṣita (725-783 de n.è.) et commenté par son élève Kamalaśīla (740-795 de n.è.). Il traite d’un topos de la pensée indienne : l’éternité et l’infaillibilité du Veda. Cette double thèse est défendue par le mīmāṃsaka contre le bouddhiste dans les śloka’s 2084-2131, portion qui emprunte de nombreux versets au Ślokavārttika de Kumārila. Le présent article suit le débat en précisant les références à Kumārila. Les sujets traités sont : -la nature du son, son éternité et son contact avec l’oreille, -l’apauruṣeyatā du Veda, càd l’absence de tout auteur, humain ou divin, à cette œuvre -le rejet de ce postulat par le bouddhiste qui tient le Veda comme une œuvre humaine et donc faillible. L’autorité morale du Veda découle des ex)plications de ses exégètes humains, comme Manu, Vyāsa -même débat à propos des injonctions fondatrices du rituel védique, par ex. « que celui qui désire le ciel sacrifie » -débat sur la nature du mot. Contrairement à ce que prétend la Mīmāṃsā, ni le mot, ni les lettres ne sont permanents sous peine de ne plus pouvoir exprimer la diversité de la condition humaine et de rendre toute erreur impossible -la connexion mot-chose, selon le bouddhisme, n’est pas innée mais conventionnelle. Même les mots-clès de la Mīmāṃsā (comme ‘ciel’, ‘sacrifice’) sont arbitraires . -la phrase n’est pas non plus éternelle. Tous ces débats qui peuvent apparaître excentriques, reflètent l’antagonisme entre la vision instantanéiste de la réalité typique du bouddhisme et la primauté de la permanence défendue par l’orthodoxie brahmanique. [less ▲]

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See detail25 Years ago - Yannick Bruynoghe
Sacré, Robert ULg

in Soul Bag (1983), (94), 27-28

Interview de Yannick Bruynoghe + photo

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